Tumor Current Events

Tumor Current Events, Tumor News Articles.
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Retraining immune cells to kill tumors
Tumors escape destruction by immune cells by turning off their tumor killing functions. A team of scientists in the UK have now found a way to retrain the impotent cells into potent tumor destroyers. Their study will be published online May 19 in the Journal of Experimental Medicine. (2008-05-19)

Competing signals shrink or grow liver tumor at the margins
Activating the Hippo molecular signaling pathway in liver tumor cells drives tumor growth -- but activating the same pathway in healthy cells surrounding the tumor suppresses tumor growth. (2019-11-21)

Jump-starting T cells in skin cancer
Advanced melanoma, the most deadly form of skin cancer, can be successfully treated in some cases by vaccinating patients with tumor proteins. How these vaccines work and why they are only effective in some patients remains unclear. Pierre Coulie and colleagues now show, in two articles in the January 17 issue of the Journal of Experimental Medicine, that these vaccines work by increasing the number of immune cells called killer T cells that can attack the tumor. (2005-01-17)

Role of autophagy in tumorigenesis
In the June 1 issue of G&D, Dr. Eileen White and colleagues at Rutgers University/University of Medicine and Dentistry of New Jersey/Cancer Institute of New Jersey, report, for the first time, that the cellular self-digesting process of autophagy can protect genome integrity -- lending new insight into the seemingly contradictory roles of autophagy as both a cell survival and tumor suppressor pathway. (2007-05-17)

Tumor size alone not always best for gauging treatment response
Not only can positron emission tomography (PET) help evaluate treatment for gastrointestinal stromal tumors (GIST) by revealing biologic changes such as how the tumor processes the fuel that makes it grow, but CT can indirectly reveal biologic changes as well by analyzing the tumor's density, say researchers from The University of Texas M. D. Anderson Cancer Center in Houston. (2004-12-07)

Microtumor-induced vascular development
Solid tumors above a critical size become hypoxic at their core. The upregulation of the angiogenic factor VEGF under these conditions is widely thought to explain tumor vascularization and continued proliferation, but Vajkoczy and coworkers point out that some metastatic tumor cells express low levels of bio-active VEGF in a constitutive manner and appear to require VEGF signaling even at a very early stage. (2002-03-13)

Endotrophin links obesity to breast cancer progression
In this issue of the Journal of Clinical Investigation, Phillip Scherer and Jiyoung Park of the University of Texas Southwestern Medical Center report that a portion of the Col6 protein, known as endotrophin, alters the tumor environment to promote tumor growth and metastasis in mice. (2012-10-08)

Uncovering the mechanisms that support the spread of ovarian cancer
In this issue of the JCI, research led by Wang Min at Yale University describes how a subtype of macrophages communicate with and support tumor cell growth to drive metastasis in ovarian cancer. (2016-10-10)

Researchers create cellular automation model to study complex tumor-host role in cancer
To better understand the role complex tumor-host interactions play in tumor growth, Princeton University researchers developed a cellular automation model for tumor growth in heterogeneous microenvironments. (2012-03-27)

New Cancer Procedure At Wake Forest University Baptist Medical Center Offers Hope
Wake Forest University Baptist Medical Center is the only facility in the Southeast offering a new procedure for malignant tumors previously thought untreatable. The procedure is called Tumor Ablation using Radiofrequency Energy. (1999-04-09)

Migration alert -- How tumor cells home in on the lymphatic system
A Swiss-based research team has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therapies. (2007-06-11)

Breaking down the walls of immunological ignorance
T cells that respond to an antigen challenge in vitro but fail to do so in a living animal are said to be in a state of immunological ignorance. Chen and his colleagues have argued for some time that this poorly understood state can help explain the workings and, crucially, the failings of immunological surveillance for tumors. (2002-02-27)

