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Venom from Chilean tarantula may prevent potentially deadly arrythmias, UB research shows
A specific protein isolated from the venom of a Chilean tarantula by University at Buffalo biophysicists shows promise as the basis for new drugs for preventing atrial fibrillation, the chaotic beating of the heart that is a major cause of death following a heart attack. (2001-01-18)

Cleveland Clinic Laboratories to provide testing and diagnostic services to ACL Laboratories
Cleveland Clinic Laboratories will now be the main provider of specialized testing and diagnostics services for ACL Laboratories, one of the largest hospital system laboratories in the United States. (2013-07-10)

Personalized medicine in warfarin therapy
Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. The related report by Yang et al., (2010-02-25)

New mouse model of ALS more closely mimics human disease
For decades, scientists have used animal models to understand what causes ALS and to test therapies to treat it. But the model has had a serious limitation. Now researchers think they've fixed this problem. (2016-11-07)

Stanford study reveals protein's Jekyll-and-Hyde role in cancer growth
The protein menin appears to have a split personality. Though menin is well-known for its ability to suppress endocrine tumors, researchers at Stanford University School of Medicine have discovered that it is also a key player in the development of some forms of acute leukemia. (2005-10-20)

UI researchers discover that aggressive cancer cells may make their own blood vessels
Until now, researchers assumed that tumors attracted blood vessels to provide tumors with nutrition and pathways for tumor cells to spread throughout the body. However, a University of Iowa study shows that highly aggressive cancer cells themselves may generate their own vascular networks independent of angiogenesis. (1999-08-30)

New study lays groundwork for potential new anti-cancer therapy
Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies. Researchers have found evidence supporting a lymphatic endothelium origin for angiomyolipoma (AML) and lymphangioleiomyomatosis (LAM), two related tumors with previously unknown cellular origins. Furthermore, the newly identified lymphatic endothelial lineage shows translational potential for pharmaceutical treatment. Their findings are published in The American Journal of Pathology. (2016-06-08)

Protein targeted to stop melanoma tumor growth
Halting the growth of melanoma tumors by targeting the MIC-1 protein that promotes blood vessel development in tumors may lead to better treatment of this invasive and deadly cancer, according to Penn State College of Medicine researchers in the Foreman Foundation Research Laboratory. (2010-12-09)

Researchers examine bacterial rice diseases, search for genetic solutions
Some types of rice are naturally resistant to the Xanthomonas bacteria. In those varieties a research team is exposing the plants to the two bacteria. They then check to see which plant genes are activated, and to what extent. (2009-04-01)

Gut environment could reduce severity of malaria
Microorganisms in the gut could play a role in reducing the severity of malaria, according to a new study co-authored by researchers at the University of Tennessee, Knoxville, and the University of Louisville. (2016-02-08)

Changes in benign tissue next to prostate tumors may predict biomedical recurrence
Changes in benign tissues next to prostate tumors may provide an early warning for patients at higher risk for biochemical recurrence after a radical prostatectomy, a study by researchers at Case Western Reserve University and Johns Hopkins Medical Institutions shows. If the preliminary findings are confirmed, the scientists recommend combining the benign-field features with tumor features extracted from patient's pathology images and Gleason scoring, to further improve the prediction of recurrence. (2016-07-06)

Speakers announced for 2017 Experimental Biology meeting
World-renowned scientists will present pioneering research and discuss key issues affecting the life sciences at the 2017 Experimental Biology meeting (EB 2017), the premier annual meeting of six scientific societies in Chicago to be held April 22-26. (2017-02-16)

Penn professor to present research on radiation-induced cancer on 20th anniversary of Chernobyl
Virginia A. LiVolsi, MD, Professor of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, will be a key presenter at the (2006-04-12)

PD-like sleep and motor problems observed in α-synuclein mutant mice
In the quest for an animal model of Parkinson's disease that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein. By studying a strain of mice bred to overexpress α-synuclein via the Thy-1 promoter, scientists have found these mice develop many of the age-related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety. Their results are published in the latest issue of Journal of Parkinson's Disease. (2013-06-07)

