Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition

Published in Communications Biology · View the paper (DOI)

Researchers at Kyoto University investigated the effects of two-hit stress on mice, finding that it leads to increased microglia activity, neuronal loss, and decreased brain connectivity. Microglia replacement therapy showed promise in rescuing affected mice, with female mice exhibiting higher stress resilience.

Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition

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