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In war with 'superbugs,' Cedars-Sinai researchers see new weapon: Immune-boosting vitamin
Cedars-Sinai researchers have found that a common vitamin may have the potential to provide a powerful weapon to fight certain (2012-08-27)

New research shows that European hedgehogs in Denmark carry a secret
Through a research collaboration between Institute of Biology at University of Southern Denmark (SDU), Naturama and Statens Serum Institut, scientists have discovered, that Danish hedgehogs carry mecC-MRSA in their snouts. (2019-09-19)

New bacteria-resistant materials discovered
Using state-of-the-art technology scientists at the University of Nottingham have discovered a new class of polymers that are resistant to bacterial attachment. These new materials could lead to a significant reduction in hospital infections and medical device failures. (2012-08-13)

Lollipops and ice fishing: Molecular rulers used to probe nanopores
Using a pair of exotic techniques including a molecular-scale version of ice fishing, a team at the National Institute of Standards and Technology has developed methods to measure accurately the length of (2010-04-28)

Scientists closing in on an new type of vaccine
When we acquire diarrhea on a vacation, it is often caused by a bacterial infection. Now a Danish research team is working on a new type of vaccine design targeting the disease causing bacterium -- if it works it may very well revolutionize not only the prevention of this disease, but also offer protection against other pathogens with a heavy disease burden such as Mycobacterium tuberculosis and antibiotic-resistant Staphylococcus aureus (MRSA). The project is supported with a 2.93 million DKK Novo Pre-Seed grant (393.677 €) from Novo Seeds, which is part of the Novo Nordisk Foundation and Novo A/S as well as the University of Southern Denmark's internal Proof of Concept Board. (2014-12-11)

Study finds extensive patient sharing among hospitals; could impact spread of infectious diseases
Renowned research expert on infectious disease and epidemiology, Dr. Susan Huang, releases new study on patient sharing and how to track and prevent the spread of infectious disease. (2009-03-19)

New research raises questions about using certain antibiotics to treat 'superbug' MRSA
A new study sheds light on how treatment of the 'superbug' known as MRSA with certain antibiotics can potentially make patients sicker. The findings by Cedars-Sinai scientists, published today in the journal Cell Host & Microbe, could have implications for managing the bug, a virulent form of the common staph infection that can be difficult to control. (2015-11-11)

N.Y. prison inmates overuse and misuse antibiotic ointments, study says
Prisoners need education on the appropriate use of topical antibiotic products, according to a study released today at the 39th Annual Educational Conference and International Meeting of the Association for Professionals in Infection Control and Epidemiology. (2012-06-04)

MRSA uses decoys to evade a last-resort antibiotic
The superbug MRSA uses decoys to evade a last-resort antibiotic, reveals new research. The findings, from scientists at Imperial College London, suggest potential new ways of tackling the bacteria, such as interfering with the decoys. (2016-10-24)

Poking holes in pathogens: scientists at The Scripps research institute build a new class of nanotube 'smart drugs'
Scientists at The Skaggs Institute for Chemical Biology, a part of The Scripps Research Institute, have published a paper in the current issue of Nature describing a broad nanochemical approach for designing drugs to combat such problems as infections with antibiotic resistant bacteria. M. Reza Ghadiri, Ph.D., and coworkers created a class of biological polymers known as cyclic peptide nanotubes, which stack inside cell membranes of bacteria, and poke holes in their membranes, killing cells. (2001-07-26)

Inexpensive rinsing effective at reducing post-op infection following joint replacement surgery
A rinsing technique with betadine that costs just a little over one dollar per patient may significantly reduce the infection rate following total knee and hip joint replacement surgery according to a study by researchers at Rush University Medical Center. (2011-02-17)

Cleaning hospital rooms with chemicals, UV rays cuts superbug transmissions
In a hospital, what you can't see could hurt you. Healthcare facilities continue to battle drug-resistant organisms such as methicillin-resistant Staphylococcus aureus that loiter on surfaces even after patient rooms have been cleaned and can cause new, sometimes-deadly infections. But a new study from Duke Medicine has found that using a combination of chemicals and UV light to clean patient rooms cut transmission of four major superbugs by a cumulative 30 percent among a specific group of patients. (2015-10-07)

Newly discovered antibiotic kills pathogens without resistance
In a breakthrough study, Northeastern University researchers discover new resistance-free antibiotic by using a novel device to extract drugs from bacteria growing in soil (2015-01-08)

