Published in Nature Communications · View the paper (DOI)
Researchers analyzed over 2700 C. elegans genomes to understand the causes of mutations. They found that DNA damage and inaccurate repair mechanisms can lead to mutations, which are a root cause of cancer. The study challenges the assumption of a single cause for mutational signatures in cancer genomes.
Coverage from 2 institutions
- DNA damage and faulty repair jointly cause mutations European Molecular Biology Laboratory - European Bioinformatics Institute · May 1, 2020 · first to report
- First systematic report on the tug-of-war between DNA damage and repair Institute for Basic Science · Jun 8, 2020