Viral Load Current Events

Viral Load Current Events, Viral Load News Articles.
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Study suggests link between decreasing viral load and proportion of COVID-19 patients needing intensive care
New research presented at this week's ESCMID Conference on Coronavirus Disease (ECCVID, online 23-25 September) suggests that, as lockdown took effect and case numbers dropped, the amount of virus patients were exposed to (viral load) fell, and this could be linked to lower proportions of patients requiring intensive care and dying. (2020-09-23)

Elevated serum HBV DNA level increases risk of hepatocarcinogenesis?
Chronic hepatitis B virus infection is still a worldwide health problem. A team led by Professor Xi-Zhong Shen from Zhongshan Hospital, Fudan Universityhas conducted a nested case-control study among male hepatitis B virus carriers in Qidong, Shanghai, China, one of the high endemic chronic HBV infection and liver cancer region. The results show that the risk of liver cancer increases with the persistent elevation of hepatitis B viral load in patients with chronic hepatitis B. (2008-05-21)

US study shows decline in viral load of patients with COVID-19 as pandemic progressed
A US study from the city of Detroit, presented at this week's ESCMID Conference on Coronavirus Disease (ECCMID, online 23-25 September) shows that the initial SARS-CoV-2 viral load in nasopharyngeal samples has been decreasing as the pandemic progressed. The authors also observed that the decline in viral load was associated with a decrease in death rate. (2020-09-23)

Risk of HIV treatment failure present even in those with low viral load
People with human immunodeficiency virus run a higher risk of virologic failure than previously thought, even when their number of RNA copies of the retrovirus per milliliter of blood is slightly above the detection threshold, according to a study by Claudie Laprise at the University of Montreal's Department of Social and Preventative Medicine. (2013-11-25)

Genetics of both virus and patient work together to influence the course of HIV infection
Viral and human genetics together account for about one third of the differences in disease progression rates seen among people infected with the human immunodeficiency virus (HIV), according to new research published in PLOS Computational Biology. The findings suggest that patient genetics influences disease progression by triggering mutations in the HIV viral genome. (2017-02-09)

HIV is spread most by people with medium levels of HIV in blood, says study
People with medium levels of HIV in their blood are likely to contribute most to the spread of the virus, according to new research published today in the journal Proceedings of the National Academy of Sciences. The study found that those with a high viral load are the most infectious group, but have only limited time to infect others, because they generally progress to AIDS quite quickly. (2007-10-22)

Dengue strains differ in rates of viral replication
Researchers test mechanisms explaining differences in dengue serotype and disease severity by statistically fitting mathematical models to viral load data from dengue-infected individuals. They find a role for viral replication in explaining serotype-specific differences in viral load -- according to a new study published in PLOS Computational Biology. (2016-11-17)

New antiretroviral drugs decrease chances of HIV sexual transmission
IDIBELL researchers prove that a triple antiretroviral regimen based on an integrase inhibitor decreases viral load in semen very quickly, reducing VIH transmission risk (2016-11-22)

The Lancet: Second case of apparent HIV 'cure' in a baby followed by reappearance of virus
Researchers today report the case of a baby, born HIV-positive, who appeared to have been cured of HIV after being given early antiretroviral treatment to combat the virus, but ultimately exhibited detectable HIV infection. (2014-10-02)

Mathematical modeling suggests optimal timing for antiviral therapies against COVID-19
A new mathematical modeling study by Ashish Goyal and colleagues, informed by data collected from 25 patients hospitalized with COVID-19 in 4 different countries, offers some important new insights into the optimal timing of 4 different antiviral therapies to combat the disease. The results indicate that (2020-10-23)

6 months after treatment start could be optimum time for making prognosis in HIV/AIDS
An international study in this week's issue of THE LANCET suggests that prognosis for patients with HIV/AIDS might be more reliably determined six months after initiation of highly active antiretroviral therapy (HAART), rather than before the start of treatment. (2003-08-28)

Scientists bring new insights into the heritability of HIV infection severity
Using a population of HIV-1 infected individuals (the 2014 Swiss HIV Cohort Study data), an international research team of 17 institutions, led by ETH Zurich's Roland Regoes of the Institute of Integrative Biology, has now examined all aspects of HIV virulence, with a particular focus on how it ravages the human immune system. (2017-10-03)

University Of Pittsburgh Researchers Detect High Levels Of HIV In Semen At All Stages Of Disease
University of Pittsburgh researchers announced today that viral load in semen of HIV-infected men at all stages of disease is up to 1,000 times greater than previously measured, antiviral therapy reduces the virus in semen to undetectable levels and AIDSvaccines are needed against unique viral strains in semen (1997-01-25)