Using game theory to understand the physics of cancer propagation
In search of a different perspective on the physics of cancer, Princeton University and University of California, San Francisco researchers teamed up to use game theory to look for simplicity within the complexity of the dynamics of cooperator and cheater cells under metabolic stress conditions and high spatial heterogeneity. (2012-03-27)

Beth Israel Deaconess Medical Center's Harold F. Dvorak, M.D., wins Gairdner Award
Harold F. Dvorak, M.D., receives the 2014 Canada Gairdner Award for landmark discovery of VPF, a key player in blood vessel formation, which forms the basis for the field of angiogenesis. (2014-03-28)

UAB will carry out an in-depth study of the effects olive oil has on the prevention of breast cancer
Ana Ripoll, rector of Universitat Autònoma de Barcelona, and Pedro Barato, president of Organización Interprofesional del Aceite de Oliva Español, signed a research agreement to carry out an in-depth study on how the intake of olive oil can work towards preventing and fighting against breast cancer. The Multidisciplinary Group on Breast Cancer Research, directed by Dr. Eduard Escrich, lecturer of the department of cell biology, physiology and immunology, will be working on this research project. (2009-12-22)

Some 500 scientists have created a Top 10 list of plant-damaging fungi
Almost 500 international experts have worked together to develop a ranking system of the 10 most important phytopathogenic fungi on a scientific and economic level. The rice blast fungus (Magnaporthe oryzae) sits at the top of the list. (2012-10-18)

Influenza: Insights into cell specificity of human vs. avian viruses
Researchers have identified which sites and cell types within the respiratory tract are targeted by human vs. avian influenza viruses, providing valuable insights into the pathogenesis of these divergent diseases. The report by van Riel et al, (2007-10-09)

Stem cells put to the test in UNC studies
More than 3,000 scientific reports are being presented at the American Society of Cell Biology's annual meeting, Dec. 13-18, and one is a landmark study demonstrating - for the first time - that genetically altered adult liver stem cells cloned from a male rat can turn into functional adult bone marrow cells in female mice. The accomplishment, known as hematopoietic transdifferentiation, may prove useful for tapping the potential for tissue repair using human adult stem cells. (2002-12-18)

Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
A detailed analysis of the epigenetics -- factors controlling when and in what tissues genes are expressed -- of Wilms tumor reveals striking similarities to stem cells normally found in fetal kidneys. These findings by Massachusetts General Hospital Cancer Center researchers have revealed new cellular pathways that are critical for Wilms tumor development and may also apply to other pediatric cancers. (2010-06-03)

Individuals with Alzheimer's disease may lose muscle mass
Lean mass -- the weight of an individual's bones, muscles and organs without body fat -- appears to decline among patients with Alzheimer's disease, according to a report in the April issue of Archives of Neurology, one of the JAMA/Archives journals. These decreases may be associated with declines in brain volume and function. (2010-04-12)

Protein complex plays role in suppressing pancreatic tumors, Stanford study shows
A well-known protein complex responsible for controlling how DNA is expressed plays a previously unsuspected role in preventing pancreatic cancer, according to researchers at the Stanford University School of Medicine. (2012-01-09)

UC Davis researchers discover new link between C-reactive protein, and heart disease and stroke
The cells that line the arteries are able to produce C-reactive protein, according to a study funded by the National Institutes of Health and published in the April issue of American Journal of Pathology. (2005-03-16)

Boston University School of Medicine awarded grants to improve early detection of lung cancer
Researchers from Boston University School of Medicine have been awarded a five-year, $2 million grant from the National Cancer Institute Early Detection Research Network, as well as a four-year, $1.3 million grant from the Department of Defense. These grants will allow the scientists to develop novel and complementary procedures for early detection of lung cancer in high-risk patients. (2010-12-14)

Study: Mediterranean diet deters overeating
Eat as much as you want and not gain weight? Sounds too good to be true. But in a study published in the April 23 issue of the journal Obesity, scientists at Wake Forest School of Medicine found that nonhuman primates on a Mediterranean diet chose not to eat all the food available to them and maintained a normal weight. (2019-04-23)

Researchers identify liver cancer progenitor cells before tumors become visible
For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma (HCC) tumors -- the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent. (2013-10-10)

Uniquely human gene may drive numerous cancers
A new study published in FASEB BioAdvances reveals a human-specific connection between advanced carcinomas and a gene called SIGLEC12. (2020-12-09)

