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Brown team finds crucial protein role in deadly prion spread
Brown University biologists have made another major advance toward understanding the deadly work of prions, the culprits behind fatal brain diseases such as mad cow and their human counterparts. In new work published online in PLoS Biology, researchers show that the protein Hsp104 must be present and active for prions to multiply and cause disease. (2007-01-23)

Antifreeze protein from ticks fights frostbite in mice
A protein that protects ticks from freezing temperatures also prevents frostbite when introduced in mice, a Yale-led study has found. The research is the first to demonstrate the protein's ability to boost frostbite resistance in an adult mammal. (2015-02-25)

Researchers find multiple proteins that stick to medical devices
Biomedical engineers at Washington University in St. Louis have found a new role for the blood protein serum amyloid P in the body's response to medical materials, which may help to explain a variety of problems associated with heart-lung bypass, hemodialysis and the use of artificial vascular grafts. (2005-10-05)

Autophagy degrades liquid droplets, but not aggregates, of proteins
Autophagy is a mechanism through which cellular protein is degraded. Selective autophagy had been thought to prevent the onset of diseases, but the state of proteins in which they could be efficiently degraded had been unclear. A team of Japanese scientists have discovered that autophagy is effective for selectively degrading protein in a state of liquid droplet that is formed through liquid-liquid phase separation but does poorly with the degradation of protein in aggregation. (2020-02-13)

A global breakthrough in the study of a protein linked to the spread of viruses
Professor Denis Archambault of the department of biological sciences of Université du Québec à Montréal, and doctoral student Andrea Corredor Gomez have made a major discovery in the field of molecular biology. They have unlocked some of the secrets of a viral protein, known as Rev, which is very different from other proteins of the same type studied to date. The results of their research were recently published in the prestigious Journal of Virology. (2010-01-05)

Protein quality: It matters
As science continues to support the role of protein in building and maintaining lean muscle, maintaining weight and aging healthy, consumers are embracing the important role of protein in the diet. But not all proteins are created equal and it turns out that protein quality really does matter. The latest on the topic of protein quality will be presented today at SupplySide West, the leading destination for the exploration, discovery, innovation and market strategy that fuels the healthier marketplace. (2013-11-15)

How manuka honey helps fight infection
Manuka honey may kill bacteria by destroying key bacterial proteins. Dr. Rowena Jenkins and colleagues from the University of Wales Institute -- Cardiff investigated the mechanisms of manuka honey action and found that its antibacterial properties were not due solely to the sugars present in the honey. The work was presented this week at the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh. (2009-09-06)

Decoding the structure of huntingtin
Determining the three dimensional structure of the protein could help to develop new treatments of Huntington's disease. (2018-02-22)

Review emphasizes the power of simple physical models for complex protein machines
The function of protein machines in biological cells is so complex that even supercomputers cannot predict their cycles at atomic detail. But, as demonstrated in this review article, many aspects of their operation at mesoscales can be already revealed by exploring simple mechanical models, amenable for simulations on common computers. The authors also show how artificial protein-like structures with machine properties can be designed. (2019-06-25)

Cascade of events leading to prion disease described
Prion diseases are deadly neurodegenerative disorders in humans and animals that are characterized by misfolded forms of prion protein (PrP). Development of effective treatments has been hampered by the lack of good experimental models. In a new study published in the American Journal of Pathology, researchers describe the distinct stages of prion disease in the mouse retina and define an experimental model to specifically test therapeutic approaches. (2016-08-09)

'Knot' to be undone, researchers discover unusual protein structure
Researchers funded by the National Institute of General Medical Sciences have determined the structure of a protein with a surprising feature: a knot. This is the first time a knot has been found in a protein from the most ancient type of single-celled organism, an archaebacterium, and one of only a few times a knot has been seen in any protein structure. This unusual finding is a result of the NIGMS Protein Structure Initiative. (2002-11-26)

Protein identified that turns off HIV-fighting T cells
In HIV-infected patients, the body's immune system is unable to fight off the virus. A new study to be published online on Nov. 10 in the Journal of Experimental Medicine shows that T cells in HIV-infected individuals express a protein called TIM-3, which inactivates their virus killing capacity. Blocking this protein, the study suggests, might one day help patients to eliminate HIV as well as other chronic infections. (2008-11-10)

A new model of cerebral cortex development
A new technique allows University of Chicago researchers to connect the mechanism involved in formation of limbs to the organization of higher brain functions, such as vision, touch and memory, and offers a simple possible mechanism for the evolution of complexity in mammalian brains. (2001-09-20)

