Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
4 institutional releases
Published in Science · View the paper (DOI)
Loss of the Y chromosome in white blood cells causes fibrosis in the heart, impaired heart function, and death from cardiovascular diseases in men. Men with this genetic change have an increased risk of developing age-related diseases such as cancer and Alzheimer's disease.
Coverage from 4 institutions
- Y chromosome loss causes heart failure and death from cardiovascular disease Uppsala University · Jul 14, 2022 · first to report
- Loss of male sex chromosome leads to earlier death for men University of Virginia Health System · Jul 14, 2022
- Mosaic loss of Y chromosome is linked to heart failure in aging men American Association for the Advancement of Science (AAAS) · Jul 14, 2022
- Y-chromosome loss due to aging and other factors worsens prognosis for heart failure Osaka Metropolitan University · Jul 15, 2022