Telomeres Current Events

Telomeres Current Events, Telomeres News Articles.
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Having children can make women's telomeres seem 11 years older
A study by George Mason University Researchers found that women who have given birth have shorter telomeres than those who haven't. Telomeres are the end caps of DNA on our chromosomes, which help in DNA replication and get shorter over time. The length of telomeres has been associated with morbidity and mortality previously, but this is the first study to examine links with having children. (2018-03-08)

Telomere length may predict risk of coronary heart disease in middle-aged men
Men with short telomeres -- repetitive strips of DNA that cap the ends of chromosomes -- may have a higher risk of developing coronary heart disease than those with long telomeres, according to an article in this week's issue of the Lancet. (2007-01-11)

Danish discovery may change cancer treatment
Danish researchers from the University of Copenhagen and Herlev Hospital have made a discovery that may change the principles for treating certain types of cancer. (2015-04-29)

How fast you age depends on your parents
In the hunt for better knowledge on the aging process, researchers from Lund University have now enlisted the help of small birds. A new study investigates various factors which affect whether chicks are born with long or short chromosome ends, called telomeres. (2014-12-11)

Telomeres and Telomerase
Telomeres & Telomerase draws together contributions from an interdisciplinary and international group of specialists concerned with research on all aspects of telomeres and telomerase. Includes discussions of the genetic structure of telomeres, and the properties, roles and expression of telomerase. Discusses the importance of telomeres and telomerase in cancer and ageing, as well as in DNA repair (1998-01-22)

Telomere length influences cancer cell differentiation
Researchers from the Japanese Foundation for Cancer Research in Tokyo have discovered that forced elongation of telomeres (extensions on the end of chromosomes) promotes the differentiation of cancer cells, probably reducing malignancy, which is strongly associated with a loss of cell differentiation. They report their findings in a manuscript published online ahead of print, in the journal Molecular and Cellular Biology. (2013-06-27)

Research points towards early cancer detection
Scientists at Cardiff University School of Medicine have achieved greater understanding of telomeres -- small DNA structures which have a role in the onset of cancer. The discovery may lead in time to the development of a very early test for tumors. (2007-10-03)

Telomeres resemble DNA fragile sites
Although telomeres are fragile, they don't have to be handled with care. Researchers at Rockefeller University now show that what keeps our fragile telomeres from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their vulnerable ends but also reveals how the genome is made more stable by them. (2009-07-09)

New genetic biomarkers could predict coronary heart disease
New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research shows that people who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres (ends of the chromosome) and, since these people are prone to CAD, an early test could indicate their susceptibility and help them to alter their lifestyle to avoid or delay the onset of the disease. (2007-03-31)

We're all going to die; DNA strands on the end of our chromosomes hint when
BYU professor Jonathan Alder is currently studying the gene mutations that cause people to have unnaturally short telomeres. Recent research he coauthored with collaborators at Johns Hopkins University, published in the Journal of Clinical Investigation and Chest, finds those mutations are connected to both pulmonary fibrosis and emphysema. (2015-02-06)

New insight into how telomeres protect cells from premature senescence
Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have further uncovered the secrets of telomeres, the caps that protect the ends of our chromosomes. They discovered that an RNA molecule called TERRA helps to ensure that very short (or broken) telomeres get fixed again. The work, which was recently published in the journal Cell, provides new insights into cellular processes that regulate cell senescence and survival in aging and cancer. (2017-06-30)

Blocking two enzymes could make cancer cells mortal
EPFL scientists have identified two enzymes that protect chromosomes from oxidative damage and shortening. Blocking them might be a new anticancer strategy for stopping telomerase, the enzyme that immortalizes tumors. (2018-05-16)

'In vivo' reprogramming induces signs of telomere rejuvenation
During the 'in vivo' reprogramming process, cellular telomeres are extended due to an increase in endogenous telomerase. This is the main conclusion of a paper published in 'Stem Cell Reports' by a team from the Spanish National Cancer Research Centre (CNIO). Their observations show, for the first time, that the reprogramming of living tissue results in telomerase activation and telomere elongation; thus reversing one of the hallmarks of aging: 'the presence of short telomeres.' (2017-02-02)

