Articles tagged with Downstream Signaling
A team at The University of Osaka has identified a signaling molecule called FGFR3 and a pathway called CREB as key in regulating bone growth. Cells carrying the genetic mutation associated with achondroplasia accumulate in the resting zone and show abnormal behaviors, which included abnormal patterns of division and migration.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
The study reveals that CBL-CIPK complex senses specific Ca2+ signals, phosphorylates ZIP12, and initiates its partial degradation to fine-tune the plant's response to Zn deficiency environments. This negative feedback mechanism effectively regulates zinc homeostasis and maintains efficient resource utilization.
A study by Tulane University researchers found that tumors in female fruit flies grew 2.5 times larger than those in male fruit flies due to sex-based differences in immune response. The stronger innate immune response in females accelerated tumor growth.
Researchers have developed a new photonic chip that can process, transmit and reconstruct images in nanoseconds, eliminating optical-electronic conversions. This technology holds promise for revolutionizing edge intelligence in machine vision applications.
Researchers have identified a conserved brain region in vertebrates essential for initiating forward movement. The mesencephalic locomotor region (MLR) stimulates reticulospinal neurons to control finer details of movement. Mapping this circuit could lead to new treatments for Parkinson's disease.
Researchers discovered cytoplasmic retinoic acid receptors, such as RARalpha, are essential for T cell linking sensing at the cell surface with downstream signaling cascades and gene expression programs. The study sheds new light on TCR signaling and its connection to cancer treatment.
Researchers found that BUB1 protein regulates EGFR signaling by reducing receptor internalization, which may lead to new therapeutic interventions for EGFR-driven cancers. The study also showed that BUB1 impacts receptor recycling and degradation, affecting signaling amplitude and duration.
Researchers found that GPR141 enhances cell migration and proliferation in breast cancer by activating the p-mTOR/p53 signaling pathway. Silencing GPR141 restores p53 expression and attenuates tumor growth, suggesting its role in regulating breast cancer progression and metastasis.
Researchers at Johns Hopkins Medicine discover that nasal cell receptors activate few G protein molecules to produce a signal, contradicting the mainstream idea of high amplification. The study found that the probability of an odorant receptor activating just one G protein is 1 in 10,000, supporting weak signaling.
Soft materials can store and release elastic energy using bistable beams, allowing for signal propagation without dissipation. The developed system enables transmission of mechanical signals through long distances in autonomous soft systems.
Researchers discovered two converging pathways regulated by leptin, which modulate energy expenditure through the TRH promoter. Thyroid hormone also suppresses TRH production, integrating various signals to control energy metabolism.