Published in JAMA · View the paper (DOI)
Researchers identified 5.05% of individuals carrying pathogenic variants in key cancer susceptibility genes, highlighting a significant association between these genetic variations and increased cancer risk. The study suggests that more extensive genetic screening for these genes may be warranted to identify high-risk individuals.
Coverage from 2 institutions
- Pathogenic germline variants in cancer susceptibility genes JAMA Network · Oct 16, 2025 · first to report
- New Cleveland Clinic research finds up to 5% of Americans carry genetic mutations associated with cancer risk Cleveland Clinic · Oct 27, 2025