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Treating rare breast cancer with radiation therapy may lower recurrence rate
Patients with a rare type of breast cancer may benefit from receiving radiation therapy in addition to surgery to prevent recurrence, according to a study in the July issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Therapeutic Radiology and Oncology. (2008-07-11)

Ablation procedure proves safe, effective and fast
Multiple-electrode radiofrequency ablation is a safe and effective way of treating patients with liver cancer that can be completed in less time than current ablation techniques, according to a recent study conducted by researchers at the University of Wisconsin in Madison. (2007-06-28)

Better treatment for brain cancer revealed by new molecular insights
Nearly a third of adults with the most common type of brain cancer develop recurrent, invasive tumors after being treated with a drug called bevacizumab. The molecular underpinnings behind these detrimental effects have now been published by Cell Press in the July issue of Cancer Cell. The findings reveal a new treatment strategy that could reduce tumor invasiveness and improve survival in these drug-resistant patients. (2012-07-09)

Protein that predicts tamoxifen resistance is identified
Researchers at the Duke Comprehensive Cancer Center have identified a protein that breast cancer tumors over-produce when they become resistant to the drug tamoxifen. The researchers said their finding could help them predict which tumors will benefit from tamoxifen -- the front-line drug used to treat operable breast cancer -- and which tumors won't. (2003-12-04)

U of M researchers discover compounds to shrink tumors
Researchers at the University of Minnesota have developed novel anti-cancer drugs to treat solid tumors. These (2006-07-05)

New insight into the genetics of brain tumor formation
In a G&D paper published online ahead of its April 1 print publication date, Dr. William Kaelin (Dana Farber Cancer Institute) and colleagues identify a potential new neuronal tumor suppressor. (2008-03-17)

Breakthrough in genetics of fibroids
Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health. Researchers at the University of Helsinki, Finland, set out to study the genetic structure of fibroids by determining the sequence of all the human genes, in a series of 18 tumors. The study revealed very specific mutations in a gene called MED12, in as many of 70 percent of the studied tumors. (2011-08-25)

The loss of a protein favors lung tumor growth
The researcher Zafira Castaño has discovered that the loss of a protein in the early phases of lung cancer favors tumor growth. This was the conclusion that the Doctor in Biochemistry reached in the dissertation which she defended at the University of Navarra. (2006-05-30)

Genetic mutations predict patient response to immunotherapy
Results of a new clinical study establish particular genetic defects in tumors as clinical indicators for successful response to a type of immunotherapy called PD-1 blockade. (2017-06-08)

Jefferson scientists find Cox-2 may play role in some brain tumors
Oncologists have shown for the first time that the enzyme cyclooxygenase-2 (COX-2), which is the target for the anti-arthritis drugs - and COX-2 inhibitors - Celebrex and Vioxx, is (2002-05-21)

Improved imaging of neonatal soft-tissue tumors can help radiologists improve patient care
Better understanding of practical imaging techniques with regard to neonatal soft-tissue tumors can improve patient care, according to an article published in the July 2017 issue of the American Journal of Roentgenology. (2017-07-25)

Limiting tumors' ability to hide from the immune system
Scientists have discovered a way to stop tumors from shedding certain proteins that the immune system uses to identify and attack tumors. (2018-03-29)

Exercise affects tumor growth and drug response in a mouse model of breast cancer
Abnormal growth of blood vessels in solid tumors creates areas of hypoxia, which, in turn makes the tumors more aggressive and resistant to therapy. Exercise has been shown to improve blood vessel growth and perfusion of normal tissues and may have the same effect in solid tumors, according to a study published March 16 in the JNCI: Journal of the National Cancer Institute. (2015-03-16)

Hijacking bacteria to kill cancer
Scientists have recruited modified bacteria to help fight cancer, which successfully infiltrated tumors and activated the immune system to kill malignant cells, a new study reports. (2017-02-08)

Study identifies potential targets for treating triple negative breast cancer
In this issue of the JCI, a team led by Eldad Zacksenhaus at Toronto General Research Institute discovered that the growth of TNBC-like breast tumors is supported by enhanced mitochondrial function. (2016-08-29)

