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Scientists use bear saliva to rapidly test for antibiotics
If you're looking into the mouth of a brown bear, which is among the world's top predators, your chances of survival probably aren't good. But a team of Rutgers and other scientists has discovered a technology that rapidly assesses potentially lifesaving antibiotics by using bacteria in saliva from an East Siberian brown bear. (2018-09-13)

Superbug's CPU revealed
A team from the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University has revealed that a small chemical, made by the superbug Staphylococcus aureus and its drug-resistant forms, determines this disease's strength and ability to infect. (2010-06-03)

MRSA's 'weak point' visualized by scientists
An enzyme that lives in MRSA and helps the dangerous bacterium to grow and spread infection through the human body has been visualised for the first time, according to a study out today in Proceedings of the National Academy of Sciences. (2009-01-19)

Workers at industrial farms carry drug-resistant bacteria associated with livestock
A new study found drug-resistant bacteria associated with livestock in the noses of industrial livestock workers in North Carolina but not in the noses of antibiotic-free livestock workers. The drug-resistant bacteria examined were Staphylococcus aureus, commonly known as (2013-07-02)

Animals now picking up bugs from people, study shows
Globalization and industrialization are causing diseases to spread from humans to animals, a study has shown. Researchers from the Roslin Institute of the University of Edinburgh have shown that a strain of bacteria has jumped from humans to chickens. (2009-10-26)

Research shows how pathogenic bacteria hide inside host cells
A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections. (2011-01-26)

Trojan horses for hospital bugs
Staphylococcus aureus usually is a formidable bacterial pathogen. Sometimes, however, weakened forms are found in the blood of patients. Researchers of the University of Würzburg have now identified one mutation responsible for that phenomenon. (2016-05-16)

Pattern recognition receptors on mast cells
The Toll-like receptors (TLRs) fit the definition of pattern-recognition molecules, which were originally postulated to allow the innate immune system to detect the 'molecular signatures' of various infectious agents. Although the innate immune system has no memory, it shows a degree of specificity, in part because the various TLRs recognize different sets of pathogen-associated molecules. (2002-05-15)

Technology leads to better treatment for Staphylococcus aureus sepsis
A new testing and treatment approach led to shorter hospital stays for patients with Staphylococcus aureus bloodstream infections. Study results were presented at the ASM Microbe 2017 conference in New Orleans, LA, on June 3, 2017. (2017-06-03)

Protective shield: How pathogens withstand acidic environments in the body
Certain bacteria, including the dangerous nosocomial pathogen MRSA, can protect themselves from acidic conditions in our body and thus ensure their survival. Researchers at the Biozentrum of the University of Basel have now elucidated an important mechanism in this process. A transport protein involved in cell wall biosynthesis plays a key role, they report in the journal 'Nature Structural & Molecular Biology.' (2020-05-05)

An aspirin a day keeps Staphylococcus aureus away
In the July 15 issue of The Journal of Clinical Investigation, Ambrose Cheung and colleagues at Dartmouth School of Medicine in New Hampshire, USA, report that salicylic acid (SAL), the major metabolite of aspirin, downregulates two Staphylococcus aureus genes key to this organism's pathogenesis. The report is the first description of aspirin-mediated genetic effects against S. aureus and represents an exciting new prospect for this widely used and established drug. (2003-07-15)

MRSA in Sweden: A quarter of cases infected abroad
A quarter of all people with methicillin-resistant Staphylococcus aureus (MRSA) in Sweden between 2000 and 2003 were infected abroad. A study published today in the open access journal 'BMC Infectious Diseases' reveals that the number of MRSA infections in Sweden nearly doubled between 2000 and 2003. The study also shows that 25 percent of all cases came from abroad. (2006-02-20)

Additive restores antibiotic effectiveness against MRSA
Researchers from North Carolina State University have increased the potency of a compound that reactivates antibiotics against methicillin-resistant Staphylococcus aureus, an antibiotic-resistant form of Staphylococcus that is notoriously difficult to treat. Their improved compound removes the bacteria's antibiotic resistance and allows the antibiotic to once again become effective at normal dosage levels. (2012-10-22)

Antibacterial silver nanoparticles are a blast
Writing in the International Journal of Nanoparticles, Rani Pattabi and colleagues at Mangalore University, explain how blasting silver nitrate solution with an electron beam can generate nanoparticles that are more effective at killing all kinds of bacteria, including gram-negative species that are not harmed by conventional antibacterial agents. (2010-05-24)

