Cardiology

Enlisting pharmacists and nurse practitioners in medication management can fill critical gaps in heart failure care, save lives, and reduce hospital stays

Expanding heart failure care to pharmacists and nurse practitioner-led medication management can save approximately 10 lives and prevent 25 hospitalizations per 1,000 patients. This service is estimated to be cost-effective and improve patient outcomes, providing a roadmap for a stronger healthcare system.

Investigational J-valve system shows favorable one-year outcomes for severe aortic regurgitation

A recent study evaluated the safety and effectiveness of the J-Valve Transfemoral System in treating symptomatic severe aortic regurgitation. The study showed sustained valve performance, meaningful symptom improvement, and evidence of reverse left ventricular remodeling at one year.

Study links sugary drinks in childhood to higher hypertension risk later in life

A large long-term study found that children who consume sugar-sweetened beverages and fruit juice have a higher risk of hypertension later in life. Replacing these beverages with whole fruits or water was associated with lower risk of hypertension.

Biological pacemaker dogma challenged: TBX18 fails, Hcn2 deliver

A new preclinical study by Amsterdam UMC researchers overturns a key assumption in the biological pacemaker field. They show that transcription factor TBX18 does not generate true pacemaker activity, while ion channel Hcn2 produces robust pacemaker function in the heart.

Inaugural cohort selected for Fuster Prevention Forum

The American College of Cardiology has selected 47 clinicians to participate in its inaugural Fuster Prevention Forum, which focuses on early cardiovascular disease prevention. Participants will gain skills to enact change and foster a culture of prevention in their communities.

Sodium bicarbonate for in-hospital cardiac arrest

A new study published in JAMA found no significant difference between sodium bicarbonate and placebo in sustaining return of spontaneous circulation. The findings suggest that routine administration of sodium bicarbonate for patients with in-hospital cardiac arrest may not be necessary.

RCSI researchers develop first synthetic mitral valve model to replicate the heart's natural mechanics

Researchers at RCSI University of Medicine and Health Sciences have developed an artificial model of the mitral heart valve that faithfully mimics its complex mechanical behavior. The study could help researchers better understand valve disease and develop new treatment approaches.

Researchers uncover how aging cells may trigger heart attacks and strokes

Senescent cells that stop dividing but don't die can become abnormally active, causing inflammation and instability in blood vessel plaques. The study found that losing key regulatory proteins activates the CD38 enzyme, leading to a higher risk of blood clots and cardiovascular events.

Heart rhythm monitoring with a smartphone could save healthcare resources

A new study by Karolinska Institutet shows that daily smartphone-based heart rhythm monitoring can reduce same-day cardioversion cancellations by 94.7% and save significant healthcare resources. The method, called CORAI, uses photoplethysmography to measure small changes in blood flow, allowing for accurate heart rhythm assessment.

Substantial variations in referrals for advanced heart failure therapies across UK and Ireland

The first national audit of advanced heart failure referrals reveals significant gaps in access to life-prolonging therapies, particularly for women. Women represent just 1 in 3 referrals, despite comparable disease burden.

A combination of five-mRNAs mitigates heart failure after myocardial infarction

Researchers from The University of Osaka found that treatment with five mRNAs effectively promoted cardiac repair and extended survival in mice with heart failure. The study showed that simultaneous administration of five therapeutic mRNAs reduced heart tissue damage and improved heart function.

RNA therapy as a novel treatment strategy for genetic heart failure

Researchers used RNA therapy to target a genetic mutation causing heart failure, reducing protein aggregation and improving cellular abnormalities. The study provides insight into the biological mechanisms underlying treatment response and may accelerate the development of personalized treatments for genetic heart disease.

The heart’s ‘natural bypass’ that could spare patients from risky procedures

A new study found that a simple angiogram scoring system can identify patients whose heart muscle is still alive even when a major artery has been completely blocked. This breakthrough could change how cardiac patients are treated and help doctors make faster, more informed decisions.

Routine heart test can track how kids grow and mature, new study finds

Researchers developed an AI-based score from standard ECGs that reflect biological development on a spectrum rather than in fixed categories. The Electrocardiographic Sex Index (ESI) captures step-by-step changes of normal growth and hormonal changes, offering a more precise way to account for developmental stage.

