Published in Nature Communications · View the paper (DOI)
A novel AI-based approach identifies a distinct physicochemical signature near the cleavage site of gamma-secretase substrates, revealing dynamic properties essential for molecular recognition. The study highlights the potential of this methodology to improve understanding of gamma-secretase's role in diseases and aid drug development.
Coverage from 2 institutions
- Novel AI method sheds light on how enzyme linked to Alzheimer’s selects its targets DZNE - German Center for Neurodegenerative Diseases · Jul 9, 2025 · first to report
- AI analysis: How an enzyme associated with Alzheimer’s chooses its target proteins Ludwig-Maximilians-Universität München · Jul 11, 2025