Published in Science · View the paper (DOI)
In a mouse model of liver cancer, researchers found that activating the Hippo molecular signaling pathway in tumor cells drives growth, while suppressing it in surrounding healthy cells inhibits tumor growth. Systemic inhibition of Yap and Taz could have unwanted consequences by blocking tumor-suppressing abilities of healthy cells.
Coverage from 2 institutions
- Competing signals shrink or grow liver tumor at the margins American Association for the Advancement of Science (AAAS) · Nov 21, 2019 · first to report
- Encouraging normal liver cells to fight cancer VIB (the Flanders Institute for Biotechnology) · Nov 25, 2019