Projected US cardiovascular disease burden from heat exposure for future greenhouse gas scenarios

A new study projects that climate change will significantly increase the risk of heat-related cardiovascular disease in the US by 2050. The Pacific Northwest and Southern/Midwestern states are expected to experience the highest and steepest increases, respectively. Targeted interventions for vulnerable communities are crucial to mitiga...

Mount Sinai opens Carolyn Rowan Center for Women’s Health and Wellness, a new model of coordinated care across the lifespan

The Mount Sinai Health System has opened the Carolyn Rowan Center for Women’s Health and Wellness, which brings together multidisciplinary clinical expertise, structured care pathways, and leading-edge research to deliver personalized, comprehensive care for women. The Center offers guided multi-visit experiences and coordinated care o...

Liver pressure monitoring using ultrasound microbubbles

Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.

MRI approach improves assessment of common valve disease

Researchers developed a new cardiac MRI-based measurement, eRVEF, to assess tricuspid regurgitation and improve mortality risk prediction. The study found that eRVEF predicted adverse outcomes better than traditional measures.

2026 Andreas Grüntzig Ethica Award presented to Roxana Mehran

Roxana Mehran is recognized for her impactful work on improving outcomes for patients undergoing interventional procedures. She has contributed to major trials, including the TWILIGHT trial, and advocates for women in medicine through initiatives like Women As One.

EuroPCR 2026 – Coronary revascularisation in patients undergoing TAVI

The ARTICA meta-analysis investigated the safety and effectiveness of coronary revascularisation in patients undergoing TAVI, providing comprehensive insights into the optimal role of PCI. The findings suggest a potential benefit of selective, physiology-informed PCI in patients with severe aortic stenosis and CAD undergoing TAVI.

Cardiac organoids show potential for myocardial repair after infarction

Researchers developed cardiac organoids to address limitations of cell-based therapies in myocardial infarction. These three-dimensional tissue constructs integrate into host tissue, improve cardiac function, and reduce scar size without arrhythmogenic effects.

EuroPCR 2026 – Outcomes with left atrial appendage closure vs. direct oral anticoagulants in patients with atrial fibrillation across different age groups

A subgroup analysis of the CHAMPION-AF trial reveals that left atrial appendage closure (LAAC) efficacy and safety are not affected by age, suggesting it can be considered for suitable candidates regardless of age. The choice between LAAC and DOAC should be made on an individualized basis in a shared decision-making process with patients.

EuroPCR 2026 – Long-term mortality following revascularisation for left main disease

A meta-analysis of 10-year data from 4 randomized trials found no significant difference in all-cause mortality between DES PCI and CABG. Long-term follow-up supports considering both approaches for suitable patients.

Mount Sinai again partners with CityPickle

Mount Sinai physicians will offer expert guidance and resources to keep pickleball players safe and healthy at more locations than ever before. The partnership aims to promote physical and mental well-being, as well as boost longevity through pickleball.

An AI–enabled cardiopulmonary resuscitation instructor

A new AI-powered cardiopulmonary resuscitation instructor has been developed to support bystanders during out-of-hospital cardiac arrests. The study suggests that this technology could be a scalable public health intervention to save lives.

Age does not appear to drive cardiovascular risk in pregnancy

Pregnancy-related cardiovascular complications account for 20-30% of maternal deaths in the US. Researchers analyzed claims data to find that underlying cardiovascular risk drives these events, rather than older age. This may encourage doctors to address cardiovascular health before pregnancy.

Results of major heart study set to save lives, reduce unneeded heart implants

UMCG studies show: Centuries-old medicine benefits heart failure patients

Association of childhood outdoor play with adult sedentary behavior and physical activity in patients with congenital heart disease

Concordia-designed CPR simulator for space use tracks the differences of blood flow in reduced gravity

A Concordia-designed simulator models hemodynamics in reduced gravity environments, revealing key differences in blood flow and pressure patterns. The system successfully reproduced effective CPR on Earth and generated consistent blood flow under both normal and hypogravity conditions.

Swimming beats running for strengthening the heart, study finds

A recent study published in Scientific Reports found that swimming is more effective than running in promoting healthy heart growth and improving heart muscle strength. Swimming promoted greater modulation of microRNAs, which control various heart adaptations, compared to running training.

Over the past decade, congestive heart failure and heart rhythm-related cardiogenic shock deaths increased by over 10%

Deaths from non-ischemic CS have risen sharply in the US, while ischemic CS deaths declined between 1999-2020. Researchers warn of a growing public health challenge that requires policy initiatives and targeted trials.

