Signaling Pathway Current Events

Signaling Pathway Current Events, Signaling Pathway News Articles.
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Insight into JAK/STAT
Dr. Norbert Perrimon and colleagues at Harvard Medical School (Boston, MA) have used a genome-wide RNAi screen in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling pathway. (2005-08-01)

Signaling pathway may explain the body clock's link to mental illness
Alterations in a cellular signaling pathway called cAMP-CREB may help explain why the body clocks of people with bipolar disease are out of sync, according to a new European Journal of Neuroscience study. (2014-06-16)

Building the blood-brain barrier
Construction of the brain's border fence is supervised by Wnt/b-catenin signaling, report Liebner et al. in the Journal of Cell Biology. (2008-10-27)

Auxin takes root
Dr. Nam-Hai Chua and his team at Rockefeller University in New York have begun to unravel the molecular mechanisms by which plants develop roots. The plant hormone, auxin, has been linked to root formation, but the actual pathway of its action has, until recently, remained a mystery. (2000-11-30)

Cancer research: Targeted elimination of leukemic stem cells
Cancer research in Bern has discovered a further mechanism to combat leukemia: a research team at Inselspital, Bern University Hospital and the University of Bern has succeeded in identifying an important signaling pathway for regulating leukemic stem cells. With this discovery, the researchers are expanding the arsenal of potentially highly effective drugs against leukemia. (2021-02-16)

Preventing cancer: Scientists identify a useful piece of JNK
A team of scientists led by Dr Roger Davis has discovered that a group of genes encoding the so-called 'JNK signaling pathway' can function to suppress tumor development by promoting tumor cell death. This finding, published in the March 1st issue of G&D, is particularly exciting since previous studies suggested that this pathway was important in promoting tumor growth. These new experiments have significant implications for the diagnosis and treatment of some forms of cancer. (2003-03-05)

'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. (2009-11-13)

CSHL Press releases new book on Wnt signaling
Written and edited by experts in the field and published by Cold Spring Harbor Laboratory Press, (2012-10-17)

Medical researcher's discovery may explain how certain cancers develop
A Florida State University College of Medicine researcher has discovered a new interaction between a cell signaling system and a specific gene that may be the cause of B-cell lymphoma. The finding suggests a similar interaction could be occurring during the development of other types of cancer, leading to further understanding of how cancer works -- and how it might be stopped. (2010-05-27)

Evolution in action: How some fish adapt to pollutants
New genetic analyses of fish reveal how some have managed to evolve and adapt to live in polluted water. The results suggest that the high genetic diversity exhibited by these fish was key -- a palette for natural selection to act on to facilitate the population's rapid adaptation to extreme pressures. (2016-12-08)

Scientists awarded $1.2 million to find drug candidates to treat wide range of cancers
Scientists from the Florida campus of The Scripps Research Institute have been awarded $1.2 million from the National Cancer Institute of the National Institutes of Health to accelerate development of drug candidates to curb one of the most important drivers of human cancer. (2015-04-09)

Cholesterol activates signaling pathway that promotes cancer
Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers at the University of Illinois at Chicago describe a new role for cholesterol in the activation of a cellular signaling pathway that has been linked to cancer. (2014-07-15)

New insight into RASopathy-associated lymphatic defects
In this issue of the Journal of Clinical Investigation, Michael Simon and colleagues report that RASopathy-associated lymphatic defects require sustained activation of the ERK protein. (2013-02-08)

Two routes to cell death in the diseased kidney
Stimulation by the ubiquitous cytokine TGF-b activates the transcription of numerous target genes and leads to an impressive range of biological effects. Central to these responses are intracellular mediators of the SMAD family, which are activated and transported to the nucleus following TGF-b treatment. Schiffer et al. show here that there are surprises left in this widely studied and highly conserved pathway. (2001-09-12)