Study shows how bacteria evolve in the lungs of cystic fibrosis patients
The bacterium Burkholderia multivorans evolves and adapts in bursts to survive in the lungs of cystic fibrosis patients, according to a study published this week in mSystems, an open access journal from the American Society for Microbiology. The work, believed to be the first retrospective look at the evolution of this microorganism, indicates that B. multivorans directly or indirectly targets adherence, metabolism and changes to the cell 'envelope' to stick around and evade antibiotics. (2016-05-24)

Overuse of antibiotics not what the doctor ordered
With increased use of antibiotics worldwide linked to growing antibiotic resistance, a world-first study co-authored by a QUT researcher has highlighted the growing impact of non-prescription supply of antibiotics in community pharmacies, and the urgent need for better enforcement of laws. South America has the highest incidence of non-prescription supply of antibiotics in community pharmacies. (2018-07-18)

Parent cleansing paramount prior to skin-to-skin care
Neonatal intensive care units increasingly encourage meaningful touch and skin-to-skin care -- aka 'kangaroo care' -- between parents and premature babies to aid the babies' development. But a Michigan children's hospital practicing skin-to-skin care noticed an unwanted side effect in 2016 -- a spike in Staphylococcus aureus (SA) infections among newborns. (2018-06-14)

UCalgary researchers discover why sepsis from a staph infection causes organ failure
Scientists have known for some time that one of the reasons a staph infection is so deadly is that the bacteria send out a toxin, known as Alpha Toxin (AT), which quickly worsens sepsis. University of Calgary scientists at the Cumming School of Medicine's Snyder Institute for Chronic Diseases have discovered the most important target of the toxin and how to neutralize the danger. (2018-07-25)

Decontamination exterminates antibiotic-resistant bacteria from pig farm
Decontamination protocols eradicated both methicillin-resistant Staphylococcus aureus (MRSA) and antibiotic resistant, pathogenic intestinal bacteria, the Enterobacteriaceae, from a pig farm. The research appears online Sept. 4 in ASM's journal Applied and Environmental Microbiology. (2015-09-04)

NIH awards will support development of therapeutic alternatives to traditional antibiotics
The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded approximately $5 million in funding for 24 research projects seeking to develop non-traditional therapeutics for bacterial infections to help address the growing health threat of antibiotic resistance. Advancing new therapeutic options to combat drug-resistant bacteria is a key goal of the President's National Action Plan for Combating Antibiotic-Resistant Bacteria. (2016-01-11)

Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
Chronic exposure to even small amounts of staph bacteria could be a risk factor for the chronic inflammatory disease lupus, Mayo Clinic research shows. (2012-08-08)

Stanford chemists develop a new way to treat antibiotic-resistant infections
Chemists have modified a common antibiotic to make it more effective at fighting off one common type of antibiotic-resistant bacterium, known as MRSA. (2018-11-05)

Identification of much-needed drug target against MRSA, gram-positive infections
Scientists at the University of Utah and the University of Georgia have uncovered a pharmacological target that could enable development of novel drugs against antibiotic-resistant pathogens, including Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant enterococci and other infectious Gram-positive organisms such as Listeria and Mycobacterium tuberculosis. The target was revealed upon discovery of a Gram-positive bacteria-specific pathway for making heme, an essential iron-carrying molecule. The findings were reported in the journal, Proceedings of the National Academy of Sciences. (2015-02-02)

MRSA blood infections are less fatal in kids, but cause significant complications
Children with bloodstream infections caused by methicillin-resistant Staphylococcus aureus (MRSA), a common antibiotic-resistant bacteria, are less likely to die than adults with this condition and have different risk factors for treatment failure, a new study led by a Children's National Health System clinician indicates. (2017-05-05)

UW study tests topical honey as a treatment for diabetic ulcers
The sore on Catrina Hurlburt's leg simply wouldn't heal. Complications from a 2002 car accident left Hurlburt, a borderline diabetic, with recurring cellulitis and staph infections. One of those infections developed into a troublesome open sore that, despite the use of oral antibiotics, continued to fester for nearly eight months. (2007-05-03)

Youki spray curbs spread of superbug MRSA
In wound care treatment bandages and dressings may become archaic tools of the past. The future is in a spray called Youki that accelerates the healing process. (2004-12-17)

URMC and Temple announce drug discovery partnership
The University of Rochester Medical Center and Temple University School of Pharmacy have announced a partnership that will help translate novel medical research into new drugs for treating diseases. (2011-08-18)

New strategies to combat MRSA in hospitals
New guidelines aim to reduce the prevalence of methicillin-resistant Staphylococcus aureus (MRSA), improve patient safety and prioritize current prevention efforts underway in hospitals. This drug resistant bacterium is a common source of patient morbidity and mortality in US hospitals, causing nearly twice the number of deaths, significantly longer hospital stays and higher hospital costs than other forms of the bacteria. (2014-06-11)

