Articles tagged with Ischemia
A study published in Translational Exercise Biomedicine found that low-intensity treadmill exercise preconditioning significantly reduced brain injury and improved neurological outcomes after ischemic stroke in mouse models. The exercise group showed lower infarct size, increased microvessel density, and reduced inflammation.
GLP-1 weight-loss drugs may prevent further tissue damage following a heart attack, significantly reducing the risk of further life-threatening complications. Researchers found that these drugs improve blood flow to the heart by activating potassium channels, relaxing constricted blood vessels and reducing heart damage risk.
Researchers identify non-contractile cell populations and their role in sustaining atrial fibrillation, a persistent and challenging-to-treat cardiac arrhythmia. The study provides insight into the cellular mechanisms involved and suggests new therapeutic strategies targeting these components.
A nationwide cohort study found that semaglutide initiators had a significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy compared to sodium-glucose cotransporter-2 inhibitor initiators. The absolute risk was low, but clinicians and patients should be aware of this rare but evident increased risk.
Research links long-term exposure to wildfire smoke with increased risk of stroke in US adults, estimating around 17,000 annual cases. The study suggests wildfire smoke may be more harmful than pollution from other sources, and highlights the need for preventative measures.
A new study suggests that gaps in the nation's stroke transfer system reduce survivors' chances of receiving critical treatment and increase disability. Patients with longer delays in hospital transfer experienced worse disability after their stroke, highlighting missed opportunities for many stroke patients.
Researchers developed a wearable Revoice device that decodes speech signals and emotional cues to enable seamless real-time communication in people with post-stroke dysarthria. The device achieved a word error rate of 4.2% and sentence error rate of 2.9%, showing promising results for stroke rehabilitation.
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
A study published in Annals of Translational Medicine found that intense light therapy can lower troponin levels and increase ANGPTL4 protein, protecting heart tissue. The treatment may reduce the risk of myocardial injuries after non-cardiac surgery, which affects 20% of patients and increases one-year mortality rates.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers at University of Pennsylvania discover red blood cells contribute to clot contraction, shrinking and stabilizing blood clots. The finding opens door to new strategies for studying and treating clotting disorders, such as excessive bleeding or dangerous clots like those seen in strokes.
The JAK2-STAT3 pathway contributes to inflammation and injury after ischemic stroke. Targeting this pathway shows promise for reducing brain swelling, neuronal death, and improving recovery. Several inhibitors have been found effective in preclinical models, including Tyrphostin AG490, Ruxolitinib, and natural compounds like genistein.
A study found that semaglutide and liraglutide use are associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in older patients with type 2 diabetes. The GLP-1 receptor agonists showed varying levels of risk, with liraglutide posing the greatest threat.
Gene therapy has been shown to significantly improve blood flow in the brains of patients with sickle cell disease, decreasing the risk of stroke. The treatment has a more substantial and long-lasting protective effect than other treatments like hydroxyurea or blood transfusions.
Patients with chronic limb-threatening ischaemia (CLTI) are at risk of serious complications, including major amputations and heart attacks. A new statement from the European Society of Cardiology recommends using dual pathway inhibition (DPI) to prevent blood clots in CLTI patients after leg artery procedures.
Researchers found that Marfan syndrome increases vulnerability to brain damage from reduced oxygen supply and raises the risk of subsequent neurological disorders. The study highlights the importance of recognizing and managing neurological risks in Marfan patients to prevent complications.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
A study of over a million people found that shingles vaccination lowers the risk of cardiovascular events, including stroke and coronary heart disease, by up to 26%. The vaccine's protective effect lasts for up to eight years, with strongest benefits in younger people and men.
A multicenter study found that radiologically unstable plaque, particularly intraplaque hemorrhage, significantly increases the risk of ischemic stroke and ocular symptoms in patients with symptomatic mild carotid stenosis. Surgical intervention, such as carotid endarterectomy, may be a protective factor for these patients.
Researchers found that adults under 50 with migraine headaches and certain heart defects are at increased risk of stroke. The study highlights the importance of assessing both traditional and nontraditional risk factors in younger people to prevent strokes.
