Articles tagged with Clinical Neuroscience
A new model predicts retinal degeneration in diabetics based on 71 plasma proteins. The Pro-DRN model can help doctors identify patients at risk earlier, potentially preventing neurodegeneration and vision loss.
Scientists have created a miniature circuit that mimics the brain and spinal cord connection, showing that previously thought irreversible nerve damage can be reversed. The researchers found that blocking specific genes in mature neurons restored axon regrowth ability.
A novel antibody, NG101, accelerates the regeneration of damaged spinal cord tissue by neutralizing a protein that blocks nerve fiber growth. This therapy enables new nerve fibers to form functional connections, allowing patients to become more independent and potentially recover arm and hand function.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
A new study from Center for BrainHealth researchers found that declining slow-wave activity during sleep explains why anxiety rises in older adults. Participants who generated fewer slow waves woke up more anxious the next morning, while those with stronger slow-wave sleep did not show the same pattern.
The EBRAINS Roadmap Symposium will bring together the global neuroscience community to shape the EBRAINS 10-Year-Roadmap. A total of 159 submissions from 134 unique contributors across 25 countries have been received, reflecting the momentum of Europe's digital neuroscience landscape.
The 2026 cohort of Leon Levy Scholars in Neuroscience will pursue research projects addressing neurological disorders and developing new treatments. The program provides scientific and professional career development opportunities, including mentorship and networking.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers have mapped a brain circuit specific to chronic pain, suggesting a promising route to treatment. Silencing this circuit eased chronic pain while preserving acute pain responses in mice. The discovery raises the possibility of developing drugs that target this circuit to ease chronic pain without impacting acute pain.
A new survey by Autism BrainNet reveals a significant disconnect between Americans' strong support for autism research and their limited understanding of postmortem brain donation. The survey found that 70% of respondents had never heard of brain donation, despite 92% agreeing its importance in advancing research.
A clinical trial by University of Auckland researchers found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery. Despite the extra therapy, neither group did better than a cohort who received standard care alone.
A clinical trial found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery beyond standard care. Despite having access to extra therapy, neither group did better than a cohort who received standard care alone.
Research suggests that persistent pain drives progressive changes in the hippocampus, a brain region involved in emotional regulation. This can shape whether people develop depression or remain emotionally resilient. The study's findings challenge the idea that depression is an inevitable consequence of long-term pain.
Dr. Cazares co-founded Colors of the Brain and advocated for GRE removal to support students from underprivileged backgrounds. He aims to bring neuroscience to underserved communities through portable, affordable, and non-invasive methods.
Researchers developed a modified high-resolution MRI technique to differentiate intra-dural from extra-dural PAs, providing a refined risk assessment for subarachnoid hemorrhage. The study found that Type S aneurysms had a higher rupture risk and required individualized imaging assessment.
A prospective multicenter study found Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients. The therapy promotes durable aneurysm occlusion with minimal risks.
Researchers at the University of Queensland have made a breakthrough in understanding the cellular changes that occur in depression. They found that cells in people with depression produce more energy molecules when resting, but have a reduced ability to increase energy production under stress. This study offers a new potential approac...
Patients with neurological diseases face profound questions about identity, purpose, and meaning, but neurologists often lack training and tools to address these concerns. A new paper offers practical strategies for incorporating spiritual assessment into routine neurological care.
Researchers found that veterans with prior concussions showed slower and less accurate eye movements, along with reduced performance on attention-based tasks. These subtle brain changes can be measured more than a decade after the original injury.
A new study from CU Anschutz links chronic back pain to heightened brain responses to everyday sounds and finds that Pain Reprocessing Therapy can improve sensory amplification. The research found specific brain changes associated with sound hypersensitivity, which can be treated with psychological therapy.
The Society for Brain Health is a new collaborative body dedicated to enhancing cognitive capacity, longevity, and proactive health optimization through cutting-edge research and tools. Its founding members include prominent neuroscientists and experts in the field of brain health.
Researchers at Amsterdam UMC found that a second pregnancy changes the female brain in unique ways, altering brain networks involved in attention and sensory cues. The study also linked structural brain changes to maternal mental health, providing new insights into postpartum depression.
Epicurrents is an open-source web browser application that enables users to view various clinical neurophysiology recordings directly in a web browser. It supports easy, secure, and cost-effective remote teaching and can be used for both educational purposes and scientific research.
Chronic alcohol consumption alters endocannabinoid gene expression in reward- and decision-related brain regions, offering insights into addiction biology. This study reveals changes in CB1 and CB2 receptor genes, as well as GPR55 and FAAH enzymes, potentially leading to targeted therapeutic strategies.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
The Korea University-Yale University Joint Forum aimed to discuss expanding cooperation in neuroscience and training physician scientists. Key findings include agreements for annualizing the joint forum and discussing research topics for future forums.
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
Researchers used MRI analysis to measure glymphatic system activity, finding changes related to IIH stage and pressure levels. The findings suggest a noninvasive test could diagnose IIH more reliably, improving treatment options for patients with symptoms including headaches and vision loss.
