Tumor Cells Current Events

Tumor Cells Current Events, Tumor Cells News Articles.
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Retraining immune cells to kill tumors
Tumors escape destruction by immune cells by turning off their tumor killing functions. A team of scientists in the UK have now found a way to retrain the impotent cells into potent tumor destroyers. Their study will be published online May 19 in the Journal of Experimental Medicine. (2008-05-19)

Competing signals shrink or grow liver tumor at the margins
Activating the Hippo molecular signaling pathway in liver tumor cells drives tumor growth -- but activating the same pathway in healthy cells surrounding the tumor suppresses tumor growth. (2019-11-21)

Jump-starting T cells in skin cancer
Advanced melanoma, the most deadly form of skin cancer, can be successfully treated in some cases by vaccinating patients with tumor proteins. How these vaccines work and why they are only effective in some patients remains unclear. Pierre Coulie and colleagues now show, in two articles in the January 17 issue of the Journal of Experimental Medicine, that these vaccines work by increasing the number of immune cells called killer T cells that can attack the tumor. (2005-01-17)

Role of autophagy in tumorigenesis
In the June 1 issue of G&D, Dr. Eileen White and colleagues at Rutgers University/University of Medicine and Dentistry of New Jersey/Cancer Institute of New Jersey, report, for the first time, that the cellular self-digesting process of autophagy can protect genome integrity -- lending new insight into the seemingly contradictory roles of autophagy as both a cell survival and tumor suppressor pathway. (2007-05-17)

Cancer patient, heal thyself
Anti-cancer immune cells are found in cancer patients, but fail to reject tumors. In the July 1 issue of the Journal of Clinical Investigation, researchers from the German Cancer Research Center, provide a method to make these cells very effective at infiltrating tumor transplants and in reducing tumor size in mice. This is a potential immunotherapy strategy for cancer treatment with appropriately reactivated anti-tumor-specific T cell subsets that already exist in patients' own body. (2004-07-01)

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth
In this issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth. (2012-09-04)

Microtumor-induced vascular development
Solid tumors above a critical size become hypoxic at their core. The upregulation of the angiogenic factor VEGF under these conditions is widely thought to explain tumor vascularization and continued proliferation, but Vajkoczy and coworkers point out that some metastatic tumor cells express low levels of bio-active VEGF in a constitutive manner and appear to require VEGF signaling even at a very early stage. (2002-03-13)

T cell response to new melanoma antigen linked to relapse-free survival
Melanoma patients infused with a special type of tumor-fighting T cell are more likely to survive without relapse, suggests a new study by researchers in France. Their report will be published online on Oct. 20 in the Journal of Experimental Medicine. (2008-10-20)

Migration alert -- How tumor cells home in on the lymphatic system
A Swiss-based research team has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therapies. (2007-06-11)

Tumor vaccines via dendritic cells
Dendritic cells (DCs) can process and present tumor cell-specific antigens, activating CD8+ T lymphocytes to destroy tumor cells. Here, Wang and colleagues propose a new route to tumor antigen presentation that they hope will help realize he promise of DC vaccines for treating cancer or blocking metastatic disease. (2002-05-29)

How bone cells promote lung cancer growth
A certain type of cell in the bone marrow can help promote tumor growth in mice with early stage lung cancer, a new study finds. (2017-11-30)

Targeting metastatic disease with gene therapy
Because hepatocytes are constantly exposed to portal blood, the liver can be readily transduced with injected transgenes. Noting that this organ is also particularly prone to taking up metastatic colorectal tumor cells, Tada and colleagues have proposed to use gene therapy to render the liver a less hospitable environment for exogenous tumors. (2001-06-26)

Unconventional treatment strategy controls -- rather than eradicates -- cancer
Can we learn to live with--rather than kill--cancer? A new study suggests that frequent, low-dose chemotherapy that keeps tumor growth under control may be more effective than standard high-dose chemotherapy that seeks to eradicate cancer cells completely. (2016-02-24)

Tumor cells in blood may indicate more aggressive breast cancer
If patients with breast cancer have tumor cells circulating in the blood, they may have a more dangerous form of the disease, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center. (2003-04-08)

Endotrophin links obesity to breast cancer progression
In this issue of the Journal of Clinical Investigation, Phillip Scherer and Jiyoung Park of the University of Texas Southwestern Medical Center report that a portion of the Col6 protein, known as endotrophin, alters the tumor environment to promote tumor growth and metastasis in mice. (2012-10-08)

Cancer: The immune system attacks tumors remotely
How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely. (2020-03-12)

Blocking common gateway to inflammation suppresses cancer
There is an intimate and complex relationship between inflammation and cancer; and it is well established that tumors secrete many different chemicals that attract host cells which drive inflammation and help to support tumor growth. Now, a new study published by Cell Press in the June issue of the journal Cancer Cell identifies a single protein that is required for trafficking of immune cells involved in inflammation. The research opens up new avenues for therapeutics that can indirectly suppress malignancy by disrupting the inflammatory response. (2011-06-13)

Photodynamic therapy against cancer
In a new study, published in Science Translational Medicine, researchers at the University of Helsinki, Finland, investigated whether eradicating tumor-associated lymphatic vessels and the tumor cells they contain using photodynamic therapy could reduce tumor metastasis. The results were promising. Previously, the cells in metastatic transit in tumor-draining lymphatic vessels have not been given much attention; so the findings are new and exciting. (2011-02-09)

