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Tumor Current Events, Tumor News Articles.
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A lack of oxygen in tumors promotes metastasis
Metastases are formed by cancer cells that break away from the primary tumor. A research group at the University of Basel has now identified lack of oxygen as the trigger for this process. The results reveal an important relationship between the oxygen supply to tumors and the formation of metastases. This research may open up new treatment strategies for cancer. (2020-09-08)

DNA vaccination places tumors in double jeopardy
The ER resident chaperone protein calreticulin plays a surprising variety of roles in cell regulation, some of which make it particularly appealing for antitumor vaccination. Cheng et al. have engineered a fusion gene encoding a known viral tumor antigen, linked directly to the chaperone. They report here that mice exposed subdermally to this DNA construct enjoy seemingly complete resistance to tumor cells that express the viral antigen. (2001-08-29)

Cancer: The immune system attacks tumors remotely
How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely. (2020-03-12)

Improving the development of new cancer models using an advanced biomedical imaging method
Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results can contribute to the development of new tumor models for cancer research. (2012-12-17)

Jefferson Researchers Report Progress In Using Vaccinia-Based Vaccine For Melanoma
The concept is straightforward: beat cancer by boosting the body's defense system. Oncologist Michael Mastrangelo and his colleagues at Jefferson Medical College have inserted a gene for an immune-system enhancing protein into the tumor cells of advanced melanoma patients, using the vaccinia virus as their vaccine vehicle. (1999-05-14)

Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
The carotenoid antioxidant lutein can normalize immune system balance in mammary tumor-bearing mice, effectively slowing tumor growth, according to a study presented today at the Federation of American Societies for Experimental Biology 1999 annual meeting. (1999-04-18)

Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects
A research team led by Prof. TIAN Huayu from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences proposed an innovative immune cocktail therapy that combined ICT along with other therapeutic approaches. The cocktail therapy achieved multiple boosting of the cancer-immunity cycle by utilizing a nano-delivery system. (2020-09-30)

Driver gene heterogeneity is minimal among untreated metastases
The growth of different metastatic lesions within an individual cancer patient is driven by the same genetic mutations, a new study reports. (2018-09-06)

Viral oncoprotein inactivation of p53
A group of scientists led by USC researcher Dr. Xiaojiang Chen lend structural insight into tumor suppressor inactivation by a viral oncoprotein. Their crystal structure of the large T antigen/p53 complex interaction will be featured on the September 1 cover of Genes & Development. (2006-08-31)

Researchers propose strategy to evaluate tumor photothermal therapy in real-time
Researchers from USTC reported an ''intelligent'' strategy of using organic nanoparticles to evaluate photothermal therapy efficiency on tumor in real time. (2020-08-06)

Researchers identify need to sample multiple tumor zones in breast cancer
Certain short strands of RNA, known as microRNAs (miRNAs), have been linked to the progression and metastasis of breast cancer and may provide information about prognosis. However, studies of miRNA expression profiles often report conflicting findings. While the potential for using miRNAs in breast cancer diagnosis is promising, scientists report in a new study published online today in the Journal of Molecular Diagnostics that differences in the amount and types of miRNA within breast tumors can be misleading. (2012-06-15)

Inactive form of scatter factor protein found to suppress tumor growth and spread
Scatter factor (SF) controls the proliferation and survival of many tissues. Produced in a precursor form, pro-SF must be cleaved in order to activate its receptor, Met tyrosine kinase. In the November 15 issue of the JCI, Paolo Michieli and colleagues administered uncleavable pro-SF at the site of tumors in mice and prevented the development of new blood vessels to the tumor, tumor growth, and tumor spread to other tissues, without affecting normal physiological functions. (2004-11-15)

Compound in grapes, red wine could be key to fighting prostate cancer
A University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors. (2012-11-09)

Chemotherapy can cause tumor evolution
Russian scientists have found that neoadjuvant chemotherapy in patients with breast cancer can stimulate evolution of the tumor. The results of the research conducted by Nicholay Litvyakov, D.Sc. at Cancer Research Institute, Head of the Tumor Virology Laboratory, and TSU researcher Marina Ibragimova, were published in 'Siberian Journal of Oncology.' (2015-12-01)

