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The ISSCR Consortium supports the FDA's draft guidance on using new approach methodologies (NAMs) in drug development, emphasizing the need for a flexible and science-driven framework. The consortium recommends clarifying biological complexity alignment with context of use and expanding recognition of computational modeling and hybrid ...
Researchers at UC Riverside have identified a key neural circuit, the locus coeruleus, which plays a central role in cognitive flexibility and adapting to new rules. Disrupting this circuit impairs the brain's ability to reorganize neural networks during complex decision-making.
Researchers use NASA's James Webb Space Telescope to analyze light passing through a distant, temperate gas giant planet's atmosphere, revealing methane and potentially other gases. The study provides insights into planetary formation and evolution, and could improve understanding of Earth's atmosphere.
The University of Texas MD Anderson Cancer Center has been awarded $19 million by CPRIT to support young cancer survivors, groundbreaking research, and faculty recruitment programs. The funding will enable UT MD Anderson to recruit world-class scientists and clinicians, pursue new discoveries, and accelerate cancer treatment advancements.
A recent study reveals that Atlantic herring rewired its reproduction to survive in the Baltic Sea's low-salinity waters through four key genetic adaptations. These adaptations enabled the species to reproduce successfully despite the challenging environmental conditions, highlighting the importance of gene function and regulation in e...
Primary care practices acquired by private equity firms tend to see more patients, provide more services, and complete annual wellness visits. They also hire more physicians and advanced practice providers, suggesting a spread of extra work across larger teams rather than individual doctors.
Researchers at the University of Texas at Arlington are developing a new technology to enable clear, detailed imaging of biological structures far beneath the skin's surface. This innovation has the potential to improve disease detection and diagnosis, particularly in areas such as cancer and vascular diseases.
Researchers at Texas Tech will develop wide/ultrawide bandgap semiconductor materials and devices with a $4.5M grant. The project aims to improve performance and reliability in harsh environments for aerospace, defense, and other industries.
A study published in Neurology found that quitting smoking is associated with a lower risk of dementia, especially for those who maintain a stable weight. The research followed 32,802 middle-aged and older individuals without dementia at the start of the study, finding a sustained lower risk of dementia with time since quitting.
Migraine with aura is linked to a 73% increased risk of ischemic stroke in middle-aged and older adults. The study found no association between migraine without aura and an increased risk of stroke. Men under age 72 with migraine also face a significantly higher risk of stroke, contradicting previous research in younger individuals.
A new report from Brookings Institution highlights the federal government's growing use of AI, but also notes significant disparities and bottlenecks to widespread adoption. Large agencies lead the way, while smaller agencies struggle with workforce capacity and trust issues.
A Simon Fraser University study found over 200 contaminants in juvenile Chinook salmon in the Lower Fraser River estuary, including priority contaminants like pharmaceuticals and pesticides. This exposure adds stress to already vulnerable fish populations.
ACM recognizes educators Yasmin Kafai and Mitchel Resnick for their contributions to creative computing and Scratch. Ed Felten receives the ACM Policy Award for his work on technology policy, while Jodi Tims is honored with the Outstanding Contribution to ACM Award for increasing women's participation in computing
Researchers found substantial declines in outpatient clinic visits (7%) and hospitalizations (13%) compared to expected levels. Long-term disruptions persist, with 65% of regions experiencing non-rebound outpatient visits and 74% with reduced hospitalizations.
Research shows that adverts featuring people with a disability increase consumer attitudes towards brands and their products. Key findings include the benefits of disability inclusion and the importance of representing individuals with disabilities as capable advocates for a product or service.
Researchers found that cows stared longer at unfamiliar faces and could match a known handler's voice with their image. The animals' heart rates showed no emotional response to the faces or voices.
Researchers at Rockefeller University have discovered the neural substrates underlying thought symbols for the first time. The study found that the ventral premotor cortex, a region in the frontal lobe, plays a key role in generating mental representations of actions, enabling compositional generalization and creative thinking.
A new study found that nearly 8 in 10 college students with psychosis needed mental health support, but only 4 in 10 received the recommended combination of therapy and antipsychotic medication. This indicates potential barriers to accessing care, including stigma.
Scientists discovered that ZNF804A is most active in glutamatergic neurons during the second trimester of neurodevelopment. Altering the gene's activity revealed changes in synaptic regulation and protein production, leading to more electrically excitable synapses.
Rising ocean temperatures cause corals to struggle with oxygen uptake due to disrupted ciliary motion. At moderate temperatures, corals accelerate ciliary motion to meet increased oxygen demand, but this compensatory mechanism fails at higher temperatures.
