Articles tagged with Peer Review
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
A new study shows AI can generate hundreds of convincing finance research papers efficiently, but also raises concerns about the potential impact on academic community and meaning of scientific discovery. The study demonstrates how AI can accelerate research paper production while highlighting areas for improvement in peer-review systems.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
The study found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species. MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
A new editorial provides guidance on writing constructive peer reviews, emphasizing key takeaways such as 'picking battles' and maintaining professional courtesy. The guidance aims to elevate scientific data quality while mitigating impacts on authors' reputation and mental wellbeing.
The American Society for Nutrition has appointed Dr. Brian Lindshield as the new Interim Editor-in-Chief of Current Developments in Nutrition (CDN). With extensive experience and a strong record of leadership in academic nutrition, Dr. Lindshield will build on CDN's foundation for continued growth and innovation.
A rare case of a small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation showed a strong response to high-dose imatinib, despite the presence of the SDHC mutation. Integrated molecular interpretation is crucial in GIST management.
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
Research finds PDX1 gene plays a tumor-promoting role in human PCa cells by influencing metabolic pathways. The study identifies PDX1 as differentially hypermethylated in prostate cancer tissues, contributing to its aggressive characteristics.
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
The Oncotarget Editorial Board discusses the journal's evolving approach to scientific integrity, highlighting the importance of modern image forensics tools. The article emphasizes the need for independent analytical and AI-based tools in journal evaluation.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
The study found that immune checkpoint inhibitors significantly improved key clinical outcomes, including disease-free survival and distant metastasis-free survival. However, no clear improvement in overall survival was observed across studies, highlighting the need for careful patient selection and monitoring.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
A new review analyzes how glioma classification research has evolved across clinical, molecular, and social domains. The study highlights the prominent role of DNA methylation profiling and advanced imaging techniques in molecular biomarker-based classification models, while finding social factors to be relatively scarce.
The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
The renewed agreement allows eligible researchers at participating UK institutions to publish unlimited articles across JMIR's portfolio of journals without APCs. This simplifies the publication workflow and increases equity for researchers at all career stages.
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
Dr Amy Shirong Lu joins JMIR Serious Games as Editor-in-Chief with extensive research on digital health technologies and their impact on physical activity and cognitive health.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
Researchers found that the three-drug combination increased autophagosome formation and autophagic flux in uveal melanoma cells, killing them via enhanced autophagy. The study suggests a potential therapeutic approach for treating metastatic uveal melanoma, particularly in liver-targeted disease.
JMIR Publications and the University of Nevada, Las Vegas announce a new Flat-Fee Unlimited Open Access Publishing Agreement. The agreement eliminates financial obstacles for researchers, reducing administrative workload for library staff and ensuring research findings are available via immediate open access in JMIR's high-impact journ...
The review emphasizes surgical excision as the cornerstone of curative treatment, with recommended margins depending on tumor risk stratification. Reconstruction should be individualized according to defect size, anatomic subunit involvement, and patient factors.
A systematic review of experimental studies found exergames to be associated with better mood outcomes, including reductions in tension and depressive symptoms. The evidence base remains small and heterogeneous, but the study calls for longer-term interventions and larger samples to determine the durability of benefits.
A study found CREB5 regulates basal and SCL transcriptional programs and tumor-forming phenotypes in prostate cancer, suggesting a central role in aggressive prostate cancer. Disrupting CREB5-regulated pathways may improve therapeutic responses in advanced disease.
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
Dr. Sara Simblett brings expertise in digital health innovation, patient engagement, and technology integration to JMIR Neurotechnology. Her research focuses on improving access, quality, and outcomes of care through digital interventions.
Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.
JMIR Publications has partnered with the University of Turku to provide unlimited open-access publishing, eliminating financial barriers and administrative hurdles for researchers. The partnership offers APC waivers for corresponding authors affiliated with the university, allowing them to publish in prestigious titles at no cost.
A new case report describes a large, calcified solid pseudopapillary neoplasm of the pancreatic head, emphasizing the importance of multidisciplinary evaluation and long-term follow-up for monitoring recurrence. The case underscores the diagnostic value of integrating imaging, histopathology, and immunohistochemistry.
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
A recent study found that higher IL6 levels are associated with increased mortality, while genetically higher IL6R levels reduce all-cause mortality through cardiovascular mechanisms. The researchers suggest that IL6R antagonism may be a potential strategy for preventing cardiovascular disease.
The article discusses recent advances in chimeric antigen receptor T-cell (CAR-T) therapy, highlighting its promise and remaining challenges. Next-generation CAR designs aim to improve specificity and reduce on-target/off-tumor toxicity, while addressing access disparities and equity issues.