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Potential new predictor of male reproductive potential identified
The distance between a man's scrotum and anus may indicate his ability to reproduce, said researchers from Baylor College of Medicine in the journal PLoS ONE. (2011-05-11)

EAU TV goes 'live' at 24th Annual EAU Congress in Stockholm
At the forthcoming 24th Annual EAU Congress in Stockholm, the EAU will broadcast news recorded on-site in the EAU TV Studio. A first in the organization's annual congresses, EAU TV webcasts will be posted on the EAU websites and broadcast live in the EAU TV area at the congress venue in Stockholm. (2009-03-02)

Suicide risk more than quadruples for people with cancer
People with cancer are more than four times more likely to commit suicide than people without cancer, according to Penn State College of Medicine researchers. (2019-01-14)

Sperm abnormalities seen in male lupus patients
A new study examined gonad function in male SLE patients and found that they have a high frequency of sperm abnormalities associated with reduced testicular volume. (2007-06-28)

Embargoed news from Annals of Internal Medicine
This release contains information about four articles being published in the Sept. 21 issue of Annals of Internal Medicine and one article being released early online. The information is not intended to substitute for articles as sources of information. Annals of Internal Medicine attribution is required for all coverage. (2010-09-20)

Pinpointing when you become a man
New data has indicated that in rats, (2008-03-13)

BPA linked to a common birth defect in boys
A new study links fetal exposure to a common chemical pollutant, bisphenol A, to defects of a testicular hormone in newborn boys with undescended testicles. The results, which were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco, suggest yet another potential harmful effect of BPA, which is widely used in many plastics, liners of food cans and dental sealants. (2013-06-17)

Standardized care may help equalize health outcomes among patients with testicular cancer
New research suggests that although sociodemographic factors have been associated with poor outcomes for patients treated for testicular cancer, guideline-directed, expert care can help to address this issue. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS). (2020-08-10)

Treatments for cancer and sickle cell disease deplete germ cells in young boys
Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, the treatment for sickle cell disease results in complete destruction of all their germ cells, which are called spermatogonia. The study is published in Human Reproduction and is the first to describe the effects of these treatments on spermatogonial quantity (2018-07-24)

UPenn Cancer Center receives two-year $500,000 grant from Lance Armstrong Foundation to establish cancer survivorship program
The UPenn Cancer Center has received a two-year $500,000 grant from the Lance Armstrong Foundation to develop a new model of care for long-term survivors of cancer. The goal of the program, (2001-04-02)

UT southwestern levels the playing field for testicular cancer patients
DALLAS - Aug. 10, 2020 - By offering the same level of care and expertise to two very different populations, UT Southwestern physicians were able to eliminate the sociodemographic disparities in survival and cancer recurrence rates typically seen nationally in testicular cancer patients. (2020-08-10)

Preservation of testicular cells to save endangered feline species
A research team at the German Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) developed a method to isolate and cryopreserve testicular cells. This will allow the safekeeping and biobanking of gametes and other cells of the male reproductive tract of threatened or endangered feline species. The findings have been published in the scientific journal 'Cryobiology.' (2020-03-31)

A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
Researchers from the Bellvitge Biomedical Research Institute in Barcelona, Spain, have studied the role of a peculiar class of small non-coding RNAs that are mainly expressed in the human male germline. (2013-11-21)

Male infertility: Urogenital infection as a possible cause
In couples who have not been able to have children, male infertility is the cause in at least half of cases. In 6-10% the cause is a urogenital infection. The risk of irreversible infertility associated with urogenital infections in men should not be underestimated, say Hans-Christian Schuppe and coauthors in a review article in the current issue of Deutsches Ă„rzteblatt International (Dtsch Arztebl Int 2017; 114: 321-7). (2017-06-14)

Heat therapy for cancer may be key to 'Lance Armstrong Effect'
Experts at Johns Hopkins have linked scientific evidence spanning more than 30 years to suggest an explanation for why testicular cancer patients like seven-time Tour de France winner Lance Armstrong survive far better than patients with other advanced cancers. (2006-07-25)

