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A key to pregnancy-associated malaria
A malaria protein that traps infected cells in the placenta may provide a promising new target for a vaccine against pregnancy-associated malaria (PAM). Salanti and colleagues show that the malaria protein VAR2CSA is displayed on malaria-infected cells that bind to the placenta, as they report in the November 1 issue of The Journal of Experimental Medicine. This causes a dangerous infection, which puts both mother and developing child at risk. (2004-11-01)

Scientists challenge recommendation that men with more muscle need more protein
Sports nutrition recommendations may undergo a significant shift after research from the University of Stirling has found individuals with more muscle mass do not need more protein after resistance exercise. (2016-08-22)

Blood protein predicts risk of heart attack
High levels of a blood protein called mannose-binding lectin (MBL) are associated with lower risk of heart attack, particularly among diabetics, report Saevardottir and colleagues. They suggest that measuring this protein in the bloodstream may help doctors decide if certain patients should receive additional treatments to decrease their heart attack risk, according to a study in the January 3rd issue of The Journal of Experimental Medicine. (2004-12-27)

Culprit implicated in neurodegenerative diseases also critical for normal cells
The propensity of proteins to stick together in large clumps -- termed (2013-06-13)

More data needed on link between inflammation and colon cancer risk
A preliminary study suggests that persistent inflammation, as indicated by increased levels of C-reactive protein in the blood, is a risk factor for the development of colon cancer. However, according to an editorial by Northwestern University researcher Boris Pasche, M.D., the link between chronic inflammation and colon cancer must be further explored before C-reactive protein is confirmed as a risk predictor. (2004-02-03)

Liver fully recovers from a low protein diet
Damage caused to the liver by a low protein diet can be repaired, a new study just published in the prestigious journal Nutrition has found. (2017-03-27)

The genetics behind hair loss
Scientists have discovered the function of the mammalian hairless gene, and have thereby provided a molecular basis for congenital hair loss disorders in humans. This discovery represents a stepping stone upon which researchers can further delineate the genetic pathway of hair loss, and eventually design therapeutic agents. (2001-10-14)

Scientists locate disease switches
A team of scientists from the University of Copenhagen and the Max Planck Institute in Germany, has identified no less than 3,600 molecular switches in the human body. These switches, which regulate protein functions, may prove to be a crucial factor in human aging and the onset and treatment of diseases such as cancer, Alzheimer's disease and Parkinson's disease. The results of the team's work have been published in the current edition of the journal Science. (2009-07-17)

Eating more protein may not benefit older men
A randomized, clinical trial conducted by Brigham and Women's Hospital investigator Shalender Bhasin, MD, and colleagues has found that higher protein intake did not increase lean body mass, muscle performance, physical function or other well-being measures among older men. (2018-04-02)

1 step closer to a vaccine for a common respiratory disease
Young children and the elderly are especially susceptible to respiratory syncytial virus. The three-dimensional structure of respiratory syncytial virus has been solved by an international team from Finland and Switzerland. (2013-06-17)

High-protein diets, like the Dukan diet, increase the risk of developing kidney disease
An experiment by scientists at the University of Granada, Spain, shows a high-protein diet increases the chance of developing kidney stones and other renal diseases. They warn that this type of diet may have potentially serious negative effects and needs to be monitored. (2014-01-21)

DTU researchers film protein quake for the first time
One of nature's mysteries is how plants survive impact by the huge amounts of energy contained in the sun's rays, while using this energy for photosynthesis. The hypothesis is that the light-absorbing proteins in the plant's blades quickly dissipate the energy throughout the entire protein molecule through so-called protein quakes. Researchers at DTU Physics have now managed to successfully 'film' this process. (2014-08-27)

High protein diets, from both animal and plant sources, improve blood sugar control in diabetic patients
New research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) shows that high protein diets improve blood sugar control in patients with type 2 diabetes without any adverse effects on kidney function. (2015-09-17)

Low levels of toxic proteins linked to brain diseases, study suggests
Neurodegenerative diseases such as Alzheimer's could be better understood thanks to insight into proteins linked to such conditions, a study suggests. (2013-07-02)