Researchers image atomic structure of important immune regulator
A new study by investigators from Brigham and Women's Hospital provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 (hTIM-3). Understanding the atomic structure of hTIM-3 provides new insights for targeting this protein for numerous cancer and autoimmune therapeutics currently under clinical development. (2018-12-10)

Alpha-2 integrin: A protein predictor of tumor spread?
Researchers, publishing in the Journal of Clinical Investigation, have generated data that lead them to suggest that decreased expression of the protein alpha-2 integrin is predictive of tumor dissemination to distant sites and decreased survival in individuals with either breast or prostate cancer. (2010-12-06)

Low-protein high-carb diet shows promise for healthy brain aging
Low-protein high-carbohydrate diets may be the key to longevity, and healthy brain ageing in particular, according to a new mice study from the University of Sydney. (2018-11-20)

Solving the mystery of mutated proteins and the brain
In some neurological diseases, too much of what is usually a good thing can be bad, said researchers at Baylor College of Medicine in a report in this week's issue of the journal Cell. Dr. Huda Zoghbi and her colleagues have determined that a genetic mutation actually enhances the normal activity of a protein, and in the case of ataxin-1, the disease spinocerebellar ataxia type 1 results. (2005-08-25)

Powerful online tool for protein analysis provided pro bono by Stanford geneticist
Scientists around the world may benefit from a powerful new database, available for free online, that will help them to hone in on the parts of proteins most necessary for their function. Arend Sidow, Ph.D., associate professor of pathology and of genetics at the Stanford University School of Medicine, recently launched the novel bioinformatics tool, which enlists evolution as the guide to determining the role different proteins play in a wide array of organisms. (2008-12-01)

Stress protein expression in early phase spinal cord ischemia/reperfusion injury
Spinal cord ischemia/reperfusion injury is a stress injury to the spinal cord. Therefore, research on the expression of stress-related protein in neurons could be of great significance for the pathological mechanism and control measures for spinal cord ischemia/reperfusion injury. (2013-09-10)

New research examines how HIV infections occur on the molecular level
The UK's National Physical Laboratory with the University of Edinburgh and IBM's TJ Watson Research Center have published new research about the structure of an HIV-1 protein that could help to develop new drugs to stop the virus infecting healthy cells. (2011-01-18)

Clarified longtime mystery -- transporter protein involved in renal reabsorption of cystine
An international research group clarified that AGT1/SLC7A13, a membrane protein in kidneys, is identified as a transporter protein involved in renal reabsorption of cystine. AGT1 is an unknown factor that binds with the protein rBAT/SLC3A2, whose mutations may cause cystinuria leading to serious kidney failure. The group demonstrated the possibility that changes in AGT1 may contribute to the development of cystinuria. This achievement may lead to the development of new therapeutic methods for cystinuria. (2016-04-04)

New Soy Protein Adhesive: Water Resistant, Strong And Non-Toxic
A soy-based, formaldehyde-free adhesive that's water resistant and strong has been developed by Kansas State University researcher Xiuzhi Susan Sun. (1998-08-23)

Mycotoxin protects against nematodes
Researchers at ETH Zurich have isolated a protein from a fungus of the spruce which combats nematodes. The scientists hope that toxins of this kind will become the basis for the vaccination of livestock or domestic animals against zooparasitic nematodes. (2014-05-27)

New technology offers insight into cholesterol
With new advanced techniques developed by the Copenhagen Center for Glycomics at the University of Copenhagen it is possible to study cells in greater detail than ever before. The findings have just been published in the Journal of Biological Chemistry and may, in the long term, improve the treatment of high cholesterol. (2014-08-14)

Language protein differs in males, females
Male rat pups have more of a specific brain protein associated with language development than females, according to a study published Feb. 20 in The Journal of Neuroscience. The study also found sex differences in the brain protein in a small group of children. The findings may shed light on sex differences in communication in animals and language acquisition in people. (2013-02-19)

Scientists find hidden piece of influenza virus
For nearly 20 years, scientists have labored under the assumption that the influenza virus comprises only 10 protein molecules that form its structure and carry out its activities. However, this week in Nature Medicine researchers report finding a new, (2001-11-30)

