Articles tagged with Nephropathies
ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
A nationwide Danish study comparing outcomes between patients treated with minimally invasive ablation and surgery found no difference in cancer progression but more frequent local recurrence of the disease following ablation. Ablation patients had shorter hospital stays and fewer complications.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
The American Heart Association reports that millions of US adults with diabetes are unaware they have it, while nine in ten with chronic kidney disease do not know they have it. Regular screening can catch problems early, with approximately 80% of heart attacks and strokes being preventable.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly lowers risks of limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared to dipeptidyl peptidase-4 inhibitors in patients with diabetes. GLP-1 RAs are preferred for secondary prevention in this high-risk population.
Salk Institute scientists discover that dietary supplementation of the amino acid methionine protects infected mice against inflammation-related wasting, blood-brain barrier dysfunction, and death. Methionine boosts kidney filtration, reducing circulating cytokine levels and improving disease outcomes.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers developed a highly sensitive blood test that can detect initial thrombin generation, a key trigger in blood clot formation. The test distinguishes between pathway-specific clotting abnormalities and suggests personalized treatment strategies, potentially predicting clinical outcomes.
Researchers have developed a web-based tool to identify people at risk of developing chronic kidney disease through subtle abnormalities in kidney function. The study shows that individuals with an eGFR below the 25th percentile had a markedly higher risk of developing kidney failure.
A new study found that light intensity activities, such as walking or household chores, were associated with a lower risk of death for people with CKM syndrome. The researchers used data from the National Health and Nutrition Examination Survey to compare activity level duration for each CKM syndrome stage.
Early recognition of cast nephropathy through novel biomarkers can guide timely treatment, while tailored extracorporeal therapies show promise in preventing irreversible kidney damage. The review emphasizes the need for standardized biomarker-guided pathways and multicenter trials to advance personalized kidney support.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Insilico Medicine and Taigen Biotechnology collaborate to develop and commercialize ISM4808, an AI-driven PHD inhibitor for treating anemia of Chronic Kidney Disease (CKD). The partnership grants TaiGen exclusive rights for further development, commercialization, and sub-licensing in the Greater China area.
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
Researchers from the University of Missouri-Columbia have identified several genes that may be potential therapeutic targets for Chronic Kidney Disease (CKD) by regulating gene activity. These genes are involved in the signs of kidney damage, including fibrosis and inflammation.
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
The book covers genetic, epigenetic, and molecular foundations of renal dysfunction, as well as microbiota, immune interactions, and nephrotoxicity. It also highlights novel therapies and precision medicine approaches for better diagnostic and treatment strategies.
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
A recent FAU Engineering study leverages quantum computing to enhance the accuracy of chronic kidney disease (CKD) diagnosis. The research team developed and compared two automated systems: Classical Support Vector Machine (CSVM) and Quantum Support Vector Machine (QSVM). CSVM achieved remarkable 98.75% accuracy, while QSVM reached 87....
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
The study found CKD affects nearly 800 million worldwide, with diabetes and high blood pressure driving the greatest loss of healthy years. Access to kidney replacement therapies remains limited, highlighting the need for preventive measures and equitable care.
A new study reveals that a large gap between two common kidney function tests may indicate future disease, particularly among older adults. The research found that over a third of hospitalized participants had a significant difference in their creatinine and cystatin C readings, which can predict serious health problems.
A new study estimates that about 14% of adults worldwide have chronic kidney disease, with 1.5 million deaths in 2023. Early detection and treatment are crucial to prevent severe interventions like dialysis and transplantation.
Researchers investigated GnT-V, a cancer-related glycosylation enzyme, and found its selectivity relies on protein structure and subcellular trafficking. Two enzymes, metalloproteases, were identified as major substrates in the kidney.
A randomized clinical trial has shown that rituximab is effective in preventing relapses and reducing the need for corticosteroids in adults with relapsing nephrotic syndrome. The study involved 66 adult patients treated with either rituximab or a placebo, with impressive results at the 49-week follow-up.
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
A simple blood test is being developed to detect acute kidney injury hours faster, allowing for earlier intervention and better management of chronic kidney disease. The test uses patented DNA aptamers to directly investigate structural kidney damage.
Researchers found that over 30% of children referred for Alport syndrome testing at age 3 already required therapeutic intervention, highlighting the potential benefits of early detection. The study suggests introducing a urine testing system may enable intervention before kidney dysfunction onset.
