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Mice become first animals to produce other species' sperm
With pinhead-sized grafts of testicular tissue from newborn mammals, scientists at the University of Pennsylvania have induced mice to produce fully functional sperm from evolutionarily distant species. The result has important implications for preserving the germ lines of critically endangered species as well as prized livestock. (2002-08-14)

Freezing sperm taken directly from testicles is effective option for infertile couples
Frozen sperm taken by biopsy from testicles in men with no sperm in their semen is as effective as fresh sperm taken by biopsy in helping couples conceive through in vitro fertilization, according to a study at Washington University School of Medicine in St. Louis. (2013-08-06)

Young cancer survivors have twice the risk of suicide
Survivors of cancer diagnosed before the age of 25 had a more than two-fold increased risk of suicide compared to their non-cancer peers. (2016-11-30)

Male cancer survivors less likely to reproduce
Young male cancer survivors are three times as likely to turn to assisted fertilization to have children as males without a cancer diagnosis. This knowledge makes it possible to develop concrete treatment protocols, which affect fertility to a lesser degree. Measures like preserving sperm before starting treatment can be optimized. Close to 80 percent of those diagnosed during childhood or adolescence will survive their cancer. (2016-02-16)

Cancer survival rates higher than previously assumed
Conventional estimates for life expectancy after cancer diagnosis have been too pessimistic, suggests a study in this week's issue of THE LANCET. (2002-10-10)

Atrazine alters the sex ration in Blanchard's cricket frogs
A study published recently in Environmental Toxicology and Chemistry found that Blanchard's cricket frogs are highly sensitive to atrazine. When exposed, there were up to 55 percent fewer males than females compared with the control group, indicating that atrazine can affect the sex ratio. However, cricket frog populations do persist in areas with widespread atrazine application, despite reports of range contractions for enigmatic reasons. (2017-10-13)

Other highlights in the July 20 JNCI
Other highlights in the July 20 JNCI include a study identifying HPV types that may help manage cancer risk in women with cervical abnormalities, a study examining the risk of contralateral testicular cancer, a study that looks at the association between higher urinary melatonin levels and breast cancer risk, and a study examining how accurately Medicare claims data reflect chemotherapy use in elderly beneficiaries. (2005-07-19)

Alarmingly low awareness of urology across Europe
Results of a new international survey of more than 2,500 responders from five countries show that women know more about men's health issues than men do, men have poor knowledge of key urological symptoms and don't take early signs of potentially life-threatening urological conditions seriously. The low level of awareness indicated by the survey is of particular concern as urological conditions are on a rise due to the ageing European population. (2018-09-24)

Other highlights in the Dec. 25 JNCI
Also in the Dec. 25 JNCI are studies on cancer care in nursing homes, a possible link between testicular cancer and environmental exposures early in life, the suppression of cancer cell invasion by cannabinoids, and a new method for classifying new and recurrent cancers. (2007-12-25)

Health insurance coverage among cancer patients varies greatly by demographics and cancer type
A new analysis has found that, among patients with cancer, rates of health insurance coverage vary by patient demographics and by cancer type. (2015-04-27)

New platinum-phosphate compounds kill ovarian cancer cells
A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, according to a new study published this week in the journal Proceedings of the National Academy of Sciences. (2008-11-19)

A genetic variation that could protect skin from sun damage fuels testicular cancer
A Ludwig Cancer Research study published in Cell today identifies a common mutation that dramatically increases the risk for testicular cancer -- and describes a likely molecular mechanism by which it exerts that effect. The researchers also suggest why, despite its potential lethality, the genetic variation has been favored by natural selection to become common in light-skinned people. (2013-10-10)

Cancer is avoidable as you grow older. Here's how.
Although it is widely thought that cancer is an inevitable consequence of aging, the risk of developing several common cancers decreases with age. (2014-07-14)

Zebrafish journal publishes cancer biology special issue
The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying the cause, growth, and spread of tumors using strategies and methods presented in the current cancer biology special issue of Zebrafish, a peer-reviewed journal published by Mary Ann Liebert Inc. (2010-01-07)