A recent study found that ischemic stroke mortality rates have increased in the US over the past two decades, particularly among racial minorities and rural residents. The majority of these deaths now occur at home, rather than in hospitals or medical facilities.
A global study led by UCalgary researchers found that one in five people who experience a minor stroke or TIA will have another stroke within 10 years. The study analyzed data from over 171,000 patients across four continents and shows a persistently high risk of future strokes for at least a decade.
A University of Minnesota Medical School study identified a key heart marker predicting ischemic stroke and dementia, which could lead to improved patient outcomes. The left atrium's ability to stretch was found to be the most accurate predictor.
In an open-label study, patients hospitalized for a serious heart attack who received rivaroxaban or warfarin had similar efficacy and safety outcomes. Rivaroxaban showed comparable results in dissolving left ventricular blood clots at three months follow-up.
A cohort study found semaglutide use is associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in people with diabetes. However, the retrospective design limits the study's ability to establish causality, necessitating further research.
A study published in JAMA found that patients who have experienced a transient ischemic attack (TIA) or minor stroke are at a persistently high risk of subsequent stroke. The findings highlight the need for improved long-term stroke prevention measures in this patient group.
Patients with severe ischemic stroke show impaired gastric motility and autonomic dysfunction, with reduced normal gastric slow waves and increased sympathetic activity. These findings suggest a link between gastric myoelectrical rhythms and autonomic function in ischemic stroke.
The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.
A POSTECH research team developed a photoacoustic computed tomography (PACT) system that non-invasively monitors cerebrovascular changes in small animals with early stages of an ischemic stroke. The technology also measures oxygen saturation in blood vessels, allowing precise tracking of vascular recovery after stroke.
A study published in JAMA Ophthalmology found a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy among individuals with type 2 diabetes associated with semaglutide use. The findings suggest that further investigation is needed into the clinical implications of this association.
Researchers analyzed data from three trials and found nerinetide provided a clinically significant benefit to patients. The findings suggest that treating early, fast, and administering the drug can lead to improved patient outcomes.
Emboa Medical creates a microstructured catheter called TRAP, which mimics a boa constrictor's teeth arrangement to grab onto blood clots without tearing them. The TRAP design has shown significant benefits in removing clots on the first attempt and improving outcomes for stroke patients.
Researchers found that clot-dissolving medication alteplase improved stroke patients' recovery by more than 50% when given up to 24 hours after the beginning of an ischemic stroke. This breakthrough may provide hope for stroke patients worldwide who may not have access to clot-dissolving medications within the approved time window.
UCalgary researchers confirm that endovascular thrombectomy (EVT) is not effective for patients with blockages in medium-sized blood vessels. The ESCAPE-MeVO clinical trial found no improvement in outcomes for these patients compared to standard care. EVT was previously shown to improve patient outcomes after large-vessel strokes.
Researchers at the University of Cincinnati presented studies on intracerebral hemorrhage treatment eligibility, finding only 3% of patients are eligible for a minimally invasive procedure. Additionally, a study found racial disparities in stroke recovery, with Black individuals experiencing worse functional outcomes after ischemic str...
The DISTAL trial found that endovascular therapy in addition to best medical therapy did not reduce disability more than clot-busting treatment alone for patients with medium distal vessel blockages. The study showed that mechanical clot removal was a safe option, but its benefits were uncertain.
The summit features live case demonstrations, interactive debates, hands-on training, and the latest evidence-based practices in structural heart care. Attendees will witness innovation in action, exploring breakthroughs in surgical techniques, transcatheter interventions, and personalized treatment strategies.
Researchers found that brief ozone exposure reduces blood oxygen saturation, triggers hypoxia-related biomarkers, and increases arterial stiffness. Ozone pollution is a worldwide health issue, linked to increased risk of cardiovascular diseases.
Persistent microvascular over-dilation may cause muscle hypoxia, worsening chronic limb-threatening ischemia outcomes. Research suggests this phenomenon could be used to screen and treat patients with the disease.
Researchers at Gladstone Institutes have shown that modified stem cells can improve brain activity after a stroke, even when administered one month later. The treatment reversed brain hyperexcitability and restored balance in neural networks, leading to long-lasting effects on brain function and repair.
Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.
Researchers at Osaka Metropolitan University developed a world-first system to automatically recommend optimal rehabilitation programs for stroke patients based on their motor paralysis degree. This system uses data from Teijin Pharma Ltd.'s ReoGo-J robot, providing tailored care even for staff without robotic experience.
A meta-analysis of four randomized clinical trials found that endovascular therapy significantly reduces patient mortality and overall post-stroke disability for vertebrobasilar stroke patients. EVT is nearly 2½ times more likely to achieve a positive outcome compared to standard medical management.
A study published in JACC found that children who started tobacco smoking at age 10 were significantly more likely to experience premature cardiac injury and increase their risk of cardiovascular mortality. Researchers also discovered that continued smoking from childhood can cause lasting damage to heart muscle and function.
A new study published in the Journal of the American Heart Association found that Mexican American women are more likely to miss prescribed doses of stroke prevention medications. The study highlights sex-associated disparities in stroke care, particularly among racial and ethnic minorities.
A new study published in Nature Communications reveals that energy imbalances in podocytes contribute to kidney damage and proteinuria after ischemia-reperfusion injury. The researchers found that interventions targeting mitochondrial dynamics held promise in alleviating foot process effacement and improving podocyte outcomes.
A new study maps genetic traits to cellular composition of atherosclerotic plaques, predicting future stroke or heart attack risk. The research improves risk assessment and treatment for patients with atherosclerosis.
Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.
A recent study published at the American Heart Association's Scientific Sessions 2024 found that blood thinners did not reduce cognitive decline in adults younger than age 65 who have atrial fibrillation (AFib) but no other risk factors for stroke. The trial included over 1,200 participants and followed them for an average of 3.7 years...
This study explores the efficacy of Herba Siegesbeckiae subfractions in protecting against myocardial ischemia/reperfusion injury. The HS-C subfraction exhibited significant protective effects, attributed to its ability to inhibit the UCHL5/NLRP3 pathway.
A recent study published in Topics in Stroke Rehabilitation found that slightly overweight stroke survivors (BMI 22.1-27.5 kg/m²) have a lower risk of sustaining disabilities compared to those with normal weight. The research suggests that a higher-than-normal BMI may be beneficial for recovering from a stroke with less disability.
Yihao Zheng and his team are developing a fiber-optic probe that analyzes artery blockages in the brain and guides procedures for blockage removal. The technology uses light and advanced calculations to determine the properties of blood clots, enabling doctors to make informed decisions about how to remove them.
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
A new study found that initial prescriptions of benzodiazepines for older stroke survivors often include excessive doses, posing a risk of dependence, falls, and other harmful effects. Guidelines recommend avoiding benzodiazepine prescriptions if possible, but some cases may require limited use under close monitoring.
The RESILIENCE clinical trial explores the effectiveness of remote ischemic conditioning to prevent cardiotoxicity in lymphoma patients undergoing anthracycline-based chemotherapy. The trial aims to reduce heart failure prevalence and improve quality of life for cancer survivors.
A study published in JAMA finds that balloon angioplasty plus aggressive medical management reduces the risk of any stroke or death within 30 days. The treatment approach may be effective for symptomatic intracranial atherosclerotic stenosis, but with consideration for increased stroke risk after balloon angioplasty.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
Researchers developed a game-changing blood test that can quickly and accurately identify large vessel occlusion strokes, which have the potential to bring life-saving care to patients globally. The test combines biomarkers with a clinical score to detect strokes with 93% specificity and 81% sensitivity.
A study published in Circulation found that revascularization significantly enhances the health-related quality of life (HRQoL) for patients with chronic limb-threatening ischemia. Patients who underwent endovascular intervention (Endo) showed slight statistical superiority over those who received surgical bypass (Bypass) in some HRQoL...
The 2024 AHA/ACC Guideline on the Management of Lower Extremity Peripheral Artery Disease aims to improve patient outcomes by emphasizing timely diagnosis and treatment. Coordinated care among a multispecialty team is crucial in reducing the risk of amputation, heart attack, stroke, and death for individuals with PAD.