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Scientists 'see' through the sun to find stormy regions on the other side
A week's warning of potential bad weather in space is now possible thanks to a new use of the Solar and Heliospheric Observatory (SOHO) spacecraft. Two astrophysicists supported by the National Science Foundation (NSF) have developed a technique to image explosive regions on the far side of the sun, using ripples on the sun's surface to probe its interior. (2000-03-08)

Advanced cancer drug shrinks and intercalates DNA
A new study published in EPJ E has found that the drug first forces itself between the strands of the DNA molecule's double helix, prising them apart. It then compacts the structures by partially neutralising their phosphate backbones. (2019-10-28)

Changing Drug Delivery For Rheumatoid Arthritis Patients Increases Effectiveness, Lowers Costs
Researchers show that giving the medication, methotrexate, to patients who suffer from juvenile rheumatoid arthritis or rheumatoid arthritis by injection, rather than orally, significantly improved the patients' health and at a dramatically reduced cost. (1998-11-09)

Genetic alterations caused by cancer therapies identified
Scientists at IRB Barcelona determine the genetic alterations in the cells of cancer patients caused by the main cancer therapies. This is an important step towards understanding the long-term side effects and optimizing treatments against cancer. The results have been published in the journal Nature Genetics. (2019-11-18)

Pinch away the pain
Prof. Michael Gurevitz of Tel Aviv University's department of plant sciences is investigating new ways for developing a novel painkiller based on natural compounds found in the venom of scorpions. These compounds have gone through millions of years of evolution and some show high efficacy and specificity for certain components of the body with no side effects, he says. (2010-02-16)

In the quest for safer treatment for systemic lupus erythematosus
Researchers at the UPV/EHU-University of the Basque Country study what the best treatment is to minimise the side effects of glucocorticoids (2014-06-17)

New drug-delivery approach holds potential for treating obesity
Researchers from MIT and Brigham and Women's Hospital have developed targeted nanoparticles that can deliver anti-obesity drugs. Obese mice that received the treatment lost 10 percent of their body weight. (2016-05-02)

Too little attention is paid to the side effects of emission-limiting measures
With measures aimed at reducing the emission of pollutants such as ammonia, policy makers pay too little attention to the consequences for the emission of other substances. This is revealed in a computer model constructed by Corjan Brink from Wageningen University during his doctoral research. For example, the model shows that reducing the amount of ammonia emitted leads to an increase in the emission of nitrous oxide (laughing gas). (2003-01-24)

Drugs widely used in cancer therapy increase toxicity of chemotherapy in mice
A short-term fast appears to counteract increases in blood sugar caused by common cancer drugs and protect healthy cells in mice from becoming too vulnerable to chemotherapy, according to new research from the University of Southern California. (2017-04-04)

An eye for an eye
Revenge cuts both ways in the Israeli-Palestinian conflict. Scientists of the University of Zurich, the Massachusetts Institute of Technology, and Tel Aviv and Quinnipiaq Universities show that attacks by either side lead to violent retaliation from the other. Both Israelis and Palestinians may underestimate their own role in perpetuating the conflict. (2010-10-04)

Scripps Florida scientists identify novel compound to alleviate pain and itch
In a new study, scientists from the Florida campus of the Scripps Research Institute have identified a possible drug candidate that suppresses pain and itch in animal models. (2016-12-01)

Overeating caused by a hormone deficiency in brain?
Rutgers scientists have found that when hormone glucagon like peptide-1 was reduced in the central nervous system of laboratory mice, they overate and consumed more high fat food. Although this is not the only reason why people overeat, the study provides new evidence that targeting neurons in the mesolimbic dopamine system -- a reward circuit in the brain -- rather than targeting the whole body might be a better way to control overeating and obesity with fewer side effects. (2015-07-23)

New guideline: Corticosteroids recommended for duchenne muscular dystrophy
Corticosteroids can be beneficial in the treatment of Duchenne muscular dystrophy and can be offered as a treatment option, according to the American Academy of Neurology and the Child Neurology Society in a new practice guideline published in the January 11 issue of Neurology, the scientific journal of the American Academy of Neurology. (2005-01-10)

