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Optogenetic β-cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6

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2 institutional releases

Published in Science Advances · View the paper (DOI)

The study reveals a functional hierarchy of beta cells, with a small group acting as 'first responders' to initiate the glucose response. These cells produce and supply Vitamin B6 to regulate the activity of other beta cells, offering new insights into diabetes pathology and potential treatments.

Coverage from 2 institutions

  • Researchers identify key cells for blood sugar control using optogenetics
    • Article 1 Technische Universität Dresden · Jul 4, 2024 · first to report
    • Article 2 Deutsches Zentrum fuer Diabetesforschung DZD · Jul 16, 2024