Researchers developed a new strategy to engineer biochar with enhanced sunlight-driven chemical activity, boosting its ability to drive light-powered reduction reactions. The findings suggest that biochar can dynamically transform under sunlight, participating in complex photochemical reactions that affect pollutant behavior and metal ...
Researchers discovered potent and selective SARS-CoV-2 PLpro and RIPK1 inhibitors, SHY1643 and QY1892, that demonstrate synergistic effects in reducing viral loads and cytokine release syndromes in mice. These findings establish a proof-of-concept combination therapy strategy for treating severe COVID-19.
A new global review emphasizes that tackling climate change requires coordinated integration of financial systems, technological solutions, and governance reforms. The study presents a comprehensive framework designed to help countries implement effective and equitable climate strategies.
Researchers designed macrocyclic TRPC5 inhibitors exhibiting exceptional potency and selectivity, overcoming lipid-binding site challenges. JDIC-127 demonstrated unprecedented potency and specificity, aligning with preclinical evidence supporting its potential in treating neuropsychiatric disorders.
This study reveals that palmitoylation of Tfr1 enhances platelet ferroptosis, leading to liver injury in heat stroke. Inhibiting Tfr1-mediated ferroptosis mitigates thrombocytopenia and improves liver function.
DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targets IMPDH2 to inhibit triple-negative breast cancer cell proliferation and migration. It induces G2/M cell cycle arrest and apoptosis, and increases ROS levels and cellular DNA damage.
This study introduces Chinese medicine and intermittent fasting integration therapy, which synergistically enhances calcium-phosphorus homeostasis regulation and vascular repair, demonstrating significantly greater efficacy than traditional therapies. The miR21-5p/Tpm1 axis mediates the anti-calcification effect, promoting VSMC overpro...
Researchers developed a data-driven classification-generation cascade model to discover new chemotype antitumor drugs. WJ0976 and WJ0909, two tetrahydrocarbazole derivatives, displayed potent broad-spectrum antitumor activity against multidrug-resistant cancer cells.
Researchers developed a self-assembling peptide-based vaccine to create a localized immune niche, demonstrating its remarkable efficacy in inducing durable and potent immunity. The vaccine served as a reservoir for antigens and adjuvants, recruiting antigen-presenting dendritic cells to accumulate within the scaffold.
Developed by Compuscript Ltd, the innovative mRNA-LNP microneedle vaccine induces effective innate immune responses and robust systemic humoral responses in the spleen. It also elicits multifunctional cellular immunity, providing some protection against lung invasion by SARS-CoV-2 pseudovirus.
A new study reveals cyanobacteria as major carriers of antibiotic resistance genes in estuarine ecosystems. The researchers found strong connections between microbial carbon and nitrogen cycling and the presence of resistance genes.
A new study found that tuberculosis is a major cause of deadly sepsis among people living with HIV, particularly in Africa. Early treatment of TB has been shown to significantly reduce sepsis deaths, with a 23% reduction in mortality rate.
Acta Pharmaceutica Sinica B Volume 16, Issue 1 publishes original articles on various pharmaceutical sciences topics. The journal covers pharmacology, pharmaceutics, medicinal chemistry, natural products, and more. Recent studies explore the use of neg-entropy as a drug target for chronic diseases and psoriasis treatment.
The new S-PTP MN patch improves psoriasis therapy by facilitating deep drug penetration and sustained release of triamcinolone acetonide. It achieves superior therapeutic efficacy compared to conventional topical treatments, reducing epidermal thickness and inflammatory cytokine levels.
This guideline standardizes therapeutic drug monitoring of biologics in IBD to improve patient outcomes. It addresses five key questions, including the indicators to be monitored and the therapeutic drug trough concentration thresholds.
Researchers propose neg-entropy as key strategy for discovering new drugs targeting 'head goose molecules', which restore order from disorder in the human body. Clinically proven effective drugs that target these molecules illustrate the concept and offer hope for treating chronic diseases.
A new cross-cultural study suggests that children's behavior in situations involving fairness, trust, forgiveness, and honesty is shaped by local cultural norms. As children enter middle childhood, their behavior aligns with community values, refining their understanding of social norms and cooperation.
A Phase III clinical trial found that neuroprotective medication loberamisal improved brain cell recovery in stroke patients treated within 48 hours. The study, conducted at 32 centers in China, compared loberamisal to a placebo and showed significant benefits.