Quorn protein on par with animal sources
Protein found in Quorn meat-free foods may be just as good for muscles as animal proteins, new research suggests. (2017-10-10)

Story ideas from Molecular and Cellular Proteomics
A set of 15 proteins found in urine can distinguish healthy individuals from those who have coronary artery disease, a new study has found. (2008-02-11)

Close-up of SARS-CoV-2 protein shows how it interferes with host anti-viral immunity
A detailed study of a SARS-Cov-2 protein, Nsp1, with a central role in weakening the host anti-viral immune response shows that it effectively shuts down production ofproteins in the host. (2020-07-17)

Hebrew University researchers discover molecular machinery for bacterial cell death
Researchers at the Hebrew University of Jerusalem and the University of Vienna have revealed for the first time a stress-induced machinery of protein synthesis that is involved in bringing about cell death in bacteria. (2011-11-30)

MARC travel awards announced for the 25th Symposium of the Protein Society
FASEB's MARC (Minority Access to Research Careers) Program has announced the travel award recipients for The 25th Symposium of the Protein Society in Boston, Mass., from July 23-27, 2011. These awards are meant to promote the entry of underrepresented minority students, post-doctorates and scientists into the mainstream of the basic science community and to encourage the participation of young scientists at the 25th Symposium of the Protein Society. (2011-06-13)

Protein folding made easy
Computational methods of modeling protein folding have existed for a couple of decades. But they required hundreds of thousands of CPU hours to compute the folding dynamics of 40 amino acids proteins. Now, McGill researchers have developed algorithms able to predict correctly in 10 minutes on a single laptop, a coarse-grained representation of the folding pathways of a protein with 60 amino acids. (2011-06-07)

Prion protein can trigger spongiform encephalopathy and neurodegeneration
Zhiqi Song and coworkers from China Agricultural University, China introduce two types of disease-associated prion proteins, the cytosolic form and the transmembrane form, during biosynthesis through the endoplasmic reticulum quality-control system, and propose an effective model and testing method for cytosolic forms of prion protein. (2013-12-08)

Soy-based protein boosts hunger hormone and stimulates appetite
Researchers have discovered a protein that stimulates secretion of ghrelin, an appetite-stimulating hormone produced in the stomach. When fed to mice, the protein, called soy-ghretropin, increased blood levels of ghrelin and boosted their appetite. (2016-07-19)

The lock shapes the key
Proteins normally recognize each other by their specific 3-D structure. If the key fits in the lock, a reaction can take place. However there are reactions at the onset of which the key does not really have a shape. Chemists at the Technische Universitaet Muenchen and the Max Planck Research Unit for Enzymology of Protein Folding (Halle/Saale) have now shown how this might work. Their results will appear in PNAS this week. (2011-02-15)

New cancer gene found
Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears in Nature's cancer journal Oncogene. (2008-05-08)

Blooming health thanks to a frog
In the October 15 issue of the scientific journal Genes & Development, Dr. Hong Yan and his team at Fox Chase Cancer Center in Philadelphia detail their use of frogs to investigate how the gene defective in patients with Bloom's Syndrome functions. (2000-10-14)

Aspirin discovery may improve cancer treatments
Scientists have uncovered the molecular pathways involved in the inhibition of protein synthesis in cells by aspirin, a discovery that may have implications for the treatment of cancer. (2007-04-04)

PERK protein opens line of communication between inside and outside of the cell
PERK is known to detect protein folding errors in the cell. Researchers at the Laboratory of Cell Death Research & Therapy at KU Leuven (University of Leuven, Belgium) have now revealed a hidden perk: the protein also coordinates the communication between the inside and the outside of the cell. These findings open up new avenues for further research into treatments for cancer, Alzheimer's, and diabetes. (2017-02-23)

UCI team finds method to reduce accumulation of damaging Huntington's disease protein
A study appearing April 14 in the journal Neuron suggests there may be a new way to change the damaging course of Huntington disease. Researchers have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice. (2016-04-15)