Cranberry juice shows promise blocking Staph infections
Expanding their scope of study on the mechanisms of bacterial infection, researchers at Worcester Polytechnic Institute have reported the surprise finding from a small clinical study that cranberry juice cocktail blocked a strain of Staphylococcus aureus from beginning the process of infection. The data was reported in a poster presentation at the American Chemical Society's recent national meeting by Terri Camesano, professor of chemical engineering at WPI. (2010-09-01)

Community-acquired staph pneumonia appears more common, including MRSA
Preliminary research from the Centers for Disease Control and Prevention suggests that community acquired pneumonia caused by the Staphylococcus aureus bacterium may be more common than originally suspected, including that caused by antibiotic resistant strains. (2008-03-19)

Staphylococcus aureus bacteria turns immune system against itself
Around 20 percent of all humans are persistently colonized with Staphylococcus aureus bacteria, a leading cause of skin infections and one of the major sources of hospital-acquired infections, including the antibiotic-resistant strain MRSA. University of Chicago scientists have recently discovered one of the keys to the immense success of S. aureus -- the ability to hijack a primary human immune defense mechanism and use it to destroy white blood cells. The study was published Nov 15 in Science. (2013-11-19)

Hospital acquired infections present major problem for infants in developing countries
Rates of neonatal infections in hospital born babies are up to 20 times higher in developing countries than in industrialised countries, reveals a review in this week's issue of The Lancet. (2005-03-24)

MRSA risk doubled in critically ill patients with glucose in their airways
Critically ill patients with glucose in their airways seem to be at double the risk of picking up serious hospital acquired infections, including MRSA, suggests research in Thorax. The authors base their findings on a study of 98 critically ill patients in intensive care who required mechanical help with their breathing for more than 48 hours. The patients were drawn from medical and surgical specialties. (2005-08-31)

Families of kids with staph infections have high rate of drug-resistant germ
Family members of children with a staph infection often harbor a drug-resistant form of the germ, although they don't show symptoms, a team of researchers from Washington University School of Medicine in St. Louis has found. (2012-06-04)

Adding bacteria to wounds
How do you stop wounds becoming infected with dangerous superbugs? By adding other bugs, say Canadian researchers who have found that a cousin of the yoghurt bacterium can stop the growth of harmful bugs. (2000-11-19)

Study examines effect of antibiotic susceptibility for patients with bloodstream infection
In an analysis of more than 8,000 episodes of Staphylococcus aureus bloodstream infections, there were no significant differences in the risk of death when comparing patients exhibiting less susceptibility to the antibiotic vancomycin to patients with more vancomycin susceptible strains of S. aureus, according to a study published in JAMA. The study is being released early online to coincide with the IDWeek 2014 meeting. (2014-10-09)

The Trojan horse of Staphylococcus aureus
A weapons of Staphylococcus aureus is α-toxin, which destroys host cells by forming pores in their membranes. Researchers at UNIGE have identified the mechanism that allows these pores to be harmful. They uncover how proteins of human cells assemble into a complex to which pores are docked. They also demonstrate that blocking the assembly of the complex by removing one of its elements allows pores to be removed from the membrane and cells to survive. (2018-11-20)

Methicillin resistance among clinical isolates of Staphylococcus aureus in Egypt
In this article that appeared in Infectious Disorders - Drug Targets, Dr. AlaaAbouelfetouh, Associate Professor of Microbiology at the Faculty of Pharmacy, Alexandria University, is gathering the published data describing methicillin resistance in S. aureus (MRSA) in Egypt. (2017-05-26)

Discovery pinpoints new therapeutic target for atopic dermatitis
Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe. By identifying a major mechanism through which Staphylococcus aureus binds to the skin of patients with AD the team has opened the possibility of targeting this pathway as a therapeutic option in AD. (2021-01-11)

Severe childhood pneumonia linked to specific strain of Staphylococcus aureus
Authors of a French study in this week's issue of THE LANCET highlight the link between a specific strain of the bacterium Staphylococcus aureus and a severe form of pneumonia in children. (2002-02-28)

Return of the Staphylococcus aureus 'superbug'
In the December 15 issue of the JCI, researchers from University Medical Center Rotterdam examined Staphylococcus aureus strains from healthy and infected individuals and compared their genetic relatedness. 5 distinct clusters were revealed and they and found clear evidence that while all strains of S. aureus have the potential to cause infection, some appear to be more virulent that others and are associated with particularly invasive types of disease. (2004-12-15)

