Tumor Growth Current Events

Tumor Growth Current Events, Tumor Growth News Articles.
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Competing signals shrink or grow liver tumor at the margins
Activating the Hippo molecular signaling pathway in liver tumor cells drives tumor growth -- but activating the same pathway in healthy cells surrounding the tumor suppresses tumor growth. (2019-11-21)

Researchers create cellular automation model to study complex tumor-host role in cancer
To better understand the role complex tumor-host interactions play in tumor growth, Princeton University researchers developed a cellular automation model for tumor growth in heterogeneous microenvironments. (2012-03-27)

Retraining immune cells to kill tumors
Tumors escape destruction by immune cells by turning off their tumor killing functions. A team of scientists in the UK have now found a way to retrain the impotent cells into potent tumor destroyers. Their study will be published online May 19 in the Journal of Experimental Medicine. (2008-05-19)

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth
In this issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth. (2012-09-04)

Endotrophin links obesity to breast cancer progression
In this issue of the Journal of Clinical Investigation, Phillip Scherer and Jiyoung Park of the University of Texas Southwestern Medical Center report that a portion of the Col6 protein, known as endotrophin, alters the tumor environment to promote tumor growth and metastasis in mice. (2012-10-08)

Uncovering the mechanisms that support the spread of ovarian cancer
In this issue of the JCI, research led by Wang Min at Yale University describes how a subtype of macrophages communicate with and support tumor cell growth to drive metastasis in ovarian cancer. (2016-10-10)

How bone cells promote lung cancer growth
A certain type of cell in the bone marrow can help promote tumor growth in mice with early stage lung cancer, a new study finds. (2017-11-30)

The soluble factor IFN-beta represses tumor growth
Tumors that grow to a certain size need to form new blood vessels if they are to continue to grow and spread to other sites. Although the molecules and signaling pathways that control this new blood vessel growth are potential therapeutic targets, they have not been completely defined. However, researchers have now identified the soluble factor IFN-beta as a natural inhibitor of tumor blood vessel growth that limits tumor growth in mice. (2010-03-08)

Inactive form of scatter factor protein found to suppress tumor growth and spread
Scatter factor (SF) controls the proliferation and survival of many tissues. Produced in a precursor form, pro-SF must be cleaved in order to activate its receptor, Met tyrosine kinase. In the November 15 issue of the JCI, Paolo Michieli and colleagues administered uncleavable pro-SF at the site of tumors in mice and prevented the development of new blood vessels to the tumor, tumor growth, and tumor spread to other tissues, without affecting normal physiological functions. (2004-11-15)

Unconventional treatment strategy controls -- rather than eradicates -- cancer
Can we learn to live with--rather than kill--cancer? A new study suggests that frequent, low-dose chemotherapy that keeps tumor growth under control may be more effective than standard high-dose chemotherapy that seeks to eradicate cancer cells completely. (2016-02-24)

Forecasting the future of brain tumor research
Researchers and students from St. Joseph's Hospital and Medical Center and Arizona State University's Math Department are applying weather forecast technology to model and track the growth patterns of brain tumors. (2008-12-05)

Aspirin inhibits ovarian cancer growth, lab study finds
Aspirin may inhibit ovarian tumor growth, according to a new laboratory study by the University of South Florida College of Medicine. (2002-11-06)

Exercise affects tumor growth and drug response in a mouse model of breast cancer
Abnormal growth of blood vessels in solid tumors creates areas of hypoxia, which, in turn makes the tumors more aggressive and resistant to therapy. Exercise has been shown to improve blood vessel growth and perfusion of normal tissues and may have the same effect in solid tumors, according to a study published March 16 in the JNCI: Journal of the National Cancer Institute. (2015-03-16)

Cellular communication in the cancer microenvironment
In the Feb. 1 issue of G&D, Dr. Johanna Joyce and colleagues at Memorial Sloan Kettering Cancer Center lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression. (2010-01-15)

