A circadian checkpoint relocates neutrophils to minimize injury
2 institutional releases
Published in Journal of Experimental Medicine · View the paper (DOI)
A study by CNIC reveals that neutrophils, a type of immune cell, are less aggressive at night, resulting in less severe heart attacks. Researchers developed a pharmacological strategy to block the molecular clock in neutrophils, reducing their harmful potential during infarction.
Coverage from 2 institutions
- Neutrophils are less aggressive at night, explaining why nighttime heart attacks cause less damage than daytime events Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) · Dec 12, 2025 · first to report
- Switching immune cells to “night mode” could limit damage after a heart attack, study suggests Rockefeller University Press · Dec 12, 2025