Peptides Current Events

Peptides Current Events, Peptides News Articles.
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Abnormal combos of peptides may contribute to diabetes
Type 1 diabetes (T1D) may be linked to insulin-related peptides that mistakenly bond to other peptides within the pancreas and spleen, a new study suggests. (2016-02-11)

Cancer vaccine under development using synthetic protein
Scientists at Monash and Melbourne universities have developed a synthetic protein fragment or peptide, that could be used to produce a more effective cancer vaccine. (2005-09-26)

Peptides with brominated tryptophan analogs could protect marine animals
Bromotryptophan is a nonstandard amino acid that is rarely incorporated in ribosomally synthesized and post-translationally modified peptides (ribosomal peptides). Bromotryptophan and its analogs sometimes occur in non-ribosomal peptides. This paper presents an overview of ribosomal and non-ribosomal peptides that are known to contain bromotryptophan and its analogs. (2019-04-04)

Pigments by design
Researchers have discovered how to tune the optical and electrical properties of a synthetic polymer similar to melanin, a natural pigment that's the primary factor affecting skin color. (2017-06-08)

About TFE: Old and new findings
The fluorinated alcohol 2,2,2-Trifluoroethanol (TFE) has been implemented for many decades now in conformational studies of proteins and peptides. In peptides, which are often disordered in aqueous solutions, TFE acts as secondary structure stabilizer and primarily induces an α -helical conformation. (2019-04-04)

Tracking down cryptic peptides
Using a newly developed method, researchers from the University of Würzburg, in cooperation with the University Hospital of Würzburg, were able to identify thousands of special peptides on the surface of cells for the first time. They were able to show that these so-called cryptic peptides mark a significant proportion of tumor cells. These findings could provide a new starting point for cancer immunotherapy. (2020-06-23)

Peptides vs. superbugs
Several peptides have an antibacterial effect -- but they are broken down in the human body too quickly to exert this effect. Empa researchers have now succeeded in encasing peptides in a protective coat, which could prolong their life in the human body. This is an important breakthrough because peptides are considered to be a possible solution in the fight against antibiotic-resistant bacteria. (2016-10-18)

Sea creatures' sex protein provides new insight into diabetes
A genetic accident in the sea more than 500 million years ago has provided new insight into diabetes. Professor Maurice Elphick says his findings could help to explain a rare form of the disease that causes sufferers to urinate more than three liters every day. (2010-03-22)

Gifts from the Gila monster
Who would have thought that Gila monster saliva would be the inspiration for a blockbuster new drug for Type 2 diabetes? Or that medicines for chronic pain and heart attacks would emerge from venom of the Magician's cone snail and the saw-scaled viper? These are just a few sources contributing to new (2011-06-01)

New technique moves researchers closer to new range of biosensors
Researchers from North Carolina State University have found a way of binding peptides to the surface of gallium nitride in a way that keeps the peptides stable even when exposed to water and radiation. The discovery moves researchers one step closer to developing a new range of biosensors for use in medical and biological research applications. (2014-12-18)

Closer to a cure for eczema
Scientists have found that a strain of yeast implicated in inflammatory skin conditions, including eczema, can be killed by certain peptides and could potentially provide a new treatment for these debilitating skin conditions. This research is published today in the Society for Applied Microbiology's journal, Letters in Applied Microbiology. (2011-11-23)

Screening for macrocyclic peptides
Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, a protein that helps to degrade proteins and induce cell death. The results could lead to novel drug candidates against cancer, according to the study published in the journal Angewandte Chemie. (2021-02-22)

Cyclic opioid peptides
For decades the opioid receptors have been an attractive therapeutic target for pain management and many endogenous opioid peptides have been known to produce opioid activity and analgesia. (2016-07-13)

Synthetic peptoids hold forth promise for new antibiotics
Drug-resistant bacterial infections are a growing concern, and much research has been devoted to finding new classes of antibiotics to fight them. Stanford researchers may have found some answers in peptoids, a class of manmade molecules very similar to natural proteins that play an important role in the human immune system. (2008-03-06)

