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Testicular Cancer Current Events, Testicular Cancer News Articles.
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Second gene linked to familial testicular cancer
Specific variations or mutations in a particular can gene raise a man's risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research by scientists at the National Institutes of Health. This is only the second gene to be identified that affects the risk of familial testicular cancer, and the first gene in a key biochemical pathway. The study appears in the July 2009 Cancer Research. (2009-06-29)

Men with testicular cancer benefit by writing positively about the experience, Baylor study finds
Men who channeled positive thoughts into a five-week writing assignment about their testicular cancer showed signs of improved mental health afterward, in contrast to men who wrote negatively or neutrally about their condition, according to results of a Baylor University pilot study. (2011-09-14)

International study identifies new genetic risk factors for testicular cancer
Moffitt researcherslaunched a large analysis of five major testicular cancer studies to investigate genetic risk factors linked to TGCT. Their results, which uncovered eight new genetic markers associated with TGCT, were published in the June 12 issue of Nature Genetics. (2017-06-13)

MRI: Noninvasive diagnostic tool for diagnosing testicular cancer
Researchers have found that noninvasive magnetic resonance imaging (MRI) is a good diagnostic tool for the evaluation and staging of testicular cancer and may improve patient care by sparing some men unnecessary surgery, according to a study in the March issue of the American Journal of Roentgenology. (2010-02-22)

Immediate health risk must be weighed against radiation-induced cancer risk
The lifetime risks of cancer from medical radiation may be overemphasized relative to more immediate health risks, according to a new study. (2012-12-18)

TDS - a new syndrome hitting men's reproductive health says Danish fertility expert
Danish fertility experts says doctors and scientists are almost certainly missing evidence of a new syndrome hitting men's reproductive health - Testicular Dysgenesis Syndrome (TDS) (2001-07-02)

Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
A new study in Nature Genetics looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. (2013-05-12)

Insurance status impacts survival in men with testicular cancer
Men with testicular cancer who were uninsured or on Medicaid had a higher risk of death from what is normally a curable disease than insured patients, a new study found. (2016-08-08)

Marijuana use linked to increased risk of testicular cancer
Frequent and/or long-term marijuana use may significantly increase a man's risk of developing the most aggressive type of testicular cancer. Being a marijuana smoker at the time of diagnosis was associated with a 70 percent increased risk of testicular cancer. The risk was particularly elevated (about twice that of those who never smoked marijuana) for those who used marijuana at least weekly and/or who had long-term exposure to the substance, beginning in adolescence. (2009-02-09)

Prognostic value of baseline HRQOL for survival for 11 types of cancer pointed out by EORTC study
Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables. (2013-11-06)

Disturbing trends in men's reproductive health demand urgent action
Urgent action is needed to investigate disturbing trends in men's reproductive health, argues an expert in The BMJ today. (2017-10-10)

Testicular cancer gene in mice may offer clues to origins of cancer in men
Researchers have located a gene dubbed dead end that when mutated or lost, causes testicular tumors in mice. They say their study, published in the online journal Nature, on May 18, 2005 will likely offer future insights into the genetic causes of the disease in humans because the cancer originates from the same cell type, the primordial germ cell, in both mice and men. (2005-05-18)

Side effects of testicular cancer predicted by machine learning
In collaboration with Rigshospitalet, researchers from DTU Health Technology have developed a machine learning model that can predict chemotherapy-associated nephrotoxicity, a particularly significant side effect in patients treated with cisplatin. (2020-06-26)

Gene linked to testicular cancer
In a study to be published in the June 6, 2002, issue of the journal Oncogene, researchers at Duke University Medical Center have identified the first gene known to be highly correlated to testicular cancer. (2002-06-05)

Scientists develop the first model for investigating the origins of testicular cancer in humans
Scientists have developed a model that will enable them to investigate, for the first time, how human testes develop in baby boys while they are in the womb. The research published in Human Reproduction journal will enable researchers to understand the processes that can lead to the onset of testicular germ cell cancer in young adult life, and how factors, such as common environmental chemicals, might play a role. (2010-08-03)