Ophthalmologists link immunotherapy with a serious eye condition
Eye inflammation and uveal effusion develop among patients taking anti-cancer immune checkpoint inhibitor therapy. (2018-05-07)

Drug combination effective against multiple myeloma, researchers show
Pairing a new thalidomide derivative with a steroid slows progress of multiple myeloma, an incurable bone marrow cancer, and prolongs the lives of patients who have relapsed from previous treatment, researchers report in the Nov. 22 New England Journal of Medicine. (2007-11-21)

JNCI news brief: Cost-effectiveness of HPV vaccination in the Netherlands
Even under favorable assumptions, including lifelong protection against 70 percent of all cervical cancers and no side effects, vaccination against the human papillomavirus is not cost-effective in the Netherlands, according to a study published online July 1 in the Journal of the National Cancer Institute. (2009-07-01)

Revamped experiment could detect elusive particle, physicists say
An experiment called (2007-04-24)

Budesonide is not beneficial for the treatment of diarrhea in metastatic melanoma patients
Patients with stage III or IV melanoma taking ipilimumab and the oral steroid budesonide to reduce side effects did not have less diarrhea, a known side effect of ipilimumab, according to results of a phase II trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research. (2009-08-11)

Sipuleucel-T in prostate cancer: Indication of added benefit
Information subsequently submitted by the drug manufacturer provided better evidence on mortality. However, it is not possible to exactly estimate the extent of added benefit. (2015-03-20)

Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
A group of researchers from The Scripps Research Institute (TSRI) have solved the structure of an enzyme that modulates central nervous system (CNS) functions such as pain perception, cognition, feeding, sleep, and locomotor activity. (2002-11-28)

Prostate cancer treatment comparison: seed implantation shows more side effects than external radiation
Treating prostate cancer with implanted radioactive (2001-11-06)

Addendum on regorafenib in metastatic colorectal cancer: Added benefit no longer proven
Drug manufacturer subsequently submitted data analyses that reveal additional disadvantages in quality of life. As a result, an added benefit is no longer proven despite survival advantage. (2016-03-18)

Vitamin D inhibits progression of some prostate cancers
Vitamin D can inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes, scientists report. The findings in research done in test tubes with human prostate cancer cell lines mean that vitamin D could be of benefit to prostate cancer patients with high levels of the enzymes. But patients should not consider taking vitamin D without close medical supervision, scientists say. (2006-02-08)

Drug for rare disorder shows promise for treating herpes viruses
New research shows that the antiviral activity of the drug -- called phenylbutyrate, or PBA -- was even better when used along with acyclovir, a common HSV-1 treatment. When used in combination, less acyclovir is needed to effectively suppress the virus compared to acyclovir alone -- this is important because acyclovir is also known to have toxic side effects in the kidneys. (2020-12-07)

Chemical maps hint at drug's effects on schizophrenia
Antipsychotic drugs do most of their work in the brain, but they also leave behind in the bloodstream a trail of hundreds of chemicals that may be used in the future to direct better treatment for schizophrenia and other psychiatric conditions, say Duke University Medical Center researchers. (2007-05-15)

Lithium shows no benefit for people with ALS
A new study has found that the drug lithium is not effective in treating people with amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. The research is published in the Aug. 11, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology. (2010-08-11)

UV laser photolyses to enhance diamond growth
Researchers at the University of Nebraska-Lincoln, USA, reported on a new laser-enabled synthesis route to explore the advantages of laser photochemistry in practical material synthesis in a recent article in Light: Science & Applications. In this work, it is demonstrated that UV laser photolysis of hydrocarbon species altered the flame chemistry to promote the diamond growth rate and film quality. The authors found that the UV laser photolysis plays a key role in suppressing the formation of the side products, nondiamond carbons. (2018-01-25)