Circulating tumor cells a must watch
The presence of tumor cells circulating in the blood is associated with shortened survival. Now, Toshiyoshi Fujiwara and colleagues, at Okayama University Hospital, Japan, have developed a simple imaging system to detect circulating tumor cells, which could help clinicians hoping to predict a patient's chances of survival and/or monitor a patient's response to treatment. (2009-09-01)

Uncovering the mechanisms that support the spread of ovarian cancer
In this issue of the JCI, research led by Wang Min at Yale University describes how a subtype of macrophages communicate with and support tumor cell growth to drive metastasis in ovarian cancer. (2016-10-10)

Melanoma-promoting gene discovered
Black skin cancer, also known as melanoma, is particularly aggressive and becoming increasingly common in Switzerland. Despite intensive research, however, there is still no treatment. Researchers from the University of Zurich have now discovered a gene that plays a central role in black skin cancer. Suppressing this gene in mice inhibits the development of melanoma and its proliferation - a discovery that could pave the way for new forms of therapy. (2012-07-10)

Tumor cells evade death through autophagy
Autophagy (a process that enables cells to turnover their contents) is initiated in tumor cells by chemotherapy and radiation, but it is not known if this causes tumor cell death or helps tumor cells survive. A new mouse study now indicates that autophagy is a survival mechanism for tumor cells treated with agents that initiate tumor cell death, suggesting that adjunct treatment with autophagy inhibitors might increase the efficacy of some chemotherapeutics in cancer patients. (2007-01-18)

Cancer under pressure: Visualizing the activity of the immune system on tumor development
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology on Nov. 23, 2018. (2018-11-27)

Cellular communication in the cancer microenvironment
In the Feb. 1 issue of G&D, Dr. Johanna Joyce and colleagues at Memorial Sloan Kettering Cancer Center lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression. (2010-01-15)

A new T-cell population for cancer immunotherapy
Scientists at the University of Basel in Switzerland have, for the first time, described a new T cell population that can recognize and kill tumor cells. The open access journal eLife has published the results. (2017-05-23)

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
The research group of Professor Masaharu Noda and Researcher Akihiro Fujikawa of the National Institute for Basic Biology (NIBB) showed that the enzymatic activity of PTPRZ is requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells. (2017-07-18)

Barrow researchers prove utility of imaging tool in surgeon's hand
Barrow researchers prove the utility of new brain tumor imaging tool in the surgeon's hand. (2016-05-03)

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
Effector T cells are involved in activating immune cells, while regulatory T cells act to curb the over-aggressive responses. Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape the immune response to tumors. In a new study in the June 15 version of the Journal of Clinical Investigation, researchers from Memorial Sloan-Kettering Cancer Center show greater tumor rejection when they used CTLA4 blockade in tumor bearing mice. (2006-06-15)

New insight into how tumors evade the immune system
A new research study sheds light on how cancer cells manage to evade the immune system despite the presence of tumor-specific immune cells. The researchers found that mouse and human melanoma cells secrete galectin-1, which has a negative impact on the survival of T cells, and that inhibition of Gal-1 dramatically reduces tumor formation in mice. The research has exciting implications for future anticancer therapies that may stimulate an effective immune response against tumor cells. (2004-03-22)

Finding antitumor T cells in a patient's own cancer
In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, Ph.D., at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated. (2013-11-13)

Compound in grapes, red wine could be key to fighting prostate cancer
A University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors. (2012-11-09)

Drug/radiation combo may help shrink established tumors
Researchers may be closer to understanding why anti-cancer drugs such as Ipilimumab, which boost the tumor-killing power of immune cells, haven't fared well in clinical trials. The new study, which describes a way to enhance the ability of these drugs to shrink well-established tumors, will be published online on Aug. 25 in the Journal of Experimental Medicine. (2008-08-25)

Precise decoding of breast cancer cells creates new option for treatment
Researchers at the University of Zurich and from IBM Research have investigated the vary-ing composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as well, an immune therapy could be successful for a specific group of breast cancer patients. (2019-04-15)

Strengthening the tumor-fighting ability of T cells
Researchers may have found a new way to promote immune cell attack on tumors. The new study, by a team of scientists in Milan, Italy, will be published online on March 24 in the Journal of Experimental Medicine. (2008-03-24)

New study shows promise for preventing therapy resistance in tumor cells
A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments. (2014-01-09)

Macrophages target tumor cells following monoclonal antibody therapy
In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. (2014-01-16)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

To stay a step ahead of breast cancer, make a map of the future
Cancer isn't a singular disease, even when talking about one tumor. A tumor consists of a varied mix of cells whose complicated arrangement changes all the time, especially and most vexingly as doctors and patients do their best to fight it. Researchers reporting in the Cell Press journal Cell Reports have now developed a tool to help them predict which direction a tumor is most likely to go and how it might respond to chemotherapy. (2014-01-23)

Did brain tumor stem cells originate from malignant neural stem cells?
The potential of neural stem cells to transform into brain tumor stem cells has long been considered, but has not been confirmed. (2013-10-28)

University of Pittsburgh receives award to study new theory of breast cancer development
The University of Pittsburgh has been awarded a $3.6 million Era of Hope Award by the US Department of Defense for a project on a new and potentially important target for breast cancer therapy - tumor stem cells. These cells, highly malignant and resembling adult stem cells, are hypothesized to give rise to rapidly growing cells that form the bulk of a tumor and may provide a promising new paradigm to understanding the growth of cancer. (2005-01-12)

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