Eat Your Heart Out 2012: Queen Mary to host anatomy-themed baking festival
Talented bakers and medical experts are joining forces for a disease and anatomy-themed cake festival this autumn at Queen Mary, University of London's Pathology Museum. (2012-09-18)

Century-old brains may hold future of treatment for mentally ill, Indiana University pathologist says
George Sandusky, D.V.M., Ph.D., senior research professor of pathology and laboratory science at the Indiana University School of Medicine, is working to extract DNA from brains preserved more than 100 years ago. The goal is to improve diagnosis and treatment for psychological illnesses such as bipolar disorder, schizophrenia and post-traumatic stress disorder using a simple blood test. (2011-12-06)

CSHL-led team introduces new method to closely model diseases caused by splicing defects
Researchers have developed a new way of making animal models for a broad class of human genetic diseases -- those with pathology caused by errors in the splicing of RNA messages copied from genes. The new modeling approach can provide unique insights into how certain diseases progress and is likely to boost efforts to develop novel treatments. It was tested successfully in mouse analogs of human spinal muscular atrophy. (2012-08-14)

A few drinks a day do no harm to the alcoholic heart
For alcoholics who suffer from alcohol-related heart failure, cutting back to a few drinks a day does not cause any further damage. Researchers measured the heart-pumping efficiency of a group of men who were alcoholics and were suffering from heart failure. They found that those who abstained from alcohol over a year had significant improvement in heart function. Surprisingly, those who drank moderately, from one to four drinks a day, also similarly improved. (2002-02-05)

Scientists identify new longevity genes
Scientists at the University of Washington and other institutions have identified 25 genes regulating lifespan in two organisms separated by about 1.5 billion years in evolutionary change. At least 15 of those genes have very similar versions in humans, suggesting that scientists may be able to target those genes to help slow down the aging process and treat age-related conditions. (2008-03-12)

AMP genomic sequencing procedure microcosting & health economic cost-impact analyses
The report includes aggregated cost and personnel time data from nine laboratories performing 13 GSPs. In addition, payer cost-impact models for three clinical scenarios were generated with assistance from key opinion leaders. (2016-04-13)

HSP90: New point of view on melanoma of the eye, at the MUHC
Ocular melanoma is rarely detected before it has grown large enough to impair vision or to metastasize. This makes it a particularly challenging disease to fight, especially since chemotherapy is not very effective. Now, the Ph.D. research project led by Dr. Dana Faingold may open the door for very promising new treatment options for this pathology. Her first article was featured on the cover of the February 2008 issue of Clinical Cancer Research. (2008-02-19)

Brain fatty acid levels dysregulated in Alzheimer's disease
The researchers found that the levels of six unsaturated fatty acids (UFAs) (linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, oleic acid, and arachidonic acid) in the vulnerable brain regions were associated with Alzheimer's disease. (2017-03-21)

A step toward halting Alzheimer's: Using FDDNP PET to detect disease progression, MCI
By using positron emission tomography (PET) with the radiotracer 18F-FDDNP, UCLA scientists were able to detect increases in the brain pathology (of beta-amyloid plaques and neurofibrillary tangles) associated with the progression of Alzheimer's disease. Their results were presented during SNM's 53rd Annual Meeting June 3-7 in San Diego. (2006-06-05)

Rare genetic cause of peritoneal mesothelioma points to targeted therapy
BWH investigators have uncovered a new genetic cause of mesothelioma: a genetic rearrangement in the ALK gene, observed in three patients with peritoneal mesothelioma. Unlike previously known causes, this new discovery points to a potential therapeutic approach for those few patients whose tumors harbor the mutation. The team's findings are published in JAMA Oncology. (2017-09-14)

Resolving traffic jams in human ALS motor neurons
A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological strategies that mitigate this defect. (2017-10-17)

AMP president updates CDC committee on H1N1 testing
Dr. Jan Nowak reports community molecular pathologists' efforts to confirm suspected cases of H1N1 influenza early in the outbreak and discussed the challenges encountered by the diagnostic community and opportunities to improve access to high quality rapid diagnostic tests for pandemic influenza. (2009-09-01)

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