Published in Science Translational Medicine · View the paper (DOI)
Researchers discovered a new GPCR, substance P neurokinin 1 receptor (NK1R), that signals from the inside of neurons to sustain excitation and transmit pain. Targeting NK1R internalization alleviated pain in rats using modified compounds, offering prolonged pain relief.
Coverage from 2 institutions
- Pain drugs work more effectively, from the inside American Association for the Advancement of Science (AAAS) · May 31, 2017 · first to report
- Monash University researchers develop game changing strategy for pain relief Monash University · May 31, 2017