Pathogenic variants damage cell compositions and single cell transcription in cardiomyopathies
3 institutional releases
Published in Science · View the paper (DOI)
Researchers used single-nucleus RNA-sequencing to study heart tissue from patients with cardiomyopathies and found distinct cell types involved in pathogenesis. Genotype-associated pathways were also identified, providing evidence that genotype influences pathological remodeling of the heart.
Coverage from 3 institutions
- A close-up look at cardiomyopathies provides a new view of how heart failure results American Association for the Advancement of Science (AAAS) · Aug 4, 2022 · first to report
- Genetic findings offer opportunity for personalized heart failure treatment Brigham and Women's Hospital · Aug 4, 2022
- How pathogenic gene variants lead to heart failure Max Delbrück Center for Molecular Medicine in the Helmholtz Association · Aug 4, 2022