Scientists identify unique genomic features in testicular cancer
Researchers led by scientists at Dana-Farber Cancer Institute say they have identified unique genomic changes that may be integral to testicular cancer development and explain why the great majority are highly curable with chemotherapy -- unlike most solid tumors. (2016-11-30)

Chemotherapy before radiotherapy for testicular cancer could reduce long-term side-effects
Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports. As many as 96% of men with testicular cancer now survive at least ten years from diagnosis, but more advanced forms need to be treated with combination chemotherapy -- which can have serious long-term complications. (2013-08-16)

More potent cancer drug made from platinum shows promise in clinical trials
Clinical trials of a new platinum-based cancer drug could hold promise for many cancer patients, in particular the nearly 25,000 women in the United States who develop ovarian cancer each year. The research will be presented at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu. (2000-12-13)

Clues To Impaired Male Infertility In Knockout Mouse At Jackson Lab
A unique mouse model developed by Jackson Laboratory and Canadian researchers exhibits significantly reduced male fertility, suggesting a critical role in reproduction and early embryonic development for the knocked-out gene known as PC4 (proprotein convertase 4). (1997-06-25)

Major study links gene to drug resistance in testicular cancer
A major research study has uncovered several new genetic mutations that could drive testicular cancer -- and also identified a gene which may contribute to tumors becoming resistant to current treatments. (2015-01-22)

IU study finds testicular cancer survivors may have hearing loss after cisplatin therapy
Many testicular cancer survivors experience hearing loss after cisplatin-based chemotherapy, according to researchers at Indiana University. (2016-06-27)

Penn researchers discover genetic risk factor for testicular cancer
Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer, which is the most common cancer among young men -- it now affects seven out of 100,000 white men in the United States each year. The discovery, published in the May 31, 2009, online issue of Nature Genetics, is the first step toward understanding which men are at high risk of disease. (2009-05-31)

Frequent CT scanning for testicular cancer surveillance associated with secondary malignancies
UC Davis cancer researchers have found that older men with early-stage testicular cancer who opt for surveillance with regular CT scans over lymph node removal are at greater risk for secondary cancers. (2011-03-30)

More common associations found between BRCA1 and BRCA2 mutations and cancer
BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in the Dec. 6 issue of the Journal of the National Cancer Institute. (2006-12-05)

Study shows promise of preserving fertility in boys with cancer
Scientists have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. Scientists aim to freeze a sample of the boys' testicular tissue so that when they reach adulthood, spermatogonial stem cells found in the tissue can be reproduced and transplanted back into the patients. (2014-03-27)

Chlamydia in testicular tissue linked to male infertility
The potential impact of undiagnosed sexually transmitted chlamydia infection on men's fertility has been highlighted in a study led by scientists at Queensland University of Technology (QUT), which for the first time found chlamydia in the testicular tissue biopsies of infertile men whose infertility had no identified cause. (2019-10-09)

Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation
Cancer patients who have been successfully treated for their disease face the prospect of its return if stored ovarian (or testicular) tissue is transplanted back into their bodies without adequate checks, according to researchers at two university hospitals in Israel. The study is published in Human Reproduction journal on Tuesday. (2008-04-21)

Firefighters face increased risk for certain cancers
University of Cincinnati environmental health researchers have determined that firefighters are significantly more likely to develop four different types of cancer than workers in other fields. Their findings suggest that the protective equipment firefighters have used in the past didn't do a good job in protecting them against cancer-causing agents they encounter in their profession, the researchers say. (2006-11-10)

Half the amount of chemo prevents testicular cancer from coming back, new trial shows
Testicular cancer can be prevented from coming back using half the amount of chemotherapy that is currently used, a new clinical trial has shown. The new trial showed that giving men one cycle of chemotherapy was as effective at preventing men's testicular cancer from coming back as the two cycles used as standard. (2020-01-02)