Super-resolution imaging reveals mechanism of GLUT1 clustering
Prof. WANG Hongda of the Changchun Institute of Applied Chemistry and Prof. XIONG Wenyong from the Kunming Institute of Botany, together with their team members, first investigated the distribution and assembly of GLUT1 at a nanometer resolution by direct stochastic optical reconstruction microscopy. (2018-06-20)

Microseeding: A new way to overcome hemihedral twinning?
Twinning, which is a known problem in protein crystallography, usually hampers high-quality crystal structure determination unless it is detected and either avoided or corrected. (2016-12-15)

Moffitt researchers develop novel approach to visualize, measure protein complexes in tumors
Cancer diagnosis and treatment decisions are often hampered by a lack of knowledge of the biological processes occurring within the tumor. Moffitt Cancer Center researchers have developed a new approach to analyze these processes with a technique called proximity ligation assays. PLA allows specific protein complexes to be visualized and measured in cancer specimens. This may aid in patient treatment decisions in the future. (2015-01-15)

Muscle weakness: New mutation identified
New research, published in the Journal of Physiology, has identified a novel mutation associated with muscle weakness and distal limb deformities. The study demonstrates that muscle weakness experienced by persons with a regulatory protein tropomyosin mutation is directly related to a mechanism by which the mutant tropomyosin modulates contractile speed and force-generation capacity. (2007-06-14)

How sharks recycle toxic ammonia to keep their skin moist
The Pacific spiny dogfish shark is a master at recycling the ocean's toxic ammonia and converting it into useful urea, according to new research from University of British Columbia zoologists. Animals typically eat protein in order to grow, but sharks also require protein to continually replenish urea in their tissues. The urea keeps the fish from drying out in salty seawater. (2016-10-27)

Researchers identify new group of proteins in the brains of Alzheimer's patients
Researchers from Boston University School of Medicine have identified a novel group of proteins that accumulate in the brains of patients with Alzheimer's disease. These findings, which appear online in the Journal of Neuroscience, may open up novel approaches to diagnose and stage the progression likelihood of the disease in Alzheimer's patients. (2012-06-13)

2 genes cooperate to cause aggressive leukemia
Two genes, each one of which is known to cause cancer on its own, together can lead to aggressive leukemia. This is the conclusion from new research carried out on gene-modified mice at the Sahlgrenska Academy at the University of Gothenburg, Sweden. The discovery has surprised scientists, and may lead to new treatments. (2009-11-03)

Uncovering recurring deletions in SARS-CoV-2 spike protein that drive antibody escape
Researchers have identified a pattern of deletions in the spike (S) glycoprotein of SARS-CoV-2 that can prevent antibody binding. Virus lineages featuring this mechanism are currently being transmitted between individuals globally, they say. (2021-02-03)

Orientation of antenna protein in photosynthetic bacteria described
Researchers at Washington University in St. Louis have figured out the orientation of a protein in the antenna complex to its neighboring membrane in a photosynthetic bacterium, a key find in the process of energy transfer in photosynthesis. Robert Blankenship, Ph.D., Markey Distinguished Professor of Biology and Chemistry in Arts & Sciences, led a team that for the first time combined chemical labeling with mass spectroscopy to verify the orientation. (2009-04-02)

Bionanomachines -- proteins as resistance fighters
Friction limits the speed and efficiency of macroscopic engines. Is this also true for nanomachines? (2009-08-14)

MIT: Missing protein may be key to autism
A missing brain protein may be one of the culprits behind autism and other brain disorders, researchers at MIT's Picower Institute for Learning and Memory report in the Dec. 6 issue of Neuron. (2007-12-05)

Lanosterol revealed clues for cataract prevention and treatment
On July 30, 2015, researchers from Sichuan University, Sun Yat-sen University, University of California, BGI, and others, reported the latest study on congenital cataracts. The finding, published on Nature, identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment. (2015-07-30)

Discovery of new cause of mental retardation simplifies search for treatments
Two to three children in 100 are born with a mental handicap. This can be caused by a genetic defect, but in 80 percent of the cases scientists do not know which genes are responsible. Now, VIB researchers have discovered that, in a portion of these patients, the mental retardation is caused by a two-fold production of two proteins. (2008-01-24)

New Science Press launches Proteins: From Sequence to Structure
New Science Press is pleased to announce the online publication of Proteins: From Sequence to Structure, a concise post-genomic account of the relationship between protein sequence and protein structure from the forthcoming Protein Structure and Function by Gregory Petsko and Dagmar Ringe, a new short authoritative text on the principles of protein structure and function. (2002-04-18)

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