The University of Tennessee Center for Dairy Advancement and Sustainability has received an additional $3.45 million in funding for the Southeast Dairy Business Innovation Initiative, a nationwide network to facilitate regional efforts to support dairy businesses.
Children across the globe exhibit similar cooperative behaviors, such as fairness and trustworthiness, that align with adult norms over age. As children get older, their behavior reflects local norms, but younger children tend to be self-interested.
Researchers at Washington University in St. Louis have found ways to stabilize ubiquitous iron components for use in fuel cells, replacing expensive platinum metals. This innovation aims to lower costs for fuel-cell vehicles and other niche applications, enabling widespread adoption of hydrogen fuel-cell technology.
A University of Phoenix study found that integrating AI tasks into coursework improves key learning outcomes and prepares students for AI-enabled roles. The research team redesigned a course with industry advisory councils to focus on real-world needs, yielding positive results in student gains on AI skills and career competencies.
A new study from National Jewish Health reveals that exposure to burn pit smoke and desert dust can damage the lungs of military service members. The research found that particles linked to burn pit exposure cause stronger inflammation and stress in lung immune cells, leading to chronic breathing problems.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
A new hybrid optical system noninvasively tracks tissue water dynamics during hemodialysis, identifying early signs of patient instability. The system uses near-infrared spectroscopy to gather data on tissue water content and other physiological signals, providing a high-resolution portrait of the optical properties of tissue.
A new treatment combining restricted arm use with intensive physical therapy improved function and skills on the weak side in infants with perinatal arterial ischemic stroke. While results were promising, differences in responses among children highlight the need for further research.
Ovarian cancer cells recruit protective mesothelial cells in abdominal fluid to form hybrid cell clusters that resist chemotherapy. These clusters use spike-like structures called invadopodia to invade surrounding tissue. The discovery opens new treatment possibilities and could help doctors monitor disease progression.
Researchers found that many birds don't strictly follow their supposed temperature adaptations, instead moving to efficiently acquire and use energy. This 'energy efficiency' hypothesis suggests that altitudinal migration is a behavioral mechanism allowing birds to optimize their energy budgets in the face of seasonality and competition.
Five Ochsner Health hospitals have been named among Newsweek's America's Best-in-State Hospitals 2026, exceling in clinical excellence, patient experience, and innovation. These hospitals were recognized from over 6,000 nationwide for their dedication to providing excellent care.
A new treatment developed by EMBRAPA uses modulated UV-C light to combat anthracnose in guavas. The technique increases the fruit's natural resistance to microorganisms, preserving quality and shelf life.
A new study from CU Anschutz researchers found that regular physical activity can significantly lower post-ablation atrial fibrillation recurrence risk. Adults who engaged in moderate exercise for 30 minutes three times a week had markedly lower rates of AF recurrence compared to those who were less active.
A new study suggests some early life forms evolved to use oxygen hundreds of millions of years before the Great Oxidation Event, potentially delaying oxygen's accumulation in the atmosphere. This discovery adds to our understanding of aerobic respiration and its evolution on Earth.
Researchers developed a new method to measure ecosystem resilience and predict glacier surges, enabling early warnings for natural hazards. The study applies the approach to the Amazon rainforest and mountain glaciers in Alaska and Asia.
The 2026 iEnergy Frontier Forum on Power and Energy and Editorial Board Meeting was held in Hong Kong, featuring presentations by renowned experts on materials science, artificial intelligence, and low-carbon energy systems. The meeting aimed to strengthen the journal's academic quality and global influence.
A team of researchers uses CRISPR gene editing to eliminate cells with amplified oncogenes, reducing tumour growth and increasing animal survival. The study offers a promising approach for precision therapies in resistant cancers.
The URBANK database aggregates and analyzes urban data to overcome fragmentation and variability in archaeological record. It offers a multidisciplinary platform for studying cities as dynamic networks of connected elements.
Halle Zhang joins Insilico Medicine to lead global clinical development strategy for the company's oncology portfolio. She brings over 20 years of experience in oncology clinical development and a track record of advancing therapies through registrational trials.
The USF Health Institute for Voice and Hearing Innovation is a state-of-the-art facility that combines clinical research and comprehensive patient care for voice, hearing and swallowing disorders. Every patient becomes a research partner, driving innovations from lab to real-world clinical practice.
Researchers at Tohoku University successfully synthesized π-electron compounds with a pentagonal silicon framework, 'pentasilacyclopentadienide', and elucidated their molecular structures. The new compound has delocalized π-electrons and aromaticity similar to carbon-based cyclopentadienide.