New study offers novel treatment strategy for patients with colon cancer
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. In a new study, researchers demonstrate for the first time that a previously uncharacterized protein is increased in colon cancer. The protein is immunoglobulin containing proline rich receptor-1 (IGPR-1) which was recently identified in the same laboratory as a cell adhesion molecule. (2017-09-20)

Cancer under pressure: Visualizing the activity of the immune system on tumor development
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology on Nov. 23, 2018. (2018-11-27)

Rare driver mutations disrupt NOTCH signaling to promote squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) -- a group of cancers that affect the the mouth, nose and throat -- is a disease driven by mutations in the NOTCH tumor suppressor signaling pathway, according to a new study. (2020-03-12)

Environment of tumors impacts metastasis, study finds
According to a new study, the microenvironment of a tumor cell has significant impact on cancer metastasis. This discovery by Siyuan Zhang at the University of Notre Dame and a team at the University of Texas MD Anderson Cancer Center has focused attention on fighting cancer in the tumor cell's microenvironment. (2015-11-16)

Barrow Researchers deploy novel clinical trial regimen for glioblastoma
Combating glioblastoma remains a major challenge due the complex nature of these tumors, the inability of drugs to penetrate the brain tissue, and lack of correlation between animal models and the human condition. (2018-09-21)

WT1, male fertility and tumorigenesis
Dr. Miles Wilkinson and colleagues use a new tissue-specific RNAi approach they developed to identify a novel postnatal role for the Wilms' tumor 1 (WT1) tumor suppressor in spermatogenesis. (2006-01-14)

New screening approach identifies small proteins unique to melanoma cells, Moffitt researcher says
Jamie K. Teer, Ph.D., assistant member of the Cancer Biology and Evolution Program at Moffitt Cancer Center, and colleagues have developed a new streamlined method to rapidly identify the genetic changes in small protein fragments unique to melanoma cancer cells. These fragments can be used as targets for tumor-infiltrating lymphocytes that have been shown to reduce cancerous lesions. (2013-06-25)

Tiny tool to control growing blood vessels opens new potential in tumor research
Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research. (2009-02-21)

New suppressor of common liver cancer
Tumor suppressor genes make proteins that help control cell growth. Mutations in these genes that generate nonfunctional proteins can contribute to tumor development and progression. One of the most well-known tumor suppressor genes is BRACA1, mutations in which are linked to breast cancer. Researchers have now identified SCARA5 as a candidate tumor suppressor gene in human hepatocellular carcinoma, a form of liver cancer that is the fifth most common cancer worldwide (2009-12-14)

Signal for inflammation linked to Ras-induced tumor growth
Cancer progression is dependent on the ability of tumor cells to interact with and favorably influence their environment. For instance, if a tumor is going expand, it is absolutely critical that new blood vessels are formed so that an adequate blood supply is in place to feed the growing tissue. A new research study demonstrates that a cytokine, a chemical signal that stimulates inflammation, plays a critical role in the initiation of new vasculature formation required to promote tumor progression. (2004-11-15)

The biggest isn't always best when it comes to treating cancer
Cancer vaccines containing peptides that mimic tumor antigens (known as mimotopes) are being developed in the hope that they will stimulate the immune system to mount potent antitumor responses. However, mimotopes that stimulate large responses in vitro do not always cause tumor regression in vivo. A new study now shows that only mimotopes that stimulate intermediate responses in vitro protect mice from tumor growth, thereby defining the parameters for identifying the best mimotope. (2006-08-24)

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
The research group of Professor Masaharu Noda and Researcher Akihiro Fujikawa of the National Institute for Basic Biology (NIBB) showed that the enzymatic activity of PTPRZ is requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells. (2017-07-18)

Tumor progression depends on the tumor microenvironment
Researchers from Tokyo Medical and Dental University (TMDU) and Niigata University identified a novel mechanism by which tumors progress. By studying the role of TNF-α and TGF-β in the formation of cancer-associated fibroblasts (CAFs), the researchers found that both proteins together exert a robust effect on the development of CAFs. They further found that oral cancer cells show increased tumor progression in response to TGF-β protein secreted from CAFs. The findings of this study could help develop novel cancer therapies. (2020-10-01)

Promising new imaging technology precisely tracks lung tumor motion
According to a study presented at the 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Atlanta, a new imaging technology may more precisely track tumor movement for patients under treatment for lung cancer than conventional 3D imaging. Results presented indicate that the new technology, 4D CT, or four-dimensional computed tomography, may allow radiation oncologists to determine and predict tumor movement based on the tumor's location and attachment in the lungs. (2004-10-04)

