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George Dangas, MD, PhD, receives the most coveted award from the American Heart Association’s Council on Clinical Cardiology

Cardiologist George Dangas, MD, PhD, is recognized for his lifetime achievements in caring for patients and cardiology education. He is the third interventional cardiologist from Mount Sinai to receive the Laennec Master Clinical award, which celebrates his exceptional insight in correlating cardiovascular disease with clinical findings.

In Mass General Brigham-led phase 2 trial, novel therapy significantly reduced triglyceride levels

A phase 2b clinical trial led by Mass General Brigham researchers shows that MAR001 can significantly reduce triglyceride levels within 12 weeks for patients with high triglyceride levels. The therapy targets ANGPTL4, a protein that naturally inhibits lipoprotein lipase, an enzyme that breaks down triglycerides.

SourceMass General Brigham·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial

Childhood cancers may spread by 'shape-shifting' rather than mutating

Researchers propose that childhood cancers may spread aggressively by 'shape-shifting' into different cellular states, rather than accumulating genetic mutations. This process may be reversible, and understanding these transitions could lead to new treatment opportunities and potentially predict when cancers are preparing to spread

SourceUniversity of East Anglia·JournalTrends Open·TypeLiterature review

Very strong El Niño episodes are associated with over 100,000 additional heat-related deaths worldwide per year

A new study by ISGlobal estimates that very strong El Niño episodes are associated with 107,035 additional heat-related deaths and 112,681 fewer cold-related deaths per year compared to neutral conditions. This shift towards warmer temperatures during El Niño has significant implications for global health.

SourceBarcelona Institute for Global Health (ISGlobal)·JournalNature Medicine·TypeData/statistical analysis

Concussion study upends understanding of what makes head impacts dangerous

A new study by Stanford Medicine scientists found that linear acceleration, not rotational motion, is more predictive of concussion. The research analyzed data from motion-sensing mouthguards and found that peak linear acceleration is the single most predictive factor in whether an impact leads to concussion.

SourceStanford Medicine·JournalAnnals of Biomedical Engineering·TypeExperimental study

Experimental treatment promotes repair after heart attack damage

Scientists have developed a treatment that 'reawakens' heart muscle cells, promoting repair and improving heart function after a heart attack. The treatment, using mRNA therapy, temporarily activates proteins that help regenerate heart tissue, leading to a stronger heartbeat and increased blood pump efficiency.

SourceUniversity of Cambridge·JournalNature Cardiovascular Research·TypeExperimental study

Crystals hint at a volcano’s ability to erupt

Researchers found that tiny plagioclase crystals from Andean volcanoes have the same chemical signature, indicating the same eruptive process. This discovery could help predict future eruptions by analyzing the crystals' composition, which is linked to hot magma from deeper underground.

SourceUniversity of Queensland·JournalNature Communications·TypeObservational study

Satellite monitoring of the world’s oceans is being restricted by legal barriers, study suggests

A study by the University of Plymouth found that international regulations governing marine protected areas (MPAs) are often ambiguous, failing to provide clear rules for satellite-based enforcement. This limitation hinders the effective use of satellite monitoring to prevent illegal activities, such as industrial fishing, in MPAs. The...

SourceUniversity of Plymouth·Journalnpj Ocean Sustainability·TypeSystematic review

Single-cell and spatial multiomics reveal microglia-mural interactions involved in notoginsenoside R1 protection against experimental ischemic stroke

Researchers discovered NGR1's neuroprotective effects are mediated by microglia-mural interactions and a FOXO1-associated program involving ABCA9. This study provides single-cell resolved insights into NGR1's mechanism and identifies potential therapeutic targets for cerebral blood flow regulation.

SourceInternational Society for Health Data Science·JournaliMetaMed·TypeExperimental study

Underwater record of “hidden” disasters discovered

Researchers at the University of Tokyo used a new radiocarbon analysis technique to study ocean sediment cores, revealing previously undetected history of geophysical disasters in Japan. The study found multiple 'hidden' traces of earthquakes in the Nankai Trough, which could help predict future geophysical events and prepare for poten...

SourceUniversity of Tokyo·JournalRadiocarbon·TypeObservational study

CT scanning the centuries-old head of Jeremy Bentham

The CT scans of Jeremy Bentham's head have provided valuable insights into his life and after-life, showing that he suffered from chronic toothache and a jaw riddled with arthritis. The scans also reveal further physiological factors, such as tissue structure and preservation choices, which were previously unknown.