A promising target of anti-fibrotic therapy: herbal compound 861
A research article published on May 14, 2008 in the World Journal of Gastroenterology gives a vivid picture, which shows that herbal compound 861inhibits the transforming growth factor-beta 1 (TGF beta1)-dependent effects of in vitro cultured LX-2 hepatic stellate cells by decreasing α-SMA expression, Id1 transcription, and Smad-1 phosphorylation, and exerts its effect on the inactivation of LX-2 cells by down-regulating the TGF-beta1/activin receptor-like kinase 1 signaling pathway. (2008-05-14)

Therapeutic inhibition of RANK pathway reduces breast cancer recurrence
Researchers from IDIBELL have shown that pharmacological and genetic inhibition of RANK/RANKL signaling pathway leads to a significant reduction in recurrences and metastases in breast cancer in a mouse animal model. Their findings suggest that RANK inhibitors currently used in patients with osteoporosis and bone metastases may have potential for treating breast cancer. (2016-09-13)

Endosome-mediated signaling in plants
In a paper that will be published online in advance of its July 1 publication date, Drs. Niko Geldner, Joanne Chory and colleagues (the Salk Institute and HHMI) demonstrate that endosomes can function as signaling platforms in plants, as well as in animals. (2007-06-18)

New path for colon cancer drug discovery
An old pinworm medicine is a new lead in the search for compounds that block the Wnt signaling pathway, which has been implicated in colon cancer. The findings, reported by Vanderbilt University Medical Center researchers in the November issue of Nature Chemical Biology, suggest a fresh approach for developing therapeutics that target the pathway. (2010-11-19)

Breast cancer may be 'uniquely sensitive' to inhibitors of PI3K pathway
Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center. (2004-12-10)

Researchers determine how a major tumor suppressor pathway becomes deactivated
The Hippo pathway is an important biological tumor suppressor program that controls cell growth and organ size in humans. Cancer cells have been found to frequently deactivate Hippo signaling in order to achieve increased cell growth and become more aggressive. However, how the Hippo pathway becomes deregulated in human cancers is still poorly understood. (2019-04-04)

Wnt stem cell signaling pathway implicated in colorectal cancer in patients under 50
A study of 4,699 tumor samples, presented at ASCO, finds Wnt pathway genes CTNNB1 and FAM123B specifically upregulated in colorectal cancer of patients under age 50. (2016-06-04)

The MAP kinase pathway in coxsackievirus infections
Heritable biochemical idiosyncrasies are thought to help explain the variable outcome when individuals in the outbred human population are exposed to pathogens. However, even in relatively tractable mouse models, there are surprisingly few clear examples of biochemical differences that can account for the characteristic sensitivity of some inbred strains to specific viruses. (2002-06-12)

How cancer cells start new tumor sites
A study in the Journal of Biological Chemistry has revealed details of the complex molecular process involving a protein that enables cancer cells to establish tumors in distant parts of the body. The finding could lead the way to new drugs to prevent breast cancer and other cancers from spreading to new sites. (2012-03-14)

Signaling pathway suppresses brain tumors
Researchers at the University of Basel took a close look at a signaling pathway present in most organisms and found that it suppresses the formation of specific types of brain tumor. Their results have been published by the journal Cancer Cell. (2015-12-04)

New molecular signaling cascade increases glucose uptake
Scientists have discovered a novel molecular pathway which is activated in muscles during exercise. This is important because it is known that the contraction-induced signaling to stimulate glucose transport is distinct from that utilized by insulin. Thus, for individuals in which insulin only has little effect (insulin resistance) the contraction-induced pathway represents an alternative pathway to increase glucose uptake. (2010-08-20)

Signal blocks stem cell division in the geriatric brain
Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results were published in ''Cell Reports'' and may be relevant for treating neurodegenerative disease in human brains. (2019-08-28)

CAS scientists review the basic and translational studies of hedgehog signaling
Previously, in recognition of their work on this topic, Prof. WANG Yu from the Institute of Zoology, Chinese Academy of Sciences, and Professor Andrew P. McMahon from University of South California were invited by the journal Elife to comment on latest work from scientists at Stanford, Harvard, and Oxford on newly discovered mechanisms of chemical modulation of HH signaling. (2017-03-09)

