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Transplant Current Events, Transplant News Articles.
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Organ donation in Ontario increased 57 percent since 2006 after new Canadian donation policy
Organ donation in Ontario increased 57 percent since 2006 when the province introduced a Canadian policy that allows donation of organs after circulatory functions cease, called circulatory determination of death, according to a new study published in CMAJ. (2017-09-25)

Online patient tool is associated with increased likelihood of receiving kidney transplant
Patients with kidney failure who actively used an online patient portal to track the status of their health care improved their chances of getting a kidney transplant and shortened their wait times for an operation. (2020-01-08)

Mayo Clinic develops improved tool to rank sickest patients waiting for liver transplants
Mayo Clinic researchers have developed an improved statistical model that could help ensure that the sickest patients receive liver transplants first. (2008-09-03)

Kidney transplantation prolongs survival compared with home hemodialysis
Among kidney failure patients who were followed for five years, home hemodialysis patients were four times more likely to die than kidney transplant recipients. In elderly kidney failure patients, home hemodialysis patients had nearly a five times higher risk of dying during follow-up than kidney transplant patients. The studies' findings will be presented at ASN Kidney Week 2015 Nov. 3-8 at the San Diego Convention Center in San Diego, Calif. (2015-11-06)

New approach could make bone marrow transplants safer
Bone marrow transplantation is the only curative therapy for the millions of people living with blood disorders like sickle cell anemia, thalassemia, and AIDS. However, the faulty stem cells must first be 'evicted' or killed, which requires chemotherapy and radiation -- a vicious assault on the body. HSCI researchers have developed a non-toxic transplantation procedure using antibodies to target blood stem cells in mice, an approach they hope will make bone marrow transplants far less toxic. (2016-06-06)

Speedy heart transplant for kids better than waiting for perfect match
Survival is predicted to be higher for pediatric heart transplant candidates when the first suitable donor offer is accepted -- even if they have antibodies that may lead to organ rejection. Costs of care are lower for children who don't wait for an antibody-matched heart. Researchers say the decision to perform a heart transplant should not depend solely upon the patient's antibodies. (2014-11-19)

Belatacept after a kidney transplant: Minor added benefit for certain patients
After a kidney transplant, patients receive drugs such as the new agent belatacept, to prevent rejection of the donor kidney. In a dossier assessment by IQWiG, treatment with belatacept was compared with cyclosporine A. According to the assessment, serious side effects are less frequent with belatacept in certain patients and these patients discontinue treatment due to side effects less often. An English-language extract of the assessment is now available. (2012-11-09)

Blood test enables heart-transplant recipients to undergo fewer biopsies, Stanford study shows
In what could represent a major shift in the management of heart transplant patients, a multicenter Stanford-led study to be published online April 22 in the New England Journal of Medicine shows that doctors can safely decrease the number of biopsies performed on heart transplant patients by using a commercially available blood test along with an echocardiogram to identify patients at low risk for rejecting their transplanted hearts. (2010-04-22)

Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials
Using data on almost 1,300 patients with advanced breast cancer, researchers from Duke University and other institutions have found no benefit from high dose chemotherapy followed by bone marrow transplantation. (1999-05-15)

A recipe for long-lasting livers
Researchers at the RIKEN Center for Developmental Biology have developed a new technique that extends the time that donor organs last and can also resuscitate organs obtained after cardiac arrest. (2015-04-22)

Secondhand smoke results in graft rejection
A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments. (2012-02-23)

Bold approach has lung transplant patients taking fewer anti-rejection drugs
The University of Pittsburgh has instituted a new clinical protocol that has the potential to redefine the standard of care for lung transplant patients. Bucking conventional thought that successful lung transplantation can only be achieved with a three-punch assault on the immune system, the new protocol is an important achievement for lung transplant patients, in whom studies that seek to reduce or eliminate anti-rejection drugs are rarely performed because the lungs vulnerability to rejection. (2003-06-02)

