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SARS Current Events, SARS News Articles.
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How COVID-19 causes smell loss
Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. A new study identifies the olfactory cell types most vulnerable to infection by the novel coronavirus. Surprisingly, sensory neurons involved in smell are not among the vulnerable cell types. (2020-07-24)

Coronavirus mutation may have made it more contagious
A study involving more than 5,000 COVID-19 patients in Houston finds that the virus that causes the disease is accumulating genetic mutations, one of which may have made it more contagious. This mirrors a study published in July that found that around the world, viral strains with the same genetic mutation quickly outcompeted other strains. (2020-10-30)

Benefits of inhaled nitric oxide therapy for pregnant patients with COVID-19
Inhaled nitric oxide (NO) can be a valuable adjunct respiratory therapy for pregnant women with severe and critical COVID-19. (2020-08-26)

Breakthrough blood test detects positive COVID-19 result in 20 minutes
World-first research by Monash University in Australia has been able to detect positive COVID-19 cases using blood samples in about 20 minutes, and identify whether someone has contracted the virus. (2020-07-16)

Results of comprehensive SARS-CoV-2 animal model study published in Nature Microbiology
Findings by Texas Biomed and SNPRC scientists support the rhesus macaque as an excellent animal model for vaccine development; suggest baboon as an animal model for drug development. Results provide insight on the complex lung immune response to SARS-CoV-2 infection. Defining animal models has been a critical step in advancing COVID-19 vaccines & therapeutics (2021-01-04)

Research suggests combating a pandemic is 500 times more expensive than preventing one
BU biologist and peers find investing in wildlife monitoring and deforestation could prevent costly pandemics. (2020-07-28)

New lab test clarifies the potential protective effects of COVID-19 antibodies
Knowing you have developed antibodies against the SARS-CoV-2 virus after recovering from COVID-19 doesn't tell you everything about your immunity. Scientists have developed a new lab testing procedure for the detection of antibodies against SARS-CoV-2 that gives results more quickly than existing assays and specifically identifies so-called ''neutralizing'' antibodies. (2020-10-19)

University of Minnesota researchers develop two new rapid COVID-19 diagnostic tests
University of Minnesota Medical School researchers have developed two new rapid diagnostic tests for COVID-19 - one to detect COVID-19 variants and one to help differentiate with other illnesses that have COVID-19-like symptoms. (2021-02-23)

Surge in domestic child abuse during pandemic, reports specialist UK children's hospital
There has been a surge in domestic child abuse during the coronavirus pandemic, suggests the experience of one specialist UK children's hospital, reported in Archives of Disease in Childhood. (2020-07-02)

To understand COVID-19, researchers review aging, immune response to viral infections
As clinicians learn about a new disease in real-time, researchers are also investigating what lessons from other respiratory infections could apply to COVID-19. (2020-06-09)

Study shows number and variety of issues experienced by staff wearing
A new study analysing the impact of PPE staff shows that the number and variety of issues they experience increases as their time in PPE without a break increases, ranging from tiredness and headaches in the first hour to nausea, vomiting and dizziness as they head towards four hours continuously in PPE. (2021-01-21)

Sugar-coated viral proteins hijack and hitch a ride out of cells
Many viruses - including coronaviruses ¬- have protective outer layer made of proteins, fats and sugars. New research shows targeting sugar production has potential for broad-spectrum antiviral drugs (2020-11-05)

Tips from the Journals of the American Society for Microbiology
The following are tips from the Journals of the American Society for Microbiology: (2010-05-14)

Newer variant of COVID-19-causing virus dominates global infections
Research out today in the journal Cell shows that a specific change in the SARS-CoV-2 coronavirus virus genome, previously associated with increased viral transmission and the spread of COVID-19, is more infectious in cell culture. (2020-07-02)

BIDMC-developed vaccines protect against COVID-19 in non-human primates, study finds
A pair of new studies led by researchers at Beth Israel Deaconess Medical Center (BIDMC) sheds new light on two questions: whether vaccines will prevent infection with COVID-19, and whether individuals who have recovered from COVID-19 are protected against re-exposure. Both studies were published today in the journal Science. (2020-05-20)

Autopsies reveal surprising cardiac changes in COVID-19 patients
A series of autopsies conducted by LSU Health New Orleans pathologists shows the damage to the hearts of COVID-19 patients is not the expected typical inflammation of the heart muscle associated with myocarditis, but rather a unique pattern of cell death in scattered individual heart muscle cells. (2020-07-21)