Are silver nanoparticles harmful?
Silver nanoparticles cause more damage to testicular cells than titanium dioxide nanoparticles, according to a recent study by the Norwegian Institute of Public Health. However, the use of both types may affect testicular cells with possible consequences for fertility. (2012-03-14)

Genetic copy-number variants and cancer risk
Genetics clearly plays a role in cancer development and progression, but the reason that a certain mutation leads to one cancer and not another is less clear. Furthermore, no links have been found between any cancer and a type of genetic change called (2012-08-02)

Inaugural issue of American Journal of Men's Health
Testicular cancer is the most common malignancy among 15-35-year-old young men. Men over 65 tend to get prostate cancer, the second leading cause of cancer death among American men. Researchers and physicians need to get as much information on these serious killers as possible so that men can be better informed; which is why the American Journal of Men's Health by SAGE, has published this research in its first issue debuting this month. (2007-03-09)

Sperm banks unpopular with patients - MUHC researchers investigate why
Sperm banks are unpopular, even with patients suffering from cancer and facing treatments that may make them infertile. A new study led by McGill University Health Centre (MUHC) researcher Dr. Peter Chan examines why sperm banks are such an underused resource. (2006-10-05)

First step towards a non-invasive screening test for early signs of testicular cancer
Researchers in Denmark have discovered a way to detect early signs of testicular cancer before it has started to spread. Their findings, reported in Human Reproduction Journal on March 3, are the first step towards developing a simple screening test for men at risk of the disease. The test involves identifying the protein AP-2y, which is a marker for carcinoma in situ, in semen samples. (2005-03-02)

Radiotherapy more effective than chemotherapy for early stage II testicular cancer
A large study of testicular cancer patients has shown that radiation therapy is a better treatment than chemotherapy for patients with stage IIa disease (where one or more regional lymph nodes contain cancer cells but they are less than 2 cm in diameter). These findings, presented at the ESTRO 35 conference and published simultaneously in Clinical Oncology, are important because, until now, there has been little evidence about which treatment for testicular seminoma is more effective. (2016-05-01)

Scientists discover gene required for testis development
In the October issue of Genes & Development, Christopher Raymond and colleagues detail their discovery that the gene, Dmrt1, is essential for normal mammalian testis development. This work provides the first functional evidence that Dmrt1 is required for male sexual development in vertebrates, and helps elucidate the basis of human testicular degeneration syndrome. (2000-10-04)

New pharmacon allows testicular tumors to shrink
A new active pharmaceutical ingredient may help against severe forms of testicular cancer, which only respond inadequately to other therapies. In mice, the substance kills degenerated cells and allows testicular tumors to shrink. Researchers at the University of Bonn were able to demonstrate this in a recent study. However, first clinical trials are still pending. The work has now been published in the 'Journal of Cellular and Molecular Medicine'. (2016-12-28)

Researchers map the genome of testicular cancer
In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger Comprehensive Cancer Center's Katherine Hoadley, Ph.D., analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports. (2018-06-12)

Lance Armstrong Foundation establishes Endowed Chair in Oncology at Indiana University
The Lance Armstrong Foundation is honoring Dr. Lawrence Einhorn and inspiring future innovations in cancer treatment through the establishment of the Lance Armstrong Foundation Chair in Oncology at Indiana University. Funded through a $1.5 million endowment, the chair will support the research and scholarly needs of the named professor and provide seed money for program development and growth. Dr. Einhorn is the physician who successfully treated Mr. Armstrong's testicular cancer. (2005-10-27)

Genetic variant that increases testicular cancer risk in caucasians evolved to protect light skin
One of the most important proteins implicated in cancer is p53. Researchers have identified a DNA sequence variation in a p53-binding site that is more prevalent in Caucasians than in Africans and is associated with a very large risk of testicular cancer but may protect light-skinned individuals against harmful ultraviolet rays. The study offers insights into the evolution of DNA sequence variations in p53-binding sites, and it could lead to improvements in personalized treatment strategies. (2013-10-10)

