Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance

Published in Proceedings of the National Academy of Sciences · View the paper (DOI)

Researchers have made a giant leap in fighting antibiotic resistance by using supercomputers to redesign existing antibiotics. The new approach shows that the redesigned antibiotic is up to 56 times more active than two existing antibiotics on the World Health Organisation's list, and potentially effective against three top-ranked bact...