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Retinitis Pigmentosa Current Events, Retinitis Pigmentosa News Articles.
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Lessons from flies: genetic diversity impacts disease severity
New research offers clues as to why some diseases are highly variable between individuals. The phenomenon is apparent in retinitis pigmentosa, a condition that causes the light-sensing cells in the eye to degenerate. By analyzing thousands of flies, scientists at University of Utah Health found that variation in a background gene, called Baldspot, can make a difference in severity of the disease. (2018-08-06)

First artificial retinas implanted in blind volunteers
In landmark surgeries at UIC Medical Center, the first artificial retinas made from silicon chips were implanted in the eyes of two blind patients who have lost almost all their vision because of retinal disease (2000-06-29)

Nanoparticles help researchers deliver steroids to retina
Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A collaborative research study among investigators at Wayne State University, the Mayo Clinic and Johns Hopkins Medicine shows that steroids attached to the dendrimers targeted the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision. (2011-12-13)

Knockdown and replace: A gene therapy twofer to treat blindness
More than 150 different mutations in the light-sensing molecule rhodopsin can cause retinitis pigmentosa, characterized by a progressive loss of night and peripheral vision. A team from the University of Pennsylvania, together with University of Florida collaborators, have developed a treatment for the condition. Successful results in dogs set the stage for testing in humans. (2018-08-20)

Progression of retinal disease linked to cell starvation
A new study illuminates an incurable eye disease that afflicts approximately 100,000 Americans. Your retina contains two types of cells that send signals when they detect light: rods and cones. In patients with Retinitis Pigmentosa, first the rods, then the cones die, leading to blindness. While most cases of the disease are due to mutations in rod-specific genes, cones don't escape death. New data suggest that the cones die because they are starving. (2008-12-07)

Visual pigment rhodopsin forms two-molecule complexes in vivo
Researchers at Baylor College of Medicine, the University of Utah and the Johns Hopkins University School of Medicine have determined for the first time the most likely configuration of rhodopsin in a living organism, and hope this discovery will help develop future therapies for retinitis pigmentosa, a degenerative eye disease for which there is no known cure. (2016-07-25)

Gene therapy staves off blindness from retinitis pigmentosa in canine model
Gene therapy preserved vision in a study involving dogs with naturally occurring, late-stage retinitis pigmentosa, according to research funded by the National Eye Institute, part of the National Institutes of Health. The findings contribute to the groundwork needed to move gene therapy forward into clinical trials for people with the blinding eye disorder, for which there is currently no cure. (2015-10-13)

UCI-led team begins first clinical trial of stem cell-based retinitis pigmentosa treatment
Participants are being enrolled in the first clinical trial that tests the use of retinal progenitor cells to treat retinitis pigmentosa, reported project director Dr. Henry Klassen of UCI's Gavin Herbert Eye Institute and Sue & Bill Gross Stem Cell Research Center. The product of stem cell research at UCI, these retinal progenitors are similar to stem cells in terms of potential regenerative properties, but they're specific to the retina. (2015-08-12)

Researchers elucidate cause of death of photoreceptor cells in retinitis pigmentosa
Research conducted at the Angiogenesis Laboratory at Massachusetts Eye and Ear Infirmary, has for the first time, identified the mode of death of cone photoreceptor cells in an animal model of retinitis pigmentosa. This groundbreaking study has further identified the receptor interacting protein kinase pathway as a potential target for developing treatment for vision loss in patients with retinitis pigmentosa. (2012-08-20)

New clues to hereditary blinding disease found
Seeking a cure for an inherited disease that causes blindness in over one million people worldwide, Dartmouth Medical School researchers have discovered a critical role for zinc in retinitis pigmentosa. The amount of zinc, a trace metal naturally absorbed by the body, can determine whether a key protein for vision functions normally or misfolds, they found. (2004-08-18)

University at Buffalo symposium on in silico methods, high throughput screening
Twenty-first century drug discovery tools, including those targeted to develop new treatments for cancer and hereditary eye diseses, will be featured at (2010-09-02)

Researchers find potential new gene therapy for blinding disease
Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP). The strategy could one day be used to slow or prevent vision loss in people with the disease. (2018-08-20)

Researcher awarded $4.9 million grant from California Institute for Regenerative Medicine
Shaomei Wang, MD, PhD, a research scientist in the Eye Program at the Cedars-Sinai Board of Governors Regenerative Medicine Institute, received a $4.9 million grant from the California Institute for Regenerative Medicine to advance her work in retinitis pigmentosa, a type of degenerative retinal disease. (2015-05-21)