Weird Creatures Have Some Lessons For Organ Transplants
Japanese researchers have taken a tip from tiny animals called tardigrades, that can live for more than a century, to invent a new technique for storing human organs for transplant. The team has successfully revived a rat's heart after 10 days in storage by using the tardigrade's method of preservation and resuscitation. (1998-11-04)

JTCC researchers play important role in groundbreaking study that may change transplant practices
Researchers from John Theurer Cancer Center at Hackensack University Medical Center played an important role in a study published in the New England Journal of Medicine on Oct. 18 that may change the current blood and marrow transplantation practices. The phase III, multicenter study compared harvesting stem cells from bone marrow rather than blood and suggests there are benefits to both approaches, but no survival differences between the two methods. (2012-11-20)

Australian researchers identify a new disease
Researchers at the Queensland Institute of Medical Research and the Royal Brisbane Women's Hospital have identified a previously undiagnosed condition and successfully treated it by performing an experimental stem cell transplant. (2010-05-17)

Combined kidney and bone marrow transplantation allows patients to discontinue anti-rejection drugs
An experimental treatment protocol involving combined kidney and bone marrow transplantation has enabled several patients to accept their transplanted kidney without immunosuppressive drugs, reports a researcher from Massachusetts General Hospital. (2002-08-26)

Armouring anti-cancer T cells against immunosuppressants
New 'armoured' T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection. (2021-01-18)

Landmark 30-year study on Crigler-Najjar syndrome underscores the need for new therapies
A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome. The study yields novel insights about the pathophysiology of bilirubin encephalopathy, demonstrates principles of effective phototherapy, and provides a framework to judge emerging molecular therapies. (2020-04-16)

Heart transplant program at Northwestern Memorial Hospital celebrates anniversary
More than a dozen heart transplant recipients joined physicians, nurses and administrators of the Bluhm Cardiovascular Institute of Northwestern Memorial Hospital on Tuesday to celebrate the first anniversary of the re-launch of the Institute's heart transplant program. The event was a chance for hospital staff to celebrate the hard work that has resulted in 15 heart transplants in one year - with a 100 percent survival rate - and to re-connect with patients and their families. (2006-06-13)

Molecular testing impact: Heart transplant patients benefit from new technology, easier monitoring
New technology for cardiac transplant patients indicates a patient's risk of organ rejection with a simple blood test. News of this revolutionary testing method will be presented today at the International Society for Heart and Lung Transplantation's (ISHLT) Annual Meeting and Scientific Session in Philadelphia. (2005-04-06)

Kinder, gentler procedure gives superior results for stem cell transplants
An improved stem cell transplant regimen that is well-tolerated and has a high success rate has been developed by researchers at Washington University School of Medicine in St. Louis. The procedure holds promise for treatment of blood and bone marrow disorders, immune dysfunction and certain metabolic disorders. (2004-12-13)

Is ownership of dialysis facilities associated with access to kidney transplants?
An analysis that included data for nearly 1.5 million patients with end-stage kidney disease looked at whether ownership of dialysis facilities was associated with patients' access to kidney transplants. This observational study included patients treated at 6,511 dialysis facilities in the United States from 2000-2016. (2019-09-10)

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs
After transplant surgery, antirejection drugs for the organ recipient are a must. But prolonged use can have serious side effects, including infections, heart disease and even cancer. A team of researchers at Northwestern University's Feinberg School of Medicine is working with Northwestern Memorial Hospital's department of organ transplantation in a new study that seeks to eliminate the need for antirejection drugs by transplanting stem cells from a kidney donor's bone marrow into the organ recipient. (2008-01-22)

Yale joins with leader in 3-D organ printing to transform transplants
Researchers at Yale School of Medicine's Department of Surgery and Yale School of Engineering & Applied Science have joined forces with a leading three-dimensional biology company to develop 3-D printed tissues for transplant research. (2014-12-03)

