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Herpes virus offers new hope in curing cancer
In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors. Researchers successfully treated the tumor in mouse models by administering a treatment based on a weakened version of the herpes simplex virus. (2004-11-30)

University of Cincinnati team to track tumor DNA through bloodstream
In a novel effort to unravel the multiple identities of glioblastoma, a team of University of Cincinnati researchers has begun sequencing individual glioblastoma genomes and tracking abnormalities through the bloodstream. They hope that by mapping the various DNA rearrangements of glioblastoma tumors they will be able to establish biomarkers that will help them track the cancer's progress and guide their efforts to treat patients more effectively. (2011-04-04)

Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain. (2012-11-09)

Possible cause and potential treatment found for aggressive head and neck cancer
Researchers at the San Francisco VA Medical Center report that they have found a potential molecular cause for the aggressive growth and spread of human head and neck squamous cell carcinoma, a highly malignant form of cancer with a very high death rate. (2006-04-21)

Breakthrough in 3-D brain mapping enables removal of fist-sized tumor
A new technology involving the fusion of four different types of images into a 3-D map of a patient's brain has helped University of Cincinnati specialists successfully remove a fist-sized tumor from the brain of an Indiana woman. (2009-07-14)

Sensor chip for monitoring tumors
A chip implant may soon be capable of monitoring tumors that are difficult to operate on or growing slowly. Medical engineers at Technische Universitaet Muenchen have developed an electronic sensor chip that can determine the oxygen content in a patient's tissue fluid. This data can then be wirelessly transmitted to the patient's doctor to support the choice of therapy. A drop in oxygen content in tissue surrounding a tumor indicates that the tumor might be growing faster and becoming aggressive. (2011-08-26)

Antibody combined with cancer drug shows promise against breast tumors
An antibody that targets the blood vessels nourishing tumors significantly reduced breast cancer formation and growth in mice when combined with a current cancer drug, according to researchers at UT Southwestern Medical Center. (2005-05-16)

Mayo researchers discover way to prime cancer tumors for immunotherapy
A cancer tumor's ability to mutate allows it to escape from chemotherapy and other attempts to kill it. So, encouraging mutations would not be a logical path for cancer researchers. Yet a Mayo Clinic team and their collaborators took that counterintuitive approach and discovered that while it created resistance to chemotherapy, it also made tumors sensitive to immunotherapy. They also found that this approach worked successfully across tumor types and individual patient genomes. (2020-02-07)

Genetic mutations differ within a single tumor, study finds
When researchers looked at different areas within an individual rectal cancer sample, they found cases in which each area contained different genetic mutations. The findings could have significant implications for treatment recommendations. (2015-12-02)

Notre Dame researcher's paper examines the biology of tumor-derived microvesicles
A new paper by Crislyn D'Souza-Schorey, professor of biological sciences at the University of Notre Dame, discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles are membrane-bound sacs released by tumor cells and can be detected in the body fluids of cancer patients. (2012-06-21)

Scientists find new supressor gene involved in breast, prostate and other cancers
Scientists at the National Human Genome Research Institute (NHGRI) and the M.D. Anderson Cancer Center at the University of Texas have found a novel tumor suppressor gene on human chromosome 7 that appears to be involved in a wide range of cancers. Tumor suppressor genes play a key role in the regulation of cell growth. (2001-03-29)

Surgical probe seeks out where cancer ends and healthy tissue begins
A new surgical tool that uses light to make sure surgeons removing cancerous tumors 'got it all' was found to correlate well with traditional pathologists' diagnoses in a clinical study, showing that the tool could soon enable reliable, real-time guidance for surgeons. (2015-09-16)

Study provides clues to alcohol's cancer connection
For the first time scientists have demonstrated a model that may explain how alcohol stimulates tumor growth. Their study says alcohol fuels the production of a growth factor that stimulates blood vessel development in tumors, and that chronic ethanol increased tumor size and levels of the angiogenic factor and levels of the angiogenic factor and vascular endothelial growth factor (VEGF) in an experimental model. (2004-12-13)