Fewer children mean longer life?
New research into aging processes, based on modern genetic techniques, confirms theoretical expectations about the correlation between reproduction and lifespan. Studies of birds reveal that those that have offspring later in life and have fewer broods live longer. And the decisive factor is telomeres, shows research from The University of Gothenburg, Sweden. (2013-03-27)

Scientists find mechanisms to avoid telomere instability found in cancer and aging cells
Researchers from Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that a functional component of telomeres called TERRA has to constantly be kept in check to prevent telomeric and chromosomal instability, one of the underlying anomalies associated with cancer. (2018-01-22)

Young birds suffer in the city
City life is tough for young birds. But if they survive their first year, they are less susceptible to the effects of stress, according to research from Lund University in Sweden. (2017-09-08)

UT Southwestern researchers find another clue to secrets of cellular aging
A discovery by UT Southwestern Medical Center at Dallas scientists that genes near human telomeres can be silenced may help explain how and why humans age. (2001-06-14)

TERRA, the RNAs that protect telomeres
Despite their especially compact structure that is difficult to access, telomeres transcribe information like the rest of the DNA. The RNAs resulting from this process are called TERRA and their function is essential in preserving these protective structures. This is the conclusion of a new study by the Telomere and Telomerase Group at the Spanish National Cancer Research Centre, which has also located the part of the human genome where these molecules are 'manufactured.' (2016-08-17)

Longer telomeres may shield mice from age-related human diseases
Researchers in Deepak Srivastava's laboratory at the Gladstone Institute of Cardiovascular Disease hypothesized that mice may be protected from age-associated human diseases due to the relatively longer length of their telomeres, the regions at the end of chromosomes that help guard against deterioration. In work published this week in the JCI, the researchers used mice with shortened telomeres to examine a genetic defect that causes an age-associated congenital heart disease in humans. (2017-03-27)

Study provides insights on chronic lung disease
A new study shows that shorter telomeres -- which are the protective caps at the end of a cell's chromosomes -- are linked with worse survival in a progressive respiratory disease called idiopathic pulmonary fibrosis. (2015-06-15)

Children with ADHD and their mothers may live less than average population
Brazilian scientists found that ADHD children and their mothers are more likely to have shorter telomeres, a hallmark of cellular aging, which is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer. (2015-09-28)

Urban bird species risk dying prematurely due to stress
Birds of the species Parus Major (great tit) living in an urban environment are at greater risk of dying young than great tits living outside cities. Research results from Lund University in Sweden show that urban great tits have shorter telomeres than others of their own species living in rural areas. According to the researchers, the induced stress that the urban great tits are experiencing is what results in shorter telomeres and thereby increases their risk of dying young. (2016-06-20)

High levels of exercise linked to 9 years of less aging at the cellular level
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time. But new research from Brigham Young University reveals you may be able to slow one type of aging -- the kind that happens inside your cells. As long as you're willing to sweat. (2017-05-10)

Discovery by NUS researchers improves understanding of cellular aging and cancer development
A team of researchers led by Dr Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore at the National University of Singapore, has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, which are key players involved in cellular ageing. The results of the study will contribute to a better understanding of the human ageing process as well as cancer development. (2017-06-13)

Blood chromosome differences are linked to pancreatic cancer
A new study shows that a blood marker is linked to pancreatic cancer, according to a study published today by scientists at the University of Wisconsin Carbone Cancer Center and Mayo Clinic. (2012-10-23)

Born to be young?
The environment we experience in early-life is known to have major consequences on later-life health and lifespan. A new study led from the University of Turku in Finland using an avian model suggests that increased prenatal exposure to maternal thyroid hormones could have beneficial effects on the 'biological age' at birth. (2020-11-11)

Regulation of telomerase in stem cells and cancer cells
Scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have gained important insights for stem cell research which are also applicable to human tumors and could lead to the development of new treatments. (2012-06-27)

Scientists home in on the mechanism that protects cells from premature aging
A new study by EPFL researchers shows how RNA species called TERRA muster at the tip of chromosomes, where they help to prevent telomere shortening and premature cell aging. (2020-10-14)