Study examines clinical outcomes based on antiplatelet bridging dosing patterns post-PCI

A multi-center retrospective cohort study examined how cangrelor is used in real-world clinical practice around the time of surgery following PCI. The study found that varying dosing patterns can affect outcomes, with higher infusion rates associated with increased bleeding events and lower infusion rates linked to higher major adverse...

Novel blood return system cuts blood loss by 97% in pulmonary embolism procedure

A novel blood return system has been shown to significantly reduce blood loss during pulmonary embolism procedures, with a median reduction of 97%. The study found that the system improved procedural efficiency and maintained hemodynamic efficacy without added therapies or major complications.

Lipoprotein(a) linked to elevated cardiovascular risk despite standard treatment

Researchers found that elevated Lipoprotein(a) levels are associated with a higher risk of major adverse cardiovascular events, including stroke and death. Patients with high Lp(a) levels should work closely with their healthcare provider to aggressively lower LDL cholesterol and manage other cardiovascular risk factors.

REACH trial found smart algorithm using finger cuff technology detected moderate-to-severe as cases in African American patients with excellent performance

A novel detection algorithm using finger cuff technology detected moderate-to-severe aortic stenosis with a sensitivity of 90.5% and 100% in African American patients, showing excellent performance for screening purposes.

Clopidogrel seems to outperform aspirin for secondary chronic maintenance therapy

New findings suggest that clopidogrel monotherapy is associated with a lower risk of net adverse clinical events compared to aspirin monotherapy, even in patients at high risk of bleeding. This benefit is more pronounced in patients with high bleeding risk and complex procedures.

COVID-19 and severe heart attack increase mortality by 25% after one year, more than double pre-pandemic rates

A new study found that COVID-19 significantly worsens cardiovascular outcomes, leading to higher one-year mortality rates in patients with severe heart attacks. Patients who survived a heart attack and experienced COVID-19 had a 25% higher one-year mortality rate compared to those without COVID-19.

Radial arterial access demonstrates procedural safety for the treatment of peripheral artery disease

The CARPOOL study demonstrates radial-to-peripheral access achieves comparable procedural success rates to traditional common femoral artery access for lower extremity peripheral artery disease revascularization. However, the R2P group had higher major adverse limb events at six months due to target vessel revascularization.

JSCAI simultaneously publishes seven original research studies at SCAI 2026 scientific sessions

Seven original research studies on cardiometabolic therapies, structural heart disease, peripheral intervention, and shock care are published simultaneously by JSCAI at SCAI 2026. These findings highlight the intersection of cardiometabolic management and structural heart care, with implications for patient outcomes.

Electronic provider notifications increase lifesaving valve replacement by more than 50% in elderly patients with severe symptomatic aortic stenosis

A new study found that electronic provider notifications significantly increased aortic valve replacement rates and improved survival among older patients with severe symptomatic aortic stenosis. The DETECT-AS trial showed that clinicians who received automated email alerts with abnormal heart ultrasound results detected AS were more l...

Minimally invasive valve repair safe and effective for patients with mitral annular calcification

The MitraClip procedure has been shown to be safe and effective for patients with mitral annular calcification, improving symptoms and quality of life. Despite higher mortality rates, patients with MAC experienced significant reductions in mitral regurgitation and improvements in quality of life, indicating a promising treatment option.

Surgical innovation could provide thousands of children with new hearts valves that grow with them

Partial heart transplantation replaces only defective valves and related structures, eliminating need for repeat replacements. This procedure can provide thousands of additional valve transplants annually, benefiting young patients worldwide.

New STEMI-DTU data provide deeper insight into patient outcomes

The STEMI-DTU trial analyzed secondary endpoints, finding that major bleeding and vascular complications were associated with increased mortality in the control group. The study provided insight into the importance of technique and bleeding complications in heart attack treatments.

Emerging minimally invasive procedure reduces circulation concerns by 50% in patients with no-option chronic limb-threatening ischemia

Transcatheter arterialization of the deep veins (TADV) significantly improves quality of life in patients with severe CLTI, reducing concerns about poor circulation and daily activities. Six months post-procedure, patients showed a 50% reduction in circulation concerns, improved sleep patterns, and reduced foot wound symptoms.