Brain cancer vaccine shows promising findings in early research at UCLA's Jonsson Cancer Center
An experimental vaccine for brain cancer has shown promising results in preliminary investigations at UCLA's Jonsson Cancer Center. The results are published in this week's issue of the peer-reviewed journal Cancer Research. (2002-04-18)

Cutting cancer off at the head
Using a 2 ml blood sample from 100 gastric cancer patients, researchers succeeded in identifying cancer cells circulating in the bloodstream and trace them back to their origin tumor by detecting an overexpression of fibroblast growth factor receptor (FGFR2) in both the cancer cells and the tumor. This new diagnostic method may allow for real-time detection of the growth patterns of the cancer, leading to quicker and more accurate preventative action -- essentially cutting the cancer`s potential metastasizing off at the head. (2020-10-21)

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease
The authors determined that tumor-derived ANGPTL2 stimulates lung epithelial cells, which is essential for primary tumor-induced neutrophil recruitment in lung and subsequent pre-metastatic niche formation. (2020-02-05)

New paper provides important insights into carcinoma-associated fibroblasts
A new paper by a team of researchers led by Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame, offers important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood. (2014-05-08)

Lowering your cholesterol may decrease your risk of cancer
Current research suggests that lowering cholesterol may block the growth of prostate tumors. The related report by Solomon et al., (2009-02-23)

Mount Sinai researchers identify mechanisms and potential biomarkers of tumor cell dormancy
Oncologists have long puzzled over the fact that after cancer treatment, single cancer cells that are dispersed throughout the body -- so-called disseminated tumor cells -- are quick to grow and form secondary tumors called metastases in certain organs, while in other organs they metastasize more slowly, sometimes decades later. (2013-10-27)

Study identifies new role for breast cancer susceptibility gene
A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression. The findings demonstrate that, in addition to an impaired DNA damage response associated with cancer initiation, mutation of BRCA1 is also linked to manipulation of the tumor microenvironment. The research appears in the July issue of Cancer Cell, published by Cell Press. (2006-07-17)

Researchers test new therapy for advanced melanoma
Researchers at the Moffitt Cancer Center and University of South Florida are testing a promising new therapy for advanced melanoma. (2005-04-05)

All cancer cells are not created equal
A study from Massachusetts General Hospital researchers suggests that specific populations of tumor cells have different roles in the process by which tumors make new copies of themselves and grow. (2012-05-15)

First of its kind report on how children with brain tumors perform at school
While children who have had brain tumors perform worse in school than healthy kids, grades in foreign language are the most affected and girls have a harder time than boys in getting good grades, according to a study published in the July 17, 2007, issue of Neurology, the medical journal of the American Academy of Neurology. Researchers say this is the first time the actual grades and subjects of brain tumor survivors have been reported. (2007-07-16)

Protein complex linked to cancer growth may also help fight tumors, Moffitt researchers say
Researchers at Moffitt Cancer Center and Tianjin Medical University Cancer Institute and Hospital in China have discovered a gene expression signature that may lead to new immune therapies for lung cancer patients. They found that NF-κB, a protein complex known to promote tumor growth, may also have the ability to boost the immune system to eliminate cancerous cells before they harm, as well as promote antitumor responses. (2013-07-22)

Glycans as biomarkers for cancer?
Glycosylated proteins are often overexpressed in tumor cells and thus could serve as tumor markers, especially those with the interesting molecule sialic acid as their sugar moiety. In the journal Angewandte Chemie, American scientists now report on a bioorthogonal labeling test for sialylated glycoproteins based on a glycoproteomics approach. This assay not only assesses the level of sialylated glycans in the tumor cell membranes, but also identifies up- or downregulated proteins directly in the prostate cancer tissue. (2017-06-26)

Scientists find unusual lung-cancer tumor-suppressor gene
Researchers have identified a new and unusual tumor suppressor gene that may be important in cancers of the lung and head and neck. The study shows that restoring the inactivated gene can slow the growth of tumor cells. The gene, known as TCF21, is silenced in tumor cells through a chemical change known as DNA methylation, a process that is potentially reversible. (2006-01-18)