Research links telomere length to emphysema risk
Telomeres, the body's own cellular clocks, may be a crucial factor underlying the development of emphysema, according to research from Johns Hopkins University. (2011-07-15)

The CNIO links telomeres to the origins of liver diseases such as chronic hepatitis and cirrhosis
Researchers generated a mouse with dysfunctional telomeres in the liver; as a result, it developed cellular alterations present in human diseases such as hepatitis or cirrhosis. This study is the first to show that alterations in the functioning of telomeres lead to changes in the liver that are common to diseases associated with an increased risk of liver cancer. This finding provides the basis for understanding the molecular origin of these diseases, as well as identifying new therapeutic strategies for their prevention and control. (2015-04-16)

Drinking 1% rather than 2% milk accounts for 4.5 years of less aging in adults
A new study shows drinking low-fat milk -- both nonfat and 1% milk -- is significantly associated with less aging in adults. Research on 5,834 US adults by Brigham Young University exercise science professor Larry Tucker, Ph.D., found people who drink low-fat (1% and skim) milk experience several years less biological aging than those who drink high-fat (2% and whole) milk. (2020-01-15)

Weight loss from bariatric surgery appears to reverse premature aging
Weight loss from bariatric surgery appears to reverse the premature aging associated with obesity, according to research presented today at Frontiers in CardioVascular Biology 2016.1 Patients had longer telomeres and less inflammation two years later. (2016-07-08)

Chromosome 'anchors' organize DNA during cell division
For humans to grow and to replace and heal damaged tissues, the body's cells must continually reproduce, a process known as (2012-12-20)

Size matters -- when it comes to DNA
A new study at the University of Leicester is examining a sequence of DNA -- known as telomeres -- that varies in length between individual. (2010-06-11)

Preventing cancer without killing cells
Inducing senescence in aged cells may be sufficient to guard against spontaneous cancer development, according to a paper published online this week in EMBO reports. It was previously unknown whether cellular senescence or programmed cell death -- apoptosis -- was the more important safeguard mechanism for suppressing tumours arising from dysfunctional telomeres. (2007-03-30)

CNIO scientists have created mice with hyper-long telomeres without altering the genes
The Telomeres and Telomerase Group at the CNIO has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of genetic manipulation. This new technique based on epigenetic changes avoids the manipulation of genes in order to delay molecular ageing. The study also underlines the importance of this new strategy in generating embryonic stem cells and iPS cells with long telomeres for use in regenerative medicine. (2016-06-02)

CNIO experts discover the genomic origin of telomere protectors
A study led by Centro Nacional de Investigaciones Oncologicas researchers has discovered that telomeric repeat-containing RNA do not originate in all telomeres that protect the 20 murine chromosomes, but do exclusively in chromosome 18 and, to a lesser extent, in chromosome 9. This peculiarity sets the stage for future genetic manipulation in mice with the aim of researching the in vivo role of these molecules in telomere biology and in illness. The results have been published in Nature Communications. (2014-09-03)

Cold-parenting linked to premature aging, increased disease risk in offspring
New research out of Loma Linda University Health suggests that unsupportive parenting styles may have several negative health implications for children, even into their adult years. The study found that the telomeres -- protective caps on the ends of the strands of DNA -- of subjects who considered their mothers' parenting style as 'cold' were on average 25% smaller compared to those who reported having a mother whose parenting style they considered 'warm.' (2019-05-30)

Scientists discover new role for cell dark matter in genome integrity
University of Montreal researchers have discovered how telomerase, a molecule essential for cancer development, is directed to structures on our genome called telomeres in order to maintain its integrity and in turn, the integrity of the genome. (2013-10-03)

CNIO team discovers the first real indicator of longevity in mammals
A team of researchers from the Spanish National Cancer Research Centre (CNIO), headed by CNIO Director María Blasco, has demonstrated that longevity is defined at a molecular level by the length of telomeres. The work -- published today in the online edition of the journal Cell Reports -- opens the door to further study of these cellular components in order to calculate the rate at which cells age and thus be able to determine life expectancy. (2012-09-27)

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