‘Leave-nothing-behind’ strategy works as well as drug-eluting stent for heart attack and chest pain patients

A new sub-study suggests that using a sirolimus-eluting balloon can reduce the number of stents needed, making it a safe and effective way to treat certain heart attacks or unstable chest pain. At one year, the rates of target vessel failure and cardiac death were low and similar between the two groups.

TAVR Google searches surge over 300% in past decade, corresponding with expanded adoption of transcatheter approaches

Researchers found a significant increase in TAVR search volume and a decline in SAVR searches over the past decade, reflecting a shift towards minimally invasive therapies. The study also highlighted disparities in awareness across rural and low-volume treatment areas.

Novel minimally invasive treatment demonstrates significant sustained improvement for heart valve patients with limited options

A new transcatheter mitral valve replacement (TMVR) procedure has shown significant benefits for patients with severe mitral regurgitation, reducing symptoms and improving quality of life. The study found that the treatment sustained clinical improvements over one year, with no major complications.

Among women with heart attack-related cardiogenic shock, goals of care twice as likely to drive management decisions compared to men

A registry analysis found that while men and women with acute myocardial infarction-related cardiogenic shock differ in treatment options, clinical decisions are driven by objective markers of illness severity rather than sex. The study suggests significant differences in how treatment options are discussed with patients and caregivers.

GLP-1–based drug tirzepatide reduces heart risk in high-risk patients

Tirzepatide significantly reduces cardiovascular risk in high-risk patients, including those undergoing percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). The study found tirzepatide consistently reduced major adverse cardiovascular events and mortality across multiple time points.

Minimally invasive percutaneous arterial bypass shows strong outcome regardless of distal vessel flow

Researchers found that patients with single-vessel runoff maintained excellent patency through three years, and could safely benefit from minimally invasive treatment. The study results showed no significant difference in outcomes for patients with one or more vessels running blood to the lower leg.

Shock initiative demonstrates over 70% survival in patients with cardiogenic shock, with improved outcomes in stage E shock at centers with escalation capabilities

The CERAMICS registry found that most patients survived hospital discharge, with 71% overall survival and 60% of those in the most severe stage E shock. Early use of a small heart pump improves outcomes in patients experiencing cardiogenic shock after a heart attack and stenting procedure.

Midlife fitness linked to longer, healthier lives

A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.

Reimagining heart transplant allocation worldwide

A new global allocation system is being proposed to address inequities in organ allocation for heart transplants. The proposal aims to reduce disparities and ensure no viable donor heart goes unused globally.

American College of Cardiology recognizes 20 FACCs during ACC Asia 2026

The American College of Cardiology recognized 20 individuals from eight countries for earning the Fellow of ACC (FACC) designation. The award reflects a strong commitment to improving patient care and advancing cardiovascular research.

New material makes heart monitoring tech more comfortable

Researchers created a new polymer electrode that conforms to the skin, is comfortable, and can pick up ECG signals without gel or adhesives. The technology performed comparably to existing sensors in proof-of-concept testing, showcasing its potential for practical and cost-effective health monitoring applications.

Korean women with CVD face gaps in risk factor control

A study analyzing Korean National Health and Nutrition Examination Survey data reveals higher awareness and treatment of major risk factors among Korean women with CVD, but lower control rates. Sex differences were observed in most management indicators, with men having more risk factors on average.

Images and risk communication boost motivation for better heart health

A study from Umeå University found that visualizing ultrasound images of atherosclerosis, combined with a motivational dialogue, increases motivation to improve lifestyle habits and take preventive medication. This results in lower estimated risk of cardiovascular disease and better development of risk factors over time.

SCAI reappoints JSCAI founding Editor-in-Chief Alexandra J. Lansky, MD, MSCAI, for second term

Alexandra J. Lansky, MD, MSCAI, has been reappointed to a second five-year term as Editor-in-Chief of JSCAI, the official peer-reviewed journal of SCAI. The journal has rapidly expanded its global reach and established itself as a trusted source for original research, clinical guidance, and educational content in interventional cardiol...

University Hospitals now offering new therapy for refractory ventricular tachycardia

Researchers at University Hospitals Cleveland Medical Center have introduced a new, non-invasive treatment option for patients with refractory ventricular tachycardia, a life-threatening heart condition. The therapy uses precision-targeted radiation to neutralize damaged heart tissue and is offered at select centers worldwide.