Researchers identified genetic changes in the virus that explain why it wasn't detected by existing tests. The new diagnostic method shows promise for future suspected cases with greater accuracy.
The Capture the Fracture program has achieved a major milestone, identifying over one million patients with fragility fractures every year. This growth reflects increasing recognition of coordinated post-fracture care services as an essential component of modern hospital care.
A team of researchers developed an MRI-guided approach to treat depression, resulting in a doubled initial success rate. By assessing brain function, clinicians can make more informed treatment decisions, similar to cancer treatment.
A survey of over 300 physicians found that one in four believed it was plausible to revive someone after preservation. Neurosurgeons were most optimistic about revival possibilities, while others showed skepticism. The study highlights the need for clear clinical and legal frameworks for preservation as an end-of-life option.
Researchers found that portfolios considering company headquarter location and housing market trends can produce returns three times higher than those focused on growth stocks. This is because companies in more expensive areas have higher labor and infrastructure costs, reducing investor returns.
A groundbreaking quadruple-organ transplant at UChicago Medicine has saved the life of a young woman with cystic fibrosis. The surgery, performed by a team of experts, successfully transplanted her liver, kidney, and two lungs, offering her a second chance at life.
A linseed oil-derived polyol compound has been patented by FIU researchers, exhibiting potential to inhibit a broad spectrum of viral and bacterial infections. The compound's low cost, biodegradability, and industrial scalability make it an attractive option for global health challenges.
Researchers found significant erosion damage to graves in a 17th-century whaling site in Svalbard, with textiles nearly completely degraded over 30 years. The study reveals the physical cost of climate change on Arctic cultural heritage sites and the need for revised policies.
A UK-based National Honey Monitoring Scheme has collected data from over 3,500 beekeepers, revealing insights into environmental changes, invasive species, and pesticide risks. The study identified over 800 plant species used by honeybees, providing a valuable resource for monitoring pollinator activity.
Research finds Gentoo penguins in Argentina adjusting their breeding schedule to avoid extreme heat events, minimizing mortality. The study, published in PLOS One, reveals a positive adaptation to climate change.
A recent study by University of Florida researchers found that commercially available AIGT detectors are not effective or robust tools for determining the presence of AI-generated text. The study examined common solutions and found wildly inconsistent efficacy rates, with false positive rates between 0.05% and 68.6%.
A case study of captive belugas reveals evidence of mirror self-recognition, suggesting this behavior may be innate in the species. The findings support the idea that some cetaceans possess cognitive abilities similar to those of humans and other animals.
A national study found that over one in 10 children with medical complexity experienced a reported incident, with medication and device errors being the most common types. The study calls for targeted interventions to keep these highly vulnerable children safe.
Researchers at Newcastle University are using quantum maths to model complex memory behaviours that traditional psychological frameworks cannot easily capture. They aim to understand how emotions alter the formation, retrieval, and sequencing of memories.
Researchers have uncovered a remarkable fossil site in Canada's Northwest Territories, revealing earlier origins of animal movement, sexual reproduction, and complex life. The discovery provides unprecedented insight into the earliest evolution of complex animal life on Earth.
Global sea level has risen by 2.06 millimeters per year since 1960, doubling in recent decades, primarily due to accelerated ocean warming and reduced land water storage. The study resolves a long-standing mystery by closing the budget gap with improved instruments and analysis.
The study shows a significant 5°C warming of intermediate waters at 800m depth in the equatorial Atlantic over the last 11,000 years. This warming is not mirrored by changes in tropical sea surface temperatures, indicating an extratropical origin.
A new study published in JAMA Network Open found that patients with low-risk pancreatic cystic lesions have a high risk of developing pancreatic cancer. The study highlights the need for long-term personalized surveillance strategies for these patients, which could enable earlier detection and treatment of the disease.
A multi-stage coupled refining process converts high-acid-value waste cooking oil into high-performance natural ester insulating oil with improved physical, chemical and electrical properties. The process increases the oil's dielectric dissipation factor and power frequency breakdown voltage.
Researchers found that positional therapy leads to long-term behavior changes and improvement for patients with positional OSA. More than two-thirds of patients continued side-sleeping behavior even after stopping therapy, suggesting a potentially self-maintained therapeutic effect.
A new code-reuse attack named SFOP exploits vulnerabilities in signal handling and Intel CET in Linux systems, achieving arbitrary code execution. The attack is enabled by 12 priorly unknown weaknesses that affect Linux signals, making it practicable across all programs running on a Linux system.