New study shows SARS-CoV-2 viral load peaks in the early stages of disease
In a retrospective study, investigators from New York University Langone Health found that the quantity of SARS-CoV-2 (viral load) collected from patients in the emergency department is significantly higher in patients with fewer or milder symptoms who did not require hospitalization--the opposite of what might be expected. Reporting in The American Journal of Pathology, they also found that a patient's history of cancer and cardiovascular disease is associated with higher viral loads even after adjusting for age. (2020-07-14)

Study: Prompt isolation of symptomatic patients is key to eliminating Ebola
Below is information about an article being published in Annals of Internal Medicine. The information is not intended to substitute for the full article as a source of information. Annals of Internal Medicine attribution is required for all coverage. (2014-10-27)

HIV-1 Levels In Semen Don't Correspond To Viral Levels In Blood, Say Pitt Researchers In A Report At 12th World AIDS Conference
Findings presented on June 30 at the 12th World AIDS Conference by University of Pittsburgh researchers emphasize that testing HIV-1 levels in semen as well as targeting treatments to sites of seminal virus production may offer physicians a better way to monitor viral activity in HIV- infected patients and also stem transmission of the virus. (1998-06-30)

Hepatitis B viral load, genotype affect liver cancer risk, study finds
Infection with a specific subtype of hepatitis B virus (HBV) and a high viral load are associated both independently and additively with an increased risk of a type of liver cancer, according to a new study in the February 16 issue of the Journal of the National Cancer Institute. (2005-02-15)

Although gender response to HIV therapy is similar, women experience more side effects
In a study of men and women treated for HIV at an inner city U.S. clinic, investigators from the Emory University Center for AIDS Research (CFAR) found that although gender did not affect the response to HAART therapy (highly active anti-retroviral therapy), women suffered significantly more side effects. (2002-07-10)

Darunavir with FUZEON provides HIV patients a better chance to reach undetectable viral load
Imminent arrival of latest HIV drug darunavir, when combined with FUZEON, will give treatment-experienced patients a better chance to achieve undetectable viral load. (2006-12-15)

HIV subtype predicts likelihood of early death from AIDS
Johns Hopkins scientists say an infected person's HIV subtype is a better predictor than viral load for determining rapid death from AIDS. Traditional testing standards help monitor the progression of an HIV infection to AIDS by keeping track of viral load, using a scale in which less than 50 viral particles per cubic milliliter of blood is considered suppressed disease and a viral load of more than 75,000 particles per cubic milliliter of blood means that the disease will progress more rapidly. (2006-02-06)

Evolution of severely immunosuppressed HIV patients depends on the immunologic and virologic response
A study with nearly 2,300 severely immunocompromised HIV patients and led by researchers from the Bellvitge University Hospital and IDIBELL concludes that even in the worst scenario if patients recover immunologic response recovers or decreases viral load, or only one of the two things, the patient is able to control the disease. The work was published in the Journal of Antimicrobial Chemotherapy. (2015-11-23)

What underlies differing disease severity in COVID-19?
Researchers have reported a significant and positive relationship between the amount of virus present in a throat swab sample and the severity of COVID disease. (2020-04-29)

New method for HIV testing holds promise for developing world
A new technique that detects the HIV virus early and monitors its development without requiring refrigeration may make AIDS testing more accessible in sub-Saharan Africa. (2009-07-21)

HIV Patients Often Experience Viral "Breakthrough," But May Still Remain Healthy, San Francisco Study Finds
Fifty-five percent of HIV patients who had achieved undetectable levels of the virus with combination antiretroviral therapy are projected to experience a resurgence of the virus within one year, according to San Francisco AIDS specialists. (1998-06-30)

What dictates hospital admission for people with HIV?
The authors of a study assessing demographic and clinical predictors of hospital admission among men and women taking anti-HIV therapies found unemployment was one of several predictors of hospitalization. (2000-03-20)

Study reveals effective anti-HIV drugs for starting treatment in children with HIV, and shows that delaying switching to second-line drugs does not affect long-term benefit
Children with HIV will need anti-HIV medicines for longer than adults, so questions about which anti-HIV drugs to start with and when to switch to different drugs if the virus levels start to increase need to be answered. (2011-01-31)

Humans MIFfed by West Nile Virus
Infection with West Nile Virus can cause lethal encephalitis and there are currently no vaccines or specific therapeutics for use in humans. However, a new study published in the Journal of Clinical Investigation has provided evidence that the proinflammatory soluble factor MIF might provide a target for developing therapeutics to treat WNV encephalitis. (2007-10-01)