Prions rapidly 'remodel' good protein into bad, Brown study shows
Brown Medical School researchers have discovered that prions - the culprits behind fatal brain diseases such as mad cow and its human counterparts - convert healthy protein into abnormal protein through an ultrafast process similar to DNA replication. The breakthrough finding, published in Nature, helps explain how prions multiply and lead to illness. (2005-09-07)

Study finds high protein diets lead to lower blood pressure
Adults who consume a high-protein diet may be at a lower risk for developing high blood pressure. The study, published in the American Journal of Hypertension, by researchers from Boston University School of Medicine, found participants consuming the highest amount of protein -- an average of 100 g protein/day -- had a 40 percent lower risk of having high blood pressure compared to the lowest intake level. (2014-09-11)

Livermore & NIH scientists create technique to examine behavior of proteins at single molecule level
A Lawrence Livermore National Laboratory physicist, in collaboration with an international team of researchers, has developed an experimental method that allows scientists to investigate the behavior of proteins under non-equilibrium conditions one molecule at a time, to better understand a fundamental biological process of protein folding that is important for many diseases. (2003-08-28)

'Digging up' 4-billion-year-old fossil protein structures to reveal how they evolved
Very little is known about how and when over the course of evolution 3-D protein structures arose. In a new study, researchers resurrected four-billion-year-old Precambrian proteins in the laboratory and gained novel insights into protein evolution by analyzing their X-ray crystal structures. This method has revealed a remarkable degree of structural similarity among proteins since life first evolved on this planet, and represents a powerful and novel approach to explore the evolution of protein structures. (2013-08-08)

Temperature, entropy and protein binding
The binding of proteins to substrates is essential for organic life. In the 54th issue of Science China, one paper investigates the relationship between environmental temperature and the capture radius for protein binding. It was found that the largest capture radius corresponds to the folding transition temperature of a protein chain. The results could provide valuable reference data for future research. (2012-01-01)

Production of toxic protein causes common neurodegenerative disorder
Researchers have recently discovered that an expansion of DNA in patients with the common neurodegenerative disorder Fragile X-associated tremor syndrome causes the production of an abnormal protein that is toxic to neurons. The findings suggest an unexpected process by which DNA expansions might lead to neurodegenerative diseases -- including Huntington's disease and ALS. This discovery reveals a common feature among these diseases that could be targeted to treat affected individuals. (2013-04-18)

Increased consumption of soy protein may help lower cholesterol
People with total cholesterol levels exceeding 240 could benefit substantially by eating 25 to 50 grams of soy protein daily, according to an American Heart Association advisory written by a University of Illinois nutritionist and directed to health-care professionals across the United States. (2000-11-30)

Infection biology: The elusive third factor
Researchers from Ludwig-Maximilians-Universit├Ąt in Munich have identified an enzyme that is involved in a modification pathway that is essential for bacterial pathogenicity. Because it shows no similarity to other known proteins, it may be an ideal target for development of novel antimicrobial drugs. (2012-06-22)

Amyloid beta protein gets bum rap
Saint Louis University research could lead to better medicines for Alzheimer's disease. (2009-11-09)

Equalizing the sexes
Two independent research papers in the February 1 issue of Genes and Development reveal that the Drosophila UNR protein is a novel regulator of X-chromosome dosage compensation in flies. (2006-01-31)

Hormones modify the type of proteins produced
Naturally occurring hormones such as estrogen, progesterone and cortisol play an important role in determining what kind of protein the cell makes in response to a genetic message, said researchers at Baylor College of Medicine.These steroid hormones are some of the things that change the protein that comes from a gene. (2002-10-10)

Architecture of cellular control center mTORC2 elucidated
The protein complex mTORC2 controls cellular lipid and carbohydrate metabolism. Researchers from the Biozentrum of the University of Basel and the ETH Zurich have now succeeded in deciphering the 3-D structure of this important protein complex. The results have recently been published in eLife. (2018-02-20)

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