Blocking common gateway to inflammation suppresses cancer
There is an intimate and complex relationship between inflammation and cancer; and it is well established that tumors secrete many different chemicals that attract host cells which drive inflammation and help to support tumor growth. Now, a new study published by Cell Press in the June issue of the journal Cancer Cell identifies a single protein that is required for trafficking of immune cells involved in inflammation. The research opens up new avenues for therapeutics that can indirectly suppress malignancy by disrupting the inflammatory response. (2011-06-13)

Driver gene heterogeneity is minimal among untreated metastases
The growth of different metastatic lesions within an individual cancer patient is driven by the same genetic mutations, a new study reports. (2018-09-06)

New study offers novel treatment strategy for patients with colon cancer
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. In a new study, researchers demonstrate for the first time that a previously uncharacterized protein is increased in colon cancer. The protein is immunoglobulin containing proline rich receptor-1 (IGPR-1) which was recently identified in the same laboratory as a cell adhesion molecule. (2017-09-20)

Pitt Researchers Find Way To Block Cellular Growth Pathways And Inhibit Tumor Growth
At the annual American Association of Cancer Research meeting in New Orleans, University of Pittsburgh Cancer Institute researchers are presenting exciting evidence from animal models that blocking two cellular growth pathways causes tumor cells to die. (1998-03-31)

Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
A University of Colorado Cancer Center study published in the journal PLoS One shows that when colorectal cancer is targeted by the drug bevacizumab (Avastin), tumors may switch dependence from VEGF-A, which is targeted by the drug, to related growth factors in including VEGF-C, VEGF-D and placental growth factor. This change to new growth-factor dependence may allow colorectal cancer to push past bevacizumab's blockage of VEGF-A to continue to drive tumor growth. (2013-10-28)

Established medications combat lung cancer tumor growth
Two research groups have discovered that the growth of an intractable type of lung cancer in mouse models can be restrained with a class of drug known as kinase inhibitors. (2018-06-20)

Tumor blood vessel protein provides potential therapeutic target
A recent study in the Journal of Clinical Investigation identifies a tumor vessel-specific protein, L1 that can be targeted to reduce tumor growth (2014-08-26)

Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
The carotenoid antioxidant lutein can normalize immune system balance in mammary tumor-bearing mice, effectively slowing tumor growth, according to a study presented today at the Federation of American Societies for Experimental Biology 1999 annual meeting. (1999-04-18)

Scientists shed new light on the fight against cancer
The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth. They have also demonstrated that blocking the protein Nrp1 can restore this anti-tumor immune response. This is a first. Nrp1 may provide an important hub for the development of new therapies against cancer. (2013-12-10)

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
The research group of Professor Masaharu Noda and Researcher Akihiro Fujikawa of the National Institute for Basic Biology (NIBB) showed that the enzymatic activity of PTPRZ is requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells. (2017-07-18)

Removal of tumor-associated immune cell protein decreases tumor progression
In this issue of the Journal of Clinical Investigation, Shelley Earp and colleagues at the University of North Carolina a Chapel Hill demonstrate that removal of the protein MerTK from immune cells decreased tumor growth in mouse models of breast cancer, melanoma, and colon cancer. (2013-07-08)

A double block of blood vessels to starve cancerous tumors
A novel strategy of blocking the growth of blood vessels with antibodies should result in improved treatment of cancerous tumors, report researchers at the University of Helsinki. (2010-12-09)

Protein inhibits cell growth, may contribute to breast cancer
A protein known as cdk6 inhibits proliferation of some cell types and may play a role in the development of breast cancer. Researchers at National Jewish Medical and Research Center. report that breast-cancer cells have low to nonexistent levels of cdk6, while normal cells have relatively high levels. Cell growth in two tumor-cell lines dropped significantly when levels of cdk6 were increased inside the cells. (2004-02-20)

Tiny tool to control growing blood vessels opens new potential in tumor research
Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research. (2009-02-21)

A low-carb diet may stunt prostate tumor growth
A diet low in carbohydrates may help stunt the growth of prostate tumors, according to a new study led by Duke Prostate Center researchers. The study, in mice, suggests that a reduction in insulin production possibly caused by fewer carbohydrates may stall tumor growth. (2007-11-13)

