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Researchers identify new brain receptor for fantasy
Researchers are closer to understanding the biology behind GHB, a transmitter substance in the brain, best known in its synthetic form as the illegal drug fantasy. (2012-07-02)
Could melatonin be the key to healthy aging?
A new British Journal of Pharmacology review highlights the role of melatonin -- a hormone that is produced at night -- in regulating sleep and the body's biological, or circadian, clock. (2018-01-10)
Europe's leading pharmacologists to meet in Manchester
Hundreds of leading pharmacologists and bioscientists from across Europe will be in Manchester next week for the 5th Congress of the Federation of European Pharmacological Societies. (2008-07-10)
Zinc lozenges help most patients recover earlier from the common cold
Zinc acetate lozenges may reduce the duration of the common cold by nearly 3 days, according to a recent analysis. (2016-07-06)
Stem cell-based screening methods may predict heart-related side effects of drugs
Coaxing stem cells from patients to become heart cells may help clinicians personalize drug treatments and prevent heart-related toxicity. (2016-10-14)
Antipsychotic drugs are linked with an increased risk of heart attacks
A review of nine observational studies found evidence supporting an increased risk of heart attacks in patients taking antipsychotic drugs. (2016-05-16)
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes. (2017-12-20)
Running away from addiction: How exercise aids smoking cessation
New research in mice sheds light on the mechanism underlining exercise's protective effect against nicotine dependence and withdrawal. (2017-12-20)
UCI study uncovers possible roots of schizophrenia
An abundance of an amino acid called methionine, which is common in meat, cheese and beans, may provide new clues to the fetal brain development that can manifest in schizophrenia, University of California, Irvine pharmacology researchers report in the journal Molecular Psychiatry. (2017-08-15)
Anti-fungal drug stops blood vessel growth
Researchers at Johns Hopkins have discovered to their surprise that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers. (2007-04-27)
Making medications safer for newborns
Although new drugs must be shown to be both safe and effective for approval by the Food and Drug Administration, sick newborns receive most of their drug treatment off-label and without the evidence provided for adults and older children. (2016-10-04)
Study finds epilepsy drug to be safe during pregnancy
New research indicates that use of the epilepsy drug lamotrigine during pregnancy does not increase the risk of birth malformations or neurodevelopmental disorders. (2017-10-18)
Society of Nuclear Medicine announces Image of the Year
The Society of Nuclear Medicine's 2003 Image of the Year is an example of technological improvements that show a diagnostic quality whole-body scan can be obtained in under ten minutes. (2003-06-23)
South African daffodils may be a future cure for depression
Scientists have discovered that plant compounds from a South African flower may in time be used to treat diseases originating in the brain - including depression. (2012-06-22)
Protein targeted to stop melanoma tumor growth
Halting the growth of melanoma tumors by targeting the MIC-1 protein that promotes blood vessel development in tumors may lead to better treatment of this invasive and deadly cancer, according to Penn State College of Medicine researchers in the Foreman Foundation Research Laboratory. (2010-12-09)
Chronic alcohol exposure can affect brain protein expression
Researchers at the University at Buffalo studying the effects of alcohol on the brain, using zebrafish as a model, have identified several novel central nervous system proteins that are affected by chronic alcohol exposure. (2006-08-29)
Tighter tummies: A new way to combat weight gain
Two cell proteins that relax the gut and help accommodate a big meal have been identified by UCL scientists. (2008-03-03)
Researchers examine how opioids affect proteins in the brain other than opioid receptors
In a new study, researchers have characterized the effects of a series of opioids on proteins in the brain other than opioid receptors. (2017-12-06)
Cholesterol-lowering drugs may help patients with cirrhosis
Statins used for the treatment of high cholesterol may have other beneficial effects, but there has been reluctance to prescribe them to patients with liver disease because of concerns that they may cause abnormal liver enzyme levels in the blood. (2017-09-07)
The hitch in the drug? The itch in the drug
Scratching deep beneath the surface, a team of researchers from the University of California, San Diego School of Medicine and three South Korean institutions have identified two distinct neuronal signaling pathways activated by a topical cream used to treat a variety of skin diseases. (2011-02-08)
Antidepressants and anti-anxiety drugs linked to increased risk of hip fracture
In a recent study, older individuals who had fallen and broken a hip used antidepressant and anti-anxiety medications more frequently than the general older population. (2017-03-07)