Researchers developed a flexible electrochemical sensing platform that captures dynamic small-molecule chemical signals in the gut. The platform reveals a new mechanism underlying enhanced intestinal mechanosensation under microbe-related stimulation, enabling real-time monitoring of serotonin release.
A novel paper-based device has been developed to detect cancer biomarker miRNA-21 with high sensitivity and specificity. The device utilizes nanozyme-catalytic colorimetric detection, demonstrating a wide linear detection range and remarkable detection limit.
Polymer-based electrodes can help solve safety and sustainability problems in solid-state metal-ion batteries. Researchers outline design strategies to enhance performance through molecular engineering and interface modification.
A new study published at ATS 2026 International Conference found that many patients who initially struggle to meet CPAP usage thresholds continue to use and benefit from the therapy. The research challenges long-held assumptions about CPAP adherence, suggesting that early struggles don't predict treatment failure.
Researchers developed a method to produce nylon precursor cadaverine continuously using immobilized cells entrapped in carrageenan gel and crosslinked with polyethylenimine. This approach enhances enzyme stability, allowing for a titer of 112 g/L and productivity of 44.8 g/g DCW/h, surpassing previous batch processes.
Researchers used molecular docking and computational modeling to identify a superior mutant of L-amino acid deaminase, overcoming substrate inhibition at high concentrations. The mutant showed significantly enhanced catalytic efficiency and high-substrate tolerance, demonstrating a powerful approach for optimizing industrial biocatalysts.
Research in Singapore finds that households relying heavily on air-conditioning are less likely to adopt energy-saving habits and support collective climate action. The study highlights the need for city-scale heat mitigation strategies alongside individual adaptation.
New research reveals that see-through or cut-out product packaging on a shelf increases the psychological desire to own it. Customers rely on various cues when making purchasing decisions, with visibility of a product influencing choices.
Researchers discovered that long-term exposure to high viscosity environments makes glioblastoma cells smaller and more deformable, allowing them to invade healthy tissue more effectively. The study found that viscosity is not just a passive barrier but an active driver of aggressive behavior.
Shandong University researchers have developed MuSE-Promoter, a deep learning framework that integrates multiple complementary ways of looking at DNA sequences. The method consistently outperforms state-of-the-art tools in challenging cross-cell-line transfer and promoter-enhancer discrimination tasks.
Researchers have identified blood-based proteomic biomarkers that may help predict the development of psychosis in at-risk Asian youths. The study, which used data from the Longitudinal Youth at Risk Study (LYRIKS), found that models developed using the LYRIKS dataset performed better than those based on Caucasian protein patterns.
A study identified key tumor microenvironment features that can predict immunotherapy response in rare cancers, offering new insight into treatment options. The findings suggest that analyzing the tumor microenvironment beyond genomic analysis may help improve treatment selection for patients with rare cancers.
Scientists propose a strategy to control π-electron delocalization in polycyclic aromatic hydrocarbons, enabling the synthesis of narrow-spectrum emission materials. This approach results in red emitters with high efficiency, narrow spectral width, and record-high performance in OLED devices.
The University of Maryland School of Medicine has received a $2.9 million federal grant to establish an advanced microscopy facility, enabling researchers to study cellular processes with nanoscale precision. The facility will house cutting-edge instruments like the MINFLUX microscope, which can visualize molecular events in brain cell...
Researchers found that increasing ADAR2 expression in osteosarcoma cells forces them to differentiate, slowing growth and invasive capacity. The treated cells began producing mineralized matrix, a hallmark of mature bone tissue. In mice, ADAR2-restored tumors were smaller and less invasive.
YTHDF2 plays critical roles in regulating HSC fate, immune cell development, and tumor-immune interactions. It also modulates the tumor microenvironment to promote tumor progression.
The LUNA-2 trial will pair immunotherapy with fecal microbiota transplantation (FMT) to boost treatment effectiveness in people with non-small cell lung cancer. If successful, it could provide new treatment options for those living with the disease, helping them live longer and with fewer side effects.
A study found nearly 10% of surgeons left clinical practice in 8 years, with mid-career surgeons and certain specialties most likely to depart. Researchers identified specific areas where policy changes and support are needed to retain these high-risk surgeons.
A study reveals that medical exposure can rapidly change the human microbiome, with gut microbes shifting toward patterns more commonly seen in urban populations. The research found a decline in microbial diversity and a shift towards bacterial groups more common in industrialized societies.