Amount of COVID viral RNA detected at hospital admission predicts how patients will fare
A new study published online in the Annals of the American Thoracic Society examines whether the amount of RNA, or genomic load, of SARS-CoV-2 detected in swab tests of patients being admitted to the hospital with viral pneumonia is associated with more severe COVID-19. SARS-CoV-2 is the virus that causes COVID-19. Previous studies on this question have had conflicting results. (2020-10-29)

First clinical confirmation of H7N9 virus resistance to Tamiflu
New research published in The Lancet documents the first clinical cases of resistance to treatment with Tamiflu (oseltamivir) and similar drugs in people infected with the H7N9 influenza virus. (2013-05-28)

Research on viral load of HIV patients reveals new cohort at risk of therapy failure
The findings indicate that the current WHO-defined threshold for virological failure fails to identify a large subset of patients who are at increased risk of poor outcomes of ART, and that clinical interventions should take place at lower viral loads than those proposed by the current WHO guidelines. (2017-11-27)

Study Finds Less Intensive Treatments May Not Maintain HIV Suppression
According to an NIAID-supported study, triple-drug treatment regimens appear to be superior to less intensive (1998-10-28)

HIV antibody infusions show promise for treating SHIV-infected monkeys
Two teams are reporting results from experiments in which they infused powerful anti-HIV antibodies into monkeys infected with an HIV-like virus, rapidly reducing the amount of virus, or viral load, to undetectable levels, where it remained for extended periods. One study was led by scientists at NIAID, part of NIH, and the other was led by NIAID grantees at Beth Israel Deaconess Medical Center. Both teams worked with monkeys infected with simian human immunodeficiency virus, or SHIV, which can cause AIDS in monkeys. (2013-10-31)

Host protein levels correlate with HIV-associated neurocognitive disorder
A new study in the Journal of Clinical Investigation suggests that a host protein, heme oxygenase-1, is protective against HIV-associated inflammation and cognitive decline (2014-09-09)

Young kids could spread COVID-19 as much as older children and adults
A study from Ann & Robert H. Lurie Children's Hospital of Chicago discovered that children younger than 5 years with mild to moderate COVID-19 have much higher levels of genetic material for the virus in the nose compared to older children and adults. Findings, published in JAMA Pediatrics, point to the possibility that the youngest children transmit the virus as much as other age groups. (2020-07-30)

CD4 cell count key predictive risk factor for both AIDS-defining and non-AIDS-defining cancers in patients with HIV
Immunodeficiency (falling CD4 cell count) increases the risk of at least seven cancers in people with HIV. As such, earlier diagnosis of HIV and earlier initiation of treatment with antiretroviral therapy could delay the onset of some cancers in HIV patients, finds research published online first and in an article in the November issue of the Lancet Oncology. (2009-10-07)

People with 'silent' COVID-19 have as much coronavirus as those with symptoms
People with 'silent' COVID-19 infection have as much coronavirus in their noses and throats as those with symptoms, reveals research published online in the journal Thorax. (2020-09-22)

Does peripheral T lymphocyte subpopulations correlate with hepatitis B virus load?
The clear differences in the peripheral T cell subpopulation profile in different clinical stages of chronic HBV infection and the strong relationship of peripheral T lymphocyte subpopulations with HBV load are illustrated in a new study in a large cohort of subjects which conducted by Professor Jing You and her colleagues in China and Thailand. These findings are relevant to both improved understanding of chronic HBV infection and the design of individualized new anti-viral strategies. (2009-07-29)

CD4 count is non-inferior to viral load for treatment switching in adults with HIV
For adults infected with HIV in Thailand a monitoring strategy based on CD4 count (a type of white blood cell) is non-inferior to the recommended monitoring strategy measuring the amount of HIV virus in a patient's blood, to determine when to switch from first-line to more costly second-line antiretroviral treatment according to a clinical trial published this week in PLOS Medicine. (2013-08-06)

CD4+ T-cell count useful to assess antiretroviral therapy response in HTLV-1/HIV patients?
While HIV is known to deplete CD4+ T-cells, the present study showed that patients co-infected with HTLV-1 continued to have elevated CD4+ T-cell counts despite responding unsuccessfully to their HIV medications. (2017-03-17)

HIV treatment not affected by hormonal birth control
According to researchers from the Johns Hopkins Bloomberg School of Public Health, estrogen and progesterone hormones in birth control do not influence the effectiveness of highly active antiretroviral therapy (HAART). (2005-05-02)

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