BIRC3 (encoding cIAP2) variants result in dysregulated RIPK1 signaling leading to increased epithelial cell death and are associated with Monogenic Crohn’s Disease

Published in Gastroenterology · View the paper (DOI)

Researchers have identified a previously unknown genetic cause of Crohn’s disease and uncovered its link to inflammation through the RIPK1 pathway. This discovery may guide more precise treatments and improve patient matching based on unique biology.

BIRC3 (encoding cIAP2) variants result in dysregulated RIPK1 signaling leading to increased epithelial cell death and are associated with Monogenic Crohn’s Disease

Coverage from 2 institutions