Unconventional treatment strategy controls -- rather than eradicates -- cancer
Can we learn to live with--rather than kill--cancer? A new study suggests that frequent, low-dose chemotherapy that keeps tumor growth under control may be more effective than standard high-dose chemotherapy that seeks to eradicate cancer cells completely. (2016-02-24)

Combination therapy reduces tumor resistance to radiation
Radiation is used to treat a variety of tumors as it causes hypoxia and tumor cell death. Recently, radiation-induced hypoxia was shown to trigger tumor resistance to radiation via the activation of new blood vessel formation (angiogenesis). In a new JCI study, researchers show that a combination of radiation treatment and the use of angiogenesis inhibitors such as canstatin is able to overcome HIF-1-dependent tumor survival and increase tumor cell death in mice. (2007-06-07)

Tumor vaccines via dendritic cells
Dendritic cells (DCs) can process and present tumor cell-specific antigens, activating CD8+ T lymphocytes to destroy tumor cells. Here, Wang and colleagues propose a new route to tumor antigen presentation that they hope will help realize he promise of DC vaccines for treating cancer or blocking metastatic disease. (2002-05-29)

Photodynamic therapy against cancer
In a new study, published in Science Translational Medicine, researchers at the University of Helsinki, Finland, investigated whether eradicating tumor-associated lymphatic vessels and the tumor cells they contain using photodynamic therapy could reduce tumor metastasis. The results were promising. Previously, the cells in metastatic transit in tumor-draining lymphatic vessels have not been given much attention; so the findings are new and exciting. (2011-02-09)

Cease and desist -- genome stability and epithelial carcinogenesis
Dr. Leonard Zon and colleagues at The Children's Hospital (Boston) have identified a mutated gene in zebrafish that increases susceptibility to epithelial cancers. (2006-12-31)

Blocking common gateway to inflammation suppresses cancer
There is an intimate and complex relationship between inflammation and cancer; and it is well established that tumors secrete many different chemicals that attract host cells which drive inflammation and help to support tumor growth. Now, a new study published by Cell Press in the June issue of the journal Cancer Cell identifies a single protein that is required for trafficking of immune cells involved in inflammation. The research opens up new avenues for therapeutics that can indirectly suppress malignancy by disrupting the inflammatory response. (2011-06-13)

Cancer patient, heal thyself
Anti-cancer immune cells are found in cancer patients, but fail to reject tumors. In the July 1 issue of the Journal of Clinical Investigation, researchers from the German Cancer Research Center, provide a method to make these cells very effective at infiltrating tumor transplants and in reducing tumor size in mice. This is a potential immunotherapy strategy for cancer treatment with appropriately reactivated anti-tumor-specific T cell subsets that already exist in patients' own body. (2004-07-01)

How bone cells promote lung cancer growth
A certain type of cell in the bone marrow can help promote tumor growth in mice with early stage lung cancer, a new study finds. (2017-11-30)

Many childhood brain tumor survivors experience seizures
New research reveals that seizures are frequent in childhood brain tumor survivors. (2015-09-08)

Tumor cells evade death through autophagy
Autophagy (a process that enables cells to turnover their contents) is initiated in tumor cells by chemotherapy and radiation, but it is not known if this causes tumor cell death or helps tumor cells survive. A new mouse study now indicates that autophagy is a survival mechanism for tumor cells treated with agents that initiate tumor cell death, suggesting that adjunct treatment with autophagy inhibitors might increase the efficacy of some chemotherapeutics in cancer patients. (2007-01-18)

Tumor blood vessel protein provides potential therapeutic target
A recent study in the Journal of Clinical Investigation identifies a tumor vessel-specific protein, L1 that can be targeted to reduce tumor growth (2014-08-26)

Barrow researchers prove utility of imaging tool in surgeon's hand
Barrow researchers prove the utility of new brain tumor imaging tool in the surgeon's hand. (2016-05-03)

Macrophages target tumor cells following monoclonal antibody therapy
In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. (2014-01-16)

