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Ground-breaking research on the side effects of therapy
While many people who suffer from depression and anxiety are helped by seeing a psychologist, others don't get better or actually get worse. Psychological treatment can have negative side effects, like any medicine. This unexplored territory is the focus of a new dissertation out of Stockholm University. (2017-02-07)

Preventing marijuana-induced memory problems with over-the-counter painkillers
In addition to being used as a recreational drug, marijuana has been used for centuries to treat a variety of conditions, from chronic pain to epilepsy. However, its medical value is greatly limited by debilitating side effects. A study published in the journal Cell has revealed the molecular pathways responsible for marijuana-induced learning and memory problems. The findings suggest that preventing these side effects could be as easy as taking an over-the-counter painkiller. (2013-11-21)

New method promises fewer side effects from cancer drugs
A recent achievement in the field of protein research allows for better tailored pharmaceuticals with fewer side effects. The method was developed by two University of Copenhagen researchers. (2018-09-14)

Compound created at OSU could become important new antidepressant
Chemists at Oregon State University have discovered and synthesized a new compound that in laboratory and animal tests appears to be similar to, but may have advantages over one of the most important antidepressant medications in the world. (2010-02-04)

Statement from Sandra Raymond, President and CEO, Lupus Foundation of America, Inc.
We applaud the results of a research study on the effectiveness of mycophenolate mofetil (MMF) as a potential new treatment for lupus nephritis (lupus kidney disease) which are published in the November 24, 2005 issue of the New England Journal of Medicine. The multi-center clinical study found that MMF, or CellCept®, was more effective than the current standard-of-treatment with intravenous cyclophosphamide, and had a better safety profile. (2005-11-23)

Information overload in drug side effect labeling
Lists of potential side effects that accompany prescription drugs have ballooned in size, averaging 70 reactions per drug. In a study appearing in the May 23 issue of the Archives of Internal Medicine, researchers from the Regenstrief Institute and the Indiana University School of Medicine analyzed more than 5600 labels and have quantified just how complex drug labels have become. (2011-05-23)

Side effects of antidepressants used for chronic pain relief
The study, recently published in Frontiers in Neurology, collected all reported adverse effects for these drugs in the clinical literature from the past two decades. The researchers found that almost all antidepressants presented significant side effects. Clinical data also showed that some might better tolerate certain side effects than others, and therefore. These results may help physicians improve treatment outcomes by better matching the health status of chronic pain patients to their antidepressant medication. (2017-09-05)

Amifostine makes radiation more effective, eases side effects
Doctors in Brazil have concluded that the drug amifostine eases many of the most common side effects associated with patients receiving radiation therapy to treat their cancer while simultaneously making the cancer more susceptible to radiation. The study was published in the March 1, 2006, issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology. (2006-03-01)

Vandetanib: IQWiG assessed data subsequently submitted by the manufacturer
There is now a hint of minor added benefit in patients aged under 65 years, but greater harm was shown in people aged over 65 years. (2013-10-01)

Anti-cancer drug damages brain vessels
New research may help explain why an anti-cancer drug causes potentially fatal brain inflammation in certain patients. Scientists at Harvard Medical School mimicked the drug's activity in mice and found that it damaged the cell lining that prevents fluid from leaking from the spinal cord into the brain. The results will be published online on Feb. 11 in the Journal of Experimental Medicine. (2008-02-11)

Exercise alleviates sexual side-effects of antidepressants in women, study shows
New UT Austin research shows exercise has the potential to restore sexual desire and function in women adversely affected by sexual side effects. (2013-12-10)

Chemical peels are safe for people with darker skin, result in few side effects and complications
Results from a new study led by Boston Medical Center (BMC) indicate that, when performed appropriately, chemical peels can be a safe treatment option for people with darker skin. (2018-03-16)

Prostate brachytherapy causes fewer side effects than surgery
Men with prostate cancer have a slightly better long-term side effects profile with radiation seed implants than they do with surgery, according to a study released today in the International Journal for Radiation Oncology, Biology, Physics, the official journal of Astro. (2007-02-28)