Genetically engineered salmonella in combination with radiation shown effective against tumors in Yale study
Combining Salmonella injections with radiation therapy in mice has shown promising new results for improved cancer treatment.Tumor supression by a combination of X-rays and a genetically altered strain of Salmonella was greater than that seen with X-rays or Salmonella alone. (2000-04-03)

Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases
Researchers have identified genetic markers on several chromosomes in the tissue surrounding tumor cells that are associated with breast cancer tumor grade and the presence of lymph node metastases, according to a study in the May 16 issue of JAMA. (2007-05-15)

Wistar Research Yields Information About Colorectal Cancer Cell Invasion
Using an antigen in mice that is genetically similar to the GA733 antigen in humans, Wistar scientists are gaining valuable information about the GA733 antigen's role in tumor growth and metastases. (1998-05-05)

Researchers quantify benefits of minimally invasive removal of hard-to-reach tumors
A minimally invasive endoscopic procedure holds promise for safely removing large brain tumors from an area at the bottom of the skull, near the sinus cavities, clinical researchers at the Brain Tumor Center at the University of Cincinnati Neuroscience Institute at University Hospital have found. (2010-04-01)

Antibody-drug compounds and immunotherapy to treat breast cancer
To more efficiently treat breast cancer, scientists have been researching molecules that selectively bind to cancer cells and deliver a substance that can kill the tumor cells, for several years. Researchers from the University and University Hospital Basel have now for the first time successfully combined such an antibody-drug conjugate with a therapy that stimulates the immune system to attack tumor cells. This opens the door to new therapeutic options in the treatment of breast cancer. (2015-11-25)

Stopping the spread of breast cancer
Scientists have discovered a new pathway that can stop breast cancer cells from spreading. Working with human cancer cells and a mouse model of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs. When that protein is removed from cancer cells in mice, the ability of the cells to metastasize to the lung is dramatically decreased. (2014-06-02)

Chemoembolization helps patients with liver cancer live longer
Chemoembolization, a minimally invasive procedure that delivers chemotherapy directly to a tumor and cuts off its blood supply, is helping people with liver cancer survive beyond the six-month average with other treatments. (2003-06-19)

Ingredient that makes curry yellow effective against melanoma cells
Curcumin, the yellow pigment found in the spice turmeric and a key ingredient in yellow curry inhibits melanoma cell growth and stimulates tumor cell death, according to a new study. (2005-07-11)

Parsley, celery carry crucial component for fight against breast cancer, MU researcher finds
In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing. (2011-05-09)

Early life exposure to environmental agents predicts adult tumors in animals
For gene-environment interactions, the timing of the environmental exposure may be critical, say researchers at The University of Texas M. D. Anderson Cancer Center. (2004-03-30)

CWRU dental researchers discover human beta defensins-3 ignite in oral cancer growth
Detecting oral cancer in its earliest stages can save the lives of the nearly 40,500 people diagnosed annually. But early detection has been difficult. Case Western Reserve University School of Dental Medicine researchers discovered a biomarker, called human beta defensin-3, which may serve as an early warning. The defensin is present in all oral cancers and associated with the early stages of oral cancer. (2010-07-13)

New study identifies novel role for PEA-15 protein in cancer growth
A new study from the University of Hawaii Cancer Center reveals that PEA-15, a protein previously shown to slow ovarian tumor growth and metastasis, can alternatively enhance tumor formation in kidney cells carrying a mutation in a cancer-promoting gene called H-Ras. The H-Ras oncogene is mutated in many human malignancies, and previous reports have shown the ability of H-Ras to contribute to the development, proliferation and metastasis of these tumors. (2011-11-21)

UNC researcher aims to 'unmask' cancer cells to trigger body's immune system
Cancer cells are deadly traitors, good cells gone bad. They evade the body's defense systems, passing themselves off as organisms that pose no threat. (2008-08-20)

How elephants evolved to become big and cancer-resistant
In this new study, 'We explored how elephants and their living and extinct relatives evolved to be cancer-resistant,' says University at Buffalo biologist Vincent Lynch. He adds, regarding the findings, 'Elephants have lots and lots and lots of extra copies of tumor suppressor genes, and they all contribute probably a little bit to cancer resistance.' (2021-02-04)

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