Staphylococcus aureus Achilles' heels
Staphylococcus aureus is a formidable human pathogen, ranking amongst the leading causes of soft tissue infections, as well as severe pneumonia. One of the bacterium's most impressive weapons is α-toxin, which provokes the destruction of human cells. An international project allowed to identify the components of our cells that modulate the virulence of this toxin, in particular the PLEKHA7 protein. By eliminating expression of the latter, cells gained the ability to recover from α-toxin injury. (2015-10-21)

New findings detail how beneficial bacteria in the nose suppress pathogenic bacteria
Staphylococcus aureus is a common colonizer of the human body. Although, one quarter of the US population live with the bacteria and never get sick, having S. aureus present in the nostrils is a risk for infections that range in severity from mild skin to life- threatening MRSA infections. Research from the Forsyth Institute is providing insight into how harmless Corynebacterium species, bacterial members of the nasal and skin microbiome, help protect humans from disease. (2016-08-17)

MRSA pre-screening effective in reducing otolaryngic surgical infection rates
Pre-operative screening of patients for methicillin-resistant staphylococcus aureus may be an effective way to reduce infection rates following otolaryngic surgeries, according to new research published in the January 2009 issue of Otolaryngology -- Head and Neck Surgery. (2009-01-01)

Resistant bacteria increasing source of muscle infection
An antibiotic-resistant bacteria called methicillin-resistant Staphylococcus aureus (MRSA) is increasingly a cause of muscle infections in children, said Baylor College of Medicine (BCM) researchers in a report in the journal Clinical Infectious Diseases. (2006-09-25)

Early case of resistance to new antibiotic
A fast-track research letter published in this week's issue of THE LANCET describes the case of a patient whose infecting bacterium developed resistance to one of the new so-called bug-busting antibiotics. (2001-07-19)

Drug-Resistant Infection Once Found Only In Hospitals Now Present In Community
Drug-resistant Staphylococcus aureus, a predominantly hospital-acquired infection, has been identified in children outside of the hospital setting with no identified risk factors, according to a study by researchers at the University of Chicago Children's Hospital, published in the February 25 issue of the Journal of the American Medical Association. (1998-02-25)

Aspirin could reduce the risk of deadly infections
Adding to the long list of the benefits of aspirin, researchers have found that it is responsible for reducing toxic bacteria associated with serious infections. A study led by Dartmouth Medical School describes how salicylic acid-produced when the body breaks down aspirin-disrupts the bacteria's ability to adhere to host tissue, reducing the threat of deadly infections. (2003-07-17)

Disinfectants can make bacteria resistant to treatment
Chemicals used in the environment to kill bacteria could be making them stronger, according to a paper published in the October issue of the journal Microbiology. Low levels of these chemicals, called biocides, can make the potentially lethal bacterium Staphylococcus aureus remove toxic chemicals from the cell even more efficiently, potentially making it resistant to being killed by some antibiotics. (2008-10-05)

Biochemists find new treatment options for staph infections, inflammatory diseases
Kansas State University biochemists have discovered a family of proteins that could lead to better treatments for Staphylococcus aureus, a pathogenic bacterium that can cause more than 60,000 potentially life-threatening infections each year. (2014-09-02)

Vaccine that harnesses antifungal immunity protects mice from staph infection
Immunization of mice with a new vaccine consisting of fungal particles loaded with Staphylococcus aureus (S. aureus) proteins protects mice against S. aureus infection, according to a study published August 20 2020 in the open-access journal PLOS Pathogens by David Underhill of Cedars-Sinai Medical Center, and colleague. (2020-08-20)

Bacterial toxin with healing effect
A bacterial toxin promoting tissue healing has been discovered by an international research team led by scientists from University of Jena (Germany). The compound α-Hemolysine found in Staphylococcus aureus does not just damage cells, but also stimulates tissue regeneration. (2020-10-13)

Use of glucocorticoids is associated with increased risk of serious bacterial blood infection
The risk of life-threatening blood infections by Staphylococcus aureus bacteria is more than doubled in users of systemic glucocorticoids compared with non-users. The risk escalates with increasing dose, according to a new Danish population-based case-control study published in Mayo Clinic Proceedings. (2016-06-08)

Interrupting death messages to treat bone disease
A surface molecule on bacteria that instructs bone cells to die could be the target for new treatments for bone disease, says a scientist speaking at the Society for General Microbiology's autumn meeting today. Blocking the death signal from bacteria could be a way of treating painful bone infections that are resistant to antibiotics, such as those caused by meticillin-resistant Staphylococcus aureus. (2010-09-06)

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