SARS Current Events

SARS Current Events, SARS News Articles.
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SARS without pneumonia could be common in outbreak areas
Results of research from Hong Kong in this week's issue of THE LANCET suggests that severe acute respiratory syndrome (SARS) without pneumonia could be common among populations affected by SARS outbreaks. (2004-03-11)

Antibodies from patients infected with SARS-CoV in 2003 cross-neutralized SARS-CoV-2 in vitro
Antibodies in serum samples collected from patients infected with SARS-CoV during the 2003 outbreak effectively neutralized SARS-CoV-2 infection in cultured cells, according to a new study. The authors also report that, surprisingly, mice and rabbits immunized with a receptor. (2020-10-09)

The SARS-CoV-2 receptor binding domain may provide a specific and sensitive target for population
A new analysis of blood sera taken from 63 COVID-19 patients, 71 controls, and various coronavirus-exposed animals provides strong support for the use of the SARS-CoV-2 virus' receptor-binding domain (RBD) as an antigen for reliable tests to detect antibodies to the virus. (2020-06-11)

Researchers identify a model of COVID-19 infection in nonhuman primates
After comparing how infections from SARS-CoV-2 (which causes COVID-19) and two other human coronaviruses develop in cynomolgus macaques, researchers report that SARS-CoV-2 gives the animals a mild COVID-19-like disease. (2020-04-17)

Clinical course and management of SARS
An article on the clinical course and management of SARS is being released online today by the Canadian Medical Association Journal. The article, by Drs. Monica Avendano and Peter Derkach and nurse practitioner Susan Swan, is the first to detail the course the disease took in 14 front-line health care workers in Toronto. (2003-05-28)

Medical publishing turns on the afterburners
In this editorial, CMAJ Editor John Hoey points out that the recent SARS outbreak provided a look at what the future holds for medical publishing. (2003-06-23)

Surgical masks offer best protection for hospital workers in contact with SARS patients
Research from Hong Kong in this week's issue of The Lancet emphasises how severe acute respiratory syndrome (SARS) is spread by droplet infection, with surgical masks providing the best protection for health-care workers exposed to patients with SARS. (2003-05-01)

Risk of human-to-wildlife transmission of the COVID-19 virus
There's considerable risk that humans transmit SARS-CoV-2, the virus that causes COVID-19, to wildlife, according to a perspective article published in Mammal Review. (2020-10-07)

A peptide that inhibits virus transmission among ferrets may point to a promising treatment
An engineered peptide given to ferrets two days before they were co-housed with SARS-CoV-2-infected animals prevented virus transmission to the treated ferrets, a new study shows. (2021-02-17)

Broad antivirals kill SARS-CoV-2, the MERS virus, and other coronaviruses in cells and mice
A team of scientists has engineered antiviral compounds that can kill several types of coronaviruses, including SARS-CoV-2, the virus that causes COVID-19. (2020-08-03)

Airport screening unlikely to prevent spread of SARS or influenza
Screening passengers as they arrive at UK airports is unlikely to prevent the importation of either SARS or influenza, finds a study published online by the BMJ today. (2005-09-22)

SARS-CoV-2: A new song recalls an old melody
Important lessons learned from the Severe Acute Respiratory Syndrome (SARS) outbreak of 2002-2003 could inform and guide vaccine design for COVID-19 according to University of Melbourne Professor Kanta Subbarao, Director of the WHO Centre for Reference and Research on Influenza at the Doherty Institute. (2020-05-13)

Loss of smell, taste changes associated with COVID-19: Canadian study
Loss of smell (anosmia) and changes in taste (dysgeusia) were strongly associated with SARS-CoV-2, according to a Canadian study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/content/early/2020/05/27/cmaj.200869. (2020-05-27)

Will SARS-CoV-2 become endemic?
To date, a few verified repeat SARS-CoV-2 infections have been documented around the world. (2020-10-14)

Novel coronavirus confirmed as causative agent of SARS
Leading scientists worldwide investigating the cause of Severe Acute Respiratory Syndrome (SARS) confirm that a novel coronavirus is the primary cause of the disease. The study is published on The Lancet's website ((2003-07-21)

Scientists prove SARS-CoV-2 potential to infect human brain organoids
SARS-CoV-2 can infect human neural progenitor cells and brain organoids, as shown by researchers from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences and their collaborators from The University of Hong Kong (HKU). (2020-08-25)

Animal model shows early promise for SARS vaccine
U.S. authors of a research letter in this week's issue of The Lancet highlight preliminary findings which could mark an important step in the development of a human vaccine for severe acute respiratory syndrome (SARS). A genetically engineered vaccine was found to be effective in triggering an immune reaction among six rhesus macaques. (2003-12-04)

Preexisting antibodies targeting SARS-CoV-2 discovered in small proportion of uninfected individuals
Scientists have detected preexisting antibody-driven immunity against SARS-CoV-2 in a small proportion of individuals who were uninfected at the time of sampling. (2020-11-06)

Presenting a SARS-CoV-2 mouse model to study viral responses and vaccine candidates
Researchers who generated a strain of SARS-CoV-2 that can infect mice used it to produce a new mouse model of infection that may help facilitate testing of COVID-19 vaccines and therapeutics. (2020-07-30)

Chest radiographs can predict risk of death in SARS patients
Radiologists can estimate the risk of death to a SARS patient by the seventh day from the onset of symptoms by using chest radiographs, according to a new study by researchers in Hong Kong. This early determination can allow a physician to better tailor treatment for the SARS patient. (2005-03-02)