Surgical implants coated with one of 'nature's antibiotics' could prevent infection: UBC study
Researchers at the University of British Columbia have discovered a mimic of one of (2009-01-29)

Plant kingdom provides 2 new candidates for the war on antibiotic resistance
New research has discovered peptides from two crop species that have antimicrobial effects on bacteria implicated in food spoilage and food poisoning. They are similar in structure to a human peptide used to guard against beer-spoiling bacteria. (2016-06-20)

New drug targets may lead to effective Ebola treatments
There are no approved treatments or preventatives against Ebola virus disease, but investigators have now designed peptides that mimic the virus' N-trimer, a highly conserved region of a protein that's used to gain entry inside cells. (2014-11-13)

Team finds new way to attach lipids to proteins, streamlining drug development
Protein-based drugs are used in the treatment of every kind of malady, from cancer to heart disease to rheumatoid arthritis. But the proteins are almost always modified with chemical appendages that help them navigate through the body or target specific tissues. A new study reveals an efficient means of attaching lipids (fat molecules) to peptides (the building blocks of proteins). This can improve the molecules' drug-delivery capabilities. (2016-11-21)

Peptides that can be taken as a pill
Peptides represent a billion-dollar market in the pharmaceutical industry, but they can generally only be taken as injections to avoid degradation by stomach enzymes. Scientists at EPFL have now developed a method to generate peptides that resist enzymatic degradation and can be taken orally. (2020-05-11)

Double headed hydra
In the November issue of Genes & Development, Jan Lohmann and Thomas Bosch use grafting experiments to show that a secondary head can be induced by the novel peptide, HEADY. Donor tissue is treated with HEADY and labeled using fluorescent latex beads prior to transplantation into an unlabeled host. After five days, the transplanted tissue develops into a fluorescent secondary head. (2000-10-31)

Double-bridged peptides bind any disease target
EPFL scientists have developed a new type of 'double-bridged peptide' that can be tailored to bind tightly to disease targets of interest. The peptides' highly efficient binding, combined with their small size and high stability make them ideal for drug therapies. The work is published in Nature Chemistry. (2018-04-30)

New technique has potential to protect oranges from citrus greening
Citrus greening, also called Huanglongbing (HLB), is devastating the citrus industry. Florida alone has experienced a 50 to 75 percent reduction in citrus production. There are no resistant varieties of citrus available and limited disease control measures. Three plant pathologists at the University of California-Berkeley and United States Department of Agriculture conducted research into ways to boost citrus immunity and protect the valuable fruit against citrus greening. (2020-03-18)

A better way to purify peptide-based drugs
During the production of peptide drugs, amino acids attach to each other in chains, but some of the chains are never completed. To separate these truncated peptides from the good ones, Shiyue Fang's team adds a polymerizable group of atoms to the mix. These atoms bind to either the perfect peptides or the unfinished ones, but not to both. The polymerized peptides become insoluble and precipitate out of the solution. (2014-02-17)

An alternative to antibiotics
Antibiotics are among the greatest achievements of medical science. But lately the former multi-purpose weapon fails in the battle against infectious diseases. Bacteria are increasingly developing resistance to antibiotics. Researchers have now found a therapeutic equivalent which could replace penicillin and related pharmaceuticals. (2011-06-08)

Giant fire-bellied toad's brain brims with powerful germ-fighters
Frog and toad skins already are renowned as cornucopias of hundreds of germ-fighting substances. Now a new report in ACS's Journal of Proteome Research reveals that the toad brains also may contain an abundance of antibacterial and antiviral substances that could inspire a new generation of medicines. (2011-04-13)

Machine-learning discovery and design of membrane-active peptides for biomedicine
There are approximately 1,100 known antimicrobial peptides (AMP) with diverse sequences that can permeate microbial membranes. To help discover the 'blueprint' for natural AMP sequences, researchers from the University of Illinois at Urbana-Champaign and the University of California, Los Angeles, have developed a new machine learning approach to discover and design alpha-helical membrane active peptides based on their physicochemical properties. (2016-11-15)