Tumor size alone not always best for gauging treatment response
Not only can positron emission tomography (PET) help evaluate treatment for gastrointestinal stromal tumors (GIST) by revealing biologic changes such as how the tumor processes the fuel that makes it grow, but CT can indirectly reveal biologic changes as well by analyzing the tumor's density, say researchers from The University of Texas M. D. Anderson Cancer Center in Houston. (2004-12-07)

Patients with gastrointestinal tumors at higher risk of other cancers
Researchers at UC San Diego School of Medicine conducted the first population-based study that characterizes the association and temporal relationship between gastrointestinal stromal tumors (GIST) and other cancers. The results, published by Cancer on April 30, indicate that one in 5.8 patients with GIST will develop additional malignancies before and after their diagnosis. (2015-05-01)

Dogs help in breast carcinoma research
Cancer of the mammary glands in dogs is very similar to human breast carcinoma. For this reason, treatment methods from human medicine are often used for dogs. Conversely, scientific knowledge gained from canine mammary tumors may also be important to human medicine. Researchers from the University of Zurich were able to show how similar these tumors are in both dogs and humans. (2017-06-06)

New surgical technique for removing inoperable tumors of the abdomen
Abdominal tumors involving both roots of the celiac and superior mesenteric artery are deemed unresectable by conventional surgical methods, as removal would cause necrosis of the organs that are supplied by those blood vessels. A case report published in the journal American Journal of Transplantation presents a novel surgical technique that enables surgeons to remove tumors that are unresectable by the usual surgical techniques. (2012-05-01)

RFA effective for easing lung cancer symptoms; CT findings identified that verify successful RFA
CT-guided radiofrequency ablation (RFA) is effective in easing the symptoms of lung tumors that cannot be removed by surgery, and enhancement pattern and changes in the size of the tumor as shown on CT are the most important factors for determining whether that ablation has been successful, according to a pair of independent studies in the October 2004 issue of the American Journal of Roentgenology. (2004-10-01)

Radiation-guided nanoparticles zero in on metastatic cancer
Zap a tumor with radiation to trigger expression of a molecule, then attack that molecule with a drug-loaded nanoparticle. (2016-06-29)

DIPG tumor patterns offer new insight on survival
A small subset of patients with tumors that bear mutations in a gene in the basic packaging of DNA (known as histone mutations) may have better outcomes than others, suggests new research from Michigan Medicine's Pediatric Brain Tumor Research Initiative. (2018-01-17)

Immune cells determine how fast certain tumors grow
By examining brain tumors in mice, researchers at Washington University School of Medicine in St. Louis discovered that immune cells that should be defending the body against disease sometimes can be enticed into providing aid and comfort to tumor cells instead. The more immune cells a tumor can recruit to its side, the faster the tumor grows, the researchers found. (2019-06-03)

Carbon ion radiotherapy safe and effective for treating inoperable spinal tumors
A new analysis has found that a type of radiation therapy called carbon ion radiotherapy can control cancer growth and prolong survival in patients with spinal tumors. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that the treatment is a promising alternative for patients whose spinal tumors cannot be surgically removed. (2013-08-12)

Identification of all types of germ cells tumors
Germ cell tumors were considered very heterogeneous and diverse, until recently. Researchers from the Erasmus MC, Rotterdam, the Netherlands, and the Princess Máxima Center for pediatric oncology have added structure by suggesting a subdivision in seven types of germ cell tumors. This division is relevant for basic and clinical research and contributes to optimal diagnostics and healthcare in the future. (2019-08-26)

Nanopatterned 'lab-on-a-chip' noninvasively detects early and advanced breast cancer
A scalable 'lab-on-a-chip' technology based on inkjet printing methods detected breast cancer in plasma samples from patients with more than 90% accuracy, according to a new study. (2020-06-10)

Radio Frequencies Used To Kill Inoperable Liver Tumors At Penn's Cancer Center
Many liver tumors are not surgically removable because of their anatomical position within the liver. Now, surgeons at the University of Pennsylvania Cancer Center are using radio frequencies to actually char the tumors while they remain in the liver. This procedure is being done at only a few hospitals across the country and will benefit many patients previously excluded from a surgical option. (1998-03-23)