Other highlights in the Aug. 7 JNCI
Also in the Aug. 7 JNCI are a study showing vitamins and minerals do not improve liver cancer survival, another study on testicular cancer survivors' survival rates for second cancers, a gene expression pattern that predicts lung cancer prognosis and epigenetic changes in Wilms tumor. (2007-08-07)

Study sheds new light on inherited testicular cancer risk
An analysis of data from five major studies of testicular cancer has identified new genetic locations that could be susceptible to inherited testicular germ cell tumors. The findings, which researchers call a success story for genome mapping, could help doctors understand which men are at the highest risk of developing the disease and signal them to screen those patients. (2017-06-12)

Disposable nappies may explain the increase in male infertility
The use of disposable nappies may explain the increase in male infertility over the past 25 years. Nappies lined with plastic significantly increase the temperature of the scrotum--the testicular sac--in boys, the research shows. Temperature is critical to normal testicular development and sperm health. (2000-09-24)

Genetic testing could identify men at a 10-fold increased risk of testicular cancer
A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer. Testing for these variants combined with all 21 previously identified using genetic sequencing identified men with a 10-fold higher risk of testicular cancer than the population average. (2015-10-27)

New genetic region responsible for testicle development found
New research presented today at the European Society for Pediatric Endocrinology meeting has found a genetic region, which may control testicle development in the fetus. (2011-09-26)

Testicular macrophages are guardians of fertility
The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy. To elucidate the nature of these immune cells, the researchers used a novel cell tracing method. Their findings were published on Aug. 7, 2017, in the Journal of Experimental Medicine, and are of fundamental importance. They may help understand certain kinds of infertility in men and find new treatments for them. (2017-08-11)

New model for studying germ cell tumors in testes enlists embryonic stem cells
Researchers offer a new model for studying the development of testicular germ cell tumors (TGCTs) based on transplanting embryonic stem cells into mouse seminiferous tubules, resulting in tumors with gene expressions and differentiation patterns similar to those found in TGCTs. The model has (2011-07-11)

Tanning gene linked to increased risk of testicular cancer, according to NIH scientists
A gene important in skin tanning has been linked to higher risk for testicular cancer in white men, according to a study led by scientists from the US National Institutes of Health and the University of Oxford in England. Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study. (2013-10-18)

Genetic testing can pick out men at increased risk of testicular cancer
Testing for large numbers of genetic changes can identify men with over a 10-fold increased risk of testicular cancer, a new study shows. Researchers found that testing for newly identified genetic factors along with others found in their previous studies could pick out men at increased risk, who might potentially benefit from monitoring or preventative treatment. (2017-06-12)

Nearly half of testicular cancer risk comes from inherited genetic faults
Almost half of the risk of developing testicular cancer comes from the DNA passed down from our parents, a new study reports. The research suggests genetic inheritance is much more important in testicular cancer than in most other cancer types, where genetics typically accounts for less than 20 percent of risk. (2015-09-09)

The evolution of testes
Molecular vestiges resolve the controversial evolution of the testicular position in mammals. (2018-06-28)

MR imaging proves useful in diagnosing some testicular problems
If sonography has ambiguous results, MR imaging can help clarify the results and possibly avoid biopsy or surgery for patients who are having testicular problems, a new study shows. Testicular problems can include abnormal growths and inflammatory or congenital conditions, such as undescended testes, says Rahul Gupta, MD, of William Beaumont Hospital, Royal Oak, MI, and lead author of the study. These conditions can be found in males of all ages including children and elderly adults. (2003-05-05)

Other highlights in the April 4 JNCI
Also in the April 4 JNCI are a study on the risk of noncancer death among testicular cancer survivors, a report that celecoxib does not prevent cancer in Barrett's esophagus patients, and a link between bladder cancer and androgens in mice. (2007-04-03)

Other highlights in the August 20 issue of JNCI
Other highlights of the August 20 issue of JNCI include three articles on body mass index and risk of cancer, a study of Finnish immigrants suggesting that risk of testicular cancer may be determined early in life, a study reexamining the role of a carcinogen-activating enzyme in bladder cancer, and an analysis that doubles previous percentage estimates of hereditary adrenal gland tumors. (2003-08-19)

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