K-State infectious disease scientist offers road map for future COVID-19 research
A Kansas State University infectious disease scientist and collaborators are offering a possible research road map to find the answers to COVID-19 questions. (2020-05-14)

Remdesivir likely to be highly effective antiviral against SARS-CoV-2
The drug remdesivir is likely to be a highly effective antiviral against SARS-CoV-2, according to a new study by a team of UK scientists. Writing in Nature Communications, the researchers describe giving the drug to a patient with COVID-19 and a rare immune disorder, and observing a dramatic improvement in his symptoms and the disappearance of the virus. (2020-12-14)

The human helpers of SARS-CoV-2
Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from Charité -- Universitätsmedizin Berlin and from the Berlin Institute of Health (BIH), along with colleagues from the United Kingdom, Germany and the United States, have examined the corresponding genes of the helper proteins in a large study. (2020-12-16)

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
Effective antivirals with safe clinical profile are urgently needed to improve the overall COVID-19 prognosis. In an analysis of a randomly collected cohort of 124 patients with COVID-19, the authors found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease severity. By virtual screening of a U.S. FDA approved drug library, the authors identified an anticoagulation agent dipyridamole (DIP) in silico, which suppressed SARS-CoV-2 replication in vitro. (2020-07-26)

The Lancet Infectious Diseases: Preliminary results find vaccine candidate based on inactivated SARS-CoV-2 virus is safe and induces an immune response in healthy volunteers
A Chinese COVID-19 vaccine candidate based on the inactivated whole SARS-CoV-2 virus (BBIBP-CorV) is safe and elicits an antibody response, findings from a small early-phase randomised clinical trial published today in The Lancet Infectious Diseases journal have found. (2020-10-15)

New experimental vaccine produces immune response against MERS virus
The University of Maryland School of Medicine and Novavax Inc. today announced that an investigational vaccine candidate developed by Novavax against the recently emerged Middle East Respiratory Syndrome Coronavirus blocked infection in laboratory studies. UM SOM and Novavax also reported that a vaccine candidate against Severe Acute Respiratory Syndrome Coronavirus developed by Novavax on a similar platform also inhibited virus infection. Researchers reported these findings in an article published in the April 13, 2014, issue of Vaccine. (2014-04-30)

Infectious outbreaks must be combatted strategically, Dartmouth-HHS experts argue
New funding is not enough to guarantee success against emerging infectious diseases around the world. Rather, good governance, a long-term technology investment strategy and strong product management skills are essential, say a Dartmouth College researcher and her co-author. (2016-04-21)

Passive immunization may slow down SARS-CoV-2 and boost immunity in patients, buying time
The worldwide COVID-19 pandemic has infected more than 4 million people and killed close to 280,000.1 Finding a vaccine has become a global public health priority. (2020-05-12)

Computational study reveals how Ebola nucleocapsid stabilizes
Scientists at the University of Delaware report a computational study of the Ebola virus nucleocapsid and show that the binding of the ssRNA allows the nucleocapsid to maintain its shape and structural integrity. (2020-10-20)

Plasma treatments quickly kill coronavirus on surfaces
Researchers from UCLA believe using plasma could promise a significant breakthrough in the fight against the spread of COVID-19. In Physics of Fluids, modeling conducted showed strains of the coronavirus on surfaces like metal, leather, and plastic were killed in as little as 30 seconds of treatment with argon-fed, cold atmospheric plasma. The researchers used an atmospheric pressure plasma jet they built with a 3D printer to spray surfaces that were treated with SARS-CoV-2 cultures. (2020-11-10)

DNA webs may drive lung pathology in severe COVID-19
Sticky webs of DNA released from immune cells known as neutrophils may cause much of the tissue damage associated with severe COVID-19 infections, according to two new studies published September 14 in the Journal of Experimental Medicine (JEM). The research, conducted by independent groups in Belgium and Brazil, suggests that blocking the release of these DNA webs could be a new therapeutic target for the management of severe forms of COVID-19. (2020-09-14)

Rapid infectious disease shifts in Chinese children and adolescents prior to COVID-19
Deaths of children and adolescents in China due to infectious diseases were becoming rare prior to the covid-19 pandemic, according to a new study. (2020-04-03)