MR spectroscopy aids in distinguishing recurring brain tumors from changes related to treatment
MR spectroscopy may be a useful adjunct to conventional imaging to distinguish recurrent tumor from treatment-related change in the brain such as inflammation or dead cells, says a new study by researchers from the University of Michigan Medical Center in Ann Arbor, MI. (2004-05-03)

Barrow study identifies new way to biopsy brain tumors in real time
A new miniature, hand-held microscope may allow more precise removal of brain tumors and an easier recognition of tumor locations during surgery. (2009-11-11)

A comprehensive survey reveals bacteria are widespread in human tumors and differ by tumor type
Different human tumor types each harbor their own unique bacterial communities, researchers report in a new study that profiled the microbiomes of more than 1,500 individual tumors across seven types of human cancer - the most comprehensive tumor microbiome study to date. (2020-05-28)

Tailoring glioblastoma therapies: 1 size does not fit all
An upcoming G&D paper from Dr. Azad Bonni and colleagues at Harvard Medical School lends new insight into how the unique genetic signature of glioblastoma tumors affects treatment efficacy -- a finding with promising hope for the therapeutic targeting of the leading cause of cancer-related deaths in the young and middle-aged population. (2008-02-06)

Targeting metastatic disease with gene therapy
Because hepatocytes are constantly exposed to portal blood, the liver can be readily transduced with injected transgenes. Noting that this organ is also particularly prone to taking up metastatic colorectal tumor cells, Tada and colleagues have proposed to use gene therapy to render the liver a less hospitable environment for exogenous tumors. (2001-06-26)

Cellular communication in the cancer microenvironment
In the Feb. 1 issue of G&D, Dr. Johanna Joyce and colleagues at Memorial Sloan Kettering Cancer Center lend new insight into the mechanism by which tumor-associated macrophages promote malignant progression. (2010-01-15)

Scientists shed new light on the fight against cancer
The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth. They have also demonstrated that blocking the protein Nrp1 can restore this anti-tumor immune response. This is a first. Nrp1 may provide an important hub for the development of new therapies against cancer. (2013-12-10)

Removal of tumor-associated immune cell protein decreases tumor progression
In this issue of the Journal of Clinical Investigation, Shelley Earp and colleagues at the University of North Carolina a Chapel Hill demonstrate that removal of the protein MerTK from immune cells decreased tumor growth in mouse models of breast cancer, melanoma, and colon cancer. (2013-07-08)

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth
In this issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth. (2012-09-04)

Tumor cells in blood may indicate more aggressive breast cancer
If patients with breast cancer have tumor cells circulating in the blood, they may have a more dangerous form of the disease, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center. (2003-04-08)

Circulating tumor cells a must watch
The presence of tumor cells circulating in the blood is associated with shortened survival. Now, Toshiyoshi Fujiwara and colleagues, at Okayama University Hospital, Japan, have developed a simple imaging system to detect circulating tumor cells, which could help clinicians hoping to predict a patient's chances of survival and/or monitor a patient's response to treatment. (2009-09-01)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

To stay a step ahead of breast cancer, make a map of the future
Cancer isn't a singular disease, even when talking about one tumor. A tumor consists of a varied mix of cells whose complicated arrangement changes all the time, especially and most vexingly as doctors and patients do their best to fight it. Researchers reporting in the Cell Press journal Cell Reports have now developed a tool to help them predict which direction a tumor is most likely to go and how it might respond to chemotherapy. (2014-01-23)

Forecasting the future of brain tumor research
Researchers and students from St. Joseph's Hospital and Medical Center and Arizona State University's Math Department are applying weather forecast technology to model and track the growth patterns of brain tumors. (2008-12-05)

Driving metastasis
Dr. Tak Mak and colleagues have successfully generated a strain of RhoC-deficient mice, providing long-awaited in vivo confirmation of RhoC's critical role in tumor metastasis. (2005-08-16)

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