'Metal' drugs to fight cancer
What is the mechanism of action of metal-based chemotherapy drugs (the most widely used for treating common cancers like testicular or ovarian cancer)? How can we improve their effect and reduce their toxicity? A new study combining experiments and theory has broadened our knowledge of the molecular mechanisms of these active drugs to help experimentalists devising increasingly effective drugs with fewer side effects. The study, just published in the journal ChemMedChem, was conducted with SISSA of Trieste. (2015-12-21)

New cancer drug shows promise for treating advanced melanoma
Results from the first clinical trial of lambrolizumab in patients with advanced melanoma shows significant anti-tumor activity with very manageable side effects in patients with advanced melanoma, the deadliest form of skin cancer. (2013-06-02)

Mobile phone use not linked to increased risk of glioma brain tumours
Mobile phones are not associated with an increased risk of the most common type of brain tumour, finds the first UK study of the relationship between mobile phone use and risk of glioma. The results are published online by the BMJ today. (2006-01-19)

Days following thyroid surgery are highest for risk of readmission
An analysis of nationwide data shows patients with symptoms are most likely to return to the hospital within a week of their thyroid surgery, suggesting avenues for better care. (2019-01-03)

How tails help geckos and other vertebrates make great strides
A wagging tail is often associated with dogs' emotions, but the side-to-side motion may also help them take longer strides and move faster, according to a study by researchers at the University of California, Riverside. The research was done on leopard geckos, which are ideal animals for the study of tail function because they naturally lose their tails as a defense mechanism against predators in a process called autotomy. (2017-09-07)

Running out of treatments: The problem superbugs resistant to everything
Doctors are running out of treatments for today's trauma victims and critically ill patients because of infections due to drug resistant microbes -- even after resorting to using medicines thrown out 20 years ago because of severe side effects, scientists heard today at the Society for General Microbiology's 162nd meeting being held this week at the Edinburgh International Conference Center. (2008-03-31)

Chemical compound shows promise as alternative to opioid pain relievers
A drug targeting a protein complex containing two different types of opioid receptors may be an effective alternative to morphine and other opioid pain medications, without any of the side effects or risk of dependence, according to research led by the Icahn School of Medicine at Mount Sinai. (2013-07-15)

Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
Most of us have had a doctor prescribe an antibiotic for a stubborn bacterial infection, or for a cut that gets infected. However, prescribing an antibiotic to fight cancer? In fact, anti-cancer antibiotics have been used since the 1950s to successfully treat several forms of cancer, but often the side effects limit the duration they can be given to a patient. (2011-06-28)

Drug tested at OHSU prevents MS-like disease in animals
Scientists at OHSU are announcing very promising results of an MS drug trial conducted in rats. The drug prevented MS-like symptoms in the animal models being studied. The data is being presented at The Endocrine Society meeting. (2004-06-18)

Misoprostol substantially reduces serious complications in early termination of pregnancy
Cervical preparation with misoprostol reduces major complications of early surgical abortion by almost a third compared with placebo, according to new research published online first in the Lancet. (2012-03-07)

Texas A&M researchers develop treatment for canine ocular condition using turmeric
Researchers at Texas A&M University have produced a therapeutic derived from turmeric, a spice long-praised for its natural anti-inflammatory properties, that shows promise in decreasing ocular inflammation in dogs suffering from uveitis, an inflammation of the eye that leads to pain and reduced vision. (2020-09-03)

Frequently prescribed drug used in concerning ways with harmful side effects
A popular class of drugs commonly used to treat sleep and mood symptoms continues to be frequently prescribed despite being known to have potentially life-threatening side effects. (2013-02-06)

Clinical trial results show new drug is better for CLL patients
Older adults with chronic lymphocytic leukemia may have an alternative to toxic chemotherapy as their first treatment, according to a national study to be reported online Dec. 6, 2015, in the New England Journal of Medicine and co-authored by a Wilmot Cancer Institute oncologist. (2015-12-06)

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