Genome surgery for eye disease moves closer to reality
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. (2018-05-11)

Fish oil may help protect against retinal degenerative diseases
A invited paper published in Trends in Neuroscience this week by Nicolas G. Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center in New Orleans, reports on the role that the omega-3 fatty acids in fish oil play in protecting cells in the retina from degenerative diseases like retinitis pigmentosa and age-related macular degeneration, the leading cause of loss of vision in those older than 65. (2006-04-05)

Blind mice shed light on human sight loss
Mutant mice could provide genetic clues to understanding incurable human sight loss resulting from retinal degeneration. Research published in the online open access journal Genome Biology uncovers a role for microRNA in retinal disease, and may point the way to future therapies. (2007-11-21)

Erectile dysfunction drugs could affect vision of genetically susceptible users
Sildenafil, the active ingredient in the erectile dysfunction drug Viagra, could cause unusual visual responses in people who carry a common mutation for eye disease, researchers warn. They studied the effects of a single dose of sildenafil on normal mice and mice with a single copy of the mutant gene. The normal mice had a transient loss of visual function after sildenafil treatment, but this effect was heightened in the mice with the mutation. (2014-09-30)

ONR researchers look to the future for defeating blindness
Neurobiologists funded by the US Office of Naval Research have discovered a potential cure for degenerative vision diseases leading to terminal blindness. Scientists at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, may have discovered a cure to degenerative vision diseases such as retinitis pigmentosa. By manipulating proteins that cause blindness in mice the scientists have successfully restored vision in the light-sensing cells of the retina. (2010-08-04)

Domestic cat genome sequenced
A report that appears in the scientific journal Genome Research details the first assembly, annotation, and comparative analysis of the domestic cat genome (Felis catus). (2007-10-31)

Nerve growth factor: Early studies and recent clinical trials
NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discovered for its action on the survival and differentiation of selected populations of peripheral neurons. (2019-01-18)

UCSD receives NIH Transformative R01 Award for stimulation of neuron regeneration in the retina
A research team led by principal investigator Kang Zhang, M.D., Ph.D., professor of ophthalmology at the University of California, San Diego's Shiley Eye Center and director of UCSD's Institute of Genomic Medicine, has been awarded a five year, $4.66 million NIH Transformative Award. (2010-09-30)

Bionic eye clinical trial results show long-term safety, efficacy vision-restoring implant
The three-year clinical trial results of the retinal implant popularly known as the 'bionic eye,' have proven the long-term efficacy, safety and reliability of the device that restores vision in those blinded by a rare, degenerative eye disease. The findings show that the Argus II significantly improves visual function and quality of life for people blinded by retinitis pigmentosa. They are being published online today in Ophthalmology, the journal of the American Academy of Ophthalmology. (2015-06-23)

Wynn Foundation grant funds further study of retinal cell transplantation at Utah's Moran Eye Center
The University of Utah's John A. Moran Eye Center has received a $100,000 grant from the Stephen A. and Elaine Wynn Charitable Foundation to fund continued research into retinal cell transplantation. The research is expected to help set the stage for human clinical trials of treatments for a blinding eye disease known as Retinitis Pigmentosa (RP). (2004-07-14)

Stem cells restore sight in mouse model of retinitis pigmentosa
An international research team led by Columbia University Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. This strategy could potentially become a new treatment for retinitis pigmentosa, a leading cause of blindness that affects approximately one in 3,000 to 4,000 people, or 1.5 million people worldwide. The study appears online ahead of print in the journal Transplantation. (2010-02-24)

Gene therapy gives long-term protection to photoreceptor cells
A collaboration between scientists in the UK and the USA has shown that gene therapy can give life-long protection to the light-sensitive photoreceptor cells responsible for color vision in a mouse model of the most common inherited eye disorder. Results published in the journal Molecular Therapy demonstrate that the preserved cells were able to drive visually-guided behavior, even in later stages of the condition and despite becoming less sensitive to light. (2015-07-15)

Augmented reality glasses may help people with low vision better navigate their environment
In a new study of patients with retinitis pigmentosa, an inherited degenerative eye disease that results in poor vision, Keck School of Medicine of USC researchers found that adapted augmented reality glasses can improve patients' mobility by 50% and grasp performance by 70%. (2019-08-26)

