AAVLINK: Potent DNA-recombination Method for Large Cargo Delivery in Gene Therapy
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Published in Cell · View the paper (DOI)
The AAVLINK method harnesses Cre/lox-mediated intermolecular DNA recombination to enable efficient full-length gene reconstitution and robust expression of therapeutic genes. This approach overcomes the limited packaging capacity of adeno-associated viruses, offering a strategy for delivering large gene cargoes in gene therapy.