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Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning

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2 institutional releases

Published in Nature Biotechnology · View the paper (DOI)

Researchers develop predictive model to control gene expression with high accuracy, enabling precise modulation of gene dosage. The AI-powered tool uses deep learning to predict on- and off-target activity of RNA-targeting CRISPRs, holding promise for treating viral infections and developing new therapies.

Coverage from 2 institutions

  • AI and CRISPR precisely control gene expression
    • Article 1 Columbia University School of Engineering and Applied Science · Jul 3, 2023 · first to report
    • Article 2 New York University · Jul 3, 2023