Unravelling the secret of antibiotic resistance
Scientists from the University of Leeds have solved a 25-year-old question about how a family of proteins allow bacteria to resist the effects of certain antibiotics. (2016-03-22)

Emerging multi-drug resistant infections lack standard definition and treatment
Infection control practices for detecting and treating patients infected with emerging multidrug-resistant gram-negative bacteria vary significantly between hospitals. A study from the Society for Healthcare Epidemiology of America Research Network, a consortium of more than 200 hospitals collaborating on multi-center research projects, found this inconsistency could be contributing to the increase in multidrug-resistant bacteria. The study is published in the April issue of Infection Control and Hospital Epidemiology. (2014-03-07)

3 payloads built by CU-Boulder set for launch on space shuttle Atlantis
NASA's space shuttle Atlantis will make its final flight May 14 carrying three University of Colorado at Boulder-built biomedical payload devices, including one to help scientists understand how and why slimy and troublesome clumps of microorganisms flourish in the low-gravity conditions of space. (2010-05-12)

Universal screening for MRSA may be too costly
Universal MRSA screening and isolation of high-risk patients will help prevent MRSA infections but may be too economically burdensome for an individual hospital to adopt, researchers find. (2014-10-08)

Arming the fight against resistant bacteria
In 1928, Alexander Fleming opened the door to treating bacterial infections when he stumbled upon the first known antibiotic in a penicillium mold growing in a discarded experiment. (2007-04-27)

JILA frequency comb helps evaluate novel biomedical decontamination method
JILA researchers are using a laser frequency comb -- a technique for making extraordinarily precise measurements of frequency -- to identify specific molecules in gases. The project is helping biomedical researchers evaluate a novel instrument that kills harmful bacteria without the use of liquid chemicals or high temperatures. (2012-06-14)

The smallest Cas9 genetic scissors (so far)
IBS scientists present the smallest member of the CRISPR-Cas9 family developed to date and show that it can fit inside adeno-associated viruses and mutate blindness-causing genes (2017-02-21)

Graphene underpins a new platform to selectively ID deadly strains of bacteria
A team led by Boston College researchers has developed a prototype sensor that uses an atom-deep sheet of graphene and peptides to rapidly reveal which bacterial species is in a sample and whether it is antibiotic resistant. The graphene field effect transistor (G-FET) achieved single-cell resolution and a 5-minute detection time, which could lead to more accurate targeting of infections with appropriate antibiotics. (2020-03-19)

KETEK highly active in vitro against European isolates of community-acquired respiratory pathogens
New studies presented today at the 22nd International Congress of Chemotherapy (ICC), in Amsterdam, Netherlands may change the way patients are treated with infections in the future. Whilst antibiotic resistance to penicillins and macrolides has been steadily increasing across the world over the last few years, the launch of a new global surveillance project - PROTEKT - is now beginning to shed light on patterns of antimicrobial resistance and the implications for future treatments. For further information about the new global surveillance project, please visit www.protekt.org. (2001-07-03)

Computer model shows how to better control MRSA outbreaks
A research team led by scientists at the Columbia University Mailman School of Public Health report on a new method to help health officials control outbreaks of methicillin-resistant Staphylococcus aureus, or MRSA, a life-threatening antibiotic-resistant infection often seen in hospitals. The researchers are the first to reveal the invisible dynamics governing the spread of these outbreaks and demonstrate a new, more effective method to prevent their spread. Findings are published in the journal eLife. (2019-01-02)

New Systems Biology Awards enable detailed study of microbes
NIAID will award five-year contracts estimated to be up to $68.7 million to establish programs in Systems Biology for Infectious Disease Research at four research institutions. Scientists at each facility will apply novel techniques to study diseases that include severe acute respiratory syndrome, tuberculosis and influenza. (2008-10-09)

Expensive hospital readmissions linked to health-care-associated infections
New research finds a strong link between healthcare-associated infections and patient readmission after an initial hospital stay. The findings, published in the June 2012 issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, suggest that reducing such infections could help reduce readmissions, considered to be a major driver of unnecessary healthcare spending and increased patient morbidity and mortality. (2012-05-04)

Combo of 3 antibiotics can kill deadly staph infections
Three antibiotics that, individually, are not effective against a drug-resistant staph infection can kill the deadly pathogen when combined as a trio, according to researchers at Washington University School of Medicine in St. Louis. They have killed the bug -- methicillin-resistant Staphylococcus aureus -- in test tubes and laboratory mice, and believe the same strategy may work in people. (2015-09-14)

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