Stanford scientists identify protein involved in fast-spreading cancers
Researchers at the Stanford University School of Medicine have found a protein that may explain why tumors in a low-oxygen environment are more deadly. (2006-04-26)

Stress granules ease the way for cancer metastasis
Tumors that produce more stress granules are more likely to metastasize, according to researchers in Canada. The results suggest that drugs to inhibit the formation of these structures might rein in cancer metastasis. (2015-03-23)

Cell phone use not linked to cancer risk
Long- or short-term cell phone use is not associated with increased cancer risk, according to a study in the Dec. 6 issue of the Journal of the National Cancer Institute. (2006-12-05)

Hormone replacement therapy may improve breast cancer detection and survival rate
A study of nearly 300 breast cancer patients in Oregon found that the tumors in those women, who had been receiving hormone replacement therapy (HRT), were less aggressive and easier to detect on mammograms. It also reports that HRT users had higher survival rates than nonusers. (2002-09-12)

Modeling lung cancer
In a new report in the February 15 issue of G&D, Dr. Martin McMahon and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis. Their paper provides evidence to support the use of a relatively new class of drugs, called MEK inhibitors, for lung cancer patients whose tumors contain mutations in the BRaf gene. (2007-02-12)

Freezing kidney tumors is a safe alternative to surgery
Percutaneous cryoablation, a relatively non-invasive technique that destroys tumors by freezing them, is a safe method for treating kidney tumors in selected patients who are not considered candidates for surgery, according to a new study by researchers from the Mayo Clinic in Rochester, MN. (2006-05-01)

Cyberknife radiosurgery is a safe and effective treatment for benign tumors
Treating benign tumors outside the brain with CyberKnife Frameless Radiosurgery resulted in significant improvement in symptoms and minimal toxicity, according to a University of Pittsburgh study presented today at the 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Atlanta. The findings provide evidence that CyberKnife may offer a promising treatment option for patients with benign tumors who are not candidates for surgery or whose tumors are not amenable to surgery. (2004-10-05)

MR-guided laser effective in treating liver tumors
A large-scale, 12-year study has found that laser ablation with magnetic resonance (MR) guidance is as effective as traditional surgery in the treatment of liver tumors in some patients. The study was presented today at the annual meeting of the Radiological Society of North America (RSNA). (2005-11-29)

MIT nanoparticles may help detect, treat tumors
A new technique devised by MIT engineers may one day help physicians detect cancerous tumors during early stages of growth. The technique allows nanoparticles to group together inside cancerous tumors, creating masses with enough of a magnetic signal to be detectable by a magnetic resonance imaging (MRI) machine. (2006-05-01)

Our normal genetics may influence cancer growth, too
New research suggests that the genes we are born with might influence the changes that occur when we develop cancer. It found that the genetic variations we inherit contribute to the kinds of DNA changes that occur in tumor cells. The findings may offer a new way to identify individuals at greater risk for developing cancer, the researchers say. (2010-11-10)

Scientists use tumor-derived dendritic cells to slow tumor growth
In the human body, so-called dendritic cells are responsible for activating our immune system. While researchers previously believed that tumors could repress these dendritic cells -- blocking an adequate natural cancer defense mechanism -- a new study has painted a more positive picture. A team led by Professor Jo Van Ginderachter (VIB-Vrije Universiteit Brussel) revealed that two immune response-stimulating dendritic cell types do exist within tumors. The scientists were able to isolate these cells and use them to 'vaccinate' tumors, slowing tumor growth. (2017-01-25)

Study Demonstrates The Benefits Of Mammography In Women Under 50
Women under 50 benefit from screening mammography as much as women over 50, a University of Chicago study reports. (1997-10-03)

Some forms of cancer behave in an unexpected way
Investigators at the Research Institute of the McGill University Health Centre (MUHC) suggest that tumor size may not be an accurate method of predicting lymph node involvement and disease progression in some breast cancers. Their findings show that some types of breast tumors do not (2003-09-15)

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