Published in Science · View the paper (DOI)
Researchers replaced the Y chromosome in mice by increasing expression of two genes, Sry and Eif2s3y, allowing males to produce offspring. The study demonstrates the mammalian genome's plasticity by exchanging Y chromosome genes with those on other chromosomes.
Coverage from 2 institutions
- Replacement of the Y chromosome in male mice American Association for the Advancement of Science (AAAS) · Jan 28, 2016 · first to report
- Male mice without any Y chromosome genes can father offspring after assisted reproduction University of Hawaii at Manoa · Jan 28, 2016