Melanoma-promoting gene discovered
Black skin cancer, also known as melanoma, is particularly aggressive and becoming increasingly common in Switzerland. Despite intensive research, however, there is still no treatment. Researchers from the University of Zurich have now discovered a gene that plays a central role in black skin cancer. Suppressing this gene in mice inhibits the development of melanoma and its proliferation - a discovery that could pave the way for new forms of therapy. (2012-07-10)

Precise decoding of breast cancer cells creates new option for treatment
Researchers at the University of Zurich and from IBM Research have investigated the vary-ing composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as well, an immune therapy could be successful for a specific group of breast cancer patients. (2019-04-15)

Finding antitumor T cells in a patient's own cancer
In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, Ph.D., at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated. (2013-11-13)

A new mouse model for the study of neurofibromatosis
The research group of the neurofibromatosis of the Catalan Institute of Oncology, the Institute of Biomedical Research of Bellvitge and the Institute of Medicicina Predictive and Personalized Cancer has developed new mouse models for the study of principal malignant tumor associated with neurofibromatosis type 1. (2015-04-16)

University Of Pittsburgh Medical Center studying promising new imaging technology
A new imaging technology developed by GE Medical Systems and currently being evaluated at the University of Pittsburgh Medical Center (UPMC) may allow radiation oncologists to precisely track tumor movement and avoid excess doses of radiation for cancer patients. Results from the first 15 patients evaluated indicate that Advantage™ 4D (Adv4D) limits the exposure of radiation to healthy tissue surrounding a tumor by allowing radiation oncologists to precisely visualize and assess its structure and movement. (2004-02-18)

T cell response to new melanoma antigen linked to relapse-free survival
Melanoma patients infused with a special type of tumor-fighting T cell are more likely to survive without relapse, suggests a new study by researchers in France. Their report will be published online on Oct. 20 in the Journal of Experimental Medicine. (2008-10-20)

Tumor environment keeps tumor-fighting T cells away
Tumors have an arsenal of tricks to help them sidestep the immune system. A study published on September 19 in the Journal of Experimental Medicine reveals a new trick -- the ability to keep tumor-fighting T cells out by disabling a T cell-attracting protein within the tumor core. (2011-09-19)

Immune cells may improve accuracy of predicting survival in colorectal cancer
The density of immune cells, called tumor infiltrating lymphocytes, when combined with analysis of tumor budding may serve as a method to more accurately predict survival in patients with stage III colon cancer. The findings, by a team of researchers led by Mayo Clinic gastroenterologist and oncologist, Frank Sinicrope, M.D., were published today in Annals of Oncology. (2020-03-02)

Body's ibuprofen, SPARC, reduces inflammation and thus bladder cancer development and metastasis
A University of Colorado Cancer Center study published today in the Journal of Clinical Investigation shows that the protein SPARC (Secreted Protein Acidic and Rich in Cysteine) acts much like an anti-inflammatory drug, attempting to heal tissues inflamed by tumors. (2013-01-16)

Nanomaterials based strategies for treatment of hypoxic tumor
Hypoxic tumor microenvironment restricts efficiency of tumor therapies and leads to serious results of tumor recurrence and high mortality. Different strategies to treat hypoxic tumors based on nanomaterials have been utilized to eliminate the side effects of hypoxia on tumor therapies. The strategies could be summarized into two classes, i) elevating oxygen level in tumor by nanomaterials and ii) diminishing oxygen dependence of nanomaterials for hypoxic tumor therapy. (2020-08-31)

The first epigenetic test to diagnose tumors of unknown origin
An article published in The Lancet Oncology by Dr. Manel Esteller (IDIBELL) shows that it is possible to use a newly-developed epigenetic test called EPICUP® to find out what type of primary tumor is responsible for the metastasis in the patient in cancer of unknown primary cases, which will allow doctors to develop more specific treatments against it. (2016-08-26)

Dangerous skin cancer
The German Cancer Society has worked out new guidelines for the diagnosis and treatment of malignant melanoma -- a disease with unfavorable prognosis. Malignant melanoma is responsible for 90 percent of deaths from skin cancer. The incidence has increased five-fold within the last 30 years and UV radiation is thought to be an important cause. Caucasian populations are most affected. (2008-12-18)

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