Microtumor-induced vascular development
Solid tumors above a critical size become hypoxic at their core. The upregulation of the angiogenic factor VEGF under these conditions is widely thought to explain tumor vascularization and continued proliferation, but Vajkoczy and coworkers point out that some metastatic tumor cells express low levels of bio-active VEGF in a constitutive manner and appear to require VEGF signaling even at a very early stage. (2002-03-13)

Tumor suppressor activity of PTEN
Using transgenic mice specifically lacking the PTEN gene in endothelial cells, Dr. Akira Suzuki and colleagues demonstrate that PTEN is required for normal cardiovascular development and that its loss enhanced tumor angiogenesis. (2005-08-16)

A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
Researchers at the University of Helsinki, Finland, and the Paul Scherrer Institute in Villigen, Switzerland, have determined the crystal structure of the ligand binding domain of a vascular endothelial growth factor (VEGF) receptor in complex with one of its ligands (VEGF-C). VEGFs and their receptors have been identified as major targets for drug development in cancer therapy and the VEGF receptor that the groups analyzed is currently the most important target of such drugs. (2010-01-18)

Jefferson scientists find radiation and blood vessel inhibitor more effective against brain tumors
Combining radiation with an agent that blocks VEGF, a protein that promotes the development of blood vessels and the growth of cancerous tumors - a process known as angiogenesis - may be more effective against brain tumors than either treatment alone, researchers at Jefferson Medical College have found. (2003-11-19)

An excess of healthy cells holds leukemia in check
In one useful model of juvenile myelomonocytic leukemia (JMML), lethally irradiated mice receive hematopoietic cells from the liver of a fetal mouse lacking the growth-inhibiting protein NF1. Although this protocol reliably yields overgrowth by mutant monocytes, Zhang and colleagues note that it is highly artificial, since leukemic cells would more typically arise as a minor population within a large number of normal cells. (2001-08-29)

Immune cells determine how fast certain tumors grow
By examining brain tumors in mice, researchers at Washington University School of Medicine in St. Louis discovered that immune cells that should be defending the body against disease sometimes can be enticed into providing aid and comfort to tumor cells instead. The more immune cells a tumor can recruit to its side, the faster the tumor grows, the researchers found. (2019-06-03)

Sigma receptors play role in cocaine-induced suppression of immune system
Cocaine use is known to have negative effects on the immune system but how the drug exerts this effect is poorly understood. Now researchers have demonstrated that some of cocaine's effects on the immune system may be mediated by sigma receptors. These receptors are unique proteins found in the brain and other areas of the body and have been shown to play a role in some of the toxic and behavioral effects of the drug. (2003-05-02)

New targets for childhood brain tumors identified
People with the genetic condition neurofibromatosis type 1 (NF1) are prone to developing tumors on nervous system tissue. A new study from Washington University School of Medicine in St. Louis has found that the development and growth of such tumors are driven by nearby noncancerous neurons and immune cells. The findings point to potential new therapeutic targets for people with NF1. (2020-05-01)

Signal for inflammation linked to Ras-induced tumor growth
Cancer progression is dependent on the ability of tumor cells to interact with and favorably influence their environment. For instance, if a tumor is going expand, it is absolutely critical that new blood vessels are formed so that an adequate blood supply is in place to feed the growing tissue. A new research study demonstrates that a cytokine, a chemical signal that stimulates inflammation, plays a critical role in the initiation of new vasculature formation required to promote tumor progression. (2004-11-15)

Steering cancer inflammation to inhibit tumor growth and spread
Most cancer tissues are invaded by inflammatory cells that either stimulate or inhibit the growth of the tumor, depending on what immune cells are involved. Now a Swedish-Belgian research team has shown that a protein that naturally occurs in the body, HRG, inhibits tumor growth and metastasis into secondary organs by activating specific immune cells. The study is being published today in the online edition of the prestigious journal Cancer Cell. (2011-01-06)

A longer lasting tumor blocker
On the heels of dismaying reports that a promising anti-tumor drug could, in theory, shorten patients' long-term survival, comes a promising study by a Japanese team of researchers that suggests a potentially better option. The study appears in the May 11 issue of the Journal of Experimental Medicine. (2009-04-28)

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