Researchers at the University of California - San Diego have developed a new method to improve gene therapy by increasing the efficacy of gene delivery while minimizing harmful side effects. The new workflow allows for increased control of nuclear DNA delivery, with greater than tenfold increase in nuclear DNA delivery observed.
A study published in Microbiome found that gut microbiome-derived butyrate activates immune cells to enhance vaccine efficacy by promoting T follicular helper (Tfh) cell activity and mucosal antibody production. This discovery highlights the crucial role of gut environment regulation in controlling infections and enhancing vaccine resp...
Researchers at USC's Kanso Bioinspired Motion Lab discovered that sea stars' tube feet respond independently to changing loads, enabling local control strategy. This decentralized approach can optimize robot locomotion and adapt to environmental changes.
A study from Sweden found autism rates among male and female individuals to be comparable, with a clear catch-up effect in females during adolescence. This challenges the long-held assumption that autism predominantly affects males.
A new study reveals that more than 7,000 adult Magellanic penguins were killed by pumas in just four years, posing a significant threat to the penguin population. The research suggests that high puma predation rates could exacerbate reproductive decline and juvenile mortality, ultimately putting the colony at risk of extinction.
Three Illinois Tech engineers recognized for their contributions to sustainable wireless communication and networking. Boris Pervan also received an award for his work on satellite navigation integrity. Thomas Wong honored for his research in high-frequency electronics and materials characterization.
A new study published in BioEssays suggests that humans' increased exposure to high temperature burn injuries may have driven notable genetic adaptations, including faster inflammation and wound closure. These traits helped humans survive small to moderate burns but became harmful for large burns.
Researchers discovered five dominant patterns of protein-altering mutations that determine tumor visibility to the immune system. These 'fingerprints' help predict immunotherapy response and suggest a more personalized approach to cancer treatment.
A study from China finds that testing menstrual blood for human papillomavirus (HPV) can detect cervical cancer with high accuracy, comparable to clinician-collected samples. The non-invasive method allows women to collect samples at home, enhancing feasibility for large-scale implementation.
A new consumer survey shows nearly six in ten Americans still believe only trained individuals should perform Hands-Only CPR. Immediate CPR is proven to improve outcomes, and research indicates it can double or triple a person's chance of survival. To learn more about Hands-Only CPR, visit the American Heart Association website.
The American Heart Association and NFL collaborate to provide Hands-Only CPR instruction during Super Bowl Experience, aiming to double survival rates by 2030. Qualified trainers will be on site, offering walk-up style instruction to the public.
Researchers at the University of Illinois developed origami-inspired waveguides that can be launched in a compact, folded state and expanded to full size after deployment into space. The design aims to improve the efficiency of high-powered satellites by delivering energy from one component to another.
The American Heart Association and the National Football League have selected 136 schools nationwide to receive grants to promote physical activity and well-being for students and faculty. The grants will support four key areas, including physical activity equipment, FLAG football, and well-being resources.
The Major Arena Soccer League is launching a league-wide initiative called Play with Heart, which aims to educate fans on Hands-Only CPR and promote heart health. The campaign will run throughout February and include in-arena activations, educational resources, and public service messages.
Researchers have developed a new algae-based biochar material that breaks down PFOA with remarkable ability. The new material combines advanced nanotechnology with sustainable biomass resources, providing a promising strategy for removing difficult contaminants from water.
A new study reveals that soil acidity influences how wheat competes with microorganisms for nitrogen. Wheat absorbed more nitrogen in calcareous soil, while microbial competition was stronger in acidic soils.
Researchers create two-stage hydrothermal liquefaction approach that transforms sludge into cleaner bio-oil with lower nitrogen content and improved fuel properties. The process reduces nitrogen levels by up to 37% and increases desirable fuel compounds, offering a promising pathway for sustainable waste management.
A new review highlights the limitations of traditional self-reported dietary tools and proposes an integrated framework combining emerging technologies to improve accuracy in dietary assessment. This approach may help build a clearer picture of what people truly eat and support healthier lives and food systems.
A recent study published in Neurology Open Access found that following a Mediterranean diet is associated with a reduced risk of stroke among women. The study, which involved over 105,000 participants, showed that the diet was linked to lower rates of ischemic and hemorrhagic strokes, as well as overall stroke risk.
A new study reveals that the surrounding microenvironment plays a crucial role in driving basal cell development, leading to treatment failure. The study also discovers intermediate tumor subtypes that could lead to new therapeutic strategies.