Surgical technique helps adult male survivors of childhood cancer regain fertility
A new study has shown that a surgical technique called microdissection testicular sperm extraction can effectively locate and extract viable sperm in more than one-third of adult male childhood cancer survivors who were previously considered sterile due to prior chemotherapy treatment. (2011-03-14)

Teens with cancer present unique psychological issues
In a study of teens with cancer, Melissa Carpentier, Ph.D., of Indiana University School of Medicine, reports that aspects of dating relationships were significantly related to the teens' quality of life, distress and health behaviors. (2009-02-13)

Stem cell research provides hope for infertile cancer survivors
A professor at The University of Texas at San Antonio has demonstrated in rhesus monkeys that it is possible to remove testicular stem cells prior to chemotherapy, freeze them and later, after cancer treatments, transplant the cells where they can restart sperm production and restore fertility. (2012-12-10)

Early life and in utero factors found to influence testicular function in adulthood
A new study based on a 20-year follow-up of one of the world's largest study cohorts, suggests that exposure to several factors in utero and in early life may lead to reduced semen parameters in adulthood and potentially to a decline in male fertility. (2013-07-08)

Virus a potential future cancer medicine
In a new project, researchers from LIFE -- the Faculty of Life Sciences at the University of Copenhagen -- document that the vesicular stomatitis virus plays a previously unknown dual role in the prevention of a number of cancers. (2011-09-16)

Chemotherapy can impair speech
Patients who have received high doses of chemotherapy may find it harder to express themselves verbally, according to new research from the Sahlgrenska Academy at the University of Gothenburg, Sweden. Speech difficulties among cancer patients who received chemotherapy treatment were two times higher than among those who did not. (2011-09-06)

Anticancer compound found in American mayapple
A common weed called American mayapple may soon offer an alternative to an Asian cousin that's been harvested almost to extinction because of its anti-cancer properties. The near-extinct Asian plant, Podophyllyum emodi, produces podophyllotoxin, a compound used in manufacturing etoposide, the active ingredient in a drug used for treating lung and testicular cancer. Podophyllyum emodi is a cousin of the common mayapple weed found in the United States. (2009-09-04)

How the environment could be damaging men's reproductive health
Two Scandinavian studies have provided further evidence that environmental factors could be affecting men's reproductive health. The studies, published online in Europe's leading reproductive medicine journal Human Reproduction, suggest that environmental pollutants could be changing the ratio of sperm carrying the X or Y (sex determining) chromosomes and that they could be contributing towards male reproductive disorders. (2005-04-27)

Experimental fertility preservation provides hope for young men
Testicular tissue samples obtained from 189 males who were facing procedures that could imperil fertility were cryopreserved at one university, proving the feasibility of centralized processing and freezing of testicular tissue obtained from academic medical centers, including Children's National, scattered around the world. (2019-05-23)

Future fertility: Giving hope to men who received childhood cancer treatment
Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to males who are diagnosed with cancer and undergo chemotherapy and radiation as children. (2018-10-22)

Genetic cause of difference in sexual development uncovered
Researchers at the Francis Crick Institute, the Institut Pasteur and their clinical collaborators have identified a cause of testicular tissue developing in people with female chromosomes. (2020-06-01)

Truly informed consent must include talking about future fertility, warn experts
Talking about sex and fertility can be just as embarrassing for medical staff as for adolescent cancer patients, Drs Allan Pacey and Adam Glaser told the the 4th International Conference on Teenage and Young Adult Cancer Medicine in London. But doctors need to discuss the effect of cancer and its treatment on future fertility with their patients otherwise they cannot give truly informed consent. (2006-03-30)

Study shows long-term effects of radiation in pediatric cancer patients
Of 15 patients who received TBI before age 3, many developed endocrine and metabolic problems including testicular malfunction (78 percent), restrictive pulmonary disease due to high levels of blood triglycerides (74 percent), and cataracts (78 percent). Likewise, 90 percent of patients showed abnormally low levels of growth hormone, and 71 percent were considerably under height. Additional late effects of TBI included kidney, liver, skeletal and cardiac malfunction -- and three of four patients whose IQ had been tested before TBI showed cognitive decline. (2012-08-21)

Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have found that a signaling protein that is key to prostate cancer cell growth is turned on in nearly all recurrent prostate cancers that are resistant to hormone therapy. If the findings hold up, the protein, called Stat5, may be a specific drug target against an extremely difficult-to-treat cancer. (2007-12-31)

SEEM anniversary meeting held in Belgrade
On Oct. 9-10, the anniversary South Eastern European Meeting will be held in the Yugoslav Drama Theatre in Belgrade. Professor Michael Marberger, chairman of the Regional Office of the European Association of Urology said: (2009-10-05)

Mechanism of Marburg virus sexual transmission identified in nonhuman primates
Research by Army scientists elucidates the mechanism of sexual transmission of filoviruses, which have been shown to persist in the testes and other immune privileged sites. Sexual transmission of filoviruses was first reported in 1968 after an outbreak of Marburg virus disease and recently caused flare-ups of Ebola virus disease in the 2013-2016 outbreak. The team found that Marburg virus persists in seminiferous tubules and that Sertoli cells are the reservoir for the virus. (2018-08-30)

Contaminated poliovirus vaccine not associated with cancer
Exposure to poliovirus vaccine that was contaminated with simian virus 40 (SV40) does not appear to be associated with increased cancer incidence in Denmark, according to a large population-based study appearing in the April 2 issue of the Journal of the National Cancer Institute. (2003-04-01)

Largest study yet shows type of underwear is linked to men's semen quality
Men who wear boxer shorts have higher sperm concentrations than men who wear tighter fitting underwear, according to new research published in Human Reproduction. The study differs from previous research on this topic because it includes a larger number of men (656) than previous studies, and because it is the first to go beyond the traditional, narrow focus on semen quality and include information on a variety of indicators of testicular function, such as reproductive hormones and sperm DNA damage. (2018-08-08)

Evidence suggests COVID-19 isn't sexually transmitted
COVID-19 is unlikely to be spread through semen, according to University of Utah Health scientists who participated in an international study of Chinese men who recently had the disease. The researchers found no evidence of the virus that causes COVID-19 in the semen or testes of the men. The study could not fully rule out the possibility that the disease could be sexually transmitted. However, the chances of it occurring appear to be remote. (2020-04-22)

Embargoed news from Annals of Internal Medicine
Below is information about articles being published in the April 5 issue of Annals of Internal Medicine. The information is not intended to substitute for the full articles as sources of information. All information is under strict embargo until April 4 at 4:00 p.m. ET. Annals of Internal Medicine attribution is required for all coverage. (2011-04-04)

Experts highlight gaps in knowledge on caring for survivors of teenage and young adult cancers
US and UK experts tell Teenage Cancer Trust's conference that not enough is known about the consequences of surviving cancer and its treatment for those who were diagnosed with the disease as teenagers and young adults. More needs to be done to support cancer survivors. (2008-06-10)

Scientists find some human cancers to be 'evolutionary accidents'
New research, published in Biological Reviews and conducted by researchers from the University of Liverpool and Escola Superior de Ciências da Saúde (Brasília, Brazil) has found some type of cancers unique to humans may be a result of evolutionary accidents. (2018-04-17)

DNA of sperm taken from testicles of infertile men 'as good as sperm from fertile men'
Scientists have found that sperm DNA from the testicles of many infertile men is as good as that of ejaculated sperm of fertile men. This may explain a major cause of male infertility and opens the possibility of using sperm taken directly from the testicles of these men; to overcome their infertility. (2019-03-16)

Study finds association between male birth defect and certain genetic mutations
A small percentage of males born with cryptorchidism (failure of one or both testicles to descend into the scrotum), the most frequent congenital birth defect in male children, are more likely to have genetic mutations, including for a syndrome that is a common genetic cause of infertility, according to a study in the Nov. 19 issue of JAMA. (2008-11-18)

Hormone inhibitor promising for hard-to-treat prostate cancer
For prostate cancer patients whose tumors have continued to grow despite medical or surgical castration, a new drug candidate that inhibits production of male hormones anywhere in the body is showing promise in early trials. (2007-07-08)

Sorting out fertility after childhood cancer
In this issue of the Journal of Clinical Investigation, Orwig and colleagues report the development of a multi-parameter sorting approach to separate spermatagonial stem cells from cancerous cells. (2013-03-15)

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