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Brightsurf delivers daily science news discoveries, articles, and the latest scientific breakthroughs. Your trusted source for science news today, covering nature news, science & technology, and scientific discoveries from leading research institutions worldwide.

Uniting sequence and structure to map the protein universe

A new protein language model, CLSS, brings together sequence and structure information to produce cohesive maps of protein relationships. The model successfully integrated sequence and structure data, reproducing expert-curated classifications and demonstrating strong performance in classification tests.

SourceInstitute of Science Tokyo·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis

Giant-nucleus cells are key markers for early-stage cancer, study shows

Researchers at Nagoya University have identified giant-nucleus cells as precancerous markers in the kidneys, which emerge in response to iron toxicity and BRCA1 mutations. These cells exhibit cancer-related gene activity and can signal early cancer development in surrounding tissue, with distinct biological profiles in BRCA1-mutant rats.

SourceNagoya University·JournalRedox Biology·TypeExperimental study

Ontario study identifies potentially harmful drug combinations prescribed to older adults

A new Ontario-wide study identifies potentially harmful drug combinations prescribed to older adults, revealing common medication interactions that can lead to unnecessary prescriptions and harm. The research highlights the need for clinicians to consider medication history and potential prescribing cascades to ensure safer care.

SourceLunenfeld-Tanenbaum Research Institute·JournalBMJ·TypeData/statistical analysis

People with ADHD more likely to suffer from gut problems, major review finds

Researchers analyzed data from 23 studies and found a strong association between ADHD and gastrointestinal symptoms, including constipation, IBS, and loss of bowel control. The study suggests that doctors treating people with ADHD should be alert to gut symptoms and consider referring patients to a dietitian or gastroenterologist.

SourceUniversity of Warwick·JournalJournal of Attention Disorders·TypeMeta-analysis

Breakthrough guided Cherenkov method reads electron vortices as structured radiation

Researchers have developed a method to transfer electron topology into measurable orbital angular momentum and polarization skyrmions, enabling noninvasive diagnosis and versatile radiation sources. The approach uses guided Cherenkov emission and demonstrates reproducible electron-to-field topology-transfer interfaces.

SourceEditorial Office of Opto-Electronic Journals Group·JournalOpto-Electronic Advances·TypeExperimental study

SMART researchers discover first PLP-dependent enzyme that influences bacterial protein production

A team of researchers from SMART and MIT discovered aminovaleramididine synthetase (AvaS), a PLP-dependent enzyme involved in tRNA modification, expanding our understanding of how RNA regulates protein production in bacteria. The discovery sheds light on how bacteria use RNA modification to control protein production and offers new ave...

First-ever healthy checkout policy shows promise for reducing soda sales, increasing healthy snack purchases

A new study implemented in Berkeley, Calif. supermarkets, drug stores, and mass-market retailers in 2021 found a link between a healthy checkout ordinance and a notable decrease in soda sales overall and small-package candy in supermarkets. The study also found that greater enforcement of the policy is essential for sustained public he...

SourceBoston University School of Public Health·JournalThe Lancet Public Health·TypeExperimental study

From food export growth to carbon storage on Hainan Island

Hainan Island's food system experienced significant carbon emissions growth from 1952 to 2020, primarily driven by fertilizer-related emissions, tropical crop cultivation, and aquaculture. Integrated interventions, such as technological optimization and structural transition, could potentially lead to net sequestration by 2060, with a ...

SourceBiochar Editorial Office, Shenyang Agricultural University·JournalCarbon Research·TypeComputational simulation/modeling

First-in-human study at UCI Health attacks pancreatic cancer with laser light

A first-in-human study at UCI Health uses laser light to target and destroy pancreatic tumors, showing a high success rate in patients with localized cancer. The treatment, known as vascular targeted photodynamic therapy, uses a light-sensitive drug to break down the tumor's network of blood vessels, ultimately destroying the tumor.

SourceUCI Health·JournalJournal of Vascular and Interventional Radiology·TypeRandomized controlled/clinical trial

Sediments’ hidden electron capacity could help predict and improve groundwater cleanup

Researchers propose sediment electron exchange capacity as a quantitative measure of aquifer sediments' reactivity, influencing contaminant transformation and remediation performance. EEC can help predict and optimize groundwater cleanup, improving efficiency and sustainability.

SourceShenyang Agricultural University Collaborative Journals·JournalEnvironmental and Biogeochemical Processes·TypeLiterature review

Rare and core soil bacteria play different but complementary roles in keeping microbial communities stable

A new study reveals that rare bacteria play a crucial role in maintaining microbial community stability, while core bacteria organize complexity. Climate and soil conditions shape distinct bacterial groups, with rare bacteria responding to soil properties and core bacteria influenced by environmental selection.

SourceShenyang Agricultural University Collaborative Journals·JournalAgricultural Ecology and Environment·TypeExperimental study

Study suggests the profile of people diagnosed with ADHD and autism has changed over the past decade

A Danish study found that children and adolescents diagnosed with ADHD or autism today share more characteristics with their peers in the general population than those diagnosed a decade ago. The differences in characteristics such as pregnancy-related factors, family socioeconomic factors, and healthcare use before diagnosis have decr...

SourceBarcelona Institute for Global Health (ISGlobal)·JournalJAMA Psychiatry·TypeCase study

Bear baiting became more common following Norman invasion

Researchers at Cardiff University and the University of Nottingham found that bear baiting was an established activity in England by the twelfth century, with bears imported from Europe. The study analyzed bear bones and archival records to show the prevalence of bears in England and northern France during medieval times.

SourceCardiff University·JournalSociety and Animals·TypeData/statistical analysis

Pennington Biomedical researchers offer new perspective on how protein restriction may promote healthy aging and longevity

Pennington Biomedical researchers propose a new understanding of how protein restriction promotes healthy aging and extends lifespan by triggering a coordinated whole-body response. The response connects cellular nutrient sensing with hormones, brain function, and changes throughout the body, influencing healthy aging and longevity.

SourcePennington Biomedical Research Center·JournalCell Metabolism·TypeCommentary/editorial

Protein linked to cell death may also drive liver cancer

Research identifies MLKL as a protein that helps drive liver cancer associated with obesity-related fatty liver disease by reducing mitochondrial function, promoting tumor development. Removing MLKL reduces liver tumors but not fatty liver or liver inflammation, suggesting a new therapeutic target for liver cancer treatment

SourceUniversity of Oklahoma·JournalHepatology·TypeExperimental study

Stress hormone timing creates a different kind of obesity

A new preclinical study found that glucocorticoid-rhythm disruption concentrates insulin resistance in skeletal muscle while preserving key insulin responses in fat tissue and liver, leading to a different type of obesity. This allows fat tissue to continue storing lipids, while the liver remains largely protected from fat accumulation.

SourceWeill Cornell Medicine·JournalCell Reports

Tight light helps quantum sensing get ready for the field

Researchers at Sandia National Laboratories have developed a new method for trapping cesium atoms on a fiber, using only 5 milliwatts of optical power. The new design, which includes a heat-resistant membrane-waveguide, holds promise for creating rugged, low-power quantum inertial sensors that could aid military vehicles in navigation.

SourceDOE/Sandia National Laboratories·JournalAVS Quantum Science

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