Cancer was one of the best things to happen to me ... but I worry about the future
For Dan Savage, surviving testicular cancer has been a spur to him making the most of his life and taking more adventurous decisions, and he says, that in retrospect, it was probably one of the best things that has happened to him. But as he approaches the end of his fifth year in remission from the disease, he told Teenage Cancer Trust conference about his worries for the future. (2008-06-10)

Testicular cancer - cure rates now so high patients may be more at risk from treatment
The treatment of testicular cancer has become so successful and relapse rates are now so low that doctors face a problem unheard of 20 years ago - patients are living long enough to suffer long term side effects that are potentially life-threatening and decrease the survivors' quality of life. (2002-02-25)

Paracetamol in pregnancy may lower testosterone in unborn boys
Prolonged paracetamol use by pregnant women may reduce testosterone production in unborn baby boys, research from the University of Edinburgh has found. (2015-05-20)

Health-care disparities contribute to delayed testicular cancer diagnosis in a transgender woman
A family physician reports the case of a transgender woman whose testosterone levels rose unexpectedly while on feminizing hormones, leading eventually to a diagnosis of a rare, virilizing form of testicular cancer. The complex medical and psychosocial factors related to the care of transgender patients that contributed to the delay in diagnosis are examined in the study published in LGBT Health. (2016-02-04)

Cell biology: Endocannabinoid system may be involved in human testis physiology
The endocannabinoid system (ECS) may be directly involved in the regulation of the physiology of the human testis, including the development of sperm cells, according to a study in tissue samples from 15 patients published in Scientific Reports. (2019-09-19)

Robert Flanigan, M.D., receives Distinguished Service Award
Loyola University Medical Center urologist Robert Flanigan, M.D., has won a Distinguished Service Award from the Chicago Urological Society. (2015-04-21)

Poor semen quality in Switzerland
A marked decrease in sperm count has been observed. And in Switzerland? Researchers (UNIGE) have undertaken the first nationwide assessment of the semen quality. The scientists assessed the number of spermatozoa, their motility and morphology. The results were well below the reference values issued by the WHO. The current situation is a matter of concern since the poor semen quality of Swiss men is associated with an increase in the incidence of testicular cancer. (2019-05-22)

Scientists discover autoimmune disease associated with testicular cancer
Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer. Called 'testicular cancer-associated paraneoplastic encephalitis,' the disease causes severe neurological symptoms in men. They progressively lose control of their limbs, eye movements, and speech. The disease begins with a testicular tumor, which may cause the immune system to attack the brain. (2019-07-03)

No increased risk of birth defects in children of fathers treated for testicular cancer
New research has found no increased risk of congenital malformations associated with treatment with radiotherapy or chemotherapy in children of fathers with testicular cancer. The study, by Yahia Al-Jebari of Lund University, Sweden and colleagues, is published in the open-access journal PLOS Medicine on June 4, 2019. It followed 4,207 children of 2,380 fathers and finds that those conceived after treatment were not at a greater risk of congenital malformations than those conceived before. (2019-06-04)

Antioxidant treatment prevents sexual transmission of Zika in mice
The antioxidant drug ebselen can prevent sexual transmission of Zika virus from male to female mice, according to new research published in PLOS Pathogens by Yogy Simanjuntak and colleagues at Academia Sinica, Taipei, Taiwan. The results hint at a potential role for ebselen in preventing Zika spread among humans. (2018-02-15)

Other highlights in the September 21 JNCI
Other highlights in the September 21 JNCI include a study of the risk of second cancers in testicular cancer survivors, an examination of hormone replacement therapy and mammographic breast density, a study of antibiotic therapy for a rare type of lymphoma, a finding of a possible melanoma gene, and a study of ovarian cancer risk in hereditary breast cancer families in which BRCA mutations are not found. (2005-09-20)

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