New Genetic Risk Factor For Late-Onset Alzheimer's Disease
Scientists at the University of Oxford have discovered a gene on chromosome 3 that interacts with another gene on chromosome 19 markedly to increase the risk of developing late-onset Alzheimer's disease. (1997-10-14)
Natural tumor suppressor in body discovered by UCSD medical researchers
A natural tumor suppressor that could potentially be turned on in certain cancer cells to prevent the formation of tumors has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine. (2005-03-31)
LSU receives $3.6 million to fund center studying hazardous waste cleanup and health impacts
LSU Professor and Patrick F. Taylor Chair of Chemistry Barry Dellinger was recently awarded a grant of $3.6 million by the National Institute of Environmental Health Sciences, or NIEHS, to support a Superfund Research Center focusing on hazardous waste disposal and its impact on public health. (2009-09-04)
Antidepressant drug linked with increased risk of birth defects when taken in early pregnancy
Using paroxetine -- a medication prescribed to treat conditions including depression, obsessive-compulsive disorder, anxiety and posttraumatic stress disorder -- during the first trimester of pregnancy may increase newborns' risk of congenital malformations and cardiac malformations. (2016-01-05)
Stimulants may have detrimental effects on muscle control
Researchers have found that current or past use of methamphetamine or other stimulants may lead to psychomotor control deficits, or a reduced ability to control physical movement. (2017-04-20)
UNC-Duke ties lead to collaborative finding about cell division & metabolism
A new finding based on multiple collaborations between UNC and Duke scientists over several years points to new avenues for investigation of cell metabolism that may provide insights into diseases ranging from neurodegenerative disorders like Parkinson's and Alzheimer's disease to certain types of cancers. (2011-08-07)
Antiplatelet drugs are often inappropriately prescribed in older patients
A study has found that antiplatelet drugs, such as aspirin, are often inappropriately prescribed in acutely hospitalized older people. (2017-07-19)
Einstein's Dr. Susan Band Horwitz elected to Institute of Medicine
Susan Band Horwitz, Ph.D., distinguished professor and co-chair of the Department of Molecular Pharmacology and the Falkenstein Professor of Cancer Research at the Albert Einstein College of Medicine of Yeshiva University, has been elected to the Institute of Medicine. (2006-10-11)
The American Society for Microbiology honors George L. Drusano
The winner of the esteemed Cubist-ICAAC Award is George L. (2013-06-20)
Cancer drug helps combat asthma in mice
In a mouse model of allergic asthma, dasatinib -- an enzyme inhibitor approved for the treatment of chronic myelogenous leukemia -- reduced inflammation, enhanced airway repair, and improved lung mechanics. (2016-02-01)
Next-generation glaucoma therapeutics hold considerable promise
Elevated pressure in the eye is the most common risk factor for glaucoma, an optic neuropathy that can cause blindness and affects more than 67 million people worldwide. (2014-04-07)
Pharmacologist tip sheet: Migraine patches, nicotine therapies, allergy medication interference...
Nicotine Helps the Brain Stay Alert, Lidocaine Cream Can Help With Migraine Pain, Juices Interfere With Popular Allergy Medicine, Tracking Adherence to AIDS Medication Regimes (2001-03-06)
Resident physicians feel unprepared to counsel patients on medical cannabis
A recent study from Saint Peter's University Hospital in New Brunswick, New Jersey, highlights the need for further education among resident physicians in the use of medical cannabis. (2017-10-23)
Genetically modified mice provide information on treatments for cocaine dependence
Cocaine's rewarding effects were still apparent in mice that were lacking both the dopamine and the norepinephrine transporter. (2003-04-12)
Walking a tightrope: Regulators balancing need for safety and flexibility in approvals for new medicines
It can be challenging for regulators to keep up with advances related to medical drugs and devices. (2016-08-31)
Specific genotype could increase resistance to HIV drug therapy
A specific mutation of a gene which influences the expression of a glycoprotein transporter protein involved in the body's resistance to drugs and other toxins is detailed in a research letter in this week's issue of THE LANCET. (2001-08-02)
Risk of liver cancer from hepatitis B persists even after clearing the virus
Long-term infection with hepatitis B virus (HBV) can cause liver inflammation and increase the risk of liver cancer. (2016-04-22)
Patients with celiac disease should receive pneumonia vaccine
Researchers have found that patients with celiac disease are at high risk of acquiring pneumonia if they haven't received the pneumococcal vaccine. (2016-05-13)
University launches iPhone app to access HIV drug expertise
The University of Liverpool has launched an iPhone application, HIV iChart,that provides health care professionals and HIV patients with instant and easy access to information about drug interactions. (2010-11-15)
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