Interferons for treatment of SARS?
Authors of a research letter in this week's issue of THE LANCET suggest that recombinant interferons - synthetic versions of naturally occurring compounds of the immune system - could be a an effective treatment for Severe Acute Respiratory Syndrome (SARS). (2003-07-24)

In the Netherlands, two-way transmission of SARS-CoV-2 transmission on mink farms
In the Netherlands, whole genome sequencing of SARS-CoV-2 outbreaks on 16 mink farms has revealed virus transmission between human to mink, as well as from mink to human. (2020-11-10)

The hidden impact of SARS
Leslie Nickell and colleagues present a glimpse of the hidden toll exacted by SARS among staff at the Sunnybrook and Women's College Health Sciences Centre during the first phase of the outbreak in Toronto. (2004-03-01)

An in-depth analysis of antibody responses to SARS-CoV-2
Using a technology called VirScan to study coronavirus antibody responses in a large cohort of SARS-CoV-2-infected and control individuals, researchers identified epitopes recognized by a large fraction of COVID-19 patients, epitopes cross-reactive with antibodies developed in response to other human coronaviruses, and 10 epitopes likely recognized by neutralizing antibodies. (2020-09-29)

Guidelines on SARS should be refined
Current World Health Organisation (WHO) guidelines for diagnosing suspected SARS may not be sufficiently sensitive in assessing patients before admission to hospital, suggest researchers from Hong Kong in this week's BMJ. (2003-06-19)

Common SARS policy for schools urgently needed
The Government should urgently develop a common SARS policy for UK boarding schools, according to a letter in this week's BMJ. (2003-04-24)

HKUST scientists shed light on COVID-19 vaccine development
A team HKUST scientists has recently identified a set of potential vaccine targets for SARS-CoV-2 coronavirus, to guide experimental efforts towards vaccine development against novel pneumonia (COVID-19). (2020-02-26)

Identification of a viral factor that impairs immune responses in COVID-19 patients
A research team at The Institute of Medical Science, The University of Tokyo (IMSUT) aimed to characterize the viral factor(s) determining immune activation upon SARS-CoV-2 infection and found that ORF3b, a gene encoded by SARS-CoV-2, is a potent IFN antagonist. (2020-10-09)

Studying COVID-19's envelope protein
A likeness between genes of the SARS and COVID-19 viruses could inform research into potential treatments. (2020-07-27)

A different antiviral for treating SARS
A preliminary study published as a fast-track research letter in this week's issue of The Lancet suggests that the antiviral agent glycyrrhizin could be more effective than other antivirals in the treatment of severe acute respiratory syndrome (SARS). (2003-06-12)

Macaques show protective immunity against SARS-CoV-2 after infection or after vaccine
Two new studies in macaques offer hope that humans could develop protective immunity against SARS-CoV-2, either as the result of a natural infection or by way of a vaccine. (2020-05-20)

Close-up of SARS-CoV-2 protein shows how it interferes with host anti-viral immunity
A detailed study of a SARS-Cov-2 protein, Nsp1, with a central role in weakening the host anti-viral immune response shows that it effectively shuts down production ofproteins in the host. (2020-07-17)

Researchers engineer antibody that acts against multiple SARS-like viruses
Researchers have engineered an antibody that neutralizes SARS-CoV-2 with a potency that 'rivals' current lead SARS-CoV-2 clinical neutralizing antibodies, and that also broadly neutralizes a range of clade 1 sarbecoviruses. (2021-01-25)

Two studies point to an unrecognized avenue for anti-viral therapies against COVID-19
Helping to explain what makes SARS-CoV-2 so capable of infecting human cells, researchers in two independent studies discovered that the virus's spike protein recognizes and binds a protein on the human cell surface called neuropilin-1. (2020-10-20)

SARS virus can change quickly and unpredictably, analysis indicates
The SARS virus is capable of changing rapidly and unpredictably, which could present serious challenges for managing the disease and developing drugs and vaccines to combat it, research at the University of Michigan suggests. (2003-10-02)

Stable protein decoy neutralized SARS-CoV-2 in cells and protected hamsters from viral challenge
Researchers have designed a protein 'decoy' that mimics the interface where the SARS-CoV-2 spike protein binds a human cell, one version of which could neutralize virus infection in cells and protect hamsters from viral challenge. (2020-11-05)

Bats confirmed as SARS origin
A team of international scientists has isolated a very close relative of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) from horseshoe bats in China, confirming them as the origin of the virus responsible for the 2002-2003 pandemic. (2013-10-30)

Nanobodies that neutralize SARS-CoV-2
Two separate studies have identified nanobodies - which could be produced less expensively than monoclonal antibodies - that bind tightly to the SARS-CoV-2 spike protein and efficiently neutralize SARS-CoV-2 in cells. (2020-11-05)

Supercomputer simulations present potential active substances against coronavirus
Several drugs approved for treating hepatitis C viral infection were identified as potential candidates against COVID-19, a new disease caused by the SARS-CoV-2 coronavirus. This is the result of research based on extensive calculations using the MOGON II supercomputer at Johannes Gutenberg University Mainz (JGU). (2020-05-05)

How will SARS-CoV-2 severity change in the next decade?
What will the SARS-CoV-2 outbreak look like ten years from now as it passes from pandemic to endemic, maintained at a constant baseline level in populations without being fueled by outside infections? (2021-01-12)

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