A switch between life and death
Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Controlling growth requires that some cells divide while others die; their fates are determined by signals that are passed from molecule to molecule within the cell. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg have now discovered how one of these signaling pathways controls the life and death of cells in the fruit fly. (2006-08-28)

New findings cast light on lymphatic system, key player in human health
Defects in the lymphatic system have been linked to a wide range of health consequences, but new findings of how the system works could lead to future therapies. (2018-10-16)

Signal explains why site of origin affects fate of postnatal neural stem cells
New research may help to explain why the location of postnatal neural stem cells in the brain determines the type of new neurons that are generated. The research, published by Cell Press in the July 28 issue of the journal Neuron, demonstrates that a signaling pathway which plays a key role in development also actively regulates the fate of neural stem cells in the adult brain. (2011-07-27)

Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimer's, other brain disorders
Yale scientists have discovered that the growth of brain cells, which normally ends in adolescence, can be re- stimulated in mature neurons with a molecular mechanism known as Notch signaling. Notch signaling may also be involved in degenerative brain diseases like Alzheimer's. The results published in the Oct. 22 issue of Science could help scientists find ways to treat, or even prevent, this and other brain disorders. (1999-10-18)

Pathways activated in most K9 bone tumors not driving the worst bone tumors
CU Cancer Center and CSU Flint Animal Cancer Center study shows NOTCH signaling was elevated in K9 osteosarcoma, but aspects of Notch signaling were noticeably deactivated in the worst cancers. (2013-07-23)

Scientists pinpoint gene variations linked to higher risk of bipolar disorder
Scientists from the Florida campus of The Scripps Research Institute have identified small variations in a number of genes that are closely linked to an increased risk of bipolar disorder, a mental illness that affects nearly six million Americans, according to the National Institute of Mental Health. (2012-10-10)

New findings on intercellular communication
This is a nice example of a rather unexpected discovery: by studying the development of the blood vessels of the brain, researchers at Université libre de Bruxelles have just shed light on a question that was pending for 10 years! They provide a molecular mechanism conferring ligand specificity to Wnt signaling, an ancestral communication pathway present in all vertebrates. Their research is published in Science. (2018-07-20)

Context is key: Differential PI3K signaling and consequences for targeted therapy
In the July 15 issue of G&D, Dr. Suzanne Baker (St. Jude Children's Research Hospital) and colleagues report on their surprising discovery of cell-type specificity of PI3K signaling in the mammalian brain. This finding highlights the complexity of this clinically significant cell signaling pathway, and its relevance to the design of small molecule PI3K pathway inhibitors, to both maximize efficacy and minimize side effects. (2009-07-14)

New molecular insight into vertebrate brain development
In the Dec. 1 issue of G&D, Dr. Fred H. Gage and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors and potential therapeutic targets that may be involved in congenital brain size disorders and neurological tumor formation. (2008-11-17)

Dioxin-receptor network identified
A cell responds to pollutants - such as dioxin - via intricate and complex biochemical pathways beginning with the interaction of the pollutant molecule with a cell surface receptor. Christopher Bradfield and colleagues used yeast as a model system to elucidate the steps involved in the pathway that regulates vertebrate cell response to dioxin, the aryl hydrocarbon receptor (AHR) signal transduction pathway. (2004-03-16)

Building Immunity: MBL Whitman Center team recreates a T-cell receptor signaling pathway
By successfully re-creating a T-cell receptor signaling pathway independent of the cell itself, MBL Whitman Center scientists have gained novel insights into how protein signaling works in a complex cellular process. (2016-04-11)

Malaria's weakest link
A group of researchers from EPFL's Global Health Institute and Inserm has discovered that a class of chemotherapy drugs originally designed to inhibit key signaling pathways in cancer cells also kills the parasite that causes malaria. The discovery could quickly open up a whole new strategy for combating this deadly disease. (2011-03-08)

Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
Breast cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells. (2012-05-30)

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