Researchers from Memorial Sloan Kettering Cancer Center reveal the origins of Thetis cells, which play a crucial role in teaching immune system tolerance. The team used single-nucleus DNA sequencing to shed light on pancreatic cancer evolution and identify genetic changes that occur earlier or later in disease progression.
A University of Michigan study reveals that ancient American pronghorns were built for speed, with ankle bones remaining unchanged despite environmental change. The findings suggest that pronghorns adapted to running efficiently in a mosaic of woodlands and grasslands, implying their ability to thrive in future landscapes.
A study published in Nature Communications reveals the presence of previously unknown viruses in groundwater, which influence microbial community dynamics and nutrient cycling. The findings suggest that viruses are active players in shaping the groundwater microbiome.
A study of US veterans has identified a possible link between exposure to Agent Orange and acral melanoma, a rare form of skin cancer. The researchers found that veterans exposed to the herbicide had a 30% higher odds of developing this type of melanoma.
Researchers assembled a single-cell atlas of human breast tissue, combining data from 138 patients and 600,000 single cells. The atlas identifies new cell populations and links them to tumor features and patient outcomes.
A nationwide study found that nearly two-thirds of US hospitals using Epic have adopted ambient AI tools to reduce documentation burden and improve patient-provider communication. However, adoption rates vary significantly across hospitals with differing operating margins, size, location, ownership, and staffing levels.
A Mass General Brigham-led study found that integrating feedback and personalized palliative care can improve the quality of life for children with advanced cancer. The study showed significant improvements in symptoms and well-being for patients who received the intervention, highlighting the potential benefits of early palliative care.
A new JACR focus issue explores alternative approaches to resident education, radiology residency applications, and investing in pre-clinical medical education. The study aims to spark meaningful dialogue around how radiology education is valued, supported, and delivered amidst economic challenges.
Researchers found that while the eclipse influenced sound activity and diversity, it didn't alter acoustic complexity. The study used novel acoustic capture devices to record animal vocalizations before, during, and after the April 2024 eclipse at three Ohio sites.
Researchers discovered Chlamydia pneumoniae can cause inflammation, nerve cell death and cognitive decline in Alzheimer's disease. The study suggests targeting chronic bacterial infection may represent a new treatment strategy.
The 60th International Waterbird Census has estimated the size and trends of waterbird populations, identified priority wetlands for waterbirds, and supported wetland protection and management. La Tour du Valat has contributed significantly to these efforts, particularly in the Mediterranean region.
Researchers at Salk Institute uncover two transcription factors, ZSCAN20 and JDP2, that determine T cell fate. Turning off these genes reverses T cell exhaustion and restores their ability to kill tumors without losing immune memory. The study challenges the long-standing belief of inevitable immune exhaustion.
Post-stroke spasticity affects an estimated 30-80% of stroke survivors, causing abnormal muscle tightness and involuntary spasms. Earlier diagnosis and timely intervention may improve functional outcomes and reduce long-term disability, according to the new scientific statement.
A team led by Dr. Shmuel Bialy from the Technion has made a breakthrough measurement of cosmic-ray activity in a galactic nebula, enabling researchers to map properties and study star formation processes. The findings were published in Nature Astronomy and observed using the James Webb Space Telescope.
The American College of Cardiology's Global Quality Solutions program now allows international hospitals to use approved internal data to meet accreditation requirements. This update enables hospitals to internally collect and submit aggregated data directly into ACC Accreditation tools, streamlining the accreditation process.
Scientists have developed prototype devices with lower noise levels than conventional electronics, using unconventional materials to form nanowires. These materials exhibit a unique property where noise drops as the electrical current increases, enabling potential applications in ultralow-noise communication and sensor technologies.
A new UCLA study clarifies the complex relationship between antibody-driven immunity, viral evolution, and disease severity in SARS-CoV-2. The research found that population-wide antibody responses exert a powerful selective pressure driving the virus to mutate and evade detection.
Salesky's research team will address uncertainty in how turbulent processes contribute to cloud formation by using simulations to replicate turbulence and test environmental conditions. The study aims to improve civilian and military weather forecasting models, with significant implications for precipitation and severe weather.
A UCLA research team has identified the best design for a promising new type of immunotherapy that could be mass-produced to treat multiple solid tumors. The 4-1BB-containing CAR design emerged as superior, demonstrating strongest anti-tumor activity and persistence.