New book on retinal disorders from Cold Spring Harbor Laboratory Press
'Retinal Disorders' from Cold Spring Harbor Laboratory Press reviews recent work on retinal diseases, describing their genetic and molecular basis, their clinical characteristics, and strategies to diagnose and treat them. The contributors emphasize how genetic approaches are currently driving progress in the field. They discuss the genetic mutations and modifiers that underlie disease development and progression, the gene expression patterns that characterize them, and how this information is being used for medical applications. (2015-01-21)

Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa
In a paper published in the October 2011 issue of Experimental Biology and Medicine, a team of researchers at Columbia University Medical Center led by Stephen Tsang, M.D., Ph.D., have achieved temporary functional preservation of photoreceptors in a mouse model for retinitis pigmentosa using novel bipartite gene therapy. (2011-09-30)

Researchers report progress using iPS cells to reverse blindness
Researchers have used cutting-edge stem cell technology to correct a genetic defect present in a rare blinding disorder, another step on a promising path that may one day lead to therapies to reverse blindness caused by common retinal diseases. (2011-06-15)

NIH funds researchers using light to control and monitor neural activity
Samarendra Mohanty, assistant professor of physics at The University of Texas at Arlington, expects to receive a total of $384,269 over the next two years from the NIH's National Institute of Neurological Disorders and Stroke. His work involves using a near-infrared ultrafast laser beam to deliver genes that allow expression of light-sensitive proteins, called opsins, in specific cells. That proteins' expression allows researchers to influence neural activity through optical or light stimulation -- a technique known as optogenetics. (2013-11-07)

Simple blood or urine test to identify blinding disease
Research led by physician-scientists at Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine has produced a breakthrough discovery in diagnosing retinitis pigmentosa, a blinding disease that affects about 1 in 4,000 people in the United States. Two UM professors of ophthalmology and a Duke professor discovered a key marker in blood and urine that can id people who carry genetic mutations in a gene responsible for retinitis pigmentosa. (2013-10-14)

USC researchers begin tests on next generation of retinal implant
Researchers at the University of Southern California are moving into their next phase of an artificial retinal implant project. (2007-02-15)

Microchip gives blind chance of sight
A computer chip implanted near the eye's retina is well on its way to offering some restored vision to people blinded by eye diseases such as retinitis pigmentosa and age-related degeneration of the eye. The implant works for eye diseases where healthy retinal neurons remain intact after they lose use of the eye's photoreceptors that convert images into electric impulses. Researchers recently reported that tests show faces can be recognized and words in large type can be read. Human tests started recently. (2002-01-24)

Retinal prion disease study redefines role for brain cells
National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. In contrast, the study findings indicated that microglia might delay disease progression. (2019-03-27)

October 2004 Ophthalmology journal
Studies from the October 2004 issue of Ophthalmology, the clinical journal of the American Academy of Ophthalmology, are now available. (2003-10-01)

New urine test could diagnose eye disease
You might not think to look to a urine test to diagnose an eye disease. But a new Duke University study says it can link what is in a patient's urine to gene mutations that cause retinitis pigmentosa, or RP, an inherited, degenerative disease that results in severe vision impairment and often blindness. The findings appear online in the Journal of Lipid Research. (2013-10-08)

Mass. Eye and Ear physician awarded RPB Career Development Award
The Harvard Medical School Department of Ophthalmology has been granted a $250,000 Research to Prevent Blindness Career Development Award to support eye research conducted by Jason I. Comander, M.D., Ph.D. (2014-01-22)

How is the membrane protein folded?
A key factor in the biosynthesis and stable expression of multi-pass transmembrane proteins was discovered at Hiroshima University, Japan. The factor works especially for multi-pass membrane proteins, in the integration of polypeptides into the membrane and/or protein folding. Loss of this factor is thought to cause retinal degeneration. So in the future, researchers hope their results will contribute to the development of next-generation medical care in the treatment of retinitis pigmentosa. (2015-03-02)

USC researchers discover way to improve image sharpness for blind people with retinal implants
Retinal implants that deliver longer impulses may markedly improve image sharpness for blind individuals. (2015-12-16)

One gene, two eye diseases?
Scientists are a step closer to understanding the genetics of macular degeneration, a disease of the retina that affects 13 million Americans, and causes the loss of central vision. A new study shows that a gene associated with one retinal disease, retinitis pigmentosa, also causes a form of macular degeneration. The finding raises an intriguing question: How can a single gene cause two very different eye diseases, each affecting a different segment of vision? (2002-08-01)

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