Intravenous antiplatelet therapy may improve heart function in cardiogenic shock patients compared to oral medication

Researchers found that intravenous cangrelor improved heart function in cardiogenic shock patients, with a 73% lower risk of microvascular obstruction compared to oral ticagrelor. After one year, cangrelor patients showed a significant increase in heart pumping ability, outperforming ticagrelor.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalThe Lancet·TypeRandomized controlled/clinical trial

New treatment may cure common hormonal cause of high blood pressure

A new treatment, extended aldosterone synthase inhibition (EASI), has been shown to reverse excess aldosterone production and lower blood pressure in people with primary aldosteronism. The treatment, which involves taking a new class of drugs for 6-12 months, has been found to sustain its benefits for up to two years after treatment en...

SourceQueen Mary University of London·JournalNew England Journal of Medicine·TypeObservational study

Heart researchers unpack neutral findings from ZEUS, an anti-inflammatory clinical trial

A global phase 3 clinical trial, ZEUS, tested a drug targeting interleukin-6, but found no reduction in cardiovascular event rates compared to placebo. The study's neutral findings suggest moving upstream to find the right target, while acknowledging the effectiveness of downstream IL-6 inhibition in modifiable earlier stage disease.

SourceMass General Brigham·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial

Routine invasive procedures for stable heart disease offer no long-term survival advantage over drug therapy

A new study has found that routine invasive procedures for stable heart disease do not improve long-term survival compared to drug therapy alone. The study, which followed over 5,000 patients with stable coronary artery disease, revealed that early invasive procedures eased symptoms and improved quality of life but did not reduce the r...

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalJournal of the American Medical Association·TypeObservational study

Charged states on carbon nanotubes keep their twist

Researchers found that charged states on carbon nanotubes, known as trions, retain their chirality, which is crucial for manipulating light and electric current in nanotechnology. This discovery opens new paths for quantum optics and potential applications in next-gen optoelectronic devices.

SourceTokyo Metropolitan University·JournalNature Communications

Slow hands, quiet nights? Tai chi and a matched exercise class nudged sleep about equally in older men after cancer

A randomized controlled trial found that Tai Chi Qigong and an exercise class improved sleep quality in older male cancer survivors, with no significant difference between the two. While the changes were modest, the study suggests that a more diverse range of participants and future studies are needed to confirm the findings.

SourceGenomic Press·JournalBrain Medicine·TypeRandomized controlled/clinical trial

Worry and forgetting keep close company in Alzheimer’s disease

A recent study published in Genomic Psychiatry analyzed the Alzheimer's Disease Neuroimaging Initiative and found that people with frequent anxiety scored lower on a standard test of global cognition. The authors suggest that a single serotonin receptor may be responsible for both worry and cognitive decline in Alzheimer's disease.

SourceGenomic Press·JournalGenomic Psychiatry

Employment of people with disabilities near record high

The employment-to-population ratio for people with disabilities held near record highs at 39.9% in October, reflecting sustained labor market growth. The employment-to-population ratio for people without disabilities also increased slightly, while labor force participation rates for people with disabilities decreased slightly.

Study decodes quantum material’s ‘optical fingerprints’

A University at Buffalo-led team has predicted the optical fingerprints of known atomic defects in hexagonal boron nitride, a material with potential applications in quantum technologies. The researchers' computer models simulated how different defects affect the intensity and polarization of light produced when h-BN is hit with a laser.

SourceUniversity at Buffalo·JournalNano Letters·TypeComputational simulation/modeling

Mount Sinai study identifies single amino acid change that alters Andes virus protein behavior in human cells

A Mount Sinai study found a single amino acid difference between rodent- and human-derived Andes virus isolates affects viral protein processing and release in human cells. The change enables faster virus-like particle release and altered protein behavior, providing a starting point for studying the virus's biology.

The good, the bad and the cringy moments

Researchers developed new instruments to assess empathy and Theory of Mind in everyday life, including positive and negative social contexts. The tools, EmpaToM-pos and EmpaToM-embarrass, provide a more precise understanding of human social understanding and its applications in clinical practice.

SourceUniversity of Würzburg·JournalBehavior Research Methods

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