A new study at York University found autistic adults who are right-handed demonstrate a reduced specialization of hand use and more distinctive movement patterns. Autistic participants used their right hand less often for grasping and followed highly unique, idiosyncratic paths.
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
New research reveals that the immune system has a potent weapon against the brain parasite Toxoplasma gondii: an enzyme called caspase-8. This discovery offers new insights into how our bodies control the parasite and may lead to better treatments for patients with compromised immune systems.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
A new study found that maternal psychological distress experienced at 1 year postpartum has a stronger association with neurodevelopmental delay in toddlers compared to prenatal distress. The researchers also discovered that experiencing distress during both pregnancy and postpartum periods further amplifies the risk of delays.
The EBRAINS Summit 2025 will bring together experts to assess how neuroscience can drive medical progress, digital innovation, and responsible data use. Preliminary results from the EPINOV clinical trial, integrating virtual brain technology for epilepsy surgery planning, will be presented.
A new review emphasizes the importance of smell health, highlighting its role in nutrition, cognitive function, and psychological resilience. Researchers call for a global campaign to promote smell health through education, awareness, and targeted public health policies.
A new report warns that AI can worsen health disparities in brain disease diagnoses if proper safeguards are not implemented. Researchers call for diverse perspectives, AI education, and strong governance to ensure equitable implementation.
A new study shows a significant increase in the use of computed tomography (CT) scans of the head in emergency departments across the US from 2007 to 2022. The study found that Black people were 10% less likely to receive a head CT scan than white people, and those on Medicaid insurance were 18% less likely.
A recent study found that changes in a single gene can cause mental illnesses, with the GRIN2A gene identified as a key culprit. Variants of this gene are associated with schizophrenia and other mental disorders, which can manifest in childhood or adolescence rather than adulthood.
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
A new contactless optical-tracking registration method has been developed to simplify robot-guided SEEG surgery, reducing positioning errors and procedure time. The study demonstrates the accuracy and ease of use of this technique, making it a promising innovation in neurosurgery.
A team of researchers from Rice University and the Houston Methodist Research Institute will study how the brain responds to neural implants. They aim to develop more stable and longer-lasting brain-computer interfaces and neuroprosthetics, which could treat neurological disorders such as Parkinson’s disease, epilepsy, and stroke.
Researchers created BraDiPho, a 3D atlas of brain connections, combining clinical neuroscience, artificial intelligence, and neuroanatomy. The tool facilitates precise identification of white matter connections, opening up new therapeutic perspectives for neurological diseases.
Scientists discovered that eIF1A and eIF5B suppress toxic protein synthesis implicated in frontotemporal dementia and amyotrophic lateral sclerosis. The study sheds light on the mechanisms behind RAN translation, a process linked to neurodegenerative disorders.
A small study found that five volunteers with late-onset Alzheimer's disease showed significant improvements in cognitive tests and decreased biomarker tau proteins after two years of receiving 40Hz light and sound stimulation. This suggests that the therapy may slow cognitive decline and have direct biological impacts on Alzheimer's p...
A new clinical trial is investigating the use of advanced brain monitoring to improve epilepsy diagnosis and management. The trial involves multiple sites across Europe, including Ireland, where patients will undergo long-term outpatient monitoring using a subcutaneous EEG system.
A new study found that child neurologists often lack knowledge and education on motor difficulties in children with autism. Motor impairments are common in autistic children, affecting their development, language skills, and social interactions. The study recommends more training for medical students and residents to recognize and addr...
Researchers have identified four distinct profiles of Nonverbal Learning Disability, each with different strengths and challenges. The study suggests that current diagnostic criteria may be too broad, highlighting the importance of individualized approaches to care for children with NVLD.
Researchers created a new tool using local ancestry inference (LAI) to provide more accurate insights into genetic differences. The tool reveals that many rare variants are common in specific ancestry segments, leading to more accurate diagnoses and reclassifications of genetic variants.
Professor John O'Brien's research focuses on understanding the impact of electrical synapses and gap junction plasticity on the retina and other neurological functions. The study aims to identify proteins that control electrical synapse strength, shedding light on their role in human disorders such as autism and seizures.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
Frontal lobe seizures can cause impaired consciousness when they spread to wider areas of the brain, according to a new study published in Neurology. This understanding may help scientists develop treatments that restore consciousness during seizures.
Despite long-held assumptions, a new study reveals that the brain's somatosensory cortex holds a stable 'body map' even after limb loss. The findings have significant implications for treating phantom limb pain and restoring sensation in prosthetic limbs via brain-computer interfaces.
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
The largest neuroscience event will convene in San Diego from November 15-19, featuring over 10,000 presentations on various topics. Registered journalists will gain access to cutting-edge research, expert interviews, and press-only events.
A NUS-led global study reveals that 30-minute functional MRI scans deliver up to 22% in cost savings while retaining or improving prediction accuracy. This finding could reshape how researchers design neuroscience and mental health studies, especially for hard-to-recruit populations.
Researchers identified four clinically and biologically distinct subtypes of autism, each with distinct developmental, medical, behavioral, and psychiatric traits. The study linked subtypes to genetic profiles and developmental trajectories, offering new insights into the biology underlying autism.