Antioxidant protects islet cells used in transplants for diabetes
A synthetic antioxidant developed by researchers at National Jewish Medical and Research Center improves the survival of islet cells used in transplants for diabetes. The findings, reported in the August issue of the journal Diabetes by researchers at the University of Pittsburgh, could help overcome a significant drawback of the (2002-07-26)

Temple researchers shed new light on double-lung transplants
In the largest retrospective study to date using data from the United Network for Organ Sharing database for adult double-lung transplants, Temple University School of Medicine researchers have shown that there is no statistically significant difference between rejection and mortality rates among double-lung transplant recipients when their transplanted organs came from donors whose blood type was identical or compatible to their own. (2014-01-27)

How opt-out organ donation could affect US waiting lists
Every year in the United States, about 7,500 people die while waiting for an organ transplant, and that number is expected to increase in coming years as demographics shift. (2019-10-02)

NMDP welcomes IOM recommendation for fully integrated cord blood system
The National Marrow Donor Program agreed with the Institute of Medicine's (IOM) recommendation today calling for an integrated national cord blood and adult donor program. (2005-04-14)

Liver transplant survival rates lower in black than white pediatric patients
Novel research reveals racial and socioeconomic disparities among pediatric liver transplant patients. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that graft and patient survival was higher in white children than minorities. (2013-12-05)

How to identify early graft dysfunction preoperatively?
A research team from Italy described a condition that they define as early graft dysfunction (EGD) which can be identified preoperatively. They found EGD is associated with increased morbidity after living-related liver transplantation. (2009-10-16)

Kidney transplant tolerance mechanism identified
Researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs. (2015-03-16)

UTMB researchers successfully transplant bioengineered lung
A research team at the University of Texas Medical Branch have bioengineered lungs and transplanted them into adult pigs with no medical complication. (2018-08-01)

Damaged lungs regenerated in study
A new technique to rehabilitate lungs that are too damaged to be considered for transplant could benefit an increasing population of patients with end-stage lung disease. (2019-05-07)

Radiation, chemotherapy with liver transplant improves cancer survival
A new treatment for patients with a type of bile duct cancer promises a greater chance at survival by combining radiation, chemotherapy and liver transplantation, Mayo Clinic physicians report in the September issue of the Annals of Surgery. (2005-09-09)

Split liver transplants for young children proven to be as safe as whole organ transplantation
A new study shows that when a liver from a deceased adult or adolescent donor is split into two separate portions for transplantation--with the smaller portion going to a young child and the larger to an adult--the smaller portion used for the child will last just as long as if the child had received a whole organ from a donor close to his size. (2013-06-10)

Children's national co-leads nationwide study of landmark sickle cell treatment
Children's National Medical Center will join more than 20 institutions in a first-ever Phase II clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease. If successful, the Sickle Cell Unrelated Transplant trial has the potential to extend a promising and possibly curative treatment option to more severely affected patients. Sickle cell disease affects more than 70,000 people in the United States. (2008-08-18)

Clue to how cancer cells spread
In a second human case, a Yale-led research team has found that a melanoma cell and a white blood cell can fuse to form a hybrid with the ability to metastasize. The finding provides further insight into how melanoma and other cancers spread from solid tumors with implications for future treatment. (2017-01-27)

Lung transplant recipient thrives nearly 20 years later
UT Southwestern Medical Center has performed more than 300 lung transplants in recent decades, and Michael Young represents a remarkable success story. (2012-04-24)

Report describes details of four transplant recipients who contracted rabies from donor
A new report describes details of the clinical, radiological and pathological findings of four patients who received organs or tissue from a single donor, contracted rabies from the transplant and subsequently died, according to a study in the June issue of Archives of Neurology, one of the JAMA/Archives journals. Previous articles have already described summaries of these cases, which occurred in May 2004. (2005-06-13)

Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
A new study has shown for the first time that transplantation of peripheral blood stem cells (PBSC) from sibling donors may be more harmful than bone marrow in pediatric leukemia patients. (2004-11-01)

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