Researchers have discovered that APOL1 mutations impair mitochondrial function in podocytes, leading to impaired kidney filtering. This finding could explain why inflammation triggers the onset of AMKD in patients, paving the way for targeted treatments.
A study published in Mayo Clinic Proceedings found that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor. Lifestyle factors such as BMI, fluid intake, and smoking habits significantly contribute to the occurrence of kidney stones.
Researchers at Mayo Clinic found that transplanting patients' own stem cells into their veins can help prevent inflammation and vein narrowing in patients with end-stage kidney disease. This could extend the time before dialysis is required, reducing healthcare costs and improving patient outcomes.
A new study by the University of Arizona found that heat exposure and toxic metal exposure can increase signs of kidney injury in agricultural workers. The study suggests that providing mandatory breaks, water, electrolyte replacement, and restrooms nearby can help prevent heat-related illnesses and kidney damage.
Researchers at the University of Copenhagen discovered two new ciliary proteins that regulate cell communication and may lead to the development of new treatments for chronic diseases. The study found that defective cilia can disrupt signaling in almost all tissues and organs, leading to various diseases.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Researchers used AI models with integrated clinical and claims data to predict chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). The study found that the models outperformed single data source models and reduced racial bias. The findings can inform likelihood and management of CKD, supporting targeted interven...
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Researchers discovered that immune hubs in the kidney create a unique metabolic environment, accumulating glutathione to counter oxidative stress. Blocking this process prevents TLS formation or causes existing structures to shrink. Urine glutathione levels can serve as a non-invasive biomarker for TLSs and disease progression.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
A study analyzing Global Burden of Diseases data from 204 countries and territories found a rising global incidence of urolithiasis over the past three decades, with notable sex disparities. The disease burden is highest in males, particularly in Southeast Asia, whereas females show a higher vulnerability to the increase in risk factors.
Research from Dresden and Heidelberg demonstrates that estrogen protects the kidneys against ferroptosis, a major cause of acute kidney damage. Estradiol increases resistance to ferroptosis by intercepting harmful radicals and activating a genetic program to prevent damage.
Elevated cdc42 activity is a critical initiation event leading to proteinuria in nephrotic syndrome. Suppression of cdc42 activity could be a promising therapy.
Researchers developed a serum proteomics-based prediction model to identify biomarkers involved in ADPKD progression. The study identified 29 proteins linked to immune system, fat transport, and metabolism, which can predict kidney function decline rate. This breakthrough could lead to more accurate and earlier diagnosis of ADPKD.
A recent study published by Fujita Health University found that poor oral health can increase the risk of lifestyle-related diseases such as diabetes and heart disease. The researchers examined 118 individuals aged 50 or above and found significant links between oral function test results and blood test results.
A novel model reveals that local Ang II regulation plays a crucial role in maintaining kidney function balance. The study found that damaged kidneys compensate for the loss of function by increasing blood pressure and reducing glomerular atrophy.
A national survey of 1,000 American adults found that stress (43%) and lack of sleep (39%) are major contributors to a short attention span. The study also identified digital devices as a significant factor, with 35% of respondents citing it as a contributing factor.
A new study found that the newer generation of effective diabetes medications are not reaching enough patients. The study analyzed data from over 40,000 records and found that only 20% of patients with type 2 diabetes were taking GLP-1 drugs within a year of diagnosis, and less than 15% were taking SGLT2 drugs.
QUT researchers create novel composite traits from UK Biobank data, identifying 50,000 biomarkers that outperform eGFR in detecting CKD. Their approach uncovers genetic signals missed by traditional methods.
Long-term data from the Phase 1/2 study of zigakibart demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile in patients with IgA nephropathy. The treatment also led to reductions in serum immunoglobulins, consistent with APRIL pathway inhibition.
Researchers at CRCHUM have discovered a crucial biomarker, miR-423-5p microRNA, to predict kidney function and diagnose chronic renal failure. The breakthrough could lead to early diagnosis, targeted approaches, and improved treatment options for millions of patients worldwide.
A modified surgical face mask can detect chronic kidney disease by analyzing the wearer's breath, showing high sensitivity for CKD-related metabolites. The sensor accurately identifies patients with CKD 84% of the time and those without 88% of the time.
The American Heart Association funds research teams to investigate how risk factors for cardiovascular and kidney diseases impact women differently. The project aims to understand the biological significance of certain life cycles and societal factors on disease development.
A large US cohort study found SARS-CoV-2 infection associated with adverse postacute kidney outcomes in children and adolescents, especially those with chronic or acute kidney disease. Long-term monitoring is recommended for these patients.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.