Biological engineers discover new antibiotic candidates
Researchers from MIT and the University of Naples Federico II found that fragments of the protein pepsinogen, an enzyme used to digest food in the stomach, can kill bacteria such as Salmonella and E. coli. Such peptides could potentially be developed as new antibiotics. (2018-08-20)

A new synthetic amino acid for an emerging class of drugs
EPFL scientists have developed a new amino acid that can be used to modify the 3-D structure of therapeutic peptides. Insertion of the amino acid into bioactive peptides enhanced their binding affinity up to 40-fold. Peptides with the new amino acid could potentially become a new class of therapeutics. (2014-08-31)

Soy shows promise as natural anti-microbial agent: Study
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers. (2016-04-25)

Natural-based antibiofilm and antimicrobial peptides from microorganisms
The exploration of AMP and antibiofilm peptide (ABP) producer microorganisms brings with it a lot of challenges experimentally. In this review study, we want to highlight the importance and challenge of these natural peptides derived from microorganisms. We will also propose a new explanation for ABPs. (2018-12-31)

UCSD researchers ID peptides that bind to Alzheimer's plaques
Two short protein segments, called peptides,have been identified by UCSD researchers for their ability to recognize and bind to beta-amyloid-containing plaques that accumulate abnormally in the brains of Alzheimer's disease patients. (2003-09-08)

Origin of life insight: peptides can form without amino acids
Peptides, one of the fundamental building blocks of life, can be formed from the primitive precursors of amino acids under conditions similar to those expected on the primordial Earth, finds a new UCL study published in Nature. (2019-07-10)

MU researchers find clue to cataract formation
Cataracts, which can have devastating effects on the eye, affect 42 percent of the population between the ages of 70 and 80, and 68 percent of the population over the age of 80, according to the National Eye Institute. Now, a University of Missouri professor has identified an important step in how cataracts form. This discovery could lead to a better treatment or cure for cataracts in the future. (2008-04-17)

New NIST reference material for peptide analysis
NIST has issued its first-ever reference material designed to improve the performance and reliability of experiments to measure the masses and concentrations of peptides in biomolecular samples. The new reference material is expected to be an important tool in the analysis of proteins, both for disease diagnosis and drug discovery. (2007-05-25)

New "Bacteria Bashers" Wipe Out Infection
A new approach developed at the Weizmann Institute may lead to potent antimicrobial drugs based on a natural detergent- like mechanism. (1998-11-30)

A boundary dance of amyloid-β stepping into dementia
Alzheimer's disease is caused by aggregates of amyloid-β (Aβ) peptides. This aggregation is accelerated at a cell membrane surface. The research group at ExCELLS revealed the reason of this phenomenon by molecular dynamics simulations and NMR experiments. The findings were published in the Journal of Physical Chemistry B. (2018-12-27)

Frog slime kills flu virus
Frogs' skins were known to secrete peptides that defend them against bacteria. The finding suggests that the peptides represent a resource for antiviral drug discovery as well. (2017-04-18)

Harnessing the autoimmune response
Molecular mimicry, structural similarity between viral proteins and host molecules, is thought to explain the genesis of self-specific antibodies in autoimmune disease. Here, Chackerian and coworkers propose a means to turn this pathological response to clinical advantage. (2001-08-01)

We're not all equal in the face of the coronavirus
HLA genes, responsible for the adaptive immune system, differ between individuals. Thousands of possible variants have been identified. Not all of them are equally effective in fighting new viruses. The frequency of these variants varies from one population to another. In a study to be published in the journal HLA, scientists have pinpointed those that are potentially the most effective against the SARS-CoV-2 coronavirus. They have also brought to light significant differences between populations. (2020-06-10)

Printed biochips
Peptide arrays are powerful tools for developing new medical substances as well as for diagnosis and therapy techniques. A new production method based on laser printing will enable the potential of peptide arrays to be effectively utilized for the first time. (2008-05-29)

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