Wuhan CT scans reliable for coronavirus (COVID-19) diagnosis, limited for differentiation
An American Journal of Roentgenology open-access article by radiologists from Wuhan, China concluded that chest CT had a low rate of misdiagnosis of COVID-19 (3.9%, 2/51) and could help standardize imaging features and rules of transformation for rapid diagnosis; however, CT remains limited for the identification of specific viruses and distinguishing between viruses. The authors also found CT features of COVID-19 that differ from both severe acute respiratory syndrome and Middle East respiratory syndrome. (2020-03-05)

Effective ventilation may be a key factor in preventing the spread of COVID-19
During the first wave of COVID-19, which paralyzed the world in spring, it was initially thought that effective hand washing and 2-meter social distancing would help prevent the highly contagious virus. Scientists, however, have now come to the conclusion that proper indoor ventilation is even more effective. (2020-10-20)

WPI researcher's paper on COVID-19 published in Viruses journal
Two months after creating a structural 3D roadmap of the novel coronavirus and sharing it with the scientific community worldwide, Worcester Polytechnic Institute (WPI) bioinformatics researcher Dmitry Korkin has published a paper on the topic in Viruses, a leading academic virology journal. (2020-04-15)

Sensitive new test detects antibodies against SARS-CoV-2 in only 10 minutes
As the COVID-19 curve shows signs of flattening in the U.S. and elsewhere, public health officials are trying to grasp just how many people have been infected. Now, a proof-of-concept study in ACS' Analytical Chemistry describes a quick, sensitive test for antibodies against the coronavirus in human blood. The test could help doctors track a person's exposure to the disease, as well as confirm suspected COVID-19 cases that tested negative by other methods. (2020-04-29)

Preexisting drug shows promise in fight against COVID-19
A team of researchers at the Pritzker School of Molecular Engineering (PME) at the University of Chicago used state-of-the-art computer simulations to identify a preexisting drug that could fast-track a solution to the worldwide pandemic. (2020-08-14)

Biomarkers could help predict severe SARS-CoV-2 infection
Molecular markers in the blood shown to be predictive of severe COVID-19 outcomes resulting from SARS-CoV-2 coronavirus infection have been identified in a study by a Chinese research team. The study results extend understanding of the pathophysiology and clinical progress of COVID-19 with potential for identifying early during the course of infection which individuals are most at risk of developing severe conditions and requiring hospital care. (2020-12-14)

Investigational COVID-19 vaccine candidate prevents se-vere clinical disease in animals
In new research published in Nature Medicine, Beth Israel Deaconess Medical Center immunologist Dan H. Barouch, MD, PhD, and colleagues demonstrated that the optimal vaccine elicited robust immune response in Syrian golden hamsters and prevented severe clinical disease -- including weight loss, pneumonia and death. (2020-09-03)

HudsonAlpha investigator develops rapid response swine flu test
Dr. Jian Han, faculty investigator at the HudsonAlpha Institute for Biotechnology, has completed development of a rapid response, molecular-level assay for swine flu, the current strain of the H1N1 family of the influenza virus. The test, which can confirm swine flu in less than six hours, will be incorporated into a viral respiratory panel that will detect the current strain of swine flu, as well as Influenza A, Influenza B and other viruses. (2009-05-07)

Public health measures can contain SARS, two modeling studies suggest
The SARS virus is contagious enough to cause a very large epidemic if left unchecked, but could nonetheless be controlled with rigorous public health measures, two research teams report. These results are being released today by the journal Science, published by the American Association for the Advancement of Science (AAAS). (2003-05-23)

The Lancet Infectious Diseases: Study from Chinese city of Guangzhou provides key insights on how COVID-19 spreads in households
New modelling research, published in The Lancet Infectious Diseases journal, suggests the coronavirus (SARS-CoV-2) that causes COVID-19 may spread more easily among people living together and family members than severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS). The estimates are the first of their kind to quantify symptomless transmission. (2020-06-17)

Why remdesivir does not fully stop the coronavirus
Their results explain why the drug has a rather weak effect (2021-01-18)

Scientists discover how remdesivir works to inhibit coronavirus
By pinning down the exact mechanism by which remdesivir shuts down SARS-CoV-2's process of copying genetic material, scientists now have clues to make even more effective antivirals to fight COVID-19. Better antivirals could become urgently needed if new strains of the virus have the ability to overcome current antivirals and vaccines. They could also help in future outbreaks if entirely new coronaviruses leap from animals to humans again. (2021-01-28)

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