Researchers from Rutgers Health examine how educators approach student wellness and find that emotional and social dimensions are prioritized. The study suggests an 'Eight Dimensions of Wellness' activity can serve as a professional development tool to enhance educator wellness while strengthening protective factors for students.
Researchers developed the Meat 3G system to predict beef eating quality, combining animal characteristics, rearing conditions, and consumer expectations. The system generates €0.10-€0.55/kg of added value for farmers, improving remuneration and competitiveness.
Blautia luti produces formic acid as an electron taxi, bypassing the energetically costly production of hydrogen. The bacterium detoxifies formic acid via a special metabolic pathway, linked to sugar breakdown and acetic acid production.
A deep learning model, DeepBlastoid, enables automated and efficient evaluation of human blastoids, reducing manual assessment's subjectivity. It achieves accuracy up to 87% and processes 273.6 images per second, while also introducing a Confidence Rate metric for reliability.
Scientists have discovered that ancient Earth magnetic field reversals lasted up to 70,000 years, revealing a new perspective on the geomagnetic phenomenon. This extended reversal period had significant impacts on atmospheric chemistry, climate processes, and the evolution of living organisms.
A recent study analyzed seabird carcasses and blood from six species in Brazil, finding similar concentrations of persistent organic pollutants (POPs) among species with different diets. The researchers discovered that the great shearwater had the highest levels of PCBs and mirex, possibly due to its migratory routes and feeding habits.
Researchers have identified a chain of events connecting genetic alterations, lipid metabolism disruptions, and Parkinson's disease manifestation. The study found that a specific gene variant increases the risk of developing Parkinson's by altering lipid functions in the brain.
The study found lecanemab to be safe and effective in slowing down cognitive decline and clearing brain Aβ deposition in Chinese patients with early AD. The results demonstrate a lower incidence of infusion-related reactions and amyloid-related imaging abnormalities compared to international clinical trials.
Researchers at JGU developed a novel three-component catalyst for pulsed electrolysis, achieving more than 50% higher ammonia yields. Additionally, they simultaneously produce formic acid as an additional product, reducing waste and increasing efficiency.
A study found that 60.8% of American women prefer in-clinic cervical cancer screening, while 20.4% opt for at-home self-sampling. Marginalized groups, including those with low income and distrust of healthcare systems, are more likely to choose at-home options.
The University of Texas at Arlington has launched the Center for Space Physics and Data Science, expanding undergraduate and graduate degree programs in space physics and data science. The center will train students across six focus areas, preparing them for careers in the rapidly growing space industry.
Researchers used advanced PET imaging techniques to study the effects of traumatic spinal cord injuries on nerve cells. Additionally, whole-body PET scans were used to map brain-body immune cross-talk during immune responses.
Researchers at The Wistar Institute have developed a new chimeric molecule that targets both Aurora kinase A and HSP90 proteins in cancer cells, improving its pharmacokinetic properties and increasing its exposure in the tumor. This approach could lead to more effective treatment with reduced side effects.
Researchers at the University of Illinois have found that the ABCA1 protein plays a crucial role in directing how myeloid immune cells, particularly macrophages, behave. When ABCA1 is expressed, these cells become better at fighting cancer and supporting T cell function.
Researchers identified surface noise mechanisms that degrade NV center coherence in diamond, which limits sensor performance. The study provides physics-based guidelines for engineering diamond surfaces to preserve quantum coherence.
Researchers at Duke University and the University of Pennsylvania observed iridium oxide nanocrystals restructure and dissolve atom by atom during electrolysis. The findings provide critical insight into why current catalysts fail and how future materials might last longer, paving the way for sustainable energy solutions.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
A new study found that removing legal barriers to cannabis use may reduce daily opioid use and lower the risk of opioid-related overdoses among people who inject drugs. US states that legalized recreational cannabis saw a 9-to-11-percentage-point decline in daily opioid use among this population.
Researchers at New York University have created a new type of time crystal that levitates on a cushion of sound, defying Newton's Third Law. This breakthrough has significant implications for technology and industry, and provides insights into biological clocks and biochemical networks.
The AI-enhanced OC-PAM system allows for longitudinal tracking of organoids, evaluating drug response and viability. It also detects rare cells within dense spheroids using radiomics-based analysis.
Researchers created a model using centuries of scientific theory and scholarly research to test the accuracy of chatbots in generating images and narratives about Neanderthals. The study found that accuracy rests on AI's ability to access source information, with many generated content referencing outdated research.