NKAPL suppresses NSCLC progression by enhancing the protein stability of TRIM21 and further inhibiting the NF-κB signaling pathway

Published in Genes & Diseases · View the paper (DOI)

This study found that NKAPL downregulation in NSCLC is associated with poor prognosis and hypermethylation of its promoter. High NKAPL expression inhibits NSCLC cell proliferation, migration, and invasion. NKAPL enhances TRIM21 protein stability, leading to suppression of the NF-κB signaling pathway.

NKAPL suppresses NSCLC progression by enhancing the protein stability of TRIM21 and further inhibiting the NF-κB signaling pathway

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