New schizophrenia drugs may be no more effective than conventional therapy
There is no clear evidence that new antipsychotic drugs are any more effective or better tolerated than conventional drugs for patients with schizophrenia, despite being considered superior, finds a study in this week's BMJ. (2000-11-30)

With smaller clinical trials, it may be up to doctors to notice rare drug side effects
Study: Right-colon twist with high-dose osimertinib highlights need for doctor vigilance with new cancer drugs (2020-04-22)

Ohio State study reveals no link between hormonal birth control and depression
The vast majority of women will use some method of contraception during their lifetime. Despite there being 37 million in the United States who are currently on birth control, many still worry about potential side effects. (2018-02-26)

Reducing the side-effects of prostate hormone therapy with exercise
A prescription of short-term exercise for patients with advanced prostate cancer could help to reduce the side-effects of hormone therapy, according to new research. The trial aimed to reduce the adverse side-effects of hormone therapy such as weight gain and an increased risk of heart problems. The results show that a three month programme of aerobic and resistance training intervention prevented adverse changes in cardiopulmonary fitness and fatigue (2019-12-09)

How can medical marijuana benefit older adults?
Managing symptoms such as pain, nausea, and psychiatric illness can be challenging as people age. (2018-04-19)

Solving the 50-year-old puzzle of thalidomide
Resurgence of thalidomide use in Africa and South America raises the urgent need to isolate the negative side effects by identifying the drug's (2009-11-17)

'Dimmer switch' drug idea could tackle schizophrenia without side effects
The discovery of a new mechanism of drug action could lead to the next generation of drugs to treat schizophrenia. (2014-08-10)

New technique improves purity of medicines
Dutch researcher Roelof Mol has investigated possibilities for more accurately determining the composition of medicines. He came up with a combination of two techniques that were previously considered to be incompatible: the separation technique electrokinetic chromatography and the detection technique mass spectroscopy. (2007-10-24)

Obesity drug failing patients due to lack of education about side-effects
A new study, published today in the Journal of Health Psychology, found that patients who gained weight 18 months after taking Orlistat attributed their weight-loss failure either to the side effects which have prevented them from sticking to the medication or felt that the medication simply had not worked. (2014-05-08)

'Seeing' the other side of our galaxy
Astronomers have successfully traced a spiral arm on the far side of our Galaxy, an accomplishment that provides new insights into the structure of the Milky Way. (2017-10-12)

One in three pain patients suffer side effects after ketamine infusion therapy
As the opioid epidemic continues to devastate the United States, ketamine use has grown as a pain management alternative, yet more than one in three patients may experience side effects such as hallucinations and visual disturbances, suggests new research presented at the ANESTHESIOLOGY® 2019 annual meeting. (2019-10-21)

Expecting the worst increases side-effects in breast cancer patients on hormone therapies
A study of women receiving hormone therapies such as tamoxifen as part of their treatment for breast cancer has found that the number and seriousness of side effects they experienced were influenced by their expectations. The study, published in Annals of Oncology, found that women who had higher expectations of suffering more and worse side-effects before their treatment began did, in fact, experience more after two years of adjuvant hormone therapy. (2016-08-22)

Dopamine agonists reduce motor complications in Parkinson's disease, but increase other side effects
Dopamine agonists are increasingly used to treat people with Parkinson's disease, but there is a debate about how well they work. A review of current data indicates that there is less risk of developing motor complications with these drugs. (2008-04-15)

Potential new pain killer drug developed by scientists at Leicester and Italy
A potential new pain-killing drug developed by medical scientists at the University of Leicester and Ferrara in Italy is to be discussed at a public lecture on March 20. (2007-03-16)

Male breast cancer patients stop taking tamoxifen early because of drug-related side effects
The largest study to investigate the tolerability of the breast cancer drug tamoxifen in male breast cancer patients has shown that men stop taking their prescribed therapy early because of problems with side effects caused by the drug. (2011-11-15)