A new AI tool uses discovery learning to predict battery cycle life with just a few days' data, saving months to years of testing and substantial energy. The tool leverages physics-based features to establish parallels between historical battery designs, allowing for accurate prediction performance.
Professor John P. Smol, a leading researcher on Arctic environmental changes, received the prestigious Mohn Prize from Norwegian Prime Minister Jonas Gahr Støre. Smol's work has provided crucial knowledge for addressing acid rain and pollution, with significant impacts beyond local communities.
Scientists captured rare view of beaked whales by listening to their natural sounds, revealing deep-diving behavior. The study provides the first detailed description of Gervais' beaked whale dives anywhere in the world.
New formulations of nanopesticides with natural ingredients have appeared in specialized literature, but there is no consensus on what constitutes a green pesticide. Researchers warn that terms such as 'sustainable' must be used correctly and that the natural components of these products do not eliminate environmental concerns.
An international team has successfully documented and sampled freshened water within a zone nearly 200 metres thick beneath the ocean floor. This discovery sheds light on offshore freshened groundwater systems and their relevance to coastal communities relying on groundwater for freshwater supply.
The supplement issue documents unprecedented progress in establishing dementia as a public health priority, with brain health and caregiving now core components of public health practice. The Healthy Brain Initiative and BOLD Act have built a robust framework prioritizing brain health.
The review explores how next-generation sequencing can enhance early disease detection in newborns by analyzing DNA from dried blood spots. This genomic approach expands the benefits of NGS by identifying conditions not detectable through traditional biochemical testing.
A study found that nearly a quarter of young people taking psychotropic medications were prescribed multiple medications with serious interaction risks. The greatest increases in medication use were seen among children and young adults, highlighting the need for careful monitoring and research on long-term safety.
A new study has found that improving blood flow to the brain by opening narrowed carotid arteries does not improve cognitive skills. The CREST-2 trial compared treatments and found no difference in thinking or memory over time among participants who received stenting, surgery, or intensive medical therapy.
A new study from Rice University suggests that drivers often misunderstand cyclist hand signals, which can lead to accidents. The research found that arm signals are the most effective way for drivers to understand a cyclist's intentions, but even these signals can be misinterpreted in certain situations.
Donoghue was recognized for his foundational leadership in advancing brain–computer interfaces, enabling individuals with paralysis to regain independence. His work has shown that neural activity persists even after spinal cord injury or neurological illnesses like ALS have robbed people of their ability to move.
Researchers have developed a new hydrogel dish that sharpens embryo imaging, allowing for more accurate embryo selection in IVF. This breakthrough addresses a major challenge in the field, enabling embryologists to promote healthier growth without sacrificing visibility.
Researchers from Newcastle University and Queen Mary University of London have uncovered new molecular signatures of disease severity, metabolic factors, and genetic variants. The findings offer potential for improved disease management and personalized care for patients with psoriasis.
The Bai lab has developed two patented technologies to improve electric vehicle (EV) charging and power conversion, in collaboration with FORVIA HELLA and Volkswagen Group of America. These innovations enable more efficient energy transfer between the AC grid, high-voltage car battery, and low-voltage car battery.
A new study from George Mason University reveals that AI-driven antidepressant treatment can be less effective for African American patients due to the use of general population data. The study suggests that incorporating additional patient demographics, such as race and ethnicity, can improve the tool's effectiveness.
Researchers found that adding alteplase to thrombectomy can significantly increase the chances of an excellent recovery in patients with large-artery ischemic strokes. The CHOICE2 trial showed improved outcomes in patients who received clot-busting medication after successful thrombectomy.
A new machine-learning system has been developed to overcome challenges in reading undiacritized Arabic scripts. The system, SukounBERT.v2, is designed to accurately restore diacritics and improve text readability for native speakers and foreign learners.
A new study in Biological Psychiatry found that emotional pain (guilt, shame, sadness, loss of joy) weighs more heavily on individuals with PTSD, impairing daily functioning more than fear. The research identified two distinct PTSD profiles: one centered on fear and the other on emotional pain.
University of Toronto researchers highlight the importance of studying child obesity, gut bacteria, and metabolic conditions to prevent youth-onset diabetes. They emphasize the need for personalized interventions tailored to individual microbiome profiles.
A new study by NYU Langone Health researchers identified the high-level visual cortex as the brain region responsible for one-shot perceptual learning, a type of fast flashes of insight. The team developed an AI model that replicated human-like perception using stored priors and achieved one-shot learning capability.