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SARS Current Events, SARS News Articles.
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B cells continue to work against SARS-CoV-2 months after infection, but do not recognize mutant
A new analysis of B cells and more than 1,000 different monoclonal antibodies from 8 patients with COVID-19 shows that, contrary to previous hypotheses, protective B cell responses to the SARS-CoV-2 spike protein remain stable and continue to evolve over a 5-month period, many months after the initial period of active viral replication. (2021-02-23)

Enzymes edit SARS-CoV-2 RNA in the body, perhaps fueling the virus' evolution
Two human deaminase enzymes edit the RNA of the SARS-CoV-2 virus when it enters a patient's body, with implications for the evolution of the virus and the spread of the infection, according to a new study. The (2020-05-18)

First cases of COVID-19 in New York City primarily from European and US sources
In New York City, the first confirmed COVID-19 cases arose mostly through untracked transmission of the virus from Europe and other parts of the United States, a new molecular epidemiology study of 84 patients reports. (2020-05-29)

Study shows SARS-CoV-2 jumped between people and mink, providing strong evidence of zoonotic transmission
A study investigating SARS-CoV-2 infections across 16 mink farms in the Netherlands, being presented at the ESCMID Conference on Coronavirus Disease (ECCVID, held online from 23-25 September) shows that the virus likely jumped between people and mink and back, providing strong evidence that animal to human (zoonotic) transmission is possible. (2020-09-17)

Strategy tested in mice protects against SARS-CoV-2 & coronaviruses that represent human threats
An immunization strategy tested in mice protects against infection from SARS-CoV-2, as well as from potentially emerging animal coronaviruses, researchers say. (2021-01-12)

Household transmission of SARS: Lessons learned
A retrospective cohort of SARS-affected households was studied to determine risk factors for household transmission of SARS. (2006-11-06)

Is MERS another SARS: The facts behind Middle East Respiratory Syndrome
Experts show that while Middle East Respiratory Syndrome, a viral respiratory illness, is infecting less people, it has a higher mortality rate and affects a specific target population when compared to Severe Acute Respiratory Syndrome. This research is being presented at the International Conference on Emerging and Infectious Diseases in Atlanta, Georgia. (2015-08-24)

Better at binding SARS-CoV-2: A variant of the human receptor for the virus as a powerful decoy
By exploring variants of a soluble version of the receptor that SARS-CoV-2 uses to binds human cells - which are being considered as therapeutic candidates that neutralize COVID-19 infection by acting as a decoy - researchers identified one that binds the virus's spike protein tightly enough to compete with spike binding by monoclonal antibodies. (2020-08-04)

Mapping mutations that escape antibodies against COVID-19 suggests prior mapping incomplete
A new approach to mapping viral mutations that 'escape' leading clinical antibodies has revealed mutations in the SARS-CoV-2 virus that allow it to evade treatments, including a single amino-acid mutation that fully escapes Regeneron's antibody cocktail. (2021-01-25)

SARS-CoV-2-attacking T cells found in 10 COVID-19 patients and 2 uninfected controls
Patients suffering from severe respiratory symptoms as a result of SARS-CoV-2 infection can rapidly generate virus-attacking T cells, and can increase this production over time, suggests a new study of T cells from 10 COVID-19 patients under intensive care treatment. (2020-06-26)

Inactivated vaccine candidate protects macaques from SARS-CoV-2 infection
In mice, rats, and nonhuman primates, a newly developed SARS-CoV-2 virus vaccine candidate induced antibodies that neutralized several different SARS-CoV-2 strains. (2020-05-06)

No significant genetic difference in viruses responsible for two major Hong Kong SARS outbreaks
The possibility that two different strains of the SARS virus were responsible for the Prince of Wales Hospital and Amoy Gardens outbreaks in Hong Kong earlier this year is disputed by authors of a research letter in this week's issue of The Lancet. (2003-11-27)

Virtually screening antiviral compounds against SARS-CoV-2 structure may speed up drug and vaccine D
Virtually screening antiviral compounds to model their interactions with the SARS-CoV-2 virus may enable scientists to more easily identify antiviral drugs that work against the virus while informing the search for viable vaccine candidates, according to a new study. By screening for interactions with certain (2020-06-24)

Early functional SARS-COV-2 specific T cell response may prevent severe infection
Antibodies and T cells are components of the human immune system that directly act against viral infections and eliminate infected cells. A new study by scientists from Duke-NUS Medical School, provides evidence that an early presence of SARS-CoV-2 specific T cells in COVID-19 is likely to prevent severe disease. The study, published in Cell Reports, has important implications for the clinical management of COVID-19 patients. (2021-02-01)

Analysis shows high level of SARS-CoV-2 contamination in patient toilets, staff and public areas in hosptials
A systematic review of evidence being presented at this week's ESCMID Conference on Coronavirus Disease shows that air around patients with COVID-19, as well as patients toilets, and staff and public areas in hospitals are all show significant levels of contamination with SARS-CoV-2. (2020-09-22)

New method identifies antibody-like proteins with diagnostic and therapeutic potential for SARS-CoV-2
Scientists have used a new high-speed, in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus - 4 of which also exhibited neutralizing activity - within 4 days, according to a new study. While much research has (2020-09-18)

Small proteins against SARS-CoV-2 neutralize infection in cell culture
Using innovative computer-based approaches, researchers have developed protein inhibitors that block the interaction between the SARS-CoV-2 virus and human cell receptor ACE2. (2020-09-09)

A nanoparticle vaccine for SARS-CoV-2 produces signs of immunity in mice and macaques
A new nanoparticle vaccine for SARS-CoV-2, the virus that causes COVID-19, has shown hints of protection and immunity in a preclinical study, safely eliciting the production of antibodies and antiviral T cell responses in mice and pigtail macaques. (2020-07-20)

Annals of Internal Medicine, tip sheet, August 5, 2003
Highlights from the August 5 edition of the Annals of Internal Medicine include (2003-08-04)

Scientists chart SARS-CoV-2 origin and transmission in Brazil, harboring one of fastest growing COVID-19 epidemics in the world
A team of Brazilian and European scientists has determined the transmission rates and out-of-country origins of predominant SARS-CoV-2 strains currently circulating in Brazil, which harbors one of the fastest growing COVID-19 epidemics in the world. (2020-07-23)

Finding coronavirus's helper proteins
A group of scientists led by EMBL's Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication. (2021-02-16)

A typical communication pattern of people with Alzheimer's disease
A research group from Kumamoto University, Japan has performed the first statistical analysis of (2018-06-06)

Three new studies identify neutralizing antibodies against SARS-CoV-2
A trio of papers describes several newly discovered human antibodies that target the SARS-CoV-2 virus, isolated from survivors of SARS-CoV-2 and SARS-CoV infection. (2020-06-15)

Lessons learned from SARS pandemic should inform current contagion protocols
Radiologists in Singapore outline the ways in which both medical facilities and practitioners there have incorporated lessons learned from the SARS pandemic. (2014-10-28)

Mapping how three lethal coronaviruses engage their hosts reveals potential drug targets
Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three. (2020-10-15)

Immunity to coronaviruses: What do we know so far?
Written by top UK virologists, the article discusses the existing knowledge about immune responses to SARS-CoV-2 and other coronaviruses, and how this could be used to inform virus control strategies. The review, which is free to read in the Journal of General Virology (JGV), collates the available scientific evidence in a number of key areas, including how long immunity to coronaviruses lasts and the prospect of antibody testing. (2020-05-21)

UTEP researchers make discoveries to better understand SARS-CoV-2 virus
An effort led by Lin Li, Ph.D., assistant professor of physics at The University of Texas at El Paso, in collaboration with students and faculty from Howard University, has identified key variants that help explain the differences between the viruses that cause COVID-19 and Severe Acute Respiratory Syndrome (SARS). (2021-02-02)

Structural analysis of COVID-19 spike protein provides insight into its evolution
Researchers at the Francis Crick Institute have characterised the structure of the SARS-CoV-2 spike protein as well as its most similar relative in a bat coronavirus. The structures provide clues about how the spike evolved and could help inform vaccine design. (2020-07-09)

Coronavirus SARS-CoV2: BESSY II data accelerate drug development
A coronavirus is keeping the world in suspense. SARS-CoV-2 is highly infectious and can cause severe pneumonia (COVID-19). A team from the University of Luebeck has now found a promising approach. Using the high-intensity X-ray light from the Berlin synchrotron source BESSY II, they have decoded the 3D architecture of the main protease of SARS-CoV-2. This protein plays a central role in the reproduction of the virus. (2020-03-20)

A possible treatment for COVID-19 and an approach for developing others
SARS-CoV-2, the virus that causes COVID-19 disease is more transmissible, but has a lower mortality rate than its sibling, SARS-CoV, according to a review article published this week in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. (2020-03-26)

Middle East respiratory syndrome coronavirus has not yet reached pandemic potential
New estimates of the transmissibility of the Middle East respiratory syndrome coronavirus in humans suggest that it does not yet have pandemic potential, according to research published in The Lancet. (2013-07-04)

Census of viral spike protein antigens reveals candidates for use in a COVID-19 vaccine
A group of researchers has determined how different proteins associated with SARS-CoV-2 -- the virus that causes COVID-19 -- generate immune responses when given to rabbits as immunizations. (2020-06-08)

Emerging stronger from the China crisis
This week's Lancet Editorial comments on how China can learn from mistakes made in its handling of the SARS crisis-especially in relation to the increasing prevalence of HIV/AIDS. (2003-04-17)

Protein from algae shows promise for stopping SARS
A protein from algae may have what it takes to stop severe acute respiratory syndrome infections, according to new research. A recent study has found that mice treated with the protein, Griffithsin, had a 100 percent survival rate after exposure to the SARS coronavirus, as compared to a 30 percent survival for untreated mice. (2009-05-20)

Coronavirus structure clue to high infection rate
Cornell University researchers studying the structure of the virus that causes COVID-19 have found a unique feature that could explain why it is so transmissible between people. (2020-05-05)

Immunological memory after cured Sars-CoV-2 infection
After recovery from SARS-CoV-2 infection, immune cells are formed which remain in the body and could mediate a rapid immune response in case of re-infection. The Freiburg study was published in the online edition of Nature Medicine on November 12, 2020 and gives hope for vaccine development. (2020-11-17)

New biochemical clues in cell receptors help explain how SARS-CoV-2 may hijack human cells
The SARS-CoV-2 virus may enter and replicate in human cells by exploiting newly-identified sequences within cell receptors, according to work from two teams of scientists. (2021-01-21)

Pangolin coronavirus could jump to humans
Scientists at the Francis Crick Institute have found important structural similarities between SARS-CoV-2 and a pangolin coronavirus. (2021-02-05)

New insight into the effect of hydroxychloroquine undermines its use in COVID-19
Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. It inhibits the action of a type of white blood cells important in the first line of defense against infections. Based on this research, hydroxychloroquine is unlikely to be beneficial in clearing viral infections including the new coronavirus SARS-CoV-2, they write in their publication in Cell Reports Medicine. (2020-11-23)

Researchers find 'secret weapon' used by SARS virus
In a discovery that suggests a possible new route by which scientists might fashion a vaccine against SARS, researchers have discovered one of the weapons the SARS coronavirus uses to sabotage the immune defenses of infected cells. (2006-08-07)

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