Potential solution for side effect of Alzheimer's immunotherapy treatment
It is estimated that 46.8 million people worldwide are living with dementia, with Alzheimer's disease the most common form. Now researchers from the University of Southampton have discovered a possible solution for side effects seen in immunotherapy treatment for Alzheimer's. (2015-11-05)

Half of breast cancer patients experience severe side effects
Nearly half of women treated for early stage breast cancer reported at least one side effect from their treatment that was severe or very severe, a new study finds. (2017-01-24)

Impact of methamphetamine use depends on your genes
The research, published in Molecular Psychiatry found that variations in the gene known as BDNF strongly determine the effects of methamphetamine in the brain. This could potentially explain why some users develop methamphetamine-induced psychosis, which is similar to schizophrenia. (2019-12-19)

Researchers are on their way to predicting what side effects you'll experience from a drug
Researchers at the University of California, San Diego have developed a model that could be used to predict a drug's side effects on different patients. The proof of concept study is aimed at determining how different individuals will respond to a drug treatment and could help assess whether a drug is suitable for a particular patient based on measurements taken from the patient's blood. (2015-11-02)

Advanced radiation therapy for head and neck cancer may be better than traditional radiation at preventing side effects and cancer recurrence
Patients with head and neck cancer who are treated with an advanced form of radiation therapy may experience fewer side effects and be less likely to die from their disease than patients who receive standard radiation therapy. That is the finding of an analysis published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The study establishes so-called intensity-modulated radiation therapy as both a safe and beneficial treatment for patients with head and neck cancer. (2014-01-13)

Statins overprescribed for primary prevention
Taking cholesterol-lowering drugs, or statins, as a preventive measure can reduce the risk of cardiovascular disease. A study by the University of Zurich now shows that this measure is recommended too often, as current guidelines fail to take into account the risks of side effects. (2018-12-06)

Another step in understanding antipsychotic medication
Antipsychotic drugs are used for the treatment of mental illnesses such as bipolar disorder and schizophrenia. Unfortunately, sedation or sleepiness is a common side effect of these drugs, which makes a patient's recovery difficult. A new study from the National Centre for Biological Sciences (NCBS), Bangalore, on the antipsychotic drug Clozapine, indicates that the serotonin receptor 5-HT2A is partially responsible for the sedative effects of Clozapine. (2017-02-28)

Predicting bad side effects
Researchers from Japan's Tohoku University and colleagues have found that a simple DNA test can predict if East Asian patients are likely to have bad reactions to thiopurine medications. (2018-07-01)

New research on the brain's backup motor systems could open door to novel stroke therapies
New research published in the Journal of Physiology could open the door to new therapies to improve the movement of arms and hands of stroke survivors. (2018-02-14)

Study: Ultra-thin fibres designed to protect nerves after brain surgery
The drug nimodipine could prevent nerve cells from dying after brain surgery. Pharmacists at Martin Luther University Halle-Wittenberg (MLU), in cooperation with neurosurgeons at University Hospital Halle (Saale) (UKH), have developed a new method that enables the drug to be administered directly in the brain with fewer side effects. Their findings were published in the ''European Journal of Pharmaceutics and Biopharmaceutics''. (2020-05-27)

Patients report fewer moderate and serious side effects with IMRT than with brachytherapy
In one of the first studies to compare side effects of IMRT and permanent prostate brachytherapy (I-125) for treatment of low-risk prostate cancer, researchers say patients had fewer moderate and serious side effects when treated with IMRT. (2006-11-07)

Taking tamoxifen to prevent breast cancer can save lives and money
Tamoxifen, taken by certain women as a preventive measure against breast cancer, saves lives and reduces medical costs. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The study's results suggest that the benefits of tamoxifen to prevent cancer can sufficiently compensate for its side effects in post-menopausal women under